Digital Commons Network^™

Monitor, Shana Hoehn

Theses and Dissertations

Descriptions of a scene interwoven with thoughts on how aesthetics sets behavioral expectations, observation as proof, views from a single perspective, casting of characters, spaces that evoke complicated histories, and my own history.

Fundamental Units, Ryan M. Flores

Theses and Dissertations

Surface, Skin, Facade, Countenance, Resistance, Chinchorro Mummies,Touch, Mark Making, Residue, Intuition, Repression, Indigestion, Disassemble, Blighted,Components, Body as Containers, Levels of Hierarchy, Absorption, Plastination, Modernism and Containment, Vanitas, Disembodied, Embodiment, Fragmentation, Arches, Gothic, Typology, Stacking of Cultures, Slippage.

Hybrid Straintronics-Spintronics: Energy-Efficient Non-Volatile Devices For Boolean And Non-Boolean Computation, Ayan K. Biswas

Theses and Dissertations

Research in future generation computing is focused on reducing energy dissipation while maintaining the switching speed in a binary operation to continue the current trend of increasing transistor-density according to Moore’s law. Unlike charge-based CMOS technology, spin-based nanomagnetic technology, based on switching bistable magnetization of single domain shape-anisotropic nanomagnets, has the potential to achieve ultralow energy dissipation due to the fact that no charge motion is directly involved in switching. However, switching of magnetization has not been any less dissipative than switching transistors because most magnet switching schemes involve generating a current to produce a magnetic field, or spin transfer …

Systematic Postsynthetic Modification Of Nanoporous Organic Frameworks And Their Performance Evaluation For Selective Co2 Capture, Timur Islamoglu

Theses and Dissertations

Porous organic polymers (POPs) with high physicochemical stability have attracted significant attention from the scientific community as promising platforms for small gas separation adsorbents. Although POPs have amorphous morphology in general, with the help of organic chemistry toolbox, ultrahigh surface area materials can be synthesized. In particular, nitrogen-rich POPs have been studied intensively due to their enhanced framework-CO₂ interactions. Postsynthetic modification (PSM) of POPs has been instrumental for incorporating different functional groups into the pores of POPs which would increase the CO₂ capture properties. We have shown that functionalizing the surface of POPs with nitro and amine groups …

Are You Covered? Examining How Knowledge Of The Patient Protection And Affordable Care Act Influences Use Of Preventive Reproductive Health Services, Ashlee Sawyer

Theses and Dissertations

The Patient Protection and Affordable Care Act (PPACA) expanded access to insurance coverage and health care services for many citizens, and has increased access for women in particular by including preventive reproductive health services as essential health benefits. The current national rates of sexually transmitted infections (STIs), reproductive cancer diagnoses, and unintended pregnancy serve as major areas of concern for women’s health and public health. The present study examined how knowledge of the PPACA influences receipt of preventive reproductive health services among women. Results indicate that higher levels of knowledge of the PPACA are associated with a greater likelihood of …

Death Vegas Valley, Eric M. Diehl

Theses and Dissertations

My work explores hallucinatory landscapes of the US American West by using a combination of painting styles outside of the Western painting canon. I cross-reference painting and cinema, interweaving video, acrylic paint and the panorama to create a satirical homage to the history and present state of the USA. However, through an earnest devotion to the medium - both painting and cinema - I find my criticisms also yearn to hold onto a belief in a myth I know to be false.

