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Age-Related Liquefaction Resistance Of Pleistocene Coastal Plain Sands In South Carolina, Michael J. Hasek

Theses and Dissertations

Soils of Pleistocene age in the South Carolina Coastal Plain have experienced liquefaction due to historic and pre-historic earthquakes. Numerous field and laboratory studies have shown that aged soil deposits maintain a greater resistance to liquefaction than younger soil deposits. The currently available methods for assessing liquefaction potential are based on cases in which soils are of Holocene age or younger (< 10,000 yrs). The Pleistocene age soils that were tested and characterized varied in age from about 200,000 years old to 1,400,000 years old. Several sites were investigated using field methods that included the seismic cone penetration test, cone penetration test, standard penetration test, and flat plate dilatometer. Piezometers were installed at the sites. Undisturbed soil samples were retrieved from the subsurface and frozen ex situ to minimize sample disturbance during transportation and laboratory handling. The undisturbed samples were used for cyclic triaxial testing in the laboratory and were tested for shear wave velocity and compression wave velocity using in-cell transducers. Laboratory tests were performed to determine the specific gravity, grain size distribution, moisture content, unit weight, Atterberg limits, Unified Soil Classification, and visual-manual description. Optical petrography and scanning electron microscopy were used to determine the mineral content of the soils, to view grain characteristics, and to view microscopic features that were part of the soil aging process.

Laboratory index tests showed that Pleistocene soils consisted predominately of poorly-graded fine sands, silty sands, and clayey sands. Shear wave velocities from the cyclic triaxial test specimens were comparable to the in situ shear wave velocities measured using …

Gulf South Summit On Service Learning Program [2016], Gulf South Summit On Service-Learning

Gulf South Summit on Service-Learning (Archived)

N/A

Ultra-Compact Raman Spectrometer For Planetary Explorations, Derek Davis, James Hornef, John Lucas, Hani Elsayed-Ali, M. Nural Abedin

Electrical & Computer Engineering Faculty Publications

To develop a compact Raman spectroscopy system with features that will make it suitable for future space missions which require surface landing. Specifically, this system will be appropriate for any mission in which planetary surface samples need to be measured and analyzed.

Adams As Potential Regulators Of Stem Cell Quiescence In The Olfactory Epithelium, Elaine Elizabeth Orendorff

Master's Theses

I demonstrate that a member of the protein family A Disintegrin and Metalloprotease (ADAM), ADAM23, is expressed in the olfactory epithelium (OE) and may inhibit neural progenitor cell (NPC) proliferation. I generated a list of ten gene candidates and selected ADAM23 for further study, based on its conserved protein structure and accumulating evidence for its role in cell cycle progression of proliferative cells. I next determined ADAM23 protein localization using immunohistochemistry and measured both mRNA and protein expression post-lesion with RT-qPCR and Western blot. ADAM23 is expressed in multiple cell types of the OE, including glial Sustentacular (Sus) cells and …

Predicting Suitable Habitat Decline Of Midwestern United States Amphibians And Quantifying The Consequence Of Declines Using Pond-Breeding Salamanders, Brock Struecker

Master's Theses

With current declines of vertebrate taxa meeting or exceeding those of historic mass extinction events, there is a growing need to investigate the main drivers of declines. Amphibians are perhaps at greatest risk of global climate change and land-use changes than most other vertebrate classes and also have significant roles in ecosystem processes – combined, this creates a cause for concern. I designed a study that would investigate the effects of current and predicted climate change and land-use changes on amphibians using species distribution models and a field study to identify the potential consequences of amphibian species declines by investigating …

An Qualitative Study Of The Meaning High School Students Ascribe To Occult Media Consumption, Jalisha Tolbert

Master's Theses

This qualitative research design explored how high school students ascribe meaning to occult media in pop culture, and it explore possible effects of occult consumption impacting their life aspirations. The research conducted at a high school located on the west side of Chicago, Illinois with a sample size of 10 students from the eleventh grade. First, an exploratory assessment will show how youth ascribe meaning to occult media consumption, and in turn, qualitative interviews presented whether it imposed any effects on life aspirations. The qualitative methods included a qualitative interview, where the researcher asked each participant to explore the meaning …

