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Unconfessing Transgender: Dysphoric Youths And The Medicalization Of Madness In John Gower’S “Tale Of Iphis And Ianthe”, M W. Bychowski

Accessus

On the brink of the twenty-first century, Judith Butler argues in “Undiagnosing Gender” that the Diagnostic and Statistical Manual of Mental Disorders (DSM) defines the psychiatric condition of “Gender Identity Disorder” (or “Gender Dysphoria”) in ways that control biological diversity and construct “transgender” as a marginalized identity. By turning the study of gender away from vulnerable individuals and towards the broader systems of power, Butler works to liberate bodies from the medical mechanisms managing difference and precluding potentially disruptive innovations in forms of life and embodiment by creating categories of gender and disability.

Turning to the brink of the 15 …

Low Level Phosphorylation Of Histone H2ax On Serine 139 (Gammah2ax) Is Not Associated With Dna Double-Strand Breaks, Paulina Rybak, Agnieszka Hoang, Lukasz Bujnowicz, Tytus Bernas, Zbigniew Darzynkiewicz, Jerzy Dobrucki

NYMC Faculty Publications

Phosphorylation of histone H2AX on serine 139 (γH2AX) is an early step in cellular response to a DNA double-strand break (DSB). γH2AX foci are generally regarded as markers of DSBs. A growing body of evidence demonstrates, however, that while induction of DSBs always brings about phosphorylation of histone H2AX, the reverse is not true - the presence of γH2AX foci should not be considered an unequivocal marker of DNA double-strand breaks. We studied DNA damage induced in A549 human lung adenocarcinoma cells by topoisomerase type I and II inhibitors (0.2 μM camptothecin, 10 μM etoposide or 0.2 μM mitoxantrone for …

Slides: Policy Framework: Fpwec: First Peoples' Water Engagement Council, Phil Duncan, First Peoples' Water Engagement Council

Indigenous Water Justice Symposium (June 6)

Presenter: Phil Duncan, Gomeroi Nation, New South Wales Aboriginal Land Council

25 slides

Agenda: Indigenous Water Justice Symposium, University Of Colorado Boulder. Getches-Wilkinson Center For Natural Resources, Energy, And The Environment

Indigenous Water Justice Symposium (June 6)

Indigenous peoples throughout the world face diverse and often formidable challenges of what might be termed “water justice.” On one hand, these challenges involve issues of distributional justice that concern Indigenous communities’ relative abilities to access and use water for self-determined purposes. On the other hand, issues of procedural justice are frequently associated with water allocation and management, encompassing fundamental matters like representation within governance entities and participation in decision-making processes. Yet another realm of water justice in which disputes are commonplace relates to the persistence of, and respect afforded to, Indigenous communities’ cultural traditions and values surrounding water—more specifically, …

Design And Validate A Synthetic Circuit For Detecting Pathway Signaling In Mammalian Cells, Darisha Jhutty, Nicholas Parker

Bioengineering Senior Theses

Synthetic circuits provide novel ways for scientists to program and probe mammalian cell behavior. This allows for enhanced research tools and chemical sensors. Our project works with an engineered synthetic circuit and monitors the output of the circuit using green fluorescent protein( GFP) and luciferase. Expression of GFP is both quantifiable and observable over a time period in living cells. Luciferase can be detected by an assay in lysed cells to give data on overall expression of the circuit. By measuring and comparing output of this circuit over time, we can create a model to demonstrate the lack of expression, …

Ada News - 06/06/2016, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Exosome Engineering And Imaging, Joseph Losacco, Sophie Mcdevitt, Zachary Stickney

Bioengineering Senior Theses

There are many new pharmaceuticals being developed for the treatment of various diseases. One of the major issues these drugs face is the ability to enter a cell or the area of treatment. The current methods for drug delivery are often arduous to complete and do not make it to the diseased area because they are targeted by the immune system. In order to improve the ability for drugs to reach the desired area we propose the use of exosomes. Exosomes are subcellular vesicles that are responsible for the transport of biomaterials or signals within the cell and to other …

Aptamer Based Hybrid-Assay For Early Stage Disease Diagnosis, Riley S. Parsons, Mari A. Ueno

Bioengineering Senior Theses

The objective of the project is to use aptamers, oligonucleotides designed to selectively bind target molecules, to develop a methodology for building an enzyme-linked aptasorbent assay (ELASA). This assay is designed to detect the presence of a target protein nucleolin that is overexpressed on the surface of cancer cells, and it would act as a novel diagnostic method for the disease. The success of our project would also confirm the feasibility of using an ELASA as a diagnostic tool to detect the presence of thrombospondin-1 (TSP-1), a protein known to experience glycosylation changes in human endometrioid ovarian cancer tissue. Our …

Si Min Cen V. Attorney General United States

2016 Decisions

Agency

Connection Between Effort And Academic Success In Learning Disabled Students Identified With Learned Helplessness, Nancy D. Braunwell

Theses and Dissertations

This research was conducted with high school students eligible for special education services that have also been identified with learned helplessness. Students were given the intervention of study activity and exposure to success via assessments to determine if they would make a connection between their effort and their academic success. This connection is typically absent in learned helpless students. The data indicated that these students did make that connection and would continue the study activity on their own time after the intervention period to continue to experience success.