This is an American History conversation about artifice and consumerism through advertising. I use Las Vegas and the …

Telomere Length In Women With Breast Cancer: A Longitudinal Study Of Their Relationship To Chemotherapy And Acquired Psychoneurological Symptoms, Areej Alhareeri

Theses and Dissertations

Breast Cancer (BC) is one of the most commonly diagnosed malignancies in females. The 5-year survival rate for women with early stage BC is about 90%. However, the quality of life (QOL) for many of these women may be adversely affected due to treatment/cancer–related side effects, including a constellation of symptoms (anxiety, depression, pain, fatigue, sleep disturbance and depression), that are collectively termed psychoneurological symptoms (PNS). To gain insight into the contributory role of telomere length (TL) in the development and persistence of PNS, we have longitudinally studied 72 women (ages 23-71) with early stage BC (I-IIIA) at 5 time …

Truth And Doubt In Representation, Mathew Gasparek

Theses and Dissertations

My work deals with the connection between the act of representation and conceptions of truth in the contemporary image-mediated social environment. This thesis details elements of my paintings in exchange with methods and ideas from artists and writers in order to position my aesthetic and conceptual sensibilities within a historical and contemporary framework.

Momentum Clinic For Teen And Young Adult Cancer Patients, Merian O'Neil

Theses and Dissertations

This study explores the needs of teen and young adult cancer patients undergoing long-term chemotherapy treatments and the design of an outpatient clinic that accommodates this population’s unique needs. Most teens endure long-term treatments in a pediatric facility targeted primarily for children, while others are treated in adult facilities. Teens have different privacy and social needs than children, and while they are not adults, they are involved in their own treatment decisions, unlike children. The target age group for this study is teens and young adults, ages thirteen to twenty-two. A common theme emerged from research and interviews conducted in …

Novel Small Airway Model Using Electrospun Decellularized Lung Extracellular Matrix, Bethany M. Young

Theses and Dissertations

Chronic respiratory diseases affects many people worldwide with little known about the mechanisms diving the pathology, making it difficult to find a cure. Improving the understanding of smooth muscle and extracellular matrix (ECM) interaction is key to developing a remedy to this leading cause of death. With currently no relevant or controllable in vivo or in vitro model to investigate diseased and normal interactions of small airway components, the development of a physiologically relevant in vitro model with comparable cell attachment, signaling, and organization is necessary to develop new treatments for airway disease. The goal of this study is to …

Direct L2 Support Vector Machine, Ljiljana Zigic

Theses and Dissertations

This dissertation introduces a novel model for solving the L2 support vector machine dubbed Direct L2 Support Vector Machine (DL2 SVM). DL2 SVM represents a new classification model that transforms the SVM's underlying quadratic programming problem into a system of linear equations with nonnegativity constraints. The devised system of linear equations has a symmetric positive definite matrix and a solution vector has to be nonnegative.

Furthermore, this dissertation introduces a novel algorithm dubbed Non-Negative Iterative Single Data Algorithm (NN ISDA) which solves the underlying DL2 SVM's constrained system of equations. This solver shows significant speedup compared to several other state-of-the-art …

The Water In Between: Where I Am And Where I Come From, Carolina Aranibar-Fernandez

Theses and Dissertations

The following thesis and project is comprised of a conceptual interwoven practice that addresses exploitation of land and labor, historically from the Spanish colonization and contemporarily through imperialism and global capital. It emphasizes oral storytelling and mythologies from the Andes. It explores socio-cultural events of gender, race, and socio economic issues, particularly in decolonial regions.

Antithetical Commentaries On X, Y And The Disruption Of Being, Eva Rocha

Theses and Dissertations

Through discursive essays and poetic narrative, Antithetical Commentaries on X, Y and the Disruption of Being explores the tenuous relationship between modes of measurement and the struggle for human relevance in the post-contemporary digital age. In the introductory essay, “Not the Feather, but the Bird”, I give an overview of the inherent problems of object-oriented ontology, and how it relates to aesthetics and social issues of our times. In the Developmental Overview, I detail how I developed my installation approach and techniques, particularly with regard to the three-way dynamic of the artist:work:viewer relationship and how it can encourage …

Sensible Nonsense, Timothy J. Woodbrey

Theses and Dissertations

“Truth happens only by establishing itself in the strife and the free space opened up by truth itself. Because truth is the opposition of clearing and concealing, there belongs to it what is here called establishing.”[i]—Martin Heidegger

All things contain their own individual existence. When I look at objects I notice material, tradition, individual history. These are starting points for my imagination to seed and germinate. My ideas are fragmented, nonlinear and nonsensical to others but they hold honesty to me. Honesty is powerful and is worth sharing.

