Digital Commons Network^™

Specific Binding Affinity Of The Non-Catalytic Domain Of Eukaryotic Like Type Ib Topoisomerase Of Vaccinia Virus, Benjamin R. Reed

Dissertations, Theses, and Capstone Projects

Topoisomerases are ubiquitous proteins that alter supercoiling in double stranded DNA (dsDNA) during transcription and replication and. vaccinia and the closely related poxvirus variola virus, at 314 amino acids in length, encode the smallest of the type I topoisomerases(TopIB). TopIB is a two domain protein that recognizes the sequence 5’-T/CCCTT, cleaves at the 3’-end and relaxes supercoiling through rotation. The C-terminal domain (CTD) alone contains the catalytic activity and specificity. Deletion of the N-terminal domain results in a greatly reduced rate of relaxation and rapid dissociation. Biochemical data suggests that the N-terminal domain (NTD) is important for pre-cleavage binding and …

Bully Victimization, Depression, And The Role Of Protective Factors Among College-Age Lgbtq Students, Theresa E. Bhoopsingh

Dissertations, Theses, and Capstone Projects

This study examined the prevalence and impact (or intensity) of four different bullying-victimization forms (physical, verbal, relational, cyber) as experienced by the LGBTQ college-age population. In addition, this study also investigated LGBTQ college students’ bully victimization experiences and their links to depressive symptomatology. The relationship between self-rated victimization and its impact and depression was also explored. Furthermore, given the potential for protective factors of various types to mitigate the negative impact of bullying, this study investigated social supports from family, friends, and campus to determine the strength of their moderating effects, individually and in combination, for each of the sexual …

Gender Roles, Social Control And Digital Piracy: A Longitudinal Analysis Of Gender Differences In Software Piracy Among Korean Adolescents, Riccardo Ferraresso

Dissertations, Theses, and Capstone Projects

In order to improve our understanding of juvenile delinquency and of the factors that can affect it, researchers may need to examine the new forms of crimes emerging in the cyber world. There is still a large knowledge gap regarding the etiology of cybercrime. In particular, very little research on gender differences in cybercrime and the explanatory power of gender based theories and Hirschi’s social bond theory in cybercrime has been undertaken. The current study attempts to fill some of the gaps in the criminological literature on this modern form of crime by examining the explanatory power of traditional theories …

Mechanotransduction Modulates The Effect Of Mechanical Forces (Fluid Shear Stress And Cyclic Strain) On Embryonic Stem Cell Differentiation Toward Vascular Endothelial Cells, Maria Nikmanesh

Dissertations, Theses, and Capstone Projects

The isolation of human ES cells (hES) in 1998 remarkably elevated the interest in the cell therapy capability of ES cells and moved this concept one step closer to reality. Embryonic stem cells with their potential for both self-renewal and directed differentiation have received increasing attention in applications in tissue engineering and repair, cell therapy, and regenerative medicine.

The differentiation of embryonic stem cells into desired lineages depends on the chemical environment of the “niche”, and for certain lineages such as the vascular lineage that must function in a mechanical environment, the timely imposition of mechanical forces is critical. In …

Waking Dreams: Modernist Intoxications And The Poetics Of Altered States, Jason Ciaccio

Dissertations, Theses, and Capstone Projects

Intoxication as a poetic principle is often identified with the romantic imagination. The literature of the intoxicated reverie is commonly thought of as synonymous with works such as Coleridge’s “Kubla Khan,” DeQuincey’s accounts of numerous nightmares and reveries, a number of Keats’ odes, Novalis’ hymns, E.T.A. Hoffmann’s stories, and Poe’s oneiric Gothic tales. Each of these, in part through their opiation or the incorporation of various other draughts, evokes a realm of dreams and visions of various sorts that are commonly associated with romantic poetic practices. The ecstatic trance, the sense of passing into another domain that is …

Role Of Humor In Emotion Regulation: Differential Effects Of Adaptive And Maladaptive Forms Of Humor, Lindsay Mathews

Dissertations, Theses, and Capstone Projects

Humor is widely believed to be an adaptive method of regulating emotions; however, the empirical literature remains inconclusive. One potential explanation for inconsistent results is that humor may be a multidimensional construct. Correlational research suggests that “adaptive” humor styles (Self-Enhancing and Affiliative) are more beneficial than “maladaptive” humor styles (Self-Defeating and Aggressive). The current study examined the effects of humor styles on positive and negative emotion in a sample of 146 young adults. In Part I of the study, participants were 1) randomly assigned to three conditions (adaptive humor, maladaptive humor, and distraction), 2) instructed to write about life events …