Genetic Analysis Reveals A Hierarchy Of Interactions Between Polycystin-Encoding Genes And Genes Controlling Cilia Function During Left-Right Determination, Daniel T. Grimes, Jennifer L. Keynton, Maria T. Buenavista, Xingjian Jin, Saloni H. Patel, Shinohara Kyosuke, Jennifer Vibert, Debbie J. Williams, Hiroshi Hamada, Rohana Hussain, Surya M. Nauli, Dominic P. Norris

Pharmacy Faculty Articles and Research

During mammalian development, left-right (L-R) asymmetry is established by a cilia-driven leftward fluid flow within a midline embryonic cavity called the node. This ‘nodal flow’ is detected by peripherally-located crown cells that each assemble a primary cilium which contain the putative Ca²⁺ channel PKD2. The interaction of flow and crown cell cilia promotes left side-specific expression of Nodal in the lateral plate mesoderm (LPM). Whilst the PKD2-interacting protein PKD1L1 has also been implicated in L-R patterning, the underlying mechanism by which flow is detected and the genetic relationship between Polycystin function and asymmetric gene expression remains unknown. Here, we …

Cooled Perch Effects On Performance And Well-Being Traits In Caged White Leghorn Hens, J Y. Hu, P Y. Hester, M M. Makagon, G Vezzoli, R S. Gates, Y Xiong, H W. Cheng

Department of Animal Science: Faculty Publications

We assessed the effects of chilled water cooling perches on hen performance and physiological and behavioral parameters under “natural” high temperatures during the 2013 summer with a 4-hour acute heating episode. White Leghorns at 16 wk of age (N = 162) were randomly assigned to 18 cages (n = 9) arranged into 3 units. Each unit was assigned to one of the 3 treatments through 32 wk of age: 1) cooled perches, 2) air perches, and 3) no perches. Chilled water (10◦C) was circulated through the cooled perches when cage ambient temperature exceeded 25^◦C. At the age of …

Childhood Health Status And Adulthood Cardiovascular Disease Morbidity In Rural China: Are They Related?, Qing Wang, Jay Shen

School of Public Health Faculty Research

Cardiovascular diseases (CVDs) are among the top health problems of the Chinese population. Although mounting evidence suggests that early childhood health status has an enduring effect on late life chronic morbidity, no study so far has analyzed the issue in China. Using nationally representative data from the 2013 China Health and Retirement Longitudinal Study (CHARLS), a Probit model and Two-Stage Residual Inclusion estimation estimator were applied to analyze the relationship between childhood health status and adulthood cardiovascular disease in rural China. Good childhood health was associated with reduced risk of adult CVDs. Given the long-term effects of childhood health on …

Enterocyte-Associated Microbiome Of The Hadza Hunter-Gatherers, S. Turroni, S Rampelli, M Centanni, S. L. Schnorr, C. Consolandi, M. Severgnini, C. Peano, M. Soverini, M. Falconi, Alyssa Crittenden, A. G. Henry, P. Brigidi, M. Candela

Anthropology Faculty Research

By means of a recently developed non-invasive ex vivo minimal model based on the interaction of the human enterocyte-like HT29 cell line and fecal slurries, we explored the enterocyte-associated microbiome of 21 Hadza hunter-gatherers and nine urban living Italians. Though reductionist, this model allows inferring the microbiota structural and functional arrangement as it interacts with enterocytes. Microbial suspensions obtained from Hadza or Italian stools were first evaluated for structural integrity by high resolution-scanning electron microscopy and co-incubated with HT29 cell monolayers. The enterocyte adherent microbiota fraction was then characterized by 16S rRNA gene sequencing and predictive functional profiling using PICRUSt. …

Meet Your Milk At Unh Open Barn June 18, Lori Wright

UNH Today Archive

No abstract provided.

