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2016

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Binge Ethanol Exposure Causes Endoplasmic Reticulum Stress, Oxidative Stress And Tissue Injury In The Pancreas, Zhenhua Ren, Xin Wang, Mei Xu, Fanmuyi Yang, Jacqueline A. Frank, Zun-Ji Ke, Jia Luo Aug 2016

Binge Ethanol Exposure Causes Endoplasmic Reticulum Stress, Oxidative Stress And Tissue Injury In The Pancreas, Zhenhua Ren, Xin Wang, Mei Xu, Fanmuyi Yang, Jacqueline A. Frank, Zun-Ji Ke, Jia Luo

Pharmacology and Nutritional Sciences Faculty Publications

Alcohol abuse is associated with both acute and chronic pancreatitis. Repeated episodes of acute pancreatitis or pancreatic injury may result in chronic pancreatitis. We investigated ethanol-induced pancreatic injury using a mouse model of binge ethanol exposure. Male C57BL/6 mice were exposed to ethanol intragastrically (5 g/kg, 25% ethanol w/v) daily for 10 days. Binge ethanol exposure caused pathological changes in pancreas demonstrated by tissue edema, acinar atrophy and moderate fibrosis. Ethanol caused both apoptotic and necrotic cell death which was demonstrated by the increase in active caspase-3, caspase-8, cleaved PARP, cleaved CK-18 and the secretion of high mobility group protein …

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Summer Commencement Ceremonies, University Of North Florida Aug 2016

Summer Commencement Ceremonies, University Of North Florida

Commencement Printed Materials

Program for the Summer Commencement ceremonies.

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Inactivation Of Type I Ifn Jak-Stat Pathway In Ebv Latency, Shunbin Ning, Ling Wang Aug 2016

Inactivation Of Type I Ifn Jak-Stat Pathway In Ebv Latency, Shunbin Ning, Ling Wang

ETSU Faculty Works

Epstein-Barr Virus (EBV) latent infection is associated with a variety of lymphomas and carcinomas. Interferon (IFN) Regulatory Factors (IRFs) are a family of transcription factors, among which IRF7 is the “master” regulator of type I IFNs (IFN-I) that defends against invading viruses. Robust IFN-I responses require a positive feedback loop between IRF7 and IFN-I. In recent years, we have discovered that IRF7 is significantly induced and activated by the principal EBV oncoprotein--Latent Membrane Protein 1 (LMP1); however, IRF7 fails to trigger robust IFN-I responses in EBV latency. We believe this intriguing finding is critical for EBV latency and oncogenesis, yet …

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Effects Of Echinostoma Trivolvis Metacercariae Infection During Development And Metamorphosis Of The Wood Frog (Lithobates Sylvaticus), Sarah A. Orlofske, Lisa K. Belden, William A. Hopkins Aug 2016

Effects Of Echinostoma Trivolvis Metacercariae Infection During Development And Metamorphosis Of The Wood Frog (Lithobates Sylvaticus), Sarah A. Orlofske, Lisa K. Belden, William A. Hopkins

Biology Faculty Publications

Many organisms face energetic trade-offs between defense against parasites and other host processes that may determine overall consequences of infection. These trade-offs may be particularly evident during unfavorable environmental conditions or energetically demanding life history stages. Amphibian metamorphosis, an ecologically important developmental period, is associated with drastic morphological and physiological changes and substantial energetic costs. Effects of the trematode parasite Echinostoma trivolvis have been documented during early amphibian development, but effects during later development and metamorphosis are largely unknown. Using a laboratory experiment, we examined the energetic costs of late development and metamorphosis coupled with E. trivolvis infection in wood …

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A Primate Apol1 Variant That Kills Trypanosoma Brucei Gambiense, Anneli Cooper, Paul Capewell, Caroline Clucas, Nicola Veitch, William Weir, Russell Thompson, Jayne Raper, Annette Macleod Aug 2016

A Primate Apol1 Variant That Kills Trypanosoma Brucei Gambiense, Anneli Cooper, Paul Capewell, Caroline Clucas, Nicola Veitch, William Weir, Russell Thompson, Jayne Raper, Annette Macleod