Role Of Pkc Delta In Uv Radiation Dna Damage Repair, Gargi Patil

Master's Theses

DNA damage caused by ultraviolet radiation (UV), such as cyclobutane pyrimidine dimers (CPD), is repaired by the nucleotide excision repair (NER) pathway. When NER is defective, DNA damage is not repaired, leading to mutations and skin cancer. After DNA damage, the cell cycle is halted at various checkpoints to allow time for repair of the damage and maintain genomic integrity, however little is known about the coordination between NER DNA damage repair and cell cycle halting at checkpoints after DNA damage. Protein kinase C δ (PKCδ) plays major role in apoptosis and maintains the G2/M checkpoint in response to UV …

Prevalence And Diversity Of The Haemosporidian Blood Parasite Leucocytozoon In Sub-Saharan African Birds, Heather Skeen

Master's Theses

Our knowledge of avian Haemosporidian parasites has increased dramatically with the advent and increased used of molecular technologies. Yet Leucocytozoon, a common avian parasite, remains relatively understudied. Haemosporidian parasite diversity and prevalence has been shown to be dependent on several factors, including host family and habitat, on a microecological scale. In this study I screened 3,375 birds from sub-Saharan Africa for the presence of Leucocytozoon and demonstrate that the patterns of prevalence and diversity continue at a macroecological scale. Using molecular data, I found that the prevalence of Leucocytozoon varied between sampling areas from 3.9% to 62.64% and the diversity …

Lactobacillus Crispatus Produces A Bacteridical Molecule That Kills Uropathogenic E. Coli, Katherine Diebel

Master's Theses

As many as 1 in 2 women will have at least one urinary tract infection (UTI) in their lifetime. UTIs can cause complications in pregnancy and decrease quality of life, and their treatment and prevention are expensive. Uropathogenic E. coli (UPEC) is the primary cause of UTI. The probiotic and bactericidal capacities of gut and vaginal Lactobacillus isolates have been studied, but the same attention has not been paid to urinary strains. These urinary isolates of L. crispatus appear to have a greater killing capacity against UPEC and this bactericidal activity does not depend on the cells themselves, consistent with …

Characterization Of Il-22-Producing Cells In The Human Thymus And The Mechanism By Which Il-22 Expression Is Modulated By Thymic Epithelial Cells., Nadine N. Morgan

Master's Theses

Thymic epithelial cells (TECs) are indispensable for T cell development and maturation. Therefore, damages to the thymic epithelial cells are detrimental to thymic function and immune response. In young healthy individuals, TECs have a high regenerative potential and are capable of renewal from serious damage; however, the molecular mechanism of this recovery is unclear. A recent study has shown that IL-22-producing ILCs are present in the mouse thymus and can regenerate thymic epithelial cells following radiation induced injuries. However, it is unknown whether IL-22-producing cells are also found in the human thymus. Thus, the goal of this study is to …

Assessing The Success Of Outreach At Preventing The Movement Of Aquatic Invasive Species In Illinois, Ellen Anne Cole

Master's Theses

Overland transport of recreational boats is the major vector of dispersal for aquatic invasive species among North American waterbodies. These species have large economic and ecosystem impacts, and understanding their movement is essential to understanding the biodiversity and functioning of aquatic ecosystems across the continent. I surveyed Illinois boaters to determine patterns of recreational boat movement and the consistency with which boaters perform actions to prevent the spread of invasive species. Although most boaters perform these actions, a large minority do not and the network for invasive species spread on recreational boats still connects most waterbodies. Next, I interviewed managers …

The Role Of C-Abl Kinase In Hcc Development, Lennox Chitsike

Master's Theses

Hepatocellular Carcinoma is the second most lethal cancer after pancreatic cancer. Unresectable HCC tumors carry a poor prognosis and few treatment options are available. The dismal prognosis is mainly due to limited therapy options and molecularly targeted therapy is deemed as solution. Here, we report a novel role of c-Abl in HCC development. We provide evidence of c-Abl activation in human HCC samples compared to normal liver. Using genetic and pharmacological tools, we show that c-Abl plays a vital role in HCC progression in vitro and in vivo. We have identified Axl as an effector in processes mediated by c-Abl. …