Enterocyte Associated Microbiome Of The Hadza Hunter-Gatherers, Silvia Turroni, Simone Rampelli, Manuela Centanni, Stephanie L. Schnorr, Clarissa Consolandi, Marco Severgnini, Clelia Peano Matteo, Soverini, Mirella Falconi, Alyssa N. Crittenden Amanda, G. Henry, Patrizia Brigidi, Marco Candela

Anthropology Faculty Research

By means of a recently developed non-invasive ex vivo minimal model based on the interaction of the human enterocyte-like HT29 cell line and fecal slurries, we explored the enterocyte-associated microbiome of 21 Hadza hunter-gatherers and nine urban living Italians. Though reductionist, this model allows inferring the microbiota structural and functional arrangement as it interacts with enterocytes. Microbial suspensions obtained from Hadza or Italian stools were first evaluated for structural integrity by high resolution-scanning electron microscopy and co-incubated with HT29 cell monolayers. The enterocyte adherent microbiota fraction was then characterized by 16S rRNA gene sequencing and predictive functional profiling using PICRUSt. …

Reporting Or Reconstructing? The Zine As A Medium For Reflecting On Research Experiences, Silvia Vong

Communications in Information Literacy

In a research-based course, undergraduate third year students were asked to submit their reflections on their research experience in the zine medium. While the literature shows that the zine medium can encourage students to reflect meaningfully about their experiences, evaluating the medium, which is a mix of text and visuals, can be challenging for the instructor. This paper explores the value of zines as a medium for reflection using the 4R Reflection Scale as a framework. The 4R Scale by Ryan and Ryan (2015) outlines four levels, reporting and responding, relating, reasoning and reconstructing, to determine the depth of thinking …

The Pseudomonas Aeruginosa Efflux Pump Mexghi-Opmd Transports A Natural Phenazine That Controls Gene Expression And Biofilm Development, Hassan Sakhtah, Leslie Koyama, Yihan Zhang, Diana K. Morales, Blanche Fields, Alexa Price-Whelan, Deborah Hogan

Dartmouth Scholarship

Redox-cycling compounds, including endogenously produced phenazine antibiotics, induce expression of the efflux pump MexGHI-OpmD in the opportunistic pathogen Pseudomonas aeruginosa Previous studies of P. aeruginosa virulence, physiology, and biofilm development have focused on the blue phenazine pyocyanin and the yellow phenazine-1-carboxylic acid (PCA). In P. aeruginosa phenazine biosynthesis, conversion of PCA to pyocyanin is presumed to proceed through the intermediate 5-methylphenazine-1-carboxylate (5-Me-PCA), a reactive compound that has eluded detection in most laboratory samples. Here, we apply electrochemical methods to directly detect 5-Me-PCA and find that it is transported by MexGHI-OpmD in P. aeruginosa strain PA14 planktonic and biofilm cells. We …

Complete Design Methodology Of A Massively Parallel And Pipelined Memristive Stateful Imply Logic Based Reconfigurable Architecture, Kamela Choudhury Rahman

Dissertations and Theses

Continued dimensional scaling of CMOS processes is approaching fundamental limits and therefore, alternate new devices and microarchitectures are explored to address the growing need of area scaling and performance gain. New nanotechnologies, such as memristors, emerge. Memristors can be used to perform stateful logic with nanowire crossbars, which allows for implementation of very large binary networks that can be easily reconfigured. This research involves the design of a memristor-based massively parallel datapath for various applications, specifically SIMD (Single Instruction Multiple Data) like architecture, and parallel pipelines. The dissertation develops a new model of massively parallel memristor-CMOS hybrid datapath architectures at …

Atomistic Corrective Scheme For Supercell Density Functional Theory Calculations Of Charged Defects, Tengfei Cao, Angelo Bongiorno

Publications and Research

A new method to correct formation energies of charged defects obtained by supercell densityfunctional calculations is presented and applied to bulk, surface, and low-dimensional systems. The method relies on atomistic models and a polarizable force field to describe a material system and its dielectric properties. The polarizable force field is based on a minimal set of fitting parameters, it accounts for the dielectric screening arising from ions and electrons separately, and it can be easily implemented in any software for atomistic molecular dynamics simulations. This work illustrates both technical aspects and applications of the new corrective scheme. The method is …

Finding The Beat: From Socially Coordinated Vocalizations In Songbirds To Rhythmic Entrainment In Humans, Jonathan I. Benichov, Eitan Globerson, Ofer Tchernichovski

Publications and Research

Humans and oscine songbirds share the rare capacity for vocal learning. Songbirds have the ability to acquire songs and calls of various rhythms through imitation. In several species, birds can even coordinate the timing of their vocalizations with other individuals in duets that are synchronized with millisecond-accuracy. It is not known, however, if songbirds can perceive rhythms holistically nor if they are capable of spontaneous entrainment to complex rhythms, in a manner similar to humans. Here we review emerging evidence from studies of rhythm generation and vocal coordination across songbirds and humans. In particular, recently developed experimental methods have revealed …

My News

My News (2014-2020)

• Georgia Southern students study in the Sahara
• Rawat wins prestigious NSF CAREER award
• Carroll selected as a 2016 Governor’s Teaching Fellow
• Never too late to accomplish a goal
• Lot 21 construction is underway
• Georgia Southern student receives scholarship for work with Your Skin Is In college ambassador program
• Faculty Spotlight: Jonathan Hilpert, Ph.D.

