Digital Commons Network^™

Effects Of 17 Β-Estradiol And Progesterone On Acropora Cervicornis And Porites Astreoides Growth And Reproduction, Joshua L. Stocker

HCNSO Student Theses and Dissertations

Reef-building coral populations throughout the world are being threatened by numerous stressors and continue to decline. As potent endocrine-disrupting compounds, exogenous sex steroid contamination has been a largely overlooked stressor to corals. Previous research indicates these compounds are prevalent in marine environments, fluctuate annually along with reproductive cycles, can bioaccumulate, and have had variable effects on growth and reproduction in several cnidarian species. This project had three primary objectives: (1) establish environmental estradiol and progesterone concentrations in Broward County and lower Florida Keys reef environments, (2) conduct 17 β-estradiol and progesterone larval assays on P. astreoides larvae to determine the …

Daily Eastern News: December 06, 2016, Eastern Illinois University

December

No abstract provided.

Invasive Species Impacts On Infrastructure, Invasive Species Advisory Committee

National Invasive Species Council

Executive Summary

Invasive species represent one of the most significant threats to ecosystems, human and animal health, infrastructure, the economy, and cultural resources. Because potentially invasive, non-native species typically enter the United States through ports of entry in urban environments, some of the first observable impacts may be to infrastructure, yet little is known about the economic costs associated with these impacts to the “built” environment. In addition, federal agencies currently lack the authority necessary to effectively prevent, eradicate, and control invasive species that impact the human-built environment. This lack of authority prevents rapid response to some of the most …

Compositions Including Triciribine And Methods Of Use Thereof, Jin Q. Cheng, Said M. Sebti

USF Patents

This invention encompasses combination therapies including TCN, TCN-P, TCN-PM and/or related compounds and one or more additional anti-cancer agents, for example, taxanes a molecule that modulates the HER2/neu (erbB2) receptor, anthracyclin compounds, epidermal growth factor receptor inhibitor compounds, one or more platinum compounds and bortezomib and derivatives thereof and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.

Antibacterial S-Heterosubstituted Disulfides, Edward Turos, Praveen Ramaraju

USF Patents

Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.

Differentially Expressed Genes In Large Granular Lymphocyte Leukemia, Thomas P. Loughran Jr., Ravi Kothapalli

USF Patents

The subject invention concerns gene sequences and the use thereof as markers for large granular lymphocyte (LGL) leukemia. The gene sequences of the invention are differentially expressed in LGL. Another aspect of the invention pertains to therapeutic compositions directed to gene expression and gene products of differentially expressed genes in LGL. The invention also concerns methods for screening and identifying compositions that may be of therapeutic benefit to patients having LGL leukemia and/or autoimmune disorders. In addition, because a large fraction of patients with T-LGL leukemia also have rheumatoid arthritis, these differentially expressed genes also represent novel targets for the …

Calculating And Analyzing Night Sky Brightness For The Commerce/Greenville, Texas Area, Rebecca Bosmans

Honors Theses

No abstract provided.

The Sun Star Vol 70 No 14 (December 6th, 2016), N/A N/A

Sun Star

No abstract provided.

Hnrnpa2 Is A Novel Histone Acetyltransferase That Mediates Mitochondrial Stress-Induced Nuclear Gene Expression, Manti Guha, Satish Srinivasan, Kip Guja, Edison Mejia, Miguel Garcia-Diaz, F. Brad Johnson, Gordon Ruthel, Brett A. Kaufman, Eric F. Rappaport, M. Rebecca Glineburg, Ji-Kang Fang, Andres J. Klein-Szanto, Hiroshi Nakagawa, Jeelan Basha, Tapas Kundu, Narayan G. Avadhani

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Reduced mitochondrial DNA copy number, mitochondrial DNA mutations or disruption of electron transfer chain complexes induce mitochondria-to-nucleus retrograde signaling, which induces global change in nuclear gene expression ultimately contributing to various human pathologies including cancer. Recent studies suggest that these mitochondrial changes cause transcriptional reprogramming of nuclear genes although the mechanism of this cross talk remains unclear. Here, we provide evidence that mitochondria-to-nucleus retrograde signaling regulates chromatin acetylation and alters nuclear gene expression through the heterogeneous ribonucleoprotein A2 (hnRNAP2). These processes are reversed when mitochondrial DNA content is restored to near normal cell levels. We show that the mitochondrial stress-induced …