Estrogen Regulation Of Mir-181a Stability In Neurons, Chun Kim

Master's Theses

Estrogens are an important class of steroid hormones involved in many cellular signaling processes. Levels of estrogens fluctuate across the lifespan suggesting that they target intracellular mediators, such as microRNAs, to fine-tune homeostatic cellular processes. Previous work in our lab demonstrated that 17β-estradiol (E2), the predominant circulating estrogen, stabilized miR-181a in a neuronal cell line derived from rat hypothalamus. These results lead to the hypothesis that E2 regulated miR-181a stability by altering the pool of endogenous RNA and by recruiting PNRC2 away from the miRNA degradation machinery. By utilizing miRNA degradation assays and immunostaining techniques, it was determined that the …

Chronic Toxicity Of Binary Metal Mixtures Of Cadmium-Zinc And Cadmium-Nickelon Daphnia Magna, Edgar Ramiro Perez

Master's Theses

This study characterizes binary-metal mixture effects of cadmium (Cd2+) + zinc (Zn2+) and Cd2+ + nickel (Ni2+) on Daphnia magna. Although acute studies have shown protective Ni2+ (Traudt et al. 2016) and Zn2+ effects (Meyer et al. 2015) against Cd2+ toxicity, no study has fully characterized a protective effect on D. magna at several endpoints (survival, reproduction, growth, and accumulation) on a chronic study. In this study, the titration design was selected to characterize the 21 day (21-d) chronic effects of the binary-metal mixtures on survival, growth, reproduction, and metal accumulation in D. magna. Using this design, increasing concentrations of …

Regulation Of Gonad Morphogenesis In Drosophila Melanogaster By Broad Complex, Tramtrack And Bric À Brac Transcription Factors, Diane Silva

Master's Theses

During embryogenesis, primordial germ cells (PGCs) and somatic gonadal precursor cells (SGPs) migrate and coalesce to form the early gonad. A failure of SGPs and PGCs to form a gonad with the proper architecture not only affects germ cell development, but also can result in infertility. We have characterized the phenotypes of two genes, longitudinals lacking (lola) and ribbon (rib), required for the coalescence and compaction of the embryonic gonad in Drosophila melanogaster. Both rib and lola are expressed in the SGPs and to a lesser extent in the PGCs of the developing gonad, and genetic interaction analysis suggests these …

Interfering In A Non-Interference Policy: Defining Star Trek's Prime Directive, Andrew Steele

Master's Theses

The aim of this thesis is to provide a comprehensive definition of the Prime Directive, a concept that was developed in Star Trek: The Original Series, as well as provide a non-fictionalized version of the edict.

The Prime Directive is an edict that governs Starfleet not to interfere with a society’s development.

The first main section will discuss in further detail why The Original Series account of the Prime Directive was selected. Furthermore, it will discuss how members of academia interpret the Prime Directive.

The second main section will be an episode-by-episode analysis of each Prime Directive centered episode to …

Psychological Predictors Of Community Violence Exposure In Ethnic Minority Male Adolescents, Amanda Burnside

Master's Theses

Urban, minority males are disproportionately impacted by community violence exposure (ECV). However, person-based analyses have demonstrated variability in rates of ECV, suggesting that demographic risk factors do not always result in increased ECV, and it may be important to examine the utility of psychological factors in this relationship. Research suggests that depressive symptoms may actually exacerbate the risk of ECV. The current study examines the effect of internalizing symptoms on future ECV. Data were derived from a larger longitudinal study of adolescents who had committed a criminal offense. This subset of 184 participants ranged in age from 14-18. Results indicated …

Aquatic Insect Community Structure And Secondary Production In Southcentral Alaska Streams With Contrasting Thermal And Hydrologic Regimes, Samantha D. Hertel

Master's Theses

Streams along the Copper River Delta, southcentral Alaska, exhibit contrasting thermal and hydrologic variability associated with being primarily groundwater-fed (GWF) or surface water-fed (SWF). Groundwater-fed streams are predictable both thermally and hydrologically year round, whereas SWF streams are unpredictable and exhibit more variable thermal and hydrologic regimes. These differences may strongly influence aquatic insect community structure and secondary production. Four streams, two GWF and two SWF, were sampled twice monthly from late April 2013 through August 2013 and once seasonally in fall (September) and early winter (November). Aquatic insect community structure differed markedly in both hydrologic types. Taxa richness was …

Building And Optimizing A Spectroelectrochemical System For The Study Of Shewanella Putrefaciens, Jonathan Muscolino

Master's Theses

Shewanellaceae are among the most widely studied electroactive microorganisms. This study reports on Shewanella putrefaciens under anaerobic conditions during applied potential while monitored by spectroscopy. The attachment of the microbe Shewanella putrefaciens onto an indium tin oxide electrode was found to occur after 2 hr of +0.2 V applied potential. Microbial detachment occurred with a 5 mV/s scan rate cyclic voltammogram from +0.2 V to -0.5 V to +0.2 V. This was confirmed through use of a spectroelectrochemical apparatus utilizing a standard 3 electrode setup with evanescent wave spectroscopy.

