Digital Commons Network^™

Common Data Set 2016-2017, University Of Minnesota, Morris Office Of Institutional Research

Institutional Effectiveness and Research Reports

No abstract provided.

Stories Of Andrews: Sharyl Cubero, Sharyl Cubero

World Changers Made Here

A few weeks ago I heard a story that I decided I would like to share with you, and it goes like this.

Sharyl Cubero is a freshman biology student. Recently in the cultural night sponsored by AUSA and GAUSA she won the competition for Ms. Andrews University. I wasn’t there so heard her story later but for those of you who missed out as I did, here is something of what she shared, and maybe a bit more.

Sharyl came to the United States from Costa Rica when she was 2 years old. Her parents spoke little or no …

Nor-Bni Antagonism Of Kappa Opioid Agonist-Induced Reinstatement Of Ethanol-Seeking Behavior, Erin Harshberger, Emily A. Gilson, Kelli Gillett, Jasmine H. Stone, Laila El Amrani, Glenn Valdez

Open Access Publishing Support Funded Articles

Recent work suggests that the dynorphin (DYN)/kappa opioid receptor (KOR) system may be a key mediator in the behavioral effects of alcohol. The objective of the present study was to examine the ability of the KOR antagonist norbinaltorphimine (norBNI) to attenuate relapse to ethanol seeking due to priming injections of the KOR agonist U50,488 at time points consistent with KOR selectivity. Male Wistar rats were trained to self-administer a 10% ethanol solution, and then responding was extinguished. Following extinction, rats were injected with U50,488 (0.1–10 mg/kg, i.p.) or saline and were tested for the reinstatement of ethanol seeking. Next, the …

Fact Book 2016, Planning, Research, And Policy Analysis

Fact Book (1988-2019)

Fact Book 2016 for Illinois State University

Enrollment Report, Fall 2016, Planning, Research, And Policy Analysis

Enrollment Reports (2004-2019)

Enrollment Report for Fall 2016 for Illinois State University

Lack Of Interaction Between Erbb2 And Insulin Receptor Substrate Signaling In Breast Cancer, Sarah M. Farabaugh, Bonita T. Chan, Xiaojiang Cui, Robert Dearth, Adrian V. Lee

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Background: ErbB2 Receptor Tyrosine Kinase 2 (ErbB2, HER2/Neu) is amplified in breast cancer and associated with poor prognosis. Growing evidence suggests interplay between ErbB2 and insulin-like growth factor (IGF) signaling. For example, ErbB2 inhibitors can block IGF-induced signaling while, conversely, IGF1R inhibitors can inhibit ErbB2 action. ErbB receptors can bind and phosphorylate insulin receptor substrates (IRS) and this may be critical for ErbBmediated anti-estrogen resistance in breast cancer. Herein, we examined crosstalk between ErbB2 and IRSs using cancer cell lines and transgenic mouse models.

Methods: MMTV-ErbB2 and MMTV-IRS2 transgenic mice were crossed to create hemizygous MMTV-ErbB2/MMTVIRS2 bigenic mice. Signaling crosstalk …

The Non-Proliferation Treaty And The Political Aspects Of Nuclear Power In A Modern Context, Eve Gleeson

Independent Study Project (ISP) Collection

The Nuclear Non-Proliferation Treaty was created in 1967 in response to the growing threat of nuclear weapon detonation.1 Today, it has been signed and ratified by 190 countries who pledge to pursue efforts towards non-proliferation, peaceful nuclear energy, and nuclear disarmament. Five states remain outside of the treaty, four of which are nuclear weapon states: Israel, Pakistan, India, and North Korea. The nuclear weapon states in the NPT have been established as Britain, France, the U.S., Russia, and China.

The NPT has been created and maintained through the existence of power dynamics between nuclear and non-nuclear states. The potential to …

Evaluation Des Impacts Sociaux Et Ecologiques De La Gestion Communautaire De La Forêt D’Analabe, Nicole Israel-Meyer

Independent Study Project (ISP) Collection

Le transfert de gestion des forêts de l’Etat vers les communautés locales est l’une des approches que le gouvernement malgache a implémentées pour à la fois conserver la biodiversité locale et continuer le développement rural. Cette étude cherche à comprendre les impacts sociaux et écologiques de la gestion communautaire de la forêt d’Analabe par le VOI Fanarenana. La forêt d’Analabe se trouve dans le secteur d’Antanandava du district Majunga II dans le nord-ouest du pays. En utilisant une méthodologie mixte, l’étude a exposé que dans les trois ans d’opération du VOI Fanarenana, la forêt est plus saine et la majorité …

