Digital Commons Network^™

Emotional Fit: Developing A New Fashion Design Methodology For Mature Women, Katherine Townsend, Ania Sadkowska, Juliana Sissons

DRS Biennial Conference Series

This paper reports on a user-centered methodological approach towards fashion design for mature women (55+). Referred to as the ‘baby boomers’ the women in this study are the product of the cultural revolution of the 1960s, who consequently have a strong sense of their own ‘agency’, as conveyed through their clothing and style, but now find themselves stepping into the unknown territory of a limited market. The majority of fashion brands and stores are aimed at younger consumers, and with some exceptions, it is only high and niche designer labels who are offering stylish garments that complement the changing bodies …

(Re)Working The Past, (Dis)Playing The Future. Italy: The New Domestic Landscape At Moma, 1972, Ingrid Halland Rashidi

DRS Biennial Conference Series

Would a work—a painting, a building, a chair or a display—always operate within the framework of human intention? To bring thinking into the future, there is a need for future-focused methodologies. In this paper I will re-work the past by addressing the agency beyond human intention. By using the 1972 MoMA exhibition “Italy: The New Domestic Landscape” as the empirical case, the paper will show how not only humans conceptualize reality, but things themselves have the capacity to display the future.

Learning To Learn What Can Be Learned From Firsthand Experience With Materials?, Biljana C. Fredriksen

DRS Biennial Conference Series

A child cannot be taught how to walk – it has to sense the balance of its body, the smoothness of the floor, the strength of its muscles, and respond appropriately. The author argues that the process of learning depends on embodied functions and subjective experiences of the one who is learning. This paper discusses the first-hand perspective in the process of material transformation. During such a process, the acting person has to be attentive and make innumerable adaptive choices. Examples from a doctoral study focusing on young children (3 year olds), illustrate how the children’s first-person experiences related to …

Collaborative Imaging. The Communicative Practice Of Hand Sketching In Experimental Physics, Judith Marlen Dobler

DRS Biennial Conference Series

This paper presents on-going ethnographic fieldwork in design research conducted in an x-ray laboratory. The study investigates physicists’ hand sketching as a collaborative imaging practice and depicts collaborative drawing as a distinct form of knowledge in between the spaces of notation and verbal articulation. Physicists’ collaborative sketching is captured through methods taken from design research and STS, including participant observation, videography and drawings by the design researcher. In order to analyse the functions of the collaborative sketching, three key aspects of the research are discussed in this paper. First, the spaces and materiality of the laboratory are observed. Second, the …

Uber And Language/Action Theory, Michael Arnold Mages

DRS Biennial Conference Series

Mediated communication is the way that distributed and proximate work teams communicate, and is structured nearly completely through software. Users request and make commitments, collaborate on and complete projects, and develop new software systems through software-based conversations. Yet, software designers and developers approach designing conversation software as a series of generic submissions, rather than as an iterative and reflexive process of specific and varied types of speech-acts. This paper examines two pieces of software: The Coordinator and the Uber Partner (driver) app, and a summary of the dialog surrounding the release of the Coordinator as an implementation of Language/Action Theory.

Pharmacologic Inhibition Of Host Phosphodiesterase-4 Improves Isoniazid-Mediated Clearance Of Mycobacterium Tuberculosis, Selvakumar Subbian, Mi-Sun Koo, Liana Tsenova, Vikram Khetani, Jerome B. Zeldis, Dorothy Fallows, Gilla Kaplan

Publications and Research

The lengthy duration of multidrug therapy needed to cure tuberculosis (TB) poses significant challenges for global control of the disease. Moreover, chronic inflammation associated with TB leads to pulmonary damage that can remain even after successful cure. Thus, there is a great need for the development of effective shorter drug regimens to improve clinical outcome and strengthen TB control. Host-directed therapy (HDT) is emerging as a novel adjunctive strategy to enhance the efficacy and shorten the duration of TB treatment. Previously, we showed that the administration of CC-3052, a phosphodiesterase-4 inhibitor (PDE4i), reduced the host inflammatory response during Mycobacterium tuberculosis …

Measurements Of Hydrogen, Oxygen And Carbon Isotope Variability In Sphagnum Moss Along A Micro-Topographical Gradient In A Southern Patagonian Peatland, N. J. Loader, F. A. Street-Perrott, D. Mauquoy, T. P. Roland, Bellen S Van, T. J. Daley, D. Davies, P. D.M. Hughes, V. O. Pancotto, G. H.F. Young, M. J. Amesbury, D. J. Charman, G. Mallon, Z. C. Yu

