Digital Commons Network^™

Early-Onset Alzheimer’S: Should You Worry?, Troy Rohn

Biology Faculty Publications and Presentations

You have forgotten where you put your car keys, or you can’t seem to remember the name of your colleague you saw in the grocery store the other day. You fear the worst, that maybe these are signs of Alzheimer’s disease.

Investigation Of Succinated Protein Turnover By Autophagy, Lydia Proctor

Theses and Dissertations

Background. Diabetes is a widespread public health concern that alters the metabolism of adipocytes through high glucose stress and hormonal dysregulation. Under diabetic conditions there are excess nutrients available and subsequently an accumulation of tricarboxylic acid cycle intermediates such as fumarate. Fumarate can irreversibly react with protein cysteine residues to form S-2-succinocysteine (2SC, protein succination). Succinated proteins can be turned over by autophagy, a mechanism of removing damaged proteins and organelles that have accumulated due to metabolic stress.

Purpose. The basal flux through autophagy in adipocytes matured in non-diabetic and diabetic conditions was examined to determine the turnover of succinated …

Vitamin D And Stress Fractures In Collegiate And Professional Athletes, Christian Michael Askew

Theses and Dissertations

An important aspect of orthopedics and sports medicine is to provide quality care and oversight for the overall health and wellbeing of athletes. Research in these fields aims to understand the underlying mechanisms of sport-induced injuries in order to improve treatment plans and prevent future complications. Overuse bone stress injuries are prominent among elite athletes and can cause detrimental setbacks to training and performance. Thus, prevention of these injuries is of primary concern. Vitamin D has been known to play an integral role in skeletal metabolism. Current research suggests vitamin D status may be indicative of bone density, structural integrity, …

Textile As Intercessor: Understanding Margery Kempe's Sartorial Body, Hannah Lynn Davis

Theses and Dissertations

In this thesis, I will explore Margery Kempe’s late fourteenth, early fifteenth century mystical text. Previously, Margery Kempe has been discussed in reference to her highly erotized language with Christ and her maternal themes that appear throughout her Book. However, I urge other medieval scholars to also look at her usage of textiles and clothing as a means of gaining authority with both Christ and the medieval church. First, I discuss Margery’s gendered situation within the male-centered church and community. Margery uses her position as a woman to build her agency and, as such, uses gendered specific clothing to introduce …

Decorative Turkey Callmakers: Artists Or Craftsmen, Lauren E. Virgo

Theses and Dissertations

This thesis explores the history of the wild turkey call and the role of decorative callmakers in the world of art and craft. Is a turkey callmaker an artist or a craftsman? Are their decorative turkey calls works of art or works of craft? This debate is explored via the decorative turkey calls that have won the Decorative Turkey Call Best of Show portion of the National Wild Turkey Federation’s Grand National Callmaking Competition. These winning turkey calls are currently on display at the NWTF’s Winchester Museum in Edgefield, South Carolina.

The National Wild Turkey Federation (NWTF) is a non-profit …

Enhancing The Efficacy Of Thymidylate Synthase Inhibitors By Genetic Modulation Or Pharmacological Inhibition Of Bone Marrow Derived Cells In The Tumor Stroma, Nikeya Lashanna Tisdale

Theses and Dissertations

The impact of tumor associated stromal cells in tumor formation, progression, and response to therapy has led to a paradigm shift in cancer therapy. For many years, tumors were considered as a mass consisting only of actively proliferating cancer cells and therapies were design to target these cells. However, research in the last two decades has shown that tumors are not only comprised of a heterogeneous population of neoplastic cells, but they are also comprised of and infiltrated by a heterogeneous population of non-tumor cells that contribute to tumor progression and potentially affect the efficacy of tumor-directed chemotherapies. Tumors are …

Bayesian Nonparametric Approaches To Multiple Testing, Density Estimation, And Supervised Learning, William Cipolli Iii

Theses and Dissertations

This dissertation presents methods for several applications of Polya tree models. These novel nonparametric approaches to the problems of multiple testing, density estimation and supervised learning provide an alternative to other parametric and nonparametric models. In Chapter 2, the proposed approximate finite Polya tree multiple testing procedure is very successful in correctly classifying the observations with non-zero mean in a computationally efficient manner; this holds even when the non-zero means are simulated from a mean-zero distribution. Further, the model is capable of this for “interestingly different” observations in the cases where that is of interest. Chapter 3 proposes discrete, and …

Remembering Salinger's Franny And Zooey Through Pari And The Royal Tenenbaums, Taraneh Zohadi