This document is an examination of my work during …

Perceptions Of The Homeless Toward Nonprofit Human Service Provider, Lequan M. Hylton

Theses and Dissertations

As the debate intensifies regarding developing remedies to meet the needs of America’s homeless, one solution is for governmental agencies to collaborate with and employ organizations from the nonprofit sector to assist with the needs of the homeless population. Included in the nonprofit sector, faith-based organizations (FBOs) have historically been a source of debate and contention in terms of collaborations with the government. However, Presidents Reagan, George H. Bush, Clinton, George W. Bush, and Obama have embraced the idea of including FBOs in the pool of service providers offering human services. In the Richmond, Virginia region, FBOs and nonreligious nonprofit …

Fast Online Training Of L1 Support Vector Machines, Gabriella A. Melki

Theses and Dissertations

This thesis proposes a novel experimental environment (non-linear stochastic gradient descent, NL-SGD), as well as a novel online learning algorithm (OL SVM), for solving a classic nonlinear Soft Margin L1 Support Vector Machine (SVM) problem using a Stochastic Gradient Descent (SGD) algorithm. The NL-SGD implementation has a unique method of random sampling and alpha calculations. The developed code produces a competitive accuracy and speed in comparison with the solutions of the Direct L2 SVM obtained by software for Minimal Norm SVM (MN-SVM) and Non-Negative Iterative Single Data Algorithm (NN-ISDA). The latter two algorithms have shown excellent performances on large datasets; …

Quantitative Analysis Of 5-Chloro-2-Methoxy-N-[2-(4-Sulfamoylphenyl)Ethyl]Benzamide (Glyburide Analogue, Ga) In Mouse Plasma And Whole Blood Using A Micro-Extraction And Liquid Chromatography-Tandem Mass Spectrometry, Ankit Zalavadia

Theses and Dissertations

Pharmacokinetic evaluation of 5-chloro-2-methoxy-N-[2-(4- sulfamoylphenyl)ethyl]benzamide in mouse plasma demanded for a suitable bioanalytical method. No reported bioanalytical method exists to-date that can quantify concentration of this compound in any biological matrix. The purpose of this study was 1) to develop and validate a new bioanalytical method using a micro-extraction and LC-MS/MS to quantify the target analyte in mouse plasma and 2) to partially validate the method in whole blood. A bioanalytical method was developed and validated in both matrices for a linear concentration range of 2-1000 ng/ml. For both matrices, the reverse predicted concentration of calibration standards (-8.95% to 12.16% …

Conditional Cardiac-Specific Akap13 Knockout Induces Sex Dependent Biventricular Dilated Cardiomyopathy With Sarcomeric And Mitochondrial Defects, Kimberlyn M. Baig-Ward

Theses and Dissertations

Heart disease is a complex and heterogeneous disease. Notably, studies have demonstrated gender differences in the expression and types of cardiovascular disease, such as dilated cardiomyopathy (DCM), a major underlying cause of heart failure. Previously we showed that loss of A-Kinase Anchoring Protein 13 (Akap13), a unique proto-oncogene and estrogen receptor modulator, resulted in enlarged embryonic hearts, defective cardiac sarcomere formation, and embryonic lethality in mice. Data have also shown cAMP-dependent Protein Kinase A (PKA) to be involved in DCM pathophysiology. Given the established role of AKAP13 in cell signaling, its ability to bind and modulate ligand-activated nuclear hormone …

Exploring The Outcomes Of Rehabilitative Care For Veterans And Service Members Treated For A Disorder Of Consciousness In The Vha Emerging Conciousness Program, Janette A. Hamilton