School of Geography, Earth and Environmental Sciences

Peat archives offer a diverse range of physical and chemical proxies from which it is possible to study past environmental and ecological changes. Direct numerical calibration and verification is difficult so process-based and mechanistic studies are therefore required to establish and quantify links between environmental changes and their associated proxy-responses. Traditional ‘space-for-time’ calibrations provide a solution to this calibration problem, but are often unable to isolate a single environmental variable from other potentially confounding variables. In this study, we explored the potential of a site-specific ‘space-for-time’ approach applied to a hummock-hollow transect on an ombrotrophic raised bog in Patagonia, southern …

Bioeconomic Model Of Rainbow Trout (Oncorhynchus Mykiss) And Humpback Chub (Gila Cypha) Management In The Grand Canyon, Lucas S. Bair, Charles B. Yackulic, Michael R. Springborn, Mathew N. Reimer, Craig A. Bond

World Conference on Natural Resource Modeling

The Colorado River, from Glen Canyon Dam (GCD) to the Little Colorado River (LCR) confluence, includes both non-native Rainbow Trout (Oncorhynchus mykiss) and endangered native Humpback Chub (Gila cypha). While both Rainbow Trout and Humpback Chub are valued fish species in this system, Rainbow Trout can have a negative effect on Humpback Chub survival. We developed a bioeconomic model to determine management actions that minimize the costs of controlling Rainbow Trout abundance subject to achieving Humpback Chub population goals. The model is compartmentalized into population and management components. The population component characterizes the stylized dynamics of …

Effects Of Changing Climate And Water Availability On Four Riparian Species In The Southwestern United States, Jacek T. Giermakowski, James R. Hatten, Matthew J. Johnson, Jennifer A. Holmes, Erika M. Nowak

World Conference on Natural Resource Modeling

The Lower Colorado River and Rio Grande Basins are home to many riparian species of different degrees of rarity. In our study we focused on two species of birds and two species of gartersnakes that are associated with water: the Yellow-Breasted Chat (Icteria virens), the American Yellow Warbler (Setophaga petechia), the Mexican Gartersnake (Thamnophis eques) and the Narrow-headed Gartersnake (T. rufipunctatus). While the extent of distributions of these species is relatively large, they are often patchily distributed in populations that are small. To evaluate the vulnerability of these species at a landscape …

Development Of An Imaging/Therapy Integrated System By Using Radionuclide 192ir For Breast Cancer, Jian Fang

Open Access Dissertations

Breast cancer is the second most common cancer diagnosed among women in the United States following skin cancer. About one-third of women cancer patients have breast cancer. Following lung cancer, breast cancer has the second highest death rate compared to other types of cancer. Radiation therapy is a common way to treat breast cancer after surgery; it can significantly decrease the breast cancer recurrent rate. For early breast cancer treatment, breast-conserving surgery followed by radiation therapy is highly recommended compared to mastectomy. Since most of the local recurrences occur near the tumor bed, additional boost radiation to the tumor bed …

Vaccination As A Tool To Reduce Antimicrobial Resistance Worldwide, Bernard Vallat, Elisabeth Erlacher

Vaccine Technology VI

Antimicrobial resistance is a global human and animal health concern that is influenced by the non-appropriate use of antimicrobial agents in both human and veterinary medicine, as well as in the plant sector. To combat antimicrobial resistance, the World Organisation for Animal health (OIE) has developed science-based intergovernmental standards and guidelines covering terrestrial animals and aquaculture.

The OIE also contributed to the development of the WHO Global Action Plan on Antimicrobial Resistance, adopted in 2015 by the World Health Assembly. The 180 Member Countries of the OIE expressed their support to this plan of action through a Resolution, …

Weekly News Digest 06/16/2016, Jenna Ray

Weekly Bulletin Archive

In this Issue:

• Alumni Association Honors Three Morris Grads
• Campus Responds to Orlando Shooting
• Sleep Apnea Study Continues to Attract Attention
• Morris Mentioned on the White House Blog

Plant-Based Technologies To Enable Rapid Response To Ebola Outbreak, Jerzy Karczewski, Vidadi Yusibov

Vaccine Technology VI

Ebola is a rare and deadly disease caused by infection with a strain of Ebola virus (Zaire, Sudan or Marburg). Ebola is spread through a direct contact with body fluids of infected patients. The recent Ebola outbreak affected multiple countries in West Africa and clearly demonstrated a need for development of technologies enabling production of adequate supply of vaccines and therapeutics to treat infected patients. We have undertaken efforts to develop methods and produce plant-based recombinant vaccine as well as a series of monoclonal antibodies to fight Ebola infection.