Control Of Gene Expression By Rna Binding Protein Action On Alternative Translation Initiation Sites, Angela Re, Levi Waldron, Alessandro Quattrone

Publications and Research

Transcript levels do not faithfully predict protein levels, due to post-transcriptional regulation of gene expression mediated by RNA binding proteins (RBPs) and non-coding RNAs. We developed a multivariate linear regression model integrating RBP levels and predicted RBP-mRNA regulatory interactions from matched transcript and protein datasets. RBPs significantly improved the accuracy in predicting protein abundance of a portion of the total modeled mRNAs in three panels of tissues and cells and for different methods employed in the detection of mRNA and protein. The presence of upstream translation initiation sites (uTISs) at the mRNA 5' untranslated regions was strongly associated with improvement …

Enantiomer Signature And Carbon Isotope Evidence For The Migration And Transformation Of Ddts In Arable Soils Across China, Lili Niu, Chao Xu, Siyu Zhu, Huiming Bao, Yang Xu, Hongyi Li, Zhijian Zhang, Xichang Zhang, Jiguo Qiu, Weiping Liu

Faculty Publications

© The Author(s) 2016. Due to the adverse impact of DDTs on ecosystems and humans, a full fate assessment deems a comprehensive study on their occurrence in soils over a large region. Through a sampling campaign across China, we measured the concentrations, enantiomeric fractions (EFs), compound-specific carbon isotope composition of DDT and its metabolites, and the microbial community in related arable soils. The geographically total DDT concentrations are higher in eastern than western China. The EFs and δ13 C of o,p'-DDT in soils from western China show smaller deviations from those of racemic/standard compound, indicating the DDT residues there mainly …

Enantiomer Signature And Carbon Isotope Evidence For The Migration And Transformation Of Ddts In Arable Soils Across China, Lili Niu, Chao Xu, Siyu Zhu, Huiming Bao, Yang Xu, Hongyi Li, Zhijian Zhang, Xichang Zhang, Jiguo Qiu, Weiping Liu

Faculty Publications

© The Author(s) 2016. Due to the adverse impact of DDTs on ecosystems and humans, a full fate assessment deems a comprehensive study on their occurrence in soils over a large region. Through a sampling campaign across China, we measured the concentrations, enantiomeric fractions (EFs), compound-specific carbon isotope composition of DDT and its metabolites, and the microbial community in related arable soils. The geographically total DDT concentrations are higher in eastern than western China. The EFs and δ13 C of o,p'-DDT in soils from western China show smaller deviations from those of racemic/standard compound, indicating the DDT residues there mainly …

Improving Mental Health Treatment In Jail And Prison Systems To Decrease Post-Release Negative Outcomes And Re-Incarceration, Stephanie Olson

Nursing Capstones

No abstract provided.

Fall/Winter 2016: St. Norbert Plays In The Digital Sandbox, Rachel Mueller

St. Norbert College Magazine 2013-2018

On-campus collaborations are fostering cutting-edge technology-assisted learning opportunities. In this, the first of a two-part series, Rachel Mueller ’14 looks at the kind of build-your-own tech possibilities offered by tools like the Arduino microprocessor.

Ucc Minutes, December 6, 2016, University Curriculum Council

UCC Agendas/Minutes

No abstract provided.

Calcium-Mediated Actin Reset (Caar) Mediates Acute Cell Adaptations, Pauline Wales, Christian Schuberth, Roland Aufschnaiter, Johannes Fels, Ireth Garcia-Aguilar, Annette Janning, Christopher D. Dlugos, Marco Schaefer-Herte, Christoph Klingner, Mike Waelte, Julian Kuhlmann, Ekaterina Menis, Hockaday Kang Hockaday Kang, Kerstin C. Maier, Wenya Hou, Antonella Russo, Henry N. Higgs

Dartmouth Scholarship

Actin has well established functions in cellular morphogenesis. However, it is not well understood how the various actin assemblies in a cell are kept in a dynamic equilibrium, in particular when cells have to respond to acute signals. Here, we characterize a rapid and transient actin reset in response to increased intracellular calcium levels. Within seconds of calcium influx, the formin INF2 stimulates filament polymerization at the endoplasmic reticulum (ER), while cortical actin is disassembled. The reaction is then reversed within a few minutes. This Calcium-mediated actin reset (CaAR) occurs in a wide range of mammalian cell types and in …

Randomized Phase Ii Trial Of Fulvestrant Alone Or In Combination With Bortezomib In Hormone Receptor-Positive Metastatic Breast Cancer Resistant To Aromatase Inhibitors: A New York Cancer Consortium Trial, Miguel Villalona Calero

All Publications

No abstract provided.

