Digital Commons Network^™

The Murray Ledger And Times, August 10, 2016, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

Ptsd Symptom Severities, Interpersonal Traumas, And Benzodiazepines Are Associated With Substance-Related Problems In Trauma Patients, Jeffrey Guina, Ramzi W. Nahhas, Adam J. Goldberg, Seth Farnsworth

Population and Public Health Sciences Faculty Publications

Background: Trauma is commonly associated with substance-related problems, yet associations between specific substances and specific posttraumatic stress disorder symptoms (PTSSs) are understudied. We hypothesized that substance-related problems are associated with PTSS severities, interpersonal traumas, and benzodiazepine prescriptions. Methods: Using a cross-sectional survey methodology in a consecutive sample of adult outpatients with trauma histories (n = 472), we used logistic regression to examine substance-related problems in general (primary, confirmatory analysis), as well as alcohol, tobacco, and illicit drug problems specifically (secondary, exploratory analyses) in relation to demographics, trauma type, PTSSs, and benzodiazepine prescriptions. Results: After adjusting for multiple testing, several factors …

Lipophosphoglycans From Leishmania Amazonensis Strains Display Immunomodulatory Properties Via Tlr4 And Do Not Affect Sand Fly Infection, Paula M. Nogueira, Rafael R. Assis, Ana C. Torrecilhas, Elvira M. Saraiva, Natália L. Pessoa, Marco A. Campos, Eric F. Marialva, Cláudia M. Ríos-Velasquez, Felipe A. Pessoa, Nágila F. Secundino, Jerônimo N. Rugani, Elsa Nieves, Salvatore J. Turco, Maria N. Melo, Rodrigo P. Soares

Molecular and Cellular Biochemistry Faculty Publications

The immunomodulatory properties of lipophosphoglycans (LPG) from New World species of Leishmania have been assessed in Leishmania infantum and Leishmania braziliensis, the causative agents of visceral and cutaneous leishmaniasis, respectively. This glycoconjugate is highly polymorphic among species with variation in sugars that branch off the conserved Gal(β1,4)Man(α1)-PO₄ backbone of repeat units. Here, the immunomodulatory activity of LPGs from Leishmania amazonensis, the causative agent of diffuse cutaneous leishmaniasis, was evaluated in two strains from Brazil. One strain (PH8) was originally isolated from the sand fly and the other (Josefa) was isolated from a human case. The ability of …

08-10-2016 Dr. Les Ramos Named Associate Dean Of Swosu College Of Pharmacy, Southwestern Oklahoma State University

THE BARK ARCHIVE 2016

Dr. Les Ramos has been named Associate Dean of the Southwestern Oklahoma State University College of Pharmacy in Weatherford.

Developing A Liwc Dictionary: The Lyrical Poetry Of 2pac, Frank Waln, Litefoot, And Nataanii Means, Teresa Y. Neely, Sarah Kostelecky, Monica Etsitty Dorame, Jorge Ricardo López-Mcknight

University Libraries & Learning Sciences Faculty and Staff Publications

The researchers developed a dictionary, DKL-MN2016, to use the LIWC (http://liwc.wpengine.com/) software to analyze the lyrics of 4 activist, rapper, hiphop artists who are men of color, to answer two research questions: Do Native American male rappers address socioeconomic issues in their lyrics? and How does the lyrical content of Native American male rappers compare Tupac Shakur’s lyrical content written before 1996?

Academics: The Newsletter Of The Swosu College Of Arts And Sciences, Peter Grant

aCAdemicS: The Newsletter of the SWOSU College of Arts & Sciences

No abstract provided.

Structural Polymorphism Of Alzheimer's Β-Amyloid Fibrils As Controlled By An E22 Switch: A Solid-State Nmr Study, Matthew R. Elkins, Tuo Wang, Mimi Nick, Hyunil Jo, Thomas Lemmin, Stanley B. Prusiner, William F. Degrado, Jan Stöhr, Mei Hong

Faculty Publications

© 2016 American Chemical Society. The amyloid-β (Aβ) peptide of Alzheimer's disease (AD) forms polymorphic fibrils on the micrometer and molecular scales. Various fibril growth conditions have been identified to cause polymorphism, but the intrinsic amino acid sequence basis for this polymorphism has been unclear. Several single-site mutations in the center of the Aβ sequence cause different disease phenotypes and fibrillization properties. The E22G (Arctic) mutant is found in familial AD and forms protofibrils more rapidly than wild-type Aβ. Here, we use solid-state NMR spectroscopy to investigate the structure, dynamics, hydration and morphology of Arctic E22G Aβ40 fibrils. 13C, 15N-labeled …