Several approaches were carried out to develop vaccines based on recombinant …

How To Deliver New Vaccines Under Very Short Timelines: The Zapi Project, Jean-Christophe Audonnet

Vaccine Technology VI

The ZAPI project is the first One Health project in the European Innovative Medicine Initiative (IMI) program. Its objective is to define and validate unique methodologies that can be applied when new zoonotic infectious diseases will occur in Europe or other regions of the world. The project is supporting an entirely new approach for “anticipating the unexpected”, and is defining new ways to alleviate the technical constraints which are typically encountered with the classical vaccine development processes.

The ZAPI project involves a total of 20 partners, from academic, biotech, and industry origin. One important feature of ZAPI is that it …

Biology Alum Joins Cdc To Fight Disease In World Hot Spots, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Diversity, Structure And Convergent Evolution Of The Global Sponge Microbiome, Torsten Thomas, Lucas Moitinho-Silva, Miguel Lurgi, Johannes R. Bjork, Cole Easson, Carmen Astudillo-Garcia, Julie B. Olson, Patrick M. Erwin, Susanna Lopez-Legentil, Heidi Luter, Andia Chaves Fonnegra, Rodrigo Costa, Peter J. Schupp, Laura Steindler, Dirk Erpenbeck, Jack Gilbert, Rob Knight, Gail Ackermann, Jose V. Lopez, Michael W. Taylor, Robert W. Thacker, Jose M. Montoya, Ute Hentschel, Nicole S. Webster

Marine & Environmental Sciences Faculty Articles

Sponges (phylum Porifera) are early-diverging metazoa renowned for establishing complex microbial symbioses. Here we present a global Porifera microbiome survey, set out to establish the ecological and evolutionary drivers of these host–microbe interactions.We show that sponges are a reservoir of exceptional microbial diversity and major contributors to the total microbial diversity of the world’s oceans. Little commonality in species composition or structure is evident across the phylum, although symbiont communities are characterized by specialists and generalists rather than opportunists. Core sponge microbiomes are stable and characterized by generalist symbionts exhibiting amensal and/or commensal interactions. Symbionts that are phylogenetically unique to …

A Tale Of Two Campaigns: City Tech’S ‘No More 24!’ And Psc-Cuny’S Strike Authorization Vote, Carole Kennedy Harris

Publications and Research

No abstract provided.

N-Acetyl Cysteine May Support Dopamine Neurons In Parkinson's Disease: Preliminary Clinical And Cell Line Data., Daniel A. Monti, George Zabrecky, Daniel Kremens, Tsao-Wei Liang, Nancy A. Wintering, Jingli Cai, Xiatao Wei, Anthony J. Bazzan, Li Zhong, Brendan Bowen, Charles Intenzo, Lorraine Iacovitti, Andrew B. Newberg

Marcus Institute of Integrative Health Faculty Papers

BACKGOUND: The purpose of this study was to assess the biological and clinical effects of n-acetyl-cysteine (NAC) in Parkinson's disease (PD).

METHODS: The overarching goal of this pilot study was to generate additional data about potentially protective properties of NAC in PD, using an in vitro and in vivo approach. In preparation for the clinical study we performed a cell tissue culture study with human embryonic stem cell (hESC)-derived midbrain dopamine (mDA) neurons that were treated with rotenone as a model for PD. The primary outcome in the cell tissue cultures was the number of cells that survived the insult …

Expression Of Μ-Protocadherin Is Negatively Regulated By The Activation Of The Β-Catenin Signaling Pathway In Normal And Cancer Colorectal Enterocytes., Lucia Montorsi, Sandra Parenti, Lorena Losi, Fabrizio Ferrarini, Claudia Gemelli, A Rossi, Gianrocco Manco, Stefano Ferrari, Bruno Calabretta, Enrico Tagliafico, Tommaso Zanocco-Marani, Alexis Grande

Department of Cancer Biology Faculty Papers

Mu-protocadherin (MUCDHL) is an adhesion molecule predominantly expressed by colorectal epithelial cells which is markedly downregulated upon malignant transformation. Notably, treatment of colorectal cancer (CRC) cells with mesalazine lead to increased expression of MUCDHL, and is associated with sequestration of β-catenin on the plasma membrane and inhibition of its transcriptional activity. To better characterize the causal relationship between β-catenin and MUCDHL expression, we performed various experiments in which CRC cell lines and normal colonic organoids were subjected to culture conditions inhibiting (FH535 treatment, transcription factor 7-like 2 siRNA inactivation, Wnt withdrawal) or stimulating (LiCl treatment) β-catenin activity. We show here …