Real Gender: Identity, Loss, And The Capacity To Feel Real, Hannah Wallerstein

Dissertations, Theses, and Capstone Projects

This project concerns gender and feeling real. It begins with a seeming paradox: on the one hand, since Judith Butler (1999; 2011) we can no longer think gender as ontological in any simple sense; on the other, clinical experience and the voices of transgender and gender-queer individuals shows gender to function on the order of reality, and one exceeding the social. In other words, if feeling real depended entirely on being read as such, how would we account for the many who pass easily as “real” men or women and yet feel unreal, or come to feel more real by …

Social Cognitive Processes In The Priming Of Mental Illness Stereotypes By The Media, Ginny Chan

Dissertations, Theses, and Capstone Projects

In high-profile violent incidents, there appears to be a disproportionate focus on the perpetrator’s mental health status in relation to the incident (Angermeyer & Matschinger, 1996). Several studies have highlighted the biased nature of the media in reporting news on mental illness and its negative impact on general consensus (Corrigan et al., 2013; Wahl, 1992, 2003). Researchers have also suggested that the media is a significant source of knowledge for the public (Jorm, 2000; Wahl, 2003). Based on a social cognitive perspective, pragmatic inference and stereotype priming provide a framework to understand the reader’s comprehension. The current studies aimed to …

The Anxious Shadow Of A Coldwar: Affect, Biopower & Resistance In Fiction & Culture In The Period Of Intra-Anxiety 1989-2001, Kate Adler

Dissertations, Theses, and Capstone Projects

Don DeLillo’s 1997 novel Underworld stands as the framing text for this study of fiction, cultural affect, and resistance in the later part of the 1980’s – the exhausted, waning years of the Cold War – and the 1990’s, the period immediately following its collapse. DeLillo’s book is situated in the 1990’s, a period of what I term “intra-anxiety” following the Cold War and prior to the attacks of September 11^th and the ensuing “War on Terror.” The Cold War had provided an organizing myth for America and American culture, absorbing and structuring anxieties and governing affect. “The Cold …

Discourses Of "Cruelty-Free" Consumerism: Peta, The Vegan Society And Examples Of Contemporary Activism, Andrea Springirth

Dissertations, Theses, and Capstone Projects

This paper draws upon the principles of critical discourse analysis in order to examine the production of capitalist and consumerist discourses within contemporary nonhuman animal rights activism. The analysis presents evidence to suggest that the discourses being produced via the websites of People for the Ethical Treatment of Animals (PETA) and The Vegan Society are consistently being constructed through market-centric ideologies that treat activists mainly as middle-class consumers. This paper argues that the consistent presence of neoliberal discourse signals an instructive entanglement with broader sociopolitical issues. Specifically, there are concerns as to how this discourse relates to what is thought …

Object Relations In Children's Projective Testing: Applying The Mutuality Of Autonomy Scale To The Thematic Apperception Test, Lily A. Thom

Dissertations, Theses, and Capstone Projects

Psychodynamic assessment of object relations on projective tests has consistently been shown to contribute to a better understanding of children’s psychological functioning and to guide therapeutic interventions (Tuber, 1992). This research examines the enhanced utility of applying a psychodynamically-derived scale of children’s object relations to a commonly used projective assessment tool, the Thematic Apperception Test (TAT) (Morgan & Murray, 1935; Murray, 1943). The current study investigates the adaptation and application of the Mutuality of Autonomy Scale (MOA) (Urist, 1977; Urist & Shill, 1982), commonly used as a Rorschach Inkblot Method object relations scale, to examine verbal narratives on the TAT. …

Perceptions Of Money: Relationships Between Remembered Parental Rejection, Extrinsic Life Aspirations And Maladaptive Attitudes Toward Money, Rebecca J. Smith