Feminist Complaint Department, Sarah Taavola

Theses

This body of work and research is focused upon finding connections between the artist’s personal trajectory, Surrealist ideology, and Feminist texts. Starting with the Surrealist’s ideology of the unconscious, dreams, and use of objects, the artist investigates the eroticism and fetishization of female imagery. Surrealist work is brimming with portrayals of women as man’s mediator, muse, femme-enfant [child-woman], source and object of man’s desire, and the embodiment of l’amour fou [crazy love]. These representations of women depicted through fragmented female bodies transform into objects to be easily used and consumed, like furniture or food. The artist investigates how Surrealist women …

Um Engineering School Creates Biomedical Degree Program, Edwin Smith

University of Mississippi News

Curriculum will prepare students for range of career opportunities in cutting-edge field

Inflammatory Gene Expression In Women Diagnosed With Polycystic Ovarian Syndrome, Myles K. Taylor

Electronic Theses & Dissertations

Polycystic ovarian syndrome (PCOS) is a common endocrine disorder in women of reproductive age. The pathophysiology of PCOS has conventionally thought to originate from androgen excess. However, recent evidence suggests that androgen excess is a downstream consequence to inflammatory dysregulation and subsequent metabolic abnormalities. Inflammatory mRNA gene expression of TNFa and IL-1ß in mononuclear cells isolated from women diagnosed with PCOS was explored using qPCR. Additionally, the correlations between body mass index (BMI) and fasting glucose on mRNA expression of TNFa and IL-1ß were explored. mRNA expression of both TNFa and IL-1ß were found to be significantly higher in PCOS …

An Examination Into The Relationship Between Iron Deficiency And Postpartum Depression, Sara A. Burroughs

Senior Honors Theses

Postpartum depression is recognized as the most common complication of childbearing; however, its etiology remains fairly undetermined. Many different influences have been hypothesized as to what may cause postpartum depression, including changes in levels of various hormones (such as estrogen and progesterone), a decrease in serotonin, low levels of vitamin D, social factors, and iron deficiency. The lack of strong evidence for one specific cause makes it fairly clear that there are many factors that play a role in the development of postpartum depression. Iron deficiency is one issue that is thought to contribute to the development of postpartum depression …

As-822-16 Resolution On Proposal To Establish The Packaging Value Chain Center, Jay Singh

Academic Senate Resolutions

Establishes the Packaging Value Chain Center.

The Effect Of Social Anxiety On Social Support Behavior In Close Friendships, Marilyn Piccirillo

Arts & Sciences Graduate Student Theses and Dissertations

Quality of interpersonal relationships is a strong predictor of mental and physical health outcomes (Cacioppo, & Hawkley, 2003) and individuals with social anxiety disorder (SAD) report increased relationship impairment (Schneier et al., 1994). Evidence from the interpersonal literature suggests that individuals with SAD exhibit interpersonal constraint, in that they rate themselves as colder and more restricted in the amount of warmth they display with close others (Rodebaugh, Bielak, Vidovic, & Moscovitch, 2016). This study aimed to determine behavioral differences in the provision and receipt of support behaviors as a function of generalized SAD (GSAD). Participants (n = 92) and their …

Investigating The Impact Of Unsupervised Feature-Extraction From Multi-Wavelength Image Data For Photometric Classification Of Stars, Galaxies And Qsos, Annika Lindh

Conference papers

Accurate classification of astronomical objects currently relies on spectroscopic data. Acquiring this data is time-consuming and expensive compared to photometric data. Hence, improving the accuracy of photometric classification could lead to far better coverage and faster classification pipelines. This paper investigates the benefit of using unsupervised feature-extraction from multi-wavelength image data for photometric classification of stars, galaxies and QSOs. An unsupervised Deep Belief Network is used, giving the model a higher level of interpretability thanks to its generative nature and layer-wise training. A Random Forest classifier is used to measure the contribution of the novel features compared to a set …