Hydrothermally Processed 1d Hydroxyapatite: Mechanism Of Formation And Biocompatibility Studies, Zoran Stojanović, Nenad Ignjatović, Victoria M. Wu, Vojca Žunič, Ljiljana Veselinović, Srečo D. Škapin, Miroslav Miljković, Vuk Uskoković, Dragab Uskoković

Pharmacy Faculty Articles and Research

Recent developments in bone tissue engineering have led to an increased interest in one-dimensional (1D) hydroxyapatite (HA) nano- and micro-structures such as wires, ribbons and tubes. They have been proposed for use as cell substrates, reinforcing phases in composites and carriers for biologically active substances. Here we demonstrate the synthesis of 1D HA structures using an optimized, urea-assisted, high-yield hydrothermal batch process. The one-pot process, yielding HA structures composed of bundles of ribbons and wires, was typified by the simultaneous occurrence of a multitude of intermediate reactions, failing to meet the uniformity criteria over particle morphology and size. To overcome …

Pik3ca-Associated Developmental Disorders Exhibit Distinct Classes Of Mutations With Variable Expression And Tissue Distribution, Ghayda Mirzaa, Andrew E Timms, Valerio Conti, Evan August Boyle, Katta M Girisha, Beth Martin, Martin Kircher, Carissa Olds, Jane Juusola, Sarah Collins, Kaylee Park, Melissa Carter, Ian Glass, Inge Krägeloh-Mann, David Chitayat, Aditi Shah Parikh, Rachael Bradshaw, Erin Torti, Stephen Braddock, Leah Burke, Sondhya Ghedia, Mark Stephan, Fiona Stewart, Chitra Prasad, Melanie Napier, Sulagna Saitta, Rachel Straussberg, Michael Gabbett, Bridget C O'Connor, Catherine E Keegan, Lim Jiin Yin, Angeline Hwei Meeng Lai, Nicole Martin, Margaret Mckinnon, Marie-Claude Addor, Luigi Boccuto, Charles E Schwartz, Agustina Lanoel, Robert L Conway, Koenraad Devriendt, Katrina Tatton-Brown, Mary Ella Pierpont, Michael Painter, Lisa Worgan, James Reggin, Raoul Hennekam, Karen Tsuchiya, Colin C Pritchard, Mariana Aracena, Karen W Gripp, Maria Cordisco, Hilde Van Esch, Livia Garavelli, Cynthia Curry, Anne Goriely, Hulya Kayserilli, Jay Shendure, John Graham, Renzo Guerrini, William B Dobyns

Articles, Abstracts, and Reports

Mosaicism is increasingly recognized as a cause of developmental disorders with the advent of next-generation sequencing (NGS). Mosaic mutations of PIK3CA have been associated with the widest spectrum of phenotypes associated with overgrowth and vascular malformations. We performed targeted NGS using 2 independent deep-coverage methods that utilize molecular inversion probes and amplicon sequencing in a cohort of 241 samples from 181 individuals with brain and/or body overgrowth. We identified PIK3CA mutations in 60 individuals. Several other individuals (n = 12) were identified separately to have mutations in PIK3CA by clinical targeted-panel testing (n = 6), whole-exome sequencing ( …

The North American Grouse: Their Biology And Behavior, Paul A. Johnsgard

Zea E-Books Collection

The ten currently recognized species of grouse in North America have played an important role in America’s history, from the famous but ill-fated heath hen, a primary source of meat for the earliest New England immigrants, to the ruffed grouse, currently one of the most abundant and soughtafter upland game birds in more than 40 states and provinces. This book summarizes the ecology, reproductive biology, and social behavior of all ten of the extant North American grouse species. It also describes the current status of grouse populations, some of which are perilously close to extinction. The social behavior of grouse …

Status And Management Of Non-Native Plant Invasion In Three Of The Largest National Parks In The United States, Scott R. Abella, Nicholas A. Fisichelli, Sarah M. Schmid, Teague M. Embrey, Debra Hughson, Jane Cipra

Life Sciences Faculty Research

Globally, invasion by non-native plants threatens resources that nature reserves are designated to protect. We assessed the status of non-native plant invasion on 1,662, 0.1-ha plots in Death Valley National Park, Mojave National Preserve, and Lake Mead National Recreation Area. These parks comprise 2.5 million ha, 23% of the national park land in the contiguous USA. At least one non-native species inhabited 82% of plots. Thirty-one percent of plots contained one non-native species, 30% two, 17% three, and 4% four to ten non-native species. Red brome (Bromus rubens), an ‘ecosystem engineer’ that alters fire regimes, was most widespread, …