App Regulates Microglial Phenotype In A Mouse Model Of Alzheimer's Disease, Gunjan D. Manocha, Angela M. Floden, Keiko Rausch, Joshua A. Kulas, Brett A. Mcgregor, Lalida Rojanathammanee, Kelley R. Puig, Kendra L. Puig, Sanjib Karki, Michael R. Nichols, Diane C. Darland, James E. Porter, Colin K. Combs

Biology Faculty Publications

Prior work suggests that amyloid precursor protein (APP) can function as a proinflammatory receptor on immune cells, such as monocytes and microglia. Therefore, we hypothesized that APP serves this function in microglia during Alzheimer's disease. Although fibrillar amyloid β (Aβ)-stimulated cytokine secretion from both wild-type and APP knock-out (mAPP−/−) microglial cultures, oligomeric Aβ was unable to stimulate increased secretion from mAPP−/− cells. This was consistent with an ability of oligomeric Aβ to bind APP. Similarly, intracerebroventricular infusions of oligomeric Aβ produced less microgliosis in mAPP−/− mice compared with wild-type mice. The mAPP−/− mice crossed to an APP/PS1 transgenic mouse line …

How Reference With Demonstratives Creates Cohesion In A Physical Science Textbook, Amy Marie Petersen Sagrado

School of Education and Leadership Student Capstone Theses and Dissertations

The research question addressed in this project is How are demonstratives used as reference in a 10th grade physical science textbook? The purpose was to inform the instruction of English learners when using a grade level text through a text analysis by understanding how demonstratives are used, whether as a determiner or pronoun, the direction the demonstrative points, the distance to the referent, whether the referent is a noun phrase, clause or inference and the clarity of the referent. Among the findings, it was concluded that demonstrative determiners are used more frequently in text than demonstrative pronouns and tend to …

The Impact Of Environmental Education On Environmental Literacy And Motivation In Urban Communities, Amber Huston

School of Education and Leadership Student Capstone Theses and Dissertations

The research question addressed is does environmental education increase environmental literacy and motivation in urban communities in the United States? The motivating factor for this capstone was from evidence that environmental education can not only improve motivation and literacy, but also help improve academic achievement. This capstone details both historical and current data to support full integration of structured environmental education programs into urban academics. The author documents the results of a survey based on observations made by various academic instructors of both their personal experiences, as well as their view of their students’ experiences, both inside and outside the …

A Hybrid Technique Of Energy Harvesting From Mechanical Vibration And Ambient Illumination, M Shafiqur Rahman

LSU New Orleans Theses and Dissertations

Hybrid energy harvesting is a concept applied for improving the performance of the conventional stand-alone energy harvesters. The thesis presents the analytical formulations and characterization of a hybrid energy harvester that incorporates photovoltaic, piezoelectric, electromagnetic, and electrostatic mechanisms. The initial voltage required for electrostatic mechanism is obtained by the photovoltaic technique. Other mechanisms are embedded into a bimorph piezoelectric cantilever beam having a tip magnet and two sets of comb electrodes on two sides of its substructure. All the segments are interconnected by an electric circuit to generate combined output when subjected to vibration and solar illumination. Results for power …

Phylogenetic Relationships And Evolution Of Snakes, Alex Figueroa

LSU New Orleans Theses and Dissertations

Snakes represent an impressive evolutionary radiation of over 3,500 widely-distributed species, categorized into 515 genera, encompassing a diverse range of morphologies and ecologies. This diversity is likely attributable to their distinctive morphology, which has allowed them to populate a wide range of habitat types within most major ecosystems. In my first chapter, I provide the largest-yet estimate of the snake tree of life using maximum likelihood on a supermatrix of 1745 taxa (1652 snake species + 7 outgroup taxa) and 9,523 base pairs from 10 loci (5 nuclear, 5 mitochondrial), including previously unsequenced genera (2) and species (61). I then …

3d Printing Of A Polymer Bioactive Glass Composite For Bone Repair, Caroline Murphy, Krishna C. R. Kolan, M. Long, Ming-Chuan Leu, Julie A. Semon, D. E. Day

