Digital Commons Network^™

Diet And Lifetyle Factors Associated With Mirna Expression In Colorectal Tissue, Martha L. Slattery, Jennifer S. Herrick, Lila E. Mullany, John R. Stevens, Roger K. Wolff

Mathematics and Statistics Faculty Publications

MicroRNAs (miRNAs) are small non-protein-coding RNA molecules that regulate gene expression. Diet and lifestyle factors have been hypothesized to be involved in the regulation of miRNA expression. In this study it was hypothesized that diet and lifestyle factors are associated with miRNA expression. Data from 1,447 cases of colorectal cancer to evaluate 34 diet and lifestyle variables using miRNA expression in normal colorectal mucosa as well as for differential expression between paired carcinoma and normal tissue were used. miRNA data were obtained using an Agilent platform. Multiple comparisons were adjusted for using the false discovery rate q-value. There were 250 …

Et Tu, Android?: Regulating Dangerous And Dishonest Robots, Woodrow Hartzog

Faculty Scholarship

Consumer robots like personal digital assistants, automated cars, robot companions, chore-bots, and personal drones raise common consumer protection issues, such as fraud, privacy, data security, and risks to health, physical safety, and finances. They also raise new consumer protection issues, or at least call into question how existing consumer protection regimes might be applied to such emerging technologies. Yet it is unclear which legal regimes should govern these robots and what consumer protection rules for robots should look like.

This paper argues that the FTC's grant of authority and existing jurisprudence are well-suited for protecting consumers who buy and interact …

Wound Healing Post-Mesh Repair ― An Observational Study, Lebbe M.N, Kularajasingham J, Dioso P

ASEAN Journal on Science and Technology for Development

This study identified the best surgical mesh repair techniques for inguinal hernia and prevalence of wound healing post-mesh repair. The cross-sectional study design used cluster sampling for data collection. Of the 120 respondents, 48.3% preferred anterior tension-free mesh repair and 49.2% Lichtenstein mesh repair, both identified as the common surgical techniques in eastern Sri Lanka. About 82.5% of the respondents (n = 99) healed while 17% (n = 21) had recurrence of hernia after one month. Nevertheless, 2.5% of the total respondents said that the hernia repaired after one month but less than two months; and 97.5% of the interviewees …

Editorial Board, Kesmawan Andri Putra

ASEAN Journal on Science and Technology for Development

No abstract provided.

Parallel Session: A Study Of Buyers' And Sellers' Perception Of Organic Foods In Pakistan: Towards A More Effective Marketing Mix (Green Field Marketing), Sara Khan

International Conference on Marketing

Issues of food safety, nutritional value as well as environmental and ecological damage as a result of agricultural abuse have acquired global significance. Many people are looking for equitable, less cruel and sustainable answers to these problems. Organic foods / products are one such solution to people's food and agricultural needs. Looking at the viewpoints of both consumers (including prospective consumers) and producers, this research undertakes to study the marketing mix of the organic foods / products market in Pakistan and explores marketing solutions to enhance its development (research objective). Using qualitative interviews and thematic analysis, respondents' answers are coded …

Three- And Four-Year Olds Learn About Gears Through Arts Incorporation, Dessy Stoycheva, Leann M. Perkins

Journal of STEM Arts, Crafts, and Constructions

This research paper explores art integration into a science lesson unit that follows the Next Generation Science Standards (K-PS2-1) and focuses on the effects on memory retention of key concepts along with levels of enjoyment. An experiment was conducted with children ages 3 and 4 teaching scientific concepts about gears while incorporating student-made art products. The children were assigned to alternating experimental (art-integrated) or control (no art) conditions during the four stages of the lesson. The results did not show statistically significant differences at the alpha = 0.05 level between conditions in the amount of information retained based on the …

Fourth Graders Make Inventions Using Scamper And Animal Adaptation Ideas, Mahjabeen Hussain, Anastasia Carignan