A Study Of Defensive Mechanisms Employed By Two Species Of Nudibranchs Using Toxicity And Unpalatability Analyses, Sean Youn

Independent Study Project (ISP) Collection

Nudibranchs are marine invertebrates that have developed an intriguing defense mechanism, including warning coloration and the use of chemicals accumulated through their sponge diet. The goal of this study was to determine whether the strength of chemical defenses differs between dietary and accumulated secondary metabolites for two species: Glossodoris vespa and Ceratosoma brevicaudatum. First, NMR spectroscopy was used to not only identify specific compounds in the mantle (outer covering) and the viscera (gut) but also to analyze the possibility of nudibranch species transporting more toxic compounds for defensive purposes. Next, toxicity (brine shrimp) and palatability (Palaemon shrimp) assays …

The Effects Of Sub-Lethal Predation On The Reproductive Output Of Acanthaster Planci (Crown-Of-Thorns Starfish), Emily Mucha

Independent Study Project (ISP) Collection

Wide-scale declines in live coral cover have been observed throughout history. Modern day coral populations face a multitude of environmental disturbances, however one of the most devastating to the reefs in the Indo-Pacific is the crown-of-thorns starfish (Acanthaster planci), which feeds on the tissues of live corals. The rate at which these individuals feed combined with the explosion of populations in times of outbreak have been seen to exert some of the biggest pressures on coral reefs to date. Following recent episodes of crown-of-thorns starfish (COTS) outbreaks, research on the organism has become increasingly prevalent on the scientific …

The Effects Of Sub-Lethal Predation On The Reproductive Output Of Acanthaster Planci (Crown-Of-Thorns Starfish), Emily Mucha

Independent Study Project (ISP) Collection

Wide-scale declines in live coral cover have been observed throughout history. Modern day coral populations face a multitude of environmental disturbances, however one of the most devastating to the reefs in the Indo-Pacific is the crown-of-thorns starfish (Acanthaster planci), which feeds on the tissues of live corals. The rate at which these individuals feed combined with the explosion of populations in times of outbreak have been seen to exert some of the biggest pressures on coral reefs to date. Following recent episodes of crown-of-thorns starfish (COTS) outbreaks, research on the organism has become increasingly prevalent on the scientific …

Conservation As Mutualism: A Case Study Of Thulo Syafru, Jennifer S. Brady

Independent Study Project (ISP) Collection

This study examined the opinions, perceptions, and knowledge of residents of Thulo Syafru, a small village in the buffer zone of Langtang National Park, Nepal, regarding conservation efforts spearheaded by the Department of National Parks and Wildlife Conservation and the World Wide Fund for Nature. 26 community members were interviewed along with key figures in community leadership and the two aforementioned organizations. Thulo Syafru is an essential location for red panda conservation, leading to many conservation efforts being focused in the area. Overall, people expressed very positive opinions regarding red pandas and their protection, positive attitudes about conservation, and appreciation …

Queer Connections: Social Media As A Versatile Tool Of The Marginalized Moroccan Lgbt, Savannah Vickery

Independent Study Project (ISP) Collection

This paper examines the role of social media in the Moroccan LGBT sphere. It draws on personal narratives from LGBT men and women as well as activists in order to establish the various ways that social media is employed in the interests of the individual, the community, and the activist. While social media has been a tool to expand the LGBT community around the world, it is specifically and unusually useful in Morocco where there is considerable censorship of incoming and outgoing media. Additionally, many public displays of resistance are considered to be counter productive to the pro-LGBT movement because …

Apple Watch-Ing You: Why Wearable Technology Should Be Federally Regulated, Grant Arnow

Loyola of Los Angeles Law Review

No abstract provided.