Mechanical and Aerospace Engineering Faculty Research & Creative Works

A major limitation of synthetic bone repair is insufficient vascularization of the interior region of the scaffold. In this study, we investigated the 3D printing of adipose derived mesenchymal stem cells (AD-MSCs) with polycaprolactone (PCL)/bioactive glass composite in a single process. This offered a three-dimensional environment for complex and dynamic interactions that govern the cell’s behavior in vivo. Borate based bioactive (13-93B3) glass of different concentrations (10 to 50 weight %) was added to a mixture of PCL and organic solvent to make an extrudable paste. AD-MSCs suspended in Matrigel was extruded as droplets using a second syringe. Scaffolds measuring …

Quef And Quef-Like: Diverse Chemistries In A Common Fold, Adriana Bon Ramos

Dissertations and Theses

The tunneling fold (T-Fold) superfamily is a small superfamily of enzymes found in organisms encompassing all kingdoms of life. Seven members have been identified thus far. Despite sharing a common three-dimensional structure these enzymes perform very diverse chemistries.

QueF is a bacterial NADPH-dependent oxidoreductase that catalyzes the reduction of the nitrile group of 7-cyano-7-deazaguanine (preQ₀) to a primary amine (preQ₁) in the queuosine biosynthetic pathway. Previous work on this enzyme has revealed the mechanism of reaction but the cofactor binding residues remain unknown. The experiments discussed herein aim to elucidate the role of residues lysine 80, …

Evaluation Of Microparticulate Ovarian Cancer Vaccine Via Transdermal Route Of Delivery, Suprita A. Tawde, Lipika Chablani, Archana Akalkotkar, Martin J. D'Souza

Pharmacy Faculty/Staff Publications

Ovarian cancer is the fifth most commonly occurring malignancy in women, with the highest mortality rate among all the gynecological tumors. Microparticulate vaccine can serve as an immunotherapeutic approach with a promising antigenic delivery system without a need for conventional adjuvants. In this study, a microparticulate vaccine using whole cell lysate of a murine ovarian cancer cell line, ID8 was prepared by spray drying. Further, the effect of interleukins (ILs) such as IL-2 and IL-12 was evaluated in a separate study group by administering them with vaccine particles to enhance the immune response. The vaccine microparticles were administered to C57BL/6 …

A Study Of Integration: The Role Of Sensus Communis In Integrating Disciplinary Knowledge, Laureen Park

Publications and Research

Integration is an important notion for interdisciplinary studies. Achieving this shows that the interdisciplinary learner has successfully understood the commonalities among disciplines, as well as exercised crucial cognitive skills. This chapter attempts to elucidate how students integrated various disciplinary perspectives in the interdisciplinary course, Weird Science: Interpreting and Redefining Humanity. The study uses Hans-Georg Gadamer’s notion of the sensus communis to clarify how it was that students were processing and accomplishing the goal of integrating different disciplinary perspectives as evidenced in class observation, discussion, and especially student papers. The study demonstrates the ways in which common sense knowledge conditions and …

Liberal Arts Students Awarded Gilman International Scholarships, Laura Perille

UNH Today Archive

No abstract provided.

Habitat Suitability Modeling For The Mississippi Sandhill Crane, Grus Canadensis Pulla, Linda C. Salande

LSU New Orleans Theses and Dissertations

In this study, I modeled the suitability of habitat on the Mississippi Sandhill Crane National Wildlife Refuge for the federally endangered Mississippi Sandhill Crane (Grus Canadensis pulla). Habitat type and suitability changed over time due to seasonality of vegetation and succession in the absence of burning. Cranes used highly suitable habitat more in the non-growing than in the growing season, and may have been more constrained by resource availability during winter months. Cranes used some less-suitable areas including cypress drains, which provide roosting sites, and supplemental food plots. The mismatch between predicted quality and crane use suggests that …

Engineering Nanoarchitectures From Nanosheets, Nanoscrolls, And Nanoparticles, Taha Rostamzadeh

LSU New Orleans Theses and Dissertations

The ability to encapsulate/insert different kinds of nanoparticles (NPs) in scrolled nanosheets (NSs) may lead to the formation of new nanocomposite materials that yield novel properties. These nanostructures resemble “peapods” that consist of NPs chains (“peas”) located in a hollow space of desired nanoscrolls (“pods”). Depending on different combinations of “peas” and “pods” diverse families of nanopeapods (NPPs) can be synthesized which may exhibit interesting properties not accessible from the individual components. Though there exist various synthetic methods for the formation of NPPs, more development in terms of simplicity, flexibility, and productivity of synthetic approaches are needed so that different …