Publications and Research

Humans are protected against infection from most African trypanosomes by lipoprotein complexes present in serum that contain the trypanolytic pore-forming protein, Apolipoprotein L1 (APOL1). The human-infective trypanosomes, Trypanosoma brucei rhodesiense in East Africa and T. b. gambiense in West Africa have separately evolved mechanisms that allow them to resist APOL1-mediated lysis and cause human African trypanosomiasis, or sleeping sickness, in man. Recently, APOL1 variants were identified from a subset of Old World monkeys, that are able to lyse East African T. b. rhodesiense, by virtue of C-terminal polymorphisms in the APOL1 protein that hinder that parasite’s resistance mechanism. Such variants …

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The Parthenon, August 5, 2016, Lexi Browning Aug 2016

The Parthenon, August 5, 2016, Lexi Browning

The Parthenon

The Parthenon, Marshall University’s student newspaper, was published by students Monday through Friday during the regular semester and weekly on Thursdays during the summer. Due to budgetary constraints, beginning with the 2015 Fall semester, the newspaper is only published four days a week. There is no issue on Mondays, physical issues are printed on Tuesdays and Fridays, and online issues only are published on Wednesdays and Thursdays. The editorial staff is responsible for the news and the editorial content.

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Cultivating Minority Scientists: Undergraduate Research Increases Self-Efficacy And Career Ambitions For Underrepresented Students In Stem, Anthony Carpi, Darcy M. Ronan, Heather M. Falconer, Nathan H. Lents Aug 2016

Cultivating Minority Scientists: Undergraduate Research Increases Self-Efficacy And Career Ambitions For Underrepresented Students In Stem, Anthony Carpi, Darcy M. Ronan, Heather M. Falconer, Nathan H. Lents

Publications and Research

In this study, Social Cognitive Career Theory (SCCT) is used to explore changes in the career intentions of students in an undergraduate research experience (URE) program at a large public minority-serving college. Our URE model addresses the challenges of establishing an undergraduate research program within an urban, commuter, underfunded, Minority-Serving Institution (MSI). However, our model reaches beyond a focus on retention and remediation toward scholarly contributions and shifted career aspirations. From a student’s first days at the College to beyond their graduation, we have encouraged them to explore their own potential as scientists in a coordinated, sequential, and self-reflective process. …

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Comparative Genomics Of 9 Novel Paenibacillus Larvae Bacteriophages, Casey Stamereilers, Lucy Leblanc, Diane Yost, Penny S. Amy, Philippos K. Tsourkas Aug 2016

Comparative Genomics Of 9 Novel Paenibacillus Larvae Bacteriophages, Casey Stamereilers, Lucy Leblanc, Diane Yost, Penny S. Amy, Philippos K. Tsourkas

Life Sciences Faculty Research

American Foulbrood Disease, caused by the bacterium Paenibacillus larvae, is one of the most destructive diseases of the honeybee, Apis mellifera. Our group recently published the sequences of 9 new phages with the ability to infect and lyse P. larvae. Here, we characterize the genomes of these P. larvae phages, compare them to each other and to other sequenced P. larvae phages, and putatively identify protein function. The phage genomes are 38–45 kb in size and contain 68–86 genes, most of which appear to be unique to P. larvae phages. We classify P. larvae phages into 2 main clusters and …

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Human Observers Differ In Ability To Perceive Insect Diversity, Joseph S. Wilson, Joshua P. Jahner, Matthew L. Forister Aug 2016

Human Observers Differ In Ability To Perceive Insect Diversity, Joseph S. Wilson, Joshua P. Jahner, Matthew L. Forister

Biology Faculty Publications

Human perception of biological variation is an important and understudied issue in the conservation and management of natural resources. Here, we took a novel approach by asking 1152 participants, primarily college biology students, to score examples of insect mimicry by the number of distinct kinds of animals they saw. Latent class analysis successfully separated participants based on their accuracy of perception as well as demographic information and opinions about biodiversity. Contrary to expectations, factors such as childhood experience (growing up in urban, suburban or rural areas) did not affect the ability to see biodiversity as much as political views (location …

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Incorporating Active Learning When You Feel More Like Ant Man Than The Hulk, Ann Lindbloom Aug 2016

Incorporating Active Learning When You Feel More Like Ant Man Than The Hulk, Ann Lindbloom

SIDLIT Conference

Active Learning is a key component when attempting to increase online retention. The overwhelming number of techniques can make instructors wish for super powers to determine which to implement in their courses. Initial research suggests reflection, individualized learning, and social media as important places to start. This session will provide 30 techniques that can be implemented online or onsite, offer some real-life implementations and success, and encourage audience participation for additional discussion. The focus will not be on new technologies, but rather how to incorporate these methods using basic tools found in most LMSs.