Reed V. Reed Appellant's Brief Dckt. 44056

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Developing A Video-Based Ehealth Intervention For Hiv-Positive Gay, Bisexual, And Other Men Who Have Sex With Men: Study Protocol For A Randomized Controlled Trial, Sabina Hirshfield, Martin J. Downing Jr., Jeffrey T. Parsons, Christina Grov, Rachel J. Gordon, Steven T. Houang, Roberta Scheinmann, Patrick S. Sullivan, Irene S. Yoon, Ian Anderson, Mary Ann Chiasson

Publications and Research

Background: Gay, bisexual, and other men who have sex with men (GBMSM) accounted for 67% of new US human immunodeficiency virus (HIV) infections in 2012; however, less than 40% of HIV-positive GBMSM are virally suppressed. Preventing transmission from virally unsuppressed men who have condomless anal sex (CAS) with serodiscordant partners is a public health imperative. New HIV infections in GBMSM are attributed in part to online access to sex partners; therefore, low-cost eHealth interventions are a unique opportunity to reach men where they meet partners.

Objective: To describe the protocol of a randomized controlled trial evaluating whether video-based messaging delivered …

Knockdown Of Rna Interference Pathway Genes In Western Corn Rootworms (Diabrotica Virgifera Virgifera Le Conte) Demonstrates A Possible Mechanism Of Resistance To Lethal Dsrna, Ana María Vélez, Chitvan Khajuria, Haichuan Wang, Kenneth E. Narva, Blair D. Siegfried

Department of Entomology: Faculty Publications

RNA interference (RNAi) is being developed as a potential tool for insect pest management. Increased understanding of the RNAi pathway in target insect pests will provide information to use this technology effectively and to inform decisions related to resistant management strategies for RNAi based traits. Dicer 2 (Dcr2), an endonuclease responsible for formation of small interfering RNA’s and Argonaute 2 (Ago2), an essential catalytic component of the RNA-induced silencing complex (RISC) have both been associated with the RNAi pathway in a number of different insect species including the western corn rootworm, Diabrotica virgifera virgifera (Coleoptera: Chrysomelidae). We identified both genes …

Compressive Sensing Reconstruction Of Feed-Forward Connectivity In Pulse-Coupled Nonlinear Networks, Victor J. Barranca, D. Zhou, D. Cai

Mathematics & Statistics Faculty Works

Utilizing the sparsity ubiquitous in real-world network connectivity, we develop a theoretical framework for efficiently reconstructing sparse feed-forward connections in a pulse-coupled nonlinear network through its output activities. Using only a small ensemble of random inputs, we solve this inverse problem through the compressive sensing theory based on a hidden linear structure intrinsic to the nonlinear network dynamics. The accuracy of the reconstruction is further verified by the fact that complex inputs can be well recovered using the reconstructed connectivity. We expect this Rapid Communication provides a new perspective for understanding the structure-function relationship as well as compressive sensing principle …

Required Biochem Class Live-Streamed This Summer: Collaboration With Union College Makes Required Credits Easier To Obtain, Chris Mclean-Wheeler

Andrews Agenda: Campus News

No abstract provided.

Duplication And Remolding Of Trna Genes In The Mitochondrial Genome Of Reduvius Tenebrosus (Hemiptera: Reduviidae), Pei Jiang, Hu Li, Fan Song, Yao Cai, Jianyun Wang, Jinpeng Liu, Wanzhi Cai

Markey Cancer Center Faculty Publications

Most assassin bugs are predators that act as important natural enemies of insect pests. Mitochondrial (mt) genomes of these insects are double-strand circular DNAs that encode 37 genes. In the present study, we explore the duplication and rearrangement of tRNA genes in the mt genome of Reduvius tenebrosus, the first mt genome from the subfamily Reduviinae. The gene order rearranges from CR (control region)-trnI-trnQ-trnM-ND2 to CR-trnQ-trnI2-trnI1-trnM-ND2. We identified 23 tRNA genes, including 22 tRNAs commonly found in insects and an additional trnI (trnI2), which has high sequence similarity to trnM. We found several …

Faculty Senate Minutes Jun. 16, 2016, Missouri University Of Science And Technology Faculty Senate

Minutes & Agendas

No abstract provided.