Dissertations, Theses, and Capstone Projects

This study examined the extent to which maternal rejection, paternal rejection, maternal care, and maternal overprotection predict extrinsic life aspirations as well as maladaptive money attitudes in young adults. Additionally, this study sought to determine if the Adult Parental Acceptance-Rejection Questionnaire correlates with the Parental Bonding Instrument. The variable, extrinsic life aspirations, was examined to determine if it mediates between parental rejection and maladaptive money attitudes. Finally, the present study examined gender differences with regard to parental rejection, extrinsic life aspirations, and maladaptive money attitudes. A multiple regression analysis was conducted in a college sample of 366 participants using self-report …

Producing Discursive Change: From "Illegal Aliens" To "Unauthorized Immigration" In Library Catalogs, J. Silvia Cho

Dissertations, Theses, and Capstone Projects

Recent debates on immigration policies have included a discursive contest over the representation of unauthorized immigrants, in both the news media and the Library of Congress Subject Headings (LCSH), a subject indexing system administered by the Library of Congress. Using a mixed methods approach from a critical discourse analysis perspective, I examine the responses of the news media and the Library of Congress to societal pressures for change, showing how the Library’s complex institutional position can constrain its responses. Those obstacles, when combined with the characteristics of the Library of Congress Subject Headings (LCSH) as a linguistic tool for information …

Comparative Population Genomics And Speciation Of Snakes Across The North American Deserts, Edward A. Myers

Dissertations, Theses, and Capstone Projects

Understanding the process of speciation is of central interest to evolutionary biologists. Speciation can be studied using a phylogeographic approach, by identifying regions that promote lineage divergence, addressing whether speciation has occurred with gene flow, and when extended to multiple taxa, addressing if the same patterns of speciation are shared across codistributed groups with different ecologies. Here I examine the comparative phylogeographic histories and population genomics of thirteen snake taxa that are widely distributed and co-occur across the arid southwest of North America. I first quantify the degree to which these species groups have a shared history of population divergence …

Physiological Regulation, Psychosocial Adversity, And Proactive Versus Reactive Aggression: A Longitudinal Study, Wei Zhang

Dissertations, Theses, and Capstone Projects

Two types of aggression in children and adolescents have been identified: reactive aggression (RA) and proactive aggression (PA). Despite the accumulating evidence suggesting differential temperamental, behavioral, cognitive, social-environmental, and neurobiological correlates in relation to the two types of aggression, no study has examined emotion regulation in children with RA vs. PA using psychophysiological approaches. In this study a sample of eight to 10 years old children participated in an emotion regulation task in which they were required to either induce or inhibit their emotions. They also reported their aggressive behavior using the Reactive-Proactive Aggression questionnaire (RPQ; Raine et al., 2006). …

An Evaluation Of Pos Taggers For The Childes Corpus, Rui Huang

Dissertations, Theses, and Capstone Projects

This project evaluates four mainstream taggers on a representative collection of child-adult’s dialogues from Child Language Data Exchange System. The nine children’s files from Valian corpora and part of Eve corpora have been manually labeled, and rewrote with LARC tagset. They served as gold standard corpora in the training and testing process. Four taggers: CLAN MOR tagger, ACOPOST trigram tagger, Stanford parser, and Ver. 1.14 of Brill tagger have been tested by 10-fold cross validation. By analyzing what kinds of assumptions the tagger made about category assignment lead to failing, we identify several problematic cases of tagging. By comparing the …

The Antipolitics Of Food In Middle-Class America, Neri De Kramer

Dissertations, Theses, and Capstone Projects

This dissertation provides an ethnographic account of the food and parenting practices of a diverse group of middle-class families in the Mount Airy neighborhood of Philadelphia. It starts from the basic premise that the economic pressures on the American middle classes find expression in family life around the socially reproductive work of choosing food and parenting.

The current economic climate marked with extreme and rising income inequality, low growth, high unemployment and stagnating wages has complicated the reproduction process for all parents in this study, regardless of income. Scholars have described how this concern for the future of the next …

The Regulation Of The Phosphatidate Phosphatase Gene Pah1 And Its Regulatory Role On Cell Homeostasis, Goldie Libby Sherr

Dissertations, Theses, and Capstone Projects

The Saccharomyces cerevisiae gene, PAH1, encodes a phosphatidate (PA) phosphatase that plays a fundamental role in lipid metabolism. PA phosphatases are key enzymes that catalyze the PA dephosphorylation reaction to form diacylglycerides, the first step in the synthesis of triacylglycerols. Pah1p, one of the main PA phosphatases in yeast, has not only emerged as a key player in lipid biosynthetic pathways, but also acts as an important regulator of nuclear membrane biogenesis, the transcriptional regulation of many inositol-sensitive upstream activating sequence (UAS_INO)containing genes needed for phospholipid synthesis, vacuole homeostasis, and lipid droplet formation. Due to its …