Theses and Dissertations

This paper explores the ways in which Mehrjui’s Pari and Anderson’s The Royal Tenenbaums borrow from Salinger’s Franny and Zooey. My argument is that Salinger and the concepts he introduced in the book are remembered through both films. Being a product of their historical/cultural contexts, The Royal Tenenbaums embraces the aesthetics of the text and Pari converses with the spiritual aspect of the main text. Anderson’s film captures the United States’ preoccupation consumerism and the hollowness at turn of the twenty-first century, while Pari explores the angst and despair in the post Iran-Iraq war context of the film’s release, feelings …

Quantum Dot Metrics For Preparative Chemistry And Fluorescence Applications, Yi Shen

Theses and Dissertations

Colloidal semiconductor quantum dots (QDs) are considered to be a promising candidate for bio-imaging and solar cells because of their extraordinary photo-physical properties. The ultimate goal of this dissertation is to design a reliable matrix and a reproducible method to prepare QDs-based biocompatible probe for fluorescence applications. Synthesis of quantum dots requires a large amount of ligands to improve the stability at high temperature. However, for further application and surface modification of QDs, excess ligands must be removed. In this dissertation, I will first describe using gel permeation chromatography (GPC) as a media to purify different types of QDs. A …

Ultra-High Temperature Full Field Deformation Measurements Of Materials Subjected To Thermo-Mechanical Loading: A Dic Based Study, Guillemo A. Valeri Paoli

Theses and Dissertations

Determining the mechanical response of materials at elevated temperatures is a subject of great interest in metal forming, aerospace and aero-engine industries. For example, measurement of the deformation response under tensile loading at high temperatures is crucial for establishing thermomechanical and thermo-physical properties of materials, consequently, determining the reliability of a component or structure exposed to elevated temperatures. In order to predict the behavior of materials at ultra-high temperatures, a novel experimental approach based on Digital Image Correlation (DIC) is proposed and successfully applied to different materials at temperatures ranging from room temperature to 1100˚C. In these studies, a portable …

Emodin Regulates Macrophage Polarization: Application In Breast Cancer Treatment, Stephen Iwanowycz

Theses and Dissertations

Macrophages are pleiotropic cells capable of performing a broad spectrum of functions. Their phenotypes are classified along a continuum between the extremes of pro-inflammatory M1 macrophages and anti-inflammatory M2 macrophages. The seemingly opposing functions of M1 and M2 macrophages must be tightly regulated for an effective inflammatory response to foreign molecules or damaged tissue. Excessive activation of either M1 or M2 macrophages contributes to the pathology of many diseases. Infiltration of macrophages into breast tumors correlates with increased metastasis and decreased patient survival. Tumors recruit macrophages to the primary site as well as pre-metastatic niches, and educate them to adopt …

Interactions Between Hiv-1 Tat And Tumor Suppressor P53, Kristen Lane Spotts

Theses and Dissertations

The most well studied cancer-related gene in history, p53, is responsible for protecting the integrity of the genome. A variety of different stresses are detected by p53 and its regulators, allowing for numerous post-translational modifications that activate p53. After activation p53 can then regulate transcription of a myriad downstream targets, resulting in either cell cycle arrest or apoptosis. One of the stress signals that activates p53 is viral infection in part through the induction of type-1 interferon. However some viruses, like the DNA tumor viruses have evolved factors capable of binding to p53 and inhibiting its ability to regulate its …

Tumor Suppressor P53 Response To Uv Light In Normal Human Keratinocyte Strains From Different Individuals, Fadi Farooq Abboodi

Theses and Dissertations

Human Papillomavirus (HPV) is a causative factor in variety of diseases ranging from simple pathologic conditions to malignant ones like cervical cancer in which HPV is the primary cause in more than 90% of cases. HPV is also associated with other tumors like head and neck squamous cell carcinoma (HNSCC) and the percentage of association varies according to the anatomical site, reaching its highest level (65%) in the oropharyngeal region. HPV proteins E6 and E7 are responsible for the transforming potential of the virus. The principal action of E6 is targeting the tumor suppressor protein p53 for degradation, while E7 …

Individual Movement Rates Are Sufficient To Determine And Maintain Dynamic Spatial Positioning Within Uca Pugilator Herds, Eilea R. Knotts

Theses and Dissertations

Spatial location within aggregations (i.e. periphery, central) is of biological significance to gregarious animals. Because these positions are a potential consequence of consistent individual behavioral differences, or personality, a better understanding of potential mechanisms concerning personality is central to predicting an individuals’ location. To determine the effects of individual personality on the dynamic spatial positioning of Uca pugilator while herding, field data collection and agent-based modeling were employed. Individuals were assayed to establish their personalities and returned to the field for observation as a means of identifying location preference within selfish herds. There was a significant difference between the extreme …

Chlor-Amidine, A Novel Pad Inhibitor, As An Effective Drug For The Treatment Of Ulcerative Colitis And Prevention Of Colorectal Cancer, Erin Witalison