Ontogeny Of Hepatic Drug Transporters As Quantified By Lc-Ms/Ms Proteomics., B Prasad, Andrea Gaedigk, M Vrana, R Gaedigk, J Steven Leeder, L Salphati, X Chu, G Xiao, Ceca Hop, R Evers, L Gan, J D Unadkat

Manuscripts, Articles, Book Chapters and Other Papers

Protein expression of major hepatic uptake and efflux drug transporters in human pediatric (n = 69) and adult (n = 41) livers was quantified by liquid chromatography / tandem mass spectroscopy (LC-MS/MS). Transporter protein expression of OCT1, OATP1B3, P-gp, and MRP3 was age-dependent. Particularly, significant differences were observed in transporter expression (P < 0.05) between the following age groups: neonates vs. adults (OCT1, OATP1B3, P-gp), neonates or infants vs. adolescents and/or adults (OCT1, OATP1B3, and P-gp), infants vs. children (OATP1B3 and P-gp), and adolescents vs. adults (MRP3). OCT1 showed the largest increase, of almost 5-fold, in protein expression with age. Ontogenic expression of OATP1B1 was confounded by genotype and was revealed only in livers harboring SLCO1B1*1A/*1A. In livers >1 year, tissues harboring SLCO1B1*14/*1A showed 2.5-fold higher (P < 0.05) protein expression than SLCO1B1*15/*1A. Integration of these ontogeny data in physiologically based pharmacokinetic (PBPK) models will be a crucial step in predicting hepatic drug disposition in children.

Pharmacogenetic Discovery In Calgb (Alliance) 90401 And Mechanistic Validation Of A Vac14 Polymorphism That Increases Risk Of Docetaxel-Induced Neuropathy, Heather E. Wheeler

Bioinformatics Faculty Publications

Purpose: Discovery of SNPs that predict a patient's risk of docetaxel-induced neuropathy would enable treatment individualization to maximize efficacy and avoid unnecessary toxicity. The objectives of this analysis were to discover SNPs associated with docetaxel-induced neuropathy and mechanistically validate these associations in preclinical models of drug-induced neuropathy.

Experimental Design: A genome-wide association study was conducted in metastatic castrate-resistant prostate cancer patients treated with docetaxel, prednisone and randomized to bevacizumab or placebo on CALGB 90401. SNPs were genotyped on the Illumina HumanHap610-Quad platform followed by rigorous quality control. The inference was conducted on the cumulative dose at occurrence of grade 3+ …

Pharmacogenetic Discovery In Calgb (Alliance) 90401 And Mechanistic Validation Of A Vac14 Polymorphism That Increases Risk Of Docetaxel-Induced Neuropathy, Daniel L. Hertz, Kouros Owzar, Sherrie Lessans, Claudia Wing, Chen Jiang, William Kevin Kelly, Jai Patel, Susan Halabi, Yoichi Furukawa, Heather E. Wheeler, Alexander B. Sibley, Cameron Lassiter, Lois Weisman, Dorothy Watson, Stefanie D. Krens, Flora Mulkey, Cynthia L. Renn, Eric J. Small, Phillip G. Febbo, Ivo Shterev, Deanna L. Kroetz, Paula N. Friedman, John F. Mahoney, Michael A. Carducci, Michael J. Kelley, Yusuke Nakamura, Michiaki Kubo, Susan G. Dorsey, M. Eileen Dolan, Michael J. Morris, Howard L. Mcleod

Biology: Faculty Publications and Other Works

Purpose

Discovery of single nucleotide polymorphisms (SNPs) that predict a patient's risk of docetaxel-induced neuropathy would enable treatment individualization to maximize efficacy and avoid unnecessary toxicity. The objectives of this analysis were to discover SNPs associated with docetaxel-induced neuropathy and mechanistically validate these associations in preclinical models of drug-induced neuropathy.

Experimental Design

A genome-wide association study was conducted in metastatic castrate-resistant prostate cancer patients treated with docetaxel, prednisone and randomized to bevacizumab or placebo on CALGB 90401. SNPs were genotyped on the Illumina HumanHap610-Quad platform followed by rigorous quality control. The inference was conducted on the cumulative dose at occurrence …

Stitched To Kill, Pamela Hill Nettleton

College of Communication Faculty Research and Publications

No abstract provided.

Intersecting Motivations For Leaving Abusive Relationships, Substance Abuse, And Transactional Sex Among Hiv High-Risk Women, Naomi S. David, Sophia A. Hussen, Dawn L. Comeau, Ameeta S. Kalokhe

Journal of the Georgia Public Health Association

Background: Women bear a significant burden of the HIV epidemic in the United States. Women classified as ‘HIV high-risk’ often bring co-existing histories of intimate partner violence (IPV), drug use, and transactional sex. To help inform future comprehensive HIV prevention strategies, we aimed to explore common motivating reasons and barriers to leaving and/or terminating engagement in each of these riskpromoting situations.