Theses and Dissertations

Over the past several years, there has been an influx in patients being treated for polytraumatic injuries within the Veterans Health Administration (VHA), largely due to the wars in Afghanistan and Iraq, but also due to advances in life sustaining medical interventions. The polytrauma population includes veterans who have sustained a severe traumatic or non-traumatic brain injury, and a significant loss in cognitive and physical functioning, referred to as a disorder of consciousness. The purpose of the current study was to explore factors related to successful emergence from a disorder of consciousness, using a sample of veterans who were treated …

Response Adaptive Randomization Using Surrogate And Primary Endpoints, Hui Wang

Theses and Dissertations

In recent years, adaptive designs in clinical trials have been attractive due to their efficiency and flexibility. Response adaptive randomization procedures in phase II or III clinical trials are proposed to appeal ethical concerns by skewing the probability of patient assignments based on the responses obtained thus far, so that more patients will be assigned to a superior treatment group. General response-adaptive randomizations usually assume that the primary endpoint can be obtained quickly after the treatment. However, in real clinical trials, the primary outcome is delayed, making it unusable for adaptation. Therefore, we utilize surrogate and primary endpoints simultaneously to …

Memory Of A Landscape, Elizabeth Halliday

Theses and Dissertations

Artist Statement

Creativity is one of my strongest talents. As a visual person, I understand and interpret the world through observation and analysis. Nature intrigues me. I find it awe inspiring how the natural environment can change so dramatically day-to-day. As a result, I record my experiences and memories of landscapes and seascapes.

My areas of interest are painting and computers in the arts. I am an abstract painter and my media consists of acrylic, watercolor, mixed media, and digital imagery. I create low relief and rough textures with added materials, and develop layers of paint with a palette knife. …

Development Of An Instrument To Measure K-12 Teacher Demoralization In A Test-Based Accountability Context, Heather A. Carlson-Jaquez

Theses and Dissertations

The purpose of this study was to develop an instrument to measure K-12 teacher demoralization. An increasing body of literature has labeled modern education policies as having a demoralizing effect on teachers (Darling-Hammond & Rustique-Forrester, 2002; Noddings, 2004; Ryan & Brown, 2005; Nichols & Berliner, 2007; Santoro, 2011; Hargreaves, Braun, & Gebhardt, 2013). Teacher demoralization has been defined as a teacher’s “inability to access the moral rewards of teaching” (Santoro, 2011, p. 3). Data was collected from a population of K-12 educators through cognitive interviews (n=6) and a large scale data collection analyzed with a principal component analysis …

Catching Up And Staying Out Of Trouble: Serious Juvenile Offenders’ Facility School Experiences And Their Transition To The Community, Lena Jäggi

Theses and Dissertations

Despite recent drops in rates, juvenile incarceration remains a serious issue in the United States (Hockenberry, 2013; Mendel, 2011). One shared part of the incarceration experience across different systems and facility types is the obligation for juvenile offenders to receive correctional education. Ample research demonstrates that increased academic achievement, attending community school, and being employed are connected to better community outcomes and desistance, yet little is known about how school experiences in the facility influences these outcomes. Applying life-course theory of the development of crime (Sampson & Laub, 1997, 2005), the present study investigates whether correctional education serves as a …

Strata, Lauren Hale

Theses and Dissertations

In my mixed media pieces and sculptural books, I explore the significance of place. Place is not just a geographical location; it is a layered history that tells a story. My experiences in a specific environment and how I relate to it, study it, remember it, or imagine it drive me to create pieces. While the choices I make are influenced by my own experiences, I want to evoke feelings of familiarity, intrigue, and a sense of nostalgia.

In my process, I intuitively layer paint, printed materials, and mixed media to make a foundation for exploration. I continue to …

Capturing Memory, Morgan A. Molenda

Theses and Dissertations

In my work, I present the moments of true emotional clarity and impactful memories from my life. I strive to provide insight into my experiences and my understanding of others’ motivations. The creative process helps safely guide me through memories of the past and understanding of others.