Theses and Dissertations

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that affects the quality of life of millions of patients worldwide. This disease is associated with inflammation and ulceration of the colonic epithelium, leading to an increased risk for the development of UC-associated colorectal cancer (CRC). Current UC medications are designed to manage the symptoms and induce remission; however, several challenges are faced with current treatment options. 5-aminosalicyclic acid and corticosteroids have few side effects, but have limited efficacy and often the disease becomes refractory. Biologics are introduced after initial treatments fail, but serious side effects are often associated with these …

Examining The Effect Of Feminist Self-Labeling And Feminist Perspectives On Young Adults' Self-Efficacy, Tiffany L. Rogers

Theses and Dissertations

The current study utilized data from young adults (undergraduate and graduate students) in order to examine the effect of feminist self-identification (as measured by the Self-Identification as a Feminist Scale) and feminist perspectives (as measured by the Feminist Perspectives Scale—Short Form) on self-efficacy (as measured by General Self-Efficacy Scale total scores). Additionally, this study examined the relationship between demographics (i.e., gender, race) and outcome variables of interest (i.e., feminist self-identification, feminist perspectives, self-efficacy). Participants included 305 individuals who are at least 18 years old and enrolled as undergraduate or graduate students at the University of South Carolina. Multiple regression assessed …

Lebanon's Shouf Biosphere Reserve: A Protected Area And Sport Hunting, Robert Watkins Bowdoin Greeley

Theses and Dissertations

Fortress conservation, the act of setting aside for conservation goals and protecting them through sanction, coercion, and violence, towards local users has became the paradigmatic understanding of how protected areas are created and maintained. The fortress conservation critique is marked by a preoccupation with the negative livelihood impacts of these areas, portrays animosity and social conflict between local users and the protected areas, is primarily concerned with national parks and clearly defined protected areas, and places state power at the center of the creation and maintenance of protected areas. This dissertation takes the tenants of fortress conservation to task by …

Effects Of Cortisol Stress Response Patterns On Autism Related Behaviors In Young Adult Males With Fragile X Syndrome And Autism Spectrum Disorders, Sara M. Matherly

Theses and Dissertations

Fragile X syndrome (FXS) and autism spectrum disorders (ASD) are characterized by deficits in social interactions (reduced eye contact, topic preoccupation, and social withdrawal) and maladaptive behaviors of anxiety, social withdrawal, and restricted interests (Kau, Tierney, Bukelis, Stump, Kates, Trescher et al., 2004). Prior research with individuals who have FXS has indicated that problem behaviors (i.e. social withdrawal and inattention) were correlated with abnormal activation of the hypothalamus-pituitary-adrenal axis (HPAA; Hessl, et. al., 2002); however, very few studies have investigated physiological patterns and associations with social dysfunction and restricted and repetitive behaviors for individuals with idiopathic ASD. The present study …

Structural And Functional Studies Of Nicotinamide Adenine Dinucleotide And Streptolysin S Biosynthesis Proteins From Streptococcus Pyogenes, William T. Booth

Theses and Dissertations

Invasive infections caused by Streptococcus pyogenes, also known as Group A Strep (GAS), results in approximately 600,000 deaths annually. With evidence of antibiotic-resistant strains of this bacterium on the rise, there is a need for the identification of new drug targets to control these infections. In our approach we target the quinolinate-salvage pathway (QSP) and the streptolysin S (SLS) biosynthesis pathway. The QSP provides a secondary pathway for NAD+ biosynthesis within this organism; the SLS pathway leads to the formation of a quorum sensing molecule (SLS). We hypothesize that inhibition of the pathways will lead to GAS cell death or …

Metafiction In Mourning: The Intersections Of Gender Performance And Postdictatorial Memory In Novels By Luisa Valenzuela, Clarice Lispector, And Diamela Eltit, Jennifer L. Slobodian

Theses and Dissertations

The purpose of this project is to build on two major theoretical fields, feminism and postdictatorial memory, in the context of Latin American women’s writing. The development of Latin American feminism has run concurrently with the broader feminist movements of the 20th century, but has been shaped by the particularities and diversity of the region. Specific concerns relating to postcoloniality, religion, and nation have caused theorists like Debra A. Castillo to discuss Latin American feminism on its own, focusing on the inherent privileging of praxis over theory and the necessary pastiche of local and international theories. The development of Latin …

Cultural Perceptions Of Chikungunya In The Dominican Republic, James Preston Kerns

Theses and Dissertations

Chikungunya (CHIKV) is a mosquito-borne virus that recently (2013) entered the Western hemisphere and tore through the Caribbean and most of Latin America. The symptoms include rash, joint pain, vomiting, diarrhea, headache, and fever. In many cases, sufferers report persistent arthralgia long after the actual viral infection has subsided. There are a variety of misperceptions about CHIKV, which directly impact public health efforts aimed at reducing the prevalence of the disease. Understanding the epidemic spread of CHIKV in the DR and the growth of misconceptions about the origin, severity, cause, and treatment of the disease requires a perspective that encompasses …