Methods: Between August and November 2014, in-depth interviews were conducted with 14 HIV high-risk women in Atlanta, Georgia who had experienced IPV in the previous 12 months, and used drugs and/or engaged in transactional sex in the previous five …

Performance Of Point-Of-Care Cd4 Testing Technologies In Resource-Constrained Settings: A Systematic Review And Meta-Analysis, Minh D. Pham, Paul A. Agius, Lorena Romero, Peter Mcglynn, David Anderson, Suzanne M. Crowe, Stanley Luchters

Population Health, East Africa

Background: Point-of-care (POC) CD4 testing increases patient accessibility to assessment of antiretroviral therapy eligibility. This review evaluates field performance in low and middle-income countries (LMICs) of currently available POC CD4 technologies.

Methods: Eight electronic databases were searched for field studies published between January 2005 and January 2015 of six POC CD4 platforms: PointCare NOW™, Alere Pima™ CD4, Daktari™ CD4 Counter, CyFlow® CD4 miniPOC, BD FACSPresto™, and MyT4™ CD4. Due to limited data availability, meta-analysis was conducted only for diagnostic performance of Pima at a threshold of 350 cells/μl, applying a bivariate multi-level random-effects modelling approach. A covariate extended model was …

Epidemiology Of Hpv Genotypes Among Hiv Positive Women In Kenya: A Systematic Review And Meta-Analysis, Sonia Menon, Aibibula Wusiman, Marie Claude Boily, Mbabazi Kariisa, Hillary Mabeya, Stanley Luchters, Frode Forland, Rodolfo Rossi, Steven Callens, Davy Vanden Broeck

Population Health, East Africa

Background: There is a scarcity of data on the distribution of human papillomavirus (HPV) genotypes in the HIV positive population and in invasive cervical cancer (ICC) in Kenya. This may be different from genotypes found in abnormal cytology. Yet, with the advent of preventive HPV vaccines that target HPV 16 and 18, and the nonavalent vaccine targeting 90% of all ICC cases, such HPV genotype distribution data are indispensable for predicting the impact of vaccination and HPV screening on prevention. Even with a successful vaccination program, vaccinated women will still require screening to detect those who will develop ICC from …

A Fourier Description Of Covariance, And Separation Of Simultaneously Encoded Slices With In-Plane Acceleration In Fmri, Mary C. Kociuba

Dissertations (1934 -)

Functional magnetic resonance imaging (fMRI) studies aim to identify localized neural regions associated with a cognitive task performed by the subject. An indirect measure of the brain activity is the blood oxygenation level dependent (BOLD) signal fluctuations observed within the complex-valued spatial frequencies measured over time. The standard practice in fMRI is to discard the phase information after image reconstruction, even with evidence of biological task-related change in the phase time-series. In the first aim of this dissertation, a complex-valued time-series covariance is derived as a linear combination of second order temporal Fourier frequency coefficients. As opposed to magnitude-only analysis, …

Efficacy And Safety Of Mathurameha For Type 2 Diabetes Mellitus Treatment, Parita Permphol, Thipaporn Tharavanij, Arunporn Itharat, Yuthapong Srimongkol, Pinit Chinsoi, Orarat Chanpen

Asian Medical Journal and Alternative Medicine

Introduction: Diabetes is a non-communicable chronic illness that results in complications and die eventually. Currently, Thai Traditional Medicine, Alternative Medicine and herbs were an alternative in the treatment of chronic disease. Mathurameha is a Thai traditional remedy which has long been used by Ayuravedic (Chevagakomarapat) school more than 30 years. Wangnamyen and Watthana-nakorn hospital Sakaew province used this remedy for diabetic treatment more than 3 years but they did not collect data of efficacy and safety. Thus, the aims of this study were to investigate the glycemic efficacy and safety of Mathurameha (Nirund Pongsoiphet and foundation for the promotion of …

Variations In Geochemistry And Mineralogy Of Aeolian Dust Deposition To Mountains In Utah And Nevada, Usa, Dylan Binder Dastrup

Theses and Dissertations

Major and trace metal loading to mountains in the western US depends on dust sources, intensity of storms and their availability for transport during snowmelt and runoff. Previous work has been conducted on dust production, composition, and its affect on solar radiation and timing of snow melt. This study was conducted to 1) examine temporal and spatial variability in dust chemistry; 2) evaluate form and availability of major and trace elements in dust; and 3) identify potential dust sources affecting mountains in Utah and Nevada. Spring and summertime dust was collected across northern Utah over the course of three years …