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Full Issue, Children's Book Review Aug 2016

Full Issue, Children's Book Review

Children's Book and Media Review

No abstract provided.

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Leeches, Jessica Waite Aug 2016

Leeches, Jessica Waite

Children's Book and Media Review

No abstract provided.

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Identification And Characterization Of The Molecular Determinants Of The Anterior-Posterior Axis In The Sea Urchin Embryo, Lingyu Wang Aug 2016

Identification And Characterization Of The Molecular Determinants Of The Anterior-Posterior Axis In The Sea Urchin Embryo, Lingyu Wang

Open Access Dissertations

How the embryonic body axis emerges from a seemingly symmetrical egg and is subsequently patterned during embryogenesis is one of the most fundamental questions in developmental biology. It is now clear that localized activation of the Wnt/β-catenin signaling pathway plays a conserved role in primary body axis formation and/or endoderm/endomesoderm specification during embryo development of phylogenetically diverse animal species. In sea urchin embryos, recent experimental evidence has shown that Dishevelled (Dsh), a central hub protein in the Wnt/β-catenin pathway, is asymmetrically enriched and differentially modified in a vegetal cortical domain (VCD) of the unfertilized egg. Experimental evidence has also shown …

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Permanent Improved High-Quality Draft Genome Sequence Of Nocardia Casuarinae Strain Bmg51109, An Endophyte Ofactinorhizal Root Nodules Of Casuarina Glauca, Faten Ghodhbane-Gtari, Nicholas Beauchemin, Moussa Louati, Imen Nouioui, Amir Ktari, Karima Hezbri, Abdellatif Gueddou, Amy Chen, Marcel Huntemann, Natalia Ivanova, Nikos Kyrpides, Victor Markowitz, Kostas Mavrommatis, Ioanna Pagani, Arnab Sen, Luis Wall, Tanja Woyke, Maher Gtari, Louis S. Tisa Aug 2016

Permanent Improved High-Quality Draft Genome Sequence Of Nocardia Casuarinae Strain Bmg51109, An Endophyte Ofactinorhizal Root Nodules Of Casuarina Glauca, Faten Ghodhbane-Gtari, Nicholas Beauchemin, Moussa Louati, Imen Nouioui, Amir Ktari, Karima Hezbri, Abdellatif Gueddou, Amy Chen, Marcel Huntemann, Natalia Ivanova, Nikos Kyrpides, Victor Markowitz, Kostas Mavrommatis, Ioanna Pagani, Arnab Sen, Luis Wall, Tanja Woyke, Maher Gtari, Louis S. Tisa

New Hampshire Agricultural Experiment Station Publications

Here, we report the first genome sequence of aNocardiaplant endophyte, N. casuarinaestrain BMG51109, isolated fromCasu-arina glaucaroot nodules. The improved high-quality draft genome sequence contains 8,787,999 bp with a 68.90% GC contentand 7,307 predicted protein-coding genes.

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2016 New Faculty Orientation Handbook, Robert M. Lindsey Aug 2016

2016 New Faculty Orientation Handbook, Robert M. Lindsey

New Faculty Orientation Handbooks

Library information for Pittsburg State University Faculty.

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Mapping Mayapple Growth In Restored Forest, Jonathan Walt, Stephanie Praamsma, Tanner Vincent, David P. Warners Aug 2016

Mapping Mayapple Growth In Restored Forest, Jonathan Walt, Stephanie Praamsma, Tanner Vincent, David P. Warners

Student Papers and Reports

No abstract provided.