Exposing The “Shadow Side”: Female-Female Competition In Jane Austen’S Emma, Melissa M. Lyman

LSU New Orleans Theses and Dissertations

Many critics have examined the shifting nature of female friendship in Jane Austen’s Emma from cultural and historical angles. However, a comprehensive scientific analysis of female-female alliance and competition in the novel remains incomplete. The Literary Darwinist approach considers the motivations of fictional characters from an evolutionary perspective, focusing primarily on human cognition and behaviors linked to reproductive success, social control, and survival. While overt physical displays of male competition are conspicuous in the actions of the human species and those of their closest primate relatives, female aggression is often brandished psychologically and indirectly, which makes for a much more …

Neural Mechanisms Of Action Switching Moderate The Relationship Between Effortful Control And Aggression, Eric L. Rawls

LSU New Orleans Theses and Dissertations

Aggression and violence are social behaviors that exact a significant toll on human societies. Individuals with aggressive tendencies display deficits in effortful control, particularly in affectively charged situations. However, not all individuals with poor effortful control are aggressive. This study uses event-related potentials (ERPs) to decompose the chronology of cognitive functions underlying the link between effortful control and aggression. Specifically, this study investigates which ERPs moderate the effortful control - aggression association. We examined three successive ERP components (P2, N2 and P3) for stimuli that required effortful control. Results indicated that N2 activation, but not P2 or P3 activation, moderated …

Comparing Methods Of Euthanasia And Gill Culture For Hypoxia Research On The Gulf Killifish, Fundulus Grandis, Kristina M. Farragut

LSU New Orleans Theses and Dissertations

Aquatic hypoxia, or low dissolved oxygen, is a growing environmental concern and has detrimental effects on many fishes. Research on fish responses to hypoxia includes whole animal studies as well as organ culture systems. In this thesis, the gulf killifish, Fundulus grandis, was used to determine the interaction between hypoxic exposure and four common euthanasia techniques on selected blood and gill variables and to develop an in vitro gill incubation system. Euthanasia techniques had differential effects on blood and gill, with the common fish anesthetic MS-222 having the greatest effects, but none altered the response to hypoxia. During the …

Unprecedented Disease-Related Coral Mortality In Southeastern Florida, William F. Precht, Brooke Erin Gintert, Martha L. Robbart, Ryan Fura, Robert Van Woesik

Ocean Engineering and Marine Sciences Faculty Publications

Anomalously high water temperatures, associated with climate change, are increasing the global prevalence of coral bleaching, coral diseases, and coral-mortality events. Coral bleaching and disease outbreaks are often inter-related phenomena, since many coral diseases are a consequence of opportunistic pathogens that further compromise thermally stressed colonies. Yet, most coral diseases have low prevalence (<5%), and are not considered contagious. By contrast, we document the impact of an extremely high-prevalence outbreak (61%) of white-plague disease at 14 sites off southeastern Florida. White-plague disease was observed near Virginia Key, Florida, in September 2014, and after 12 months had spread 100 km north and 30 km south. The disease outbreak directly followed a high temperature coral-bleaching event and affected at least 13 coral species. Eusmilia fastigiata, Meandrina meandrites, and Dichocoenia stokesi were the most heavily impacted coral species, and were reduced to <3% of their initial population densities. A number of other coral species, including Colpophyllia natans, Pseudodiploria strigosa, Diploria labyrinthiformis, and Orbicella annularis were reduced to <25% of their initial densities. The high prevalence of disease, the number of susceptible species, and the high mortality of corals affected suggests this disease outbreak is arguably one of the most lethal ever recorded on a contemporary coral reef.

Integrative Approach For Inference Of Gene Regulatory Networks Using Lasso-Based Random Featuring And Application To Psychiatric Disorders, Dongchul Kim, Mingon Kang, Ashis Kumer Biswas, Chunyu Liu, Jean Gao

Computer Science Faculty Publications

Background

Inferring gene regulatory networks is one of the most interesting research areas in the systems biology. Many inference methods have been developed by using a variety of computational models and approaches. However, there are two issues to solve. First, depending on the structural or computational model of inference method, the results tend to be inconsistent due to innately different advantages and limitations of the methods. Therefore the combination of dissimilar approaches is demanded as an alternative way in order to overcome the limitations of standalone methods through complementary integration. Second, sparse linear regression that is penalized by the regularization …