Observational Assessment Of Empathy In Parent-Child Verbal Exchanges And Their Influence On Child Behavior, Patty Carambot

Dissertations, Theses, and Capstone Projects

Empathy, the ability to both experientially share in and understand others’ thoughts, behaviors, and feelings, is vital for human adaptation. Deficits in empathy development have implications across the lifespan for the development of prosocial behavior, social functioning, mental health disorders, and risk for antisocial behavior (e.g., Guajardo, Snyder, & Petersen, 2009; Moreno, Klute & Robinson, 2008). In light of these societal and individual burdens, it is imperative to foster and strengthen the development of this ability early in life to prevent or ameliorate such negative outcomes. This type of prevention can take a variety of forms, but parent and child …

A Study Of The Impact Of Interaction Mechanisms And Population Diversity In Evolutionary Multiagent Systems, Sadat U. Chowdhury

Dissertations, Theses, and Capstone Projects

In the Evolutionary Computation (EC) research community, a major concern is maintaining optimal levels of population diversity. In the Multiagent Systems (MAS) research community, a major concern is implementing effective agent coordination through various interaction mechanisms. These two concerns coincide when one is faced with Evolutionary Multiagent Systems (EMAS).

This thesis demonstrates a methodology to study the relationship between interaction mechanisms, population diversity, and performance of an evolving multiagent system in a dynamic, real-time, and asynchronous environment. An open sourced extensible experimentation platform is developed that allows plug-ins for evolutionary models, interaction mechanisms, and genotypical encoding schemes beyond the one …

Autophagy And Lipid Homeostasis In C. Elegans, Melissa J. Silvestrini

Dissertations, Theses, and Capstone Projects

The worldwide prevalence of obesity, particularly in developed nations, has become an epidemic in recent decades and the trend is continuing to rise. Moreover, the prevalence of obesity in children and adolescents is rising at an alarming rate. Obesity is associated with an increased risk of metabolic disorders including heart disease, insulin resistance, type 2 diabetes and nonalcoholic fatty liver disease. Therefore it is no surprise that lipid-related metabolic disorders have become a significant burden to our healthcare system. In recent years, the conserved cellular recycling process of autophagy has been linked to several lipid-related metabolic disorders, including insulin resistance, …

The Echo: September 30, 2016, Taylor University

2016-2017 (Volume 104)

Memorable moments from Indiana’s 200th birthday celebration – Ponchos, piggy banks and prospectives – Emmaus Immersion Project – The turning point – Family food – Senior spouses – From Freshmen to Olympians – Fall fashion spread – A high schooler came to visit and… -- Numb – The bi-weekly bachelor and bachelorette – Echograms #TaylorU -- #TaylorU’s Top Tweets – Death, celebration, fear and love – A&E Events – Creative coding – Spotify: Football Favorites – A match for the Union – Too many excuses – Campus Center: improvement or not? – Trojans take down Tigers – Weekly Preview – …

Localization And Investigation Of Secondary Metabolite Producing Styela Clava-Associated Streptomyces Bacteria, James Demayo

Master's Theses

Natural products and natural product derivatives comprise some of the most successful drugs to date. Many natural products derive from the secondary metabolite profiles of high GC content actinomycete bacteria of the genus Streptomyces, which are sometimes associated with eukaryotic hosts. Identification of biosynthetic gene sequences for natural product secondary metabolites in Streptomyces can assist in isolation of the identified natural product. Moreover, the biosynthetic pathways of drug-like secondary metabolites derived from Streptomyces bacteria often provide insight into the available metabolites that can be produced. As a result, identification of bacteria capable of producing antibacterial products, including Streptomyces, …

Peguasaan Konsep Ipa Siswa Smp Pada Materi Tekanan Pada Zat Cair Dan Aplikasinya, Ika Rahmawati, Arif Hidayat, Sri Rahayu

Jurnal Pendidikan Sains

The aim of this study is to master the concepts to determine junior high school students on the material pressure on the fluid and its application in everyday life, which learned problem based learning. The design study is a quasi-experimental non-equivalent control group using two-class research sample. The class consists of two experimental classes (class VIII B, n = 28) were dibelajarakan with problem-oriented learning (PBM) and the control class (class VIIIC, n = 28) that learned with argumentative models. Measuring instruments IPA concept championship test, consisting of 25 pieces MC questions, validated by the level of reliability r = …