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Environmental Impact Report - Lrcp, Uc Hastings College Of The Law Aug 2016

Environmental Impact Report - Lrcp, Uc Hastings College Of The Law

Long Range Campus Planning Archive

No abstract provided.

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Synthesis Of Cyclic Enolphosphonates And Enolphosphates As Inhibitors Of Serine Hydrolases, Benjamin Patrick Martin Aug 2016

Synthesis Of Cyclic Enolphosphonates And Enolphosphates As Inhibitors Of Serine Hydrolases, Benjamin Patrick Martin

Dissertations

Cyclophostin is a potent naturally occurring inhibitor of acetylcholinesterase with a novel bicyclic enolphosphate structure. The cyclipostins are a family of potent hormone-sensitive lipase inhibitors which share the same bicyclic enolphosphate core structure with cyclophostin which but differ primarily in that they are long-chain alkyl phosphate esters whereas cyclophostin is a methyl phosphate ester. Due to the novelty of the inhibitor structure, potency, and ability to select between two serine hydrolase enzymes with a simple change in the ester substituent, the ongoing structure activity relationship investigation of this family of inhibitors was continued. Methods of transesterification were investigated in order …

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Field Estimates Of Parentage Reveal Sexually Antagonistic Selection On Body Size In A Population Of Anolis Lizards, Mary C. Duryea, Patrick Bergeron, Zachary Clare-Salzler, Ryan Calsbeek Aug 2016

Field Estimates Of Parentage Reveal Sexually Antagonistic Selection On Body Size In A Population Of Anolis Lizards, Mary C. Duryea, Patrick Bergeron, Zachary Clare-Salzler, Ryan Calsbeek

Dartmouth Scholarship

Sexual dimorphism evolves when selection favors different phenotypic optima between the sexes. Such sexually antagonistic selection creates intralocus sexual conflict when traits are genetically correlated between the sexes and have sex‐specific optima. Brown anoles are highly sexually dimorphic: Males are on average 30% longer than females and 150% heavier in our study population. Viability selection on body size is known to be sexually antagonistic, and directional selection favors large male size whereas stabilizing selection constrains females to remain small. We build on previous studies of viability selection by measuring sexually antagonistic selection using reproductive components of fitness over three generations …

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The Effect Of Content-Related And Unrelated Break Activities On Test Results, Ryan Gentek Aug 2016

The Effect Of Content-Related And Unrelated Break Activities On Test Results, Ryan Gentek

Theses and Dissertations

Researchers have recently explored using brief breaks to maintain performance during prolonged tasks (Ariga and Lleras, 2011). However, research has yet to fully explore the effect of break activity content on the performance of the primary task. The present study sought to explore the differing effects of two break activities that were respectively similar and different in content to the main task. The present researcher compared past studies of task-switching and interruption studies to theories of the vigilance decrement and hypothesized that a brief similar task should result in significantly different main-task performance than the brief dissimilar task. 20 participating …

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First-Year Students: Investigating The Impact Of Participating In A Mathematics Learning Community, Lindsay Barrie Aug 2016

First-Year Students: Investigating The Impact Of Participating In A Mathematics Learning Community, Lindsay Barrie

Theses and Dissertations

The purpose of this study was to investigate how participating in a mathematics learning community can impact a first-year students’ experience in college. The total population in the Math Learning Community (MLC) was 40, 36 of these members participated in a survey and five volunteered to participate in an interview. The survey collected demographic information and responses to statements regarding the students’ transition to college, their connectedness to Rowan, their peer interaction, faculty interaction, and their overall satisfaction at Rowan. The interview questions asked about their most and least satisfying aspects of participating in the MLC and what recommendations they …

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Design Maps For Fracture Resistant Functionally Graded Materials, Muhammad Ridwan Murshed Aug 2016

Design Maps For Fracture Resistant Functionally Graded Materials, Muhammad Ridwan Murshed

Theses and Dissertations

The objective of this research is to generate design maps to identify functionally graded microstructures with enhanced fracture toughness. Several Functionally Graded Materials (FGMs) with an edge crack and membrane loading are considered and the resulting J-integral values are computed numerically using Finite Element Analysis. In order to capture the resulting stress fields accurately, Barsoum elements are used in the vicinity of the crack tip and the simulations are carried out for several crack lengths (a) and material contrasts (κ). The averages of the J-integral values are used to determine the normalized Stress Intensity Factors which are then benchmarked with …