Dewey And Sports: An Overview Of Sport In His Work, David Jaitner

Education and Culture

From beginning to end, John Dewey’s oeuvre is filled with philosophical discussions and political comments on the significance de jure and de facto of a wide range of distinct social spaces. In contrast to subjects he addresses regularly and others that he focuses on occasionally, his work does not systematically address sport. Nonetheless, sport is expressly recognized as a noteworthy environment and integrated into lines of argumentation in no small number of areas as an example. This paper provides an overview of the statements he made on this subject and their context, organizing them on the basis of their social, …

What We Can Teach When We Teach (About) Religion, Larry A. Hickman

Education and Culture

Given the increasing diversity of religious beliefs and outlooks in the United States, John Dewey’s proposals regarding “a common faith” can help educators provide the tools for their students to think critically about these and other issues related to the changing religious landscape. Particular attention is given to three groups of students: those who are adherents of dogmatic or exclusivist religious communities; those who share the belief that no legitimate value judgments about religious faith are possible; and those religiously unaffiliated students who feel excluded from the possibility of religious faith.

Effect Of Diet On Mortality And Larval Duration In Chrysodeixis Includens (Lepidoptera: Noctuidae), Andrea Przygoda, Erin E. Barding, Margaret Smith

Georgia Journal of Science

Diet mediates many life history trade-offs and therefore is an important environmental component to consider. Because some organisms share food sources with humans, they encounter anthropogenic changes to their diet, such as genetically modified crops and chemical applications, which can contribute to additional complexity in their environment. To understand the effect of diet on the life history of the soybean looper, Chrysodeixis includens, we exposed larvae to several different food sources, including genetically modified soybean leaves and the pesticide spinosad. Significant differences in larval instar duration and timing of larval mortality among treatments were observed indicating that type of diet …

Evaluation Of Parasite Resistance To Commonly Used Commercial Anthelmintics In Meat Goats On Humid Subtropical Pasture, Megan K. Goolsby, Maria Lenira Leite-Browning, Richard Browning Jr.

Agricultural and Environmental Sciences Faculty Research

Anthelmintic-resistant gastrointestinal nematode parasites are a threat to small ruminant industry sustainability. Meat goat does were administered one of four anthelmintics orally (ivermectin (n = 18), moxidectin (n = 18), levamisole hydrochloride (n = 17), or albendazole (n = 19)) or water (n = 18). Fecal samples were collected pretreatment and 12 days post-treatment. Fecal egg counts (FEC) were determined by the modified McMaster technique. The FEC reduction percentages (FECR%) were calculated using three equations. Log transformed FEC means were analyzed by treatment, sire breed of doe, and doe age. Sire breed affected (P < 0.05) pretreatment FEC, but not post-treatment FEC (P = 0.12). Pretreatment FEC did not differ (P = 0.21) by treatment group. Posttreatment FEC varied (P < 0.05) by treatment. Anthelmintic resistance determinations were based on FECR% falling below 90% or 80%, dependent on equation applied. Resistance was detected to all four anthelmintics using each equation. These results suggest the need for alternative methods of internal parasite control in goats.

Discovery Of An Enzyme And Substrate Selective Inhibitor Of Adam10 Using An Exosite-Binding Glycosylated Substrate, Franck Madoux, Daniela Dreymuller, Jean-Phillipe Pettiloud, Radleigh Santos, Christoph Becker-Pauly, Andreas Ludwig, Gregg B. Fields, Thomas Bannister, Timothy P. Spicer, Mare Cudic, Louis D. Scampavia, Dmitriy Minond

Mathematics Faculty Articles

ADAM10 and ADAM17 have been shown to contribute to the acquired drug resistance of HER2-positive breast cancer in response to trastuzumab. The majority of ADAM10 and ADAM17 inhibitor development has been focused on the discovery of compounds that bind the active site zinc, however, in recent years, there has been a shift from active site to secondary substrate binding site (exosite) inhibitor discovery in order to identify non-zinc-binding molecules. In the present work a glycosylated, exosite-binding substrate of ADAM10 and ADAM17 was utilized to screen 370,276 compounds from the MLPCN collection. As a result of this uHTS effort, a selective, …

Grand Valley Forum, Volume 041, Number 15, December 5, 2016, Grand Valley State University

2016-2017, Volume 41

Grand Valley Forum is Grand Valley State's faculty and staff newsletter, published from 1976 to the present.