Adding A Single Low-Dose Of Primaquine (0.25 Mg/Kg) To Artemether-Lumefantrine Did Not Compromise Treatment Outcome Of Uncomplicated Plasmodium Falciparum Malaria In Tanzania: A Randomized, Single-Blinded Clinical Trial, Richard Mwaiswelo, Billy Ngasala, Irina Jovel, Berit Aydin‑Schmidt, Roland Gosling, Zul Premji, Bruno Mmbando, Anders Björkman, Andreas Mårtensson

Pathology, East Africa

Background: The World Health Organization (WHO) recently recommended the addition of a single low-dose of the gametocytocidal drug primaquine (PQ) to artemisinin-based combination therapy (ACT) in low transmission set‑ tings as a component of pre-elimination or elimination programmes. However, it is unclear whether that influences the ACT cure rate. The study assessed treatment outcome of artemether-lumefantrine (AL) plus a single PQ dose (0.25 mg/kg) versus standard AL regimen for treatment of acute uncomplicated Plasmodium falciparum malaria in Tanzania.

Methods: A randomized, single-blinded, clinical trial was conducted in Yombo, Bagamoyo district, Tanzania. Acute uncomplicated P. falciparum malaria patients aged ≥1 year, …

Safety Of A Single Low-Dose Of Primaquine In Addition To Standard Artemether-Lumefantrine Regimen For Treatment Of Acute Uncomplicated Plasmodium Falciparum Malaria In Tanzania, Richard Mwaiswelo, Billy Ngasala, Irina Jovel, Roland Gosling, Zul Premji, Eugenie Poirot, Bruno Mmbando, Anders Björkman, Andreas Mårtensson

Pathology, East Africa

Background: This study assessed the safety of the new World Health Organization (WHO) recommendation of adding a single low-dose of primaquine (PQ) to standard artemisinin-based combination therapy (ACT), regardless of individual glucose-6-phosphate dehydrogenase (G6PD) status, for treatment of acute uncomplicated Plasmodium falciparum malaria in Tanzania.

Methods: Men and non-pregnant, non-lactating women aged ≥1 year with uncomplicated P. falciparum malaria were enrolled and randomized to either standard artemether-lumefantrine (AL) regimen alone or with a 0.25 mg/kg single-dose of PQ. PQ was administered concomitantly with the first AL dose. All drug doses were supervised. Safety was evaluated between days 0 and 28. …

Early Round Goby (Neogobius Melanostomus) Invasion Into Lake Michigan Tributaries And Competitive Interactions With Two Native Benthic Fishes., Margaret Ann Malone

Master's Theses

The round goby is a prolific invasive species and is currently spreading into Great Lake tributary streams. There is a high potential for negative impacts on native benthic fishes in these stream habitats and the aim of this study is to assess the impacts of the round goby on two native darter species in particular (johnny darter and blackside darter). I review the history of round goby invasion in the Great Lakes and summarize hypotheses of the invasive characters of the round goby. Using game theory, I provide a G-function approach to understanding the outcomes of the round goby invasion …

Investigating The Regulatory Mechanisms By Which Arabinose And Sypa Control Biofilm Formation In Vibrio Fischeri, Sheila Paris

Master's Theses

Biofilms are surface-associated microbial communities surrounded by an extracellular matrix. Through biofilm formation, many pathogens and symbionts are able to colonize, survive, and persist in their host. A model system used to study biofilm formation is the symbiotic bacterium Vibrio fischeri, which colonizes its host, the squid Euprymna scolopes. Complex signaling between the squid and the bacteria is essential for the proper regulation of biofilm formation as well as for persistent colonization.