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Expression Of A Grapevine Nac Transcription Factor Gene Is Induced In Response To Powdery Mildew Colonization In Salicylic Acid-Independent Manner, Zsofia Toth, Patrick Winterhagen, Balazs Kalapos, Yingcai Su, Laszlo Kovacs, Erzsebet Kiss Aug 2016

Expression Of A Grapevine Nac Transcription Factor Gene Is Induced In Response To Powdery Mildew Colonization In Salicylic Acid-Independent Manner, Zsofia Toth, Patrick Winterhagen, Balazs Kalapos, Yingcai Su, Laszlo Kovacs, Erzsebet Kiss

College of Natural and Applied Sciences

Tissue colonization by grape powdery mildew (PM) pathogen Erysiphe necator (Schw.) Burr triggers a major remodeling of the transcriptome in the susceptible grapevine Vitis vinifera L. While changes in the expression of many genes bear the signature of salicylic acid (SA) mediated regulation, the breadth of PM-induced changes suggests the involvement of additional regulatory networks. To explore PM-associated gene regulation mediated by other SA-independent systems, we designed a microarray experiment to distinguish between transcriptome changes induced by E. necator colonization and those triggered by elevated SA levels. We found that the majority of genes responded to both SA and PM, …

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A Physiologically Motivated Approach To The Classification Of Natural Sounds Using High Order Sound Statistics, Brian B. Bishop Aug 2016

A Physiologically Motivated Approach To The Classification Of Natural Sounds Using High Order Sound Statistics, Brian B. Bishop

Master's Theses

The ability of humans and animals to classify sounds into behaviorally relevant categories is an ongoing field of study in auditory neuroscience and psychophysics. We employed a physiologically motivated signal processing scheme to extract time-varying statistics from a large database of real sounds. Our hypothesis is that two sound statistics, intensity and contrast, will be sufficient to classify broad categories of sounds using a naïve Bayesian classifier. We seek to evaluate this hypothesis, determine to what extent these two time-varying statistics can be used to classify sounds and to evaluate the limitations of the technique. The sounds themselves were organized …

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Infant Exposure To Resuspended Particles From Carpeted Flooring: Experimental Chamber Study With A Simplified Mechanical Crawling Infant, Manjie Fu, Brandon E. Boor Aug 2016

Infant Exposure To Resuspended Particles From Carpeted Flooring: Experimental Chamber Study With A Simplified Mechanical Crawling Infant, Manjie Fu, Brandon E. Boor

The Summer Undergraduate Research Fellowship (SURF) Symposium

Airborne particles of biological origin – bioaerosols – are present everywhere, including the indoor environment where people spend considerable amounts of time, and exposure to such materials via inhalation can have a number of health implications. Bioaerosol dynamics can occur through a variety of mechanisms, among them resuspension of deposited particles due to human activity. Because the breathing zone of infants is at a much lower height than that of adults, there is reason to suspect that infants are exposed to greater concentrations of bioaerosols resuspended from the floor, though knowledge in this specific area is limited. To investigate, a …

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Plant Phenotyping On Mobile Devices, Ziling Chen, Jian Jin, Zhihang Song, Jialei Wang Aug 2016

Plant Phenotyping On Mobile Devices, Ziling Chen, Jian Jin, Zhihang Song, Jialei Wang

The Summer Undergraduate Research Fellowship (SURF) Symposium

Plants phenotyping is a fast and non-destructive method to obtain the physiological features of plants, compared with the expensive and time costing chemical analysis with plant sampling. Through plant phenotyping, scientists and farmers can tell plant health status more accurately compared to visual inspection, thus avoid the waste in time and resources and even to predict the productivity. However, the size and price of current plant phenotyping equipment restrict them from being widely applied at a farmer’s household level. Everyday field operation is barely achieved because of the availability of easy-to-carry and cost-effective equipment such as hyper-spectrum cameras, infrared cameras …