The Impact Of Regulatory Changes On The Development Of Mobile Medical Apps, Martin Mchugh, Deirdre Lillis

Conference papers

Mobile applications are being used to perform a wide variety of tasks in day-to-day life ranging from checking email, to controlling your home heating. Application developers have recognized the potential to transform a smart device into a medical device, by using a mobile medical application i.e. a mobile phone or a tablet. When initially conceived these mobile medical applications performed basic functions e.g. BMI calculator, accessing reference material etc.; however, increasing complexity offers clinicians and patients a range of functionality. As this complexity and functionality increases, so too does the potential risk associated with using such an application. Examples include …

Microfluidic E. Coli Detection, Kyle Pietrzyk, Scott Fukuoka, Andres Maldonado-Liu, Andy Ly

Interdisciplinary Design Senior Theses

In both developed and developing countries, there is a need for a fast diagnostic system to detect pathogens within a fluid sample. In developing a microfluidic platform, which utilizes a microfluidic chip and an optical detection method, doors may be opened for new methods of determining pathogen concentration in fluid. Most biological reactions are not instantaneous. A flow-controlling mechanism with no power requirement may be implemented in the microfluidic platform. As a proof-of-concept, our device uses a microfluidic chip, smartphone, and microlens to detect E. coli concentrations in water. The detection method is based on the latex agglutination assay which …

Mitigation Of Radiation-Induced Bone Loss By Dried Plum, Carlos Medina, Sonette Steczina

Bioengineering Senior Theses

In recent years, much attention has been given to the effects of radiation on bone deterioration. Past research has demonstrated that radiation acts to alter the balance between osteoblasts and osteoclasts, promoting a net osteoclastic activity in the affected bone tissue, but specific molecular mechanisms remain unknown. Gene expression of many osteoclast markers is upregulated early in response to radiation, leading to bone resorption. This problem is especially prominent in space, as astronauts are regularly exposed to full body ionizing radiation that, over extended periods of time, may lead to significant bone loss. Research suggests that radiation leads to an …

Computational Design Of Synthetic Antibodies For Consumer Diagnostic Tests, Jon Henry Therriault, Thomas Evans

Bioengineering Senior Theses

Described herein is a novel workflow for the synthesis of engineered peptide biomolecules that mimic the function and activity of monoclonal antibodies. The technique uses computational design and unnatural amino acid chemistry to deliver a comparable alternative to monoclonal antibodies. The software package Chimera8, developed at UCSF for molecular visualization and open-source for academic licenses, was used to select hits from a library of peptides that had strong predicted binding to disease biomarkers. Each candidate peptide was scored based on electrostatic interactions with the target and ranked in order of predicted binding affinity.

The top hits were then engineered to …

Innovations In Traumatic Hemorrhage, Joseph Anthony Ikaika Choy, Nicholas Domek, John “Patrick” Tavelli

Bioengineering Senior Theses

Traumatic hemorrhagic injuries present a great problem to humanity and a challenge to medicine in the modern world. Current methods of treating these injuries in the field are ineffective and often extremely overkill or injurious. These methods are particularly inadequate when applied to the continuous high pressure bleeding that occurs from arterial wounds. Our project focuses on lowering the barriers to entry to innovation in the field of bleeding treatment by creating a low cost model of the human circulatory system. This model can function as a low-cost testing platform for novel bleeding treatments developed by companies and individuals that …

The Influence Of Richard Wagner’S Ring Cycle On C. S. Lewis, John Macinnis

Inklings Forever: Published Colloquium Proceedings 1997-2016

No abstract provided.

A Beast’S Best Friend: Interspecies Friendship In The Thought Of C. S. Lewis, Edwin Woodruff Tait

Inklings Forever: Published Colloquium Proceedings 1997-2016

No abstract provided.

Two Strategies For Defending Naturalism Against C. S. Lewis’S And Victor Reppert’S Argument From Reason, Louis J. Swingrover

Inklings Forever: Published Colloquium Proceedings 1997-2016

No abstract provided.