The signal(s) that promote host-relevant biofilm formation are as-yet unknown, but recently it was discovered that the sugar, L-arabinose, serves as a unique signal to promote biofilm formation …

A Bioluminescence Sensor Of Nlrp3 Inflammasome Activation, Michael Alexander Winek

Master's Theses

The innate immune system is many organisms first line of defense against pathogenic insult or tissue damage. This defense strategy is intent on restoring homeostasis upon perturbation. Upon activation of the innate immune system in humans, an oligomeric protein complex termed the “Inflammasome” forms in myeloid cells. The canonical output of activation of any subset of inflammasome is Caspase-1-mediated secretion of pro-inflammatory cytokines IL1β and IL18. Chronic or uncontrolled inflammasome activation is at the core of myriad economically burdening diseases. In many of these diseases, endogenous factors chronically engage the innate immune system. To study these diseases in in vivo, …

User-Centered Collection Development: A Citation Analysis Of Graduate Biology Theses, Paula Barnett-Ellis, Yingqi Tang

Research, Publications & Creative Work

The authors sought to identify biology collection usage among graduate students at Jacksonville State University. Forty Master’s student theses from 2008-2014 were examined. A total of 2,351 citations were analyzed, of which journals accounted for 75%, books for 10%, and the remaining 15% included government documents, web sites, dissertations, and theses. Findings are consistent with previous similar studies that students referenced journals more often than books and other sources. Journal and book citations present discrepancies between number of citations and number of authors citing. Wide ranges of journal subjects were cited due to the interdisciplinary nature of graduate programs. Recommendations …

Development Of Ecogeomorphological (Egm) Stream Design And Assessment Tools For The Piedmont Of Alabama, Usa, Brian Helms, Jason Zink, David Werneke, Tom Hess, Zan Price, Greg Jennings, Eve Brantley

Research, Publications & Creative Work

Regional data needed for effective stream restoration include hydraulic geometry relationships (i.e., regional curves) and reference channel morphology parameters. Increasingly ecological conditions are being considered when designing, implementing, and assessing restoration efforts. We provide morphology relationships and associated ecological endpoint curves for reference streams in the Alabama piedmont. Twenty-one reference stream reaches were identified in the Tallapoosa drainage of Alabama, ranging from 0.2 to 242 km2 drainage area. Geomorphic surveys were conducted in each stream to measure riffle cross-sections and longitudinal profiles and related to drainage area to develop regional curves. Fish, crayfish, and benthic macroinvertebrates were collected from each …

Clinician Perceptions Of Harm Reduction, Psychotherapy And The Role Of Traditional Abstinence Models, Abigail R. Vayda

Theses, Dissertations, and Projects

This study sought to better understand clinicians’ perceptions of harm reduction, psychotherapy, and the role of traditional abstinence models when working with actively using clients. This study analyzed the results from a survey completed by 52 practicing clinicians in the United States. The survey contained demographic questions and Likert scale questions measuring attitudes toward harm reduction, abstinence, and psychotherapy with actively using clients. In addition to rating questions, there was also one open-ended question allowing participants to express their understandings of the development of a substance use disorder. The overall response to this survey was a positive attitude toward harm …

China-Taiwan Relations: The Persistent Deadlock Amid Cycles Of Stability And Change, Jordan E. Shremshock

Senior Independent Study Theses

Why does the deadlock that has defined China-Taiwan relations for 65 years persist despite periods of extreme tension and change? I use the Model of Punctuated Equilibrium from evolutionary biology as a framework to answer this question. The PE Model is comprised of two parts, positive and negative feedback. A positive feedback mechanism, or punctuation, is a self-reinforcing process in which rapid change occurs as a result of attention-shift and mimicking. A negative feedback cycle, or equilibrium, is a self-correcting mechanism, which equalizes any outside force to create a stable output. According to this model, if China and Taiwan increase …

Beyond The Binary, Petr Wiese

Senior Independent Study Theses

No abstract provided.

Attempted Identification Of The Calcium-Dependent Sodium Channel Gene In Paramecium Tetraurelia Using Rnai, Gwendolyn Kuzmishin

Senior Independent Study Theses

Ion channels play an important role in the swimming behavior of Paramecium tetraurelia. Electrophysiological experiments indicate that a calcium-dependent sodium channel exists in Paramecium, but a gene has not been identified for this channel. It is hypothesized that this channel evolved from a voltage-dependent sodium channel after a whole genome duplication event. In this paper, 13 candidate genes were identified from the Paramecium genome based on their similarity to a reference human voltage-dependent sodium channel. Bioinformatics analysis of the selectivity filter of these putative ion channel genes suggested that at least 8 of the candidate genes were sodium channels …