Genetic Counseling For Alcohol Use Disorder: Assessment Of Need In Affected And At-Risk Populations, Fayth Michelle Kalb

Theses and Dissertations

Introduction: Alcohol use disorder (AUD) is highly heritable, yet there has been no investigation regarding the possible benefits of genetic counseling for AUD. This study assessed the beliefs individuals with and at risk for AUD have regarding recurrence risk and etiology of AUD, how the presence of the condition in themselves or their family history has affected their lifestyle decisions, and potential benefit from AUD genetic counseling. Methods: An online questionnaire was distributed through social media to support groups for AUD inviting adults 18 years and older with a personal or family history of AUD. Results: Of the 122 individuals …

The Artificial Creation Of Life And What It Means To Be Human, Caroline Mosser

Theses and Dissertations

This dissertation is focused on the literary representations of the artificial creation of (human) life. This project is based on the belief that advances in bio-technologies have the potential to challenge core values of society and that literature offers a space to identify and address them before their actual appearance. While the texts studied do not provide actual answers to extremely complex moral questions, they offer a starting point for reflection. They question our morality in many ways, especially because they force us to think about who and what we are as human beings. This project is a study of …

From Near And Far: Utilization Of In-Situ And Remotely Sensed Satellite Data From Nasa And Noaa, Jessica Rochelle Price Sutton

Theses and Dissertations

Satellite remote sensing observations have been used for numerous studies to better understand physical and biological properties over varying spatial and temporal scales. Depending on the satellite and sensor, the satellite-derived observations can provide high spatial and temporal resolution for many important physical and biological variables. While there are many limitations in utilizing satellite remote sensing products, there are also many advantages. This dissertation investigates three different applications for satellite remote sensing products to address climatological and ecological concerns. This dissertation is motivated by two overall research questions: (1) How can satellite remote sensing products be used to address important …

Divine Ideas For Metaphysical Realism, Michelle Lynn Panchuk

Theses and Dissertations

In recent years more and more theist philosophers have turned their attention to an apparent tension between the existence of abstract universals and the God of classical monotheisms. In this project I argue that this tension can be relieved by adopting a Neo-Augustinian account of universals. When the doctrine of creation ex nihilo is given sufficient place within one’s theory, divine concepts can do all of the work for which abstract universals are usually posited. Over the course of 5 chapters, I argue that the problem of universals, at base, requires a theory of properties as its solution; that my …

North American Butterfly Association Counts At Congaree National Park: A Case Study For Connecting Citizen Science To Management, Austin Clarridge

Theses and Dissertations

Citizen science is becoming an ever more popular way for scientists and resource managers to deal with needs for large temporal and spatial scale datasets. It provides a free or low cost means for collection of extensive amounts of data across time and space while acting as a public education and outreach tool, empowering communities to be involved in the management decisions being made in their back yard. Though large, well-known citizen science programs such as the Christmas Bird Counts are being used extensively for peer reviewed literature and management decisions, there are numerous smaller, local counts that have the …

Like I Said, Matthew Mossman

Theses and Dissertations

Like I Said is a collection of memoir essays spanning the author’s life from his earliest memories to the present day. Topics touched on include but are not limited to: the struggle of being raised as an undiagnosed sufferer of ADHD, the cultural/familial dynamics at work in rural southeast Missouri, the author’s trial with hitting puberty and finding religion in the same year, and the ongoing shifts in the Mossman family’s relational dynamics in the years since the author’s mother was first diagnosed with breast cancer.

Structurally, the text takes inspiration from the “lyric essay,” a subgenre of creative nonfiction …

Um Biology Professor Aims To Reduce Shark Deaths, Michael Newsom

University of Mississippi News

New device could help commercial fishermen to avoid bycatch

Soundings 2016-06-30, N/A N/A

Soundings

No abstract provided.

The Effect Of Depression And Antidepressants On Cost, Survival And Adherence To Hormone Therapy In Breast Cancer, Virginia Noxon

Theses and Dissertations

Introduction: Breast cancer patients with a depression diagnosis before or after cancer diagnosis have increased cost, shorter survival time and reduced adherence to hormone therapy. Treating depression in these patients should improve these outcomes; however, there is scarce literature on this topic. Currently, no study has determined the association of concurrent depression while adjusting for a history of depression or treating depression with antidepressants with cost, survival and adherence to hormone therapy. This study has two objectives: 1) to determine the association of concurrent depression with cost, survival and adherence to hormone therapy adjusting for a history of depression 2) …