Journal of STEM Arts, Crafts, and Constructions

This study explores to what extent the SCAMPER (Substitute, Combine, Adapt, Modify, Put to another use, Eliminate, and Rearrange) technique combined with animal adaptation ideas learned through form and function analogy activities can help fourth graders generate creative ideas while augmenting their inventiveness. The sample consisted of 24 fourth grade students (14 female, 10 male) ages 9-10 at a suburban Midwestern elementary school. A repeated-measures design involving all participants alternately in the two conditions measured students under each treatment condition. In the experimental condition, students used SCAMPER charts with animal adaptation ideas to generate ideas to improve a product using …

Spatial Thinking Skills And Stem Connections: How Does This Issue Address Them?, Audrey C. Rule

Journal of STEM Arts, Crafts, and Constructions

In this editorial, the Editor considered the importance of spatial thinking skills to STEM careers, provided examples of ways scientists use spatial thinking, noted sex and socioeconomic differences in spatial skill proficiency, and reviewed ways that activities included in articles in this issue involved spatial thinking. Brief summaries and preview images were provided for the articles in the issue. The four-component spatial thinking classification scheme with categories of intrinsic-static, intrinsic-dynamic, extrinsic-static and extrinsic dynamic was applied to the activities from this issue of the Journal of STEM Arts, Crafts, and Constructions. All categories of this classification scheme were addressed, providing …

Sirt1 Regulates Glial Progenitor Proliferation And Regeneration In White Matter After Neonatal Brain Injury., Beata Jablonska, Marcin Gierdalski, Li-Jin Chew, Teresa Hawley, Mackenzie Catron, Arturo Lichauco, Juan Cabrera-Luque, Tracy Yuen, David Rowitch, Vittorio Gallo

Pediatrics Faculty Publications

Regenerative processes in brain pathologies require the production of distinct neural cell populations from endogenous progenitor cells. We have previously demonstrated that oligodendrocyte progenitor cell (OPC) proliferation is crucial for oligodendrocyte (OL) regeneration in a mouse model of neonatal hypoxia (HX) that reproduces diffuse white matter injury (DWMI) of premature infants. Here we identify the histone deacetylase Sirt1 as a Cdk2 regulator in OPC proliferation and response to HX. HX enhances Sirt1 and Sirt1/Cdk2 complex formation through HIF1α activation. Sirt1 deacetylates retinoblastoma (Rb) in the Rb/E2F1 complex, leading to dissociation of E2F1 and enhanced OPC proliferation. Sirt1 knockdown in culture …

The Interaction Network Ontology-Supported Modeling And Mining Of Complex Interactions Represented With Multiple Keywords In Biomedical Literature, Arzucan Ozgur, Junguk Hur, Yongqun He

Biomedical Sciences Faculty Publications

Background: The Interaction Network Ontology (INO) logically represents biological interactions, pathways, and networks. INO has been demonstrated to be valuable in providing a set of structured ontological terms and associated keywords to support literature mining of gene-gene interactions from biomedical literature. However, previous work using INO focused on single keyword matching, while many interactions are represented with two or more interaction keywords used in combination.

Methods: This paper reports our extension of INO to include combinatory patterns of two or more literature mining keywords co-existing in one sentence to represent specific INO interaction classes. Such keyword combinations and related INO …

Act On The Registration And Evaluation Of Chemicals (K-Reach) And Replacement, Reduction Or Refinement Best Practices, Soojin Ha, Troy Seidle, Kyung-Min Lim

Legal Regulation of Animal Research Collection

Objectives - Korea’s Act on the Registration and Evaluation of Chemicals (K-REACH) was enacted for the protection of human health and the environment in 2015. Considering that about 2000 new substances are introduced annually across the globe, the extent of animal testing requirement could be overwhelming unless regulators and companies work proactively to institute and enforce global best practices to replace, reduce or refine animal use. In this review, the way to reduce the animal use for K-REACH is discussed. Methods - Background of the enforcement of the K-REACH and its details was reviewed along with the papers and regulatory …

Feasibility Study For Rural Health Clinic, Cynthia A. Noble

Doctor of Nursing Practice Scholarly Project

An Abstract of the Scholarly Project