In my abstracted mixed media paintings and crafts, I use bold jewel tones to express strong feelings and passionate emotions. I also incorporate found objects and paints to communicate the layers and varied depth of memories. With the use of these varied materials, I have developed a personal symbolic language that allows me …

Functional Significance Of Mtdna Cytosine Modification Tested By Genome Editing, Jason M. Robinson

Theses and Dissertations

The field of epigenetics is gaining popularity and speed, due in part to its capability to answer lingering questions about the root cause of certain diseases. Epigenetics plays a crucial role in regulation of the cell and cell survival, particularly by cytosine methylation. It remains controversial if DNMT’s which facilitate methylation are present in mammalian mitochondria and what the functional significance they may have on modification of mitochondrial DNA. CRISPR-Cas9 technology enabled genome editing to remove the MTS (mitochondrial targeting sequence) from DNMT1 of HCT116 cells, purposefully minimizing effects on nuclear cytosine methylation, while exclusively impacting mitochondrial modification. Removal of …

Evaluating A Brief Web-Based Prevention Intervention For Risky Alcohol Use Among College Students, Zoe Neale

Theses and Dissertations

The purpose of this study was to evaluate a brief, web-based alcohol prevention intervention program as a universal approach to addressing the range of alcohol behaviors present on college campuses. The sample of freshman college students recruited from Spit for Science (Dick et al., 2014) included 153 intervention participants, and 151 control participants matched on demographics and baseline alcohol variables. Hierarchical multiple regression, logistic regression, and moderated multiple regression were used to compare intervention and control participants on post-intervention alcohol variables. Treatment predicted lower alcohol use disorder (AUD) symptoms, particularly among baseline drinkers. For non-drinkers, the intervention was associated with …

Human Neural Progenitor Cells Are Productively Infected By R5-Tropic Hiv-1: Opiate Interactions On Infection And Function Involve Cdk5 Signaling, Joyce Magat Balinang

Theses and Dissertations

Human immunodeficiency virus type 1 (HIV-1) is known to cause a spectrum of neurological, behavioral and motor deficits collectively termed as HIV-1 associated neurocognitive impairments (HAND). Opiates augment HIV-related CNS complications through both direct and indirect mechanisms that disrupt glial and neuronal function. All CNS macroglia and neurons derive from neural progenitor cells (NPCs) during development, and NPCs in the adult brain contribute to repair processes. Since disruptions in NPC function are known to impact CNS populations and brain function in a number of disease/injury conditions, we determined whether HIV ± opiate exposure affected the maturation and fate of human …

Information Needs And Information Sources Of Patients Diagnosed With Rare Cancers, Dana L. Ladd

Theses and Dissertations

Abstract

INFORMATION NEEDS AND INFORMATION SOURCES OF PATIENTS DIAGNOSED WITH RARE CANCERS

By Dana L. Ladd, Ph.D., MS, SLIS

BACKGROUND: Approximately 25% of all cancers diagnosed are considered rare. Patients may face many significant challenges including difficulty obtaining information about their rare conditions. Patients often have high information needs and may seek desired information from a variety of informational sources including healthcare providers, media, print, government and non-profit organizations in order to meet their needs. Accessing reliable consumer-level information can be challenging and often information needs are unmet. Dissatisfaction with health information provision can result in negative health-related outcomes and …

Behaviorally Induced Insufficient Sleep Syndrome And Insomnia: Prevalence And Relationship To Depression In College Students, Allison Baylor

Theses and Dissertations

Background: College students are at increased risk for general sleep issues as well as specific disorders, including Behaviorally Induced Insufficient Sleep Syndrome (BISS) and insomnia. These disorders can have deleterious daytime consequences, which can be compounded by exacerbating depression. The present study aims to establish college prevalence of BISS/insomnia, to characterize sleep characteristics in this sample, and to compare depression across BISS/insomnia.

Methods: Data from a college risk behaviors and health study (n=989) was used. Insomnia and BISS were defined as mutually exclusive disorders, using ICD-10/DSM-5 criteria, and Pittsburg Sleep Quality Index items.

Results: Overall, the results of this study …