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Real-Time Temperature And Heat Flux Measurements For Lyophilization Process Design And Monitoring: Part 1, Evan T. Liechty, Nicholas J. Huls, Andrew D. Strongrich, Alina A. Alexeenko Aug 2016

Real-Time Temperature And Heat Flux Measurements For Lyophilization Process Design And Monitoring: Part 1, Evan T. Liechty, Nicholas J. Huls, Andrew D. Strongrich, Alina A. Alexeenko

The Summer Undergraduate Research Fellowship (SURF) Symposium

Lyophilization is a common method used to preserve pharmaceutical and biological products. Accurately measuring temperature during the three stages of lyophilization: freezing, primary drying, and secondary drying, is important to ensure product consistency and to reduce operating costs. Wireless temperature sensors were evaluated to determine if temperature is monitored accurately and to determine if wireless temperature sensors offer advantages over traditional temperature measurement technologies. These sensors contain three capacitors to monitor temperature as the solvent is sublimated. A Millrock Technology REVO lyophilizer was used for testing. Water and 5% w/v sucrose solution were distributed in 3 mL fill volume increments …

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Analyzing Mutations Of Spt7 Protein That Disrupt Interaction With Sf3b Subunits, Arryn T. Harris, Peyton J. Spreacker, Rachel Stegeman, Vikki M. Weake, Edwin C. Acosta Aug 2016

Analyzing Mutations Of Spt7 Protein That Disrupt Interaction With Sf3b Subunits, Arryn T. Harris, Peyton J. Spreacker, Rachel Stegeman, Vikki M. Weake, Edwin C. Acosta

The Summer Undergraduate Research Fellowship (SURF) Symposium

Proper transcription, the process of converting DNA to RNA, is crucial for the health and viability of an organism. This process is regulated by many proteins, such as co-transcriptional activators; one being the protein complex known as Spt-Ada-Gcn5-acetyltransferase, or SAGA. While much is known about the roles of SAGA in cell processes, how SAGA’s subunits promote functionality is still unknown. The focus of this study is to analyze the purpose of SAGA’s SF3B subunits. These subunits are also found in the spliceosome, the compound responsible for generating mature RNA. SAGA has no known functions relating to this process, so the …

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Design And Development Of A Plasmid Vector For Protein Expression And Purification, Mahima Grover, Craig Sweet, David H. Thompson Aug 2016

Design And Development Of A Plasmid Vector For Protein Expression And Purification, Mahima Grover, Craig Sweet, David H. Thompson

The Summer Undergraduate Research Fellowship (SURF) Symposium

Production and isolation of proteins are difficult, costly and time-consuming processes. The aim of this project is for the development of plasmids, which allow for streamlined production and isolation of proteins. To allow for modular insertion of varying segments of DNA we are using ‘recursive directional ligation by plasmid reconstruction’. This technique uses type II restriction endonucleases, which cut downstream from their recognition site allowing multiple insertions without losing a restriction site. Using this process, we can ligate multiple DNA sequences together and express them to be able to construct a scar less fusion protein. In order to accomplish this, …

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Identifying The Effects Of Unprocessed Let-7a-1 And Let-7a-3 In Non-Small Cell Lung Cancer, Hana Kubo, Phillip J. Mccown, Andrea L. Kasinski Aug 2016

Identifying The Effects Of Unprocessed Let-7a-1 And Let-7a-3 In Non-Small Cell Lung Cancer, Hana Kubo, Phillip J. Mccown, Andrea L. Kasinski

The Summer Undergraduate Research Fellowship (SURF) Symposium

MicroRNAs (miRNAs) are small, noncoding RNAs that regulate protein levels typically by interacting with the 3′ untranslated region (3′-UTR) of target messenger RNA (mRNAs) and are often aberrantly expressed in cancer. The let-7 miRNA family members are commonly regarded as cancer suppressors, by down-regulating the expression of oncoproteins such as RAS, HMGA2, and MYC. However, prior work indicates that unprocessed let-7 RNAs may be positively correlated with cancer phenotypes in lung cancer cell lines. Our study aims to identify the effects of unprocessed let-7a-1 and let-7a-3 in non-small cell lung cancer, by transfecting plasmids that express unprocessed let-7a-1 and let-7a-3 …

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