Phytochemicals In Animal Health; Diet Selection And Trade-Offs Between Costs And Benefits, Juan J. Villalba, Morgane Costes-Thire, Cecile Ginane

Nutrition, Dietetics, and Food Sciences Faculty Publications

Many plant tissues contain plant secondary compounds (PSC), which have long been recognised as defensive chemicals that deter herbivory via their toxic effects. However, herbivores may also benefit from including PSC into their diets. Plant-derived phenolics, terpenes and alkaloids have antiparasitic properties and sesquiterpene lactones have antibacterial, antifungal and antiparasitic properties. These actions are in part a consequence of the negative actions that PSC exert across several trophic levels, including the bacteria, parasites and fungi that inhabit herbivores’ bodies. Given the dual action, toxin and medicine, it is possible to hypothesise that self-selection of PSC by herbivores should occur when …

Molecular Mechanisms Regulating The Calcium-Activated Slow Afterhyperpolarization, Kwang S. Kim

Doctoral Dissertations

The slow afterhyperpolarization (sAHP) is a post-spike, Ca²⁺-activated potassium conductance that limits neuronal excitability by responding to action potential-induced calcium signals. In addition to participating in learning and memory, the sAHP assumes an indispensable function underscored by its sensitivity to most neurotransmitters. Its absence, on the other hand, has been implicated in the pathophysiology of epilepsy and Alzheimer’s. Though the sAHP maintains a well-appreciated role in neurophysiology, its exact mechanism of activation remains unclear. Recent insights have emerged, however, providing us with new targets to explore in an effort to further understand sAHP physiology: (1) hippocalcin and other …

Inducing Application Of Interdisciplinary Frameworks: Experiences From The Domains Of Information Literacy And Responsible Conduct Of Research, Anne E. Leonard, Jean E. Hillstrom

Publications and Research

Constructivist frameworks for information literacy and research ethics can be developed and nurtured in the context of an interdisciplinary course. Using the frameworks of two disciplines, students went on an experiential journey in support of ethics foundations through guest lectures and active learning exercises. This study describes the development and content of the responsible conduct of research and information literacy modules and discusses the role of each in an interdisciplinary course. Learning goals for both modules were evaluated by examining student responses in a free-writing exercise at the end of the semester, concluding with a discussion of the structural and …

Spatial Attention To Social Cues Is Not A Monolithic Process, Samuel M. Harding, Ty W. Boyer, Bennett I. Bertenthal

Psychology: Faculty Presentations (2009-2022)

Social stimuli are a highly salient source of information, and seem to possess unique qualities that set them apart from other well-known categories. One characteristic is their ability to elicit spatial orienting, whereby directional stimuli like eyegaze and pointing gestures act as exogenous cues that trigger automatic shifts of attention that are difficult to inhibit. This effect has been extended to non-social stimuli, like arrows, leading to some uncertainty regarding whether spatial orienting is specialized for social cues. Using a standard spatial cueing paradigm, we found evidence that both a pointing hand and arrow are effective cues, but that the …

Integrative Approach For Inference Of Gene Regulatory Networks Using Lasso-Based Random Featuring And Application To Psychiatric Disorders, Dongchul Kim, Mingon Kang, Ashis Biswas, Chunyu Liu

Faculty Articles

Background Inferring gene regulatory networks is one of the most interesting research areas in the systems biology. Many inference methods have been developed by using a variety of computational models and approaches. However, there are two issues to solve. First, depending on the structural or computational model of inference method, the results tend to be inconsistent due to innately different advantages and limitations of the methods. Therefore the combination of dissimilar approaches is demanded as an alternative way in order to overcome the limitations of standalone methods through complementary integration. Second, sparse linear regression that is penalized by the regularization …

Co-Exploring Actuator Antagonism And Bio-Inspired Control In A Printable Robot Arm, Mf Stoelen, F Bonsignorio, A Cangelosi

School of Engineering, Computing and Mathematics

The human arm is capable of performing fast targeted movements with high precision, say in pointing with a mouse cursor, but is inherently ‘soft’ due to the muscles, tendons and other tissues of which it is composed. Robot arms are also becoming softer, to enable robustness when operating in real-world environments, and to make them safer to use around people. But softness comes at a price, typically an increase in the complexity of the control required for a given task speed/accuracy requirement. Here we explore how fast and precise joint movements can be simply and effectively performed in a soft …