Pengaruh Model Pembelajaran Ecirr Terhadap Penguasaan Konsep Fisika Pada Siswa Smk, Muhammad Effendi, Muhardjito Muhardjito, Supriyono Koes Handayanto

Jurnal Pendidikan Sains

This study aimed to examine the effect of the ECIRR learning model on physics concept acquisition in terms of students' prior knowledge. This study was a quasy-experimental using 2 x 2 factorial design. The population was a student of XII graders in SMKN 1 Prajekan Bondowoso. The samples was determined by random sampling method, and obtained XII AP-2 and XII MM-1 classes as an experimental group, and XII AP-1 and MM-2 classes as a control group. The data were analyzed with two way anova statistical test. The results showed that there are differences on the physics concept acquisition between students …

Feralisation Targets Different Genomic Loci To Domestication In The Chicken, M. Johnsson, Eben Gering, P. Willis, S. Lopez, L. Van Dorp, G. Hellenthal, R. Henriksen, U. Friberg, D. Wright

Biology Faculty Articles

Feralisation occurs when a domestic population recolonizes the wild, escaping its previous restricted environment, and has been considered as the reverse of domestication. We have previously shown that Kauai Island's feral chickens are a highly variable and admixed population. Here we map selective sweeps in feral Kauai chickens using whole-genome sequencing. The detected sweeps were mostly unique to feralisation and distinct to those selected for during domestication. To ascribe potential phenotypic functions to these genes we utilize a laboratory-controlled equivalent to the Kauai population—an advanced intercross between Red Junglefowl and domestic layer birds that has been used previously for both …

September 30, 2016, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Metabolic Profiling Of Genetically Modified Potato Periderm Tissues, Liqing Jin

Dissertations, Theses, and Capstone Projects

Potato tubers are protected from dehydration and pathogens by a covering peel (periderm) impregnated with suberin, a complex cross-linked biopolymer that contains both polyaliphatic and lignin-like aromatic domains. Current models describing the macromolecular structure of suberin assume that ferulic acid cross-links both domains as it may form carboxyl ester bonds with aliphatic monomers and non-ester radical-coupled bonds with phenolics. Ferulic acid also links by ester bonds to glycans and acts in cross-linking polysaccharides and lignin. Fatty alcohol/ω-hydroxyacid hydroxycinnamoyl transferase (FHT) is a BADH acyltransferase responsible for the synthesis of akyl-ferulates that is necessary for suberin biosynthesis. Periderm from FHT-RNAi …

Metabolic Profiling And Polymer Formation Of Gene Silenced Potato Periderms, Qing Cai

Dissertations, Theses, and Capstone Projects

Suberin is a biopolyester constituent of specialized plant periderm tissues formed within the phellem cell walls. Suberin and waxes of the periderm layer act to prevent water diffusion, mechanical breakdown and pathogenic invasion in plants. Ferulic esters, ω-hydroxyacids and α,ω-fatty diacids are considered to be the most important linkage between aliphatic and aromatic suberin domains and also linked with cell-wall polysaccharides. The potato gene FHT (fatty ω- hydroxyacid/fatty alcohol hydroxycinnamoyl transferase) esterifies ferulic acid to suberin. Diminished levels of feruloyl transferase activity have been associated with lowered amounts of feruloyl esters of fatty acids in both suberin-associated waxes and suberin …

Tuning Into Toxins And Channels: The Characterizations Of Tv1 And A Human Cardiac Sodium Channel Voltage-Sensor Domain, Mohammed H. Bhuiyan

Dissertations, Theses, and Capstone Projects

In nature, peptide toxins are an abundant resource, produced both by marine and terrestrial organisms. A major target of these peptide toxins is the group of the highly important voltage-gated ion channels. Due to their high specificity and affinity, peptide toxins have been used for over a decade in discovery and characterization of voltage-gated ion channels. Although peptide toxins have been extensively characterized structurally, the structural characterization of eukaryotic voltage-gated sodium channels has seen much less progress, due to their large size and high hydrophobicity. Voltage-gated sodium channels play crucial roles in many physiological processes, and when these processes are …