Hiv/Aids Prevention: Educating Future Generations, Carmella Williams

All Student Theses and Dissertations

The purpose of this study was to discover if implementing more educational interventions on HIV/AIDS would lead to lower incidents of HIV/AIDS among youth. A quantitative research design was used to determine the level of knowledge, perceptions, and attitudes of high school students in regard to HIV/AIDS. The targeted population were youth ages 14-18 years old, which are generally high school students who are at risk of contracting HIV/AIDS. Participants in this study were students from Human Resources Development Institute’s Teen Pregnancy Prevention Program at Harper High School in Chicago, Illinois. The researcher administered questionnaires to the students at Harper …

What Is Really Funny: Humor Ahead Of Its Time In The Twentieth Century American Novel, Timothy Baffoe

All Student Theses and Dissertations

This thesis sets out to examine a specific function that humor has played in twentieth century American literature and that is reflective of American culture today—that being a constant testing of boundaries of who and what are allowed to be considered funny. Zora Neale Hurston’s Their Eyes Were Watching God (1937) gives readers a woman whose struggle for a Black female voice lands her on an informal standup comedy stage. Lolita (1955) by Vladimir Nabokov walks a tightrope of taboo subject matter, encouraging readers to appropriately—though maybe uncomfortably—laugh at the inappropriate, and this decades before such routines like that of …

Quantitative Analysis Of Acetylsalicylic Acid By Q-Nmr (Quantitative-Nuclear Magnetic Resonance Spectroscopy), Charles Flemming Jr.

All Student Theses and Dissertations

Quantitative analysis is an important step during pharmaceutical drug development. Currently, the pharmaceutical industry uses high performance liquid chromatography (HPLC) for quantitative analysis of organic compounds as the preferred technique. The proton nuclear magnetic resonance (NMR) technique has an inherent ability to quantify a given analyte and may be used to quantify organic compounds. Quantitative nuclear magnetic resonance spectroscopy (q-NMR) of acetylsalicylic acid (ASA) was conducted using tert-butyl alcohol (tert-butanol) as the internal standard and deuterated chloroform (CDCl₃) as the solvent. Preparations of ASA solutions in low and high concentration ranges, 1.0 mM – 10.1 …

Correlation Analysis Of Enzyme Activities And Deconstruction Of Ammonia-Pretreated Switchgrass By Bacterial-Fungal Communities, Abhiney Jain, H. Sandra Pelle, J. Michael Henson

Biology Faculty Publications

The mixed microbial communities that occur naturally on lignocellulosic feedstocks can provide feedstock-specific enzyme mixtures to saccharify lignocelluloses. Bacterial-fungal communities were enriched from switchgrass bales to deconstruct ammonia-pretreated switchgrass (DSG). Correlation analysis was carried out to elucidate the relationship between microbial decomposition of DSG by these communities, enzymatic activities produced and enzymatic saccharification of DSG using these enzyme mixtures. Results of the analysis showed that β glucosidase activities and xylosidase activities limited the extent of microbial deconstruction and enzymatic saccharification of DSG. The results also underlined the importance of ligninase activity for the enzymatic saccharification of pretreated lignocellulosic feedstock. The …

Oceanic Top-Down Trophic Cascades And The Link To Anthropogenic Effects, Amanda Gangwish

Department of Environmental Studies: Undergraduate Student Theses

As the human population continues to grow, it has become obvious that we are changing Earth’s ecosystems. These anthropogenic effects can create top-down trophic cascades throughout much of the Earth’s ecosystems – including the oceans. The oceans and the species that reside there are of extreme importance to the human population because they provide food and are sources of income for much of the world. Due to this importance, there has been a growing interest in researching the anthropogenic effects on the oceans and their species. The purpose of this review is to examine the current understanding of some major …

Soil Compaction Of Hardin Hall Green Space Social Trail On The University Of Nebraska-Lincoln's East Campus, Danielle Jones

Department of Environmental Studies: Undergraduate Student Theses

Soil compaction is a common agricultural and urban landscape problem, particularly along cow paths and social trails, respectively. The social trail in the green space of Hardin Hall on the University of Nebraska- Lincoln East Campus has visual cues of soil compaction, due to the slow rate of water infiltration and lack of vegetation. Being the focus area of this study, a sampling grid was placed on the trail by measuring and sectioning it into equal sections. These sections were further divided into subsections of on-path and off-path for comparison. Soil structure, texture, bulk density, and water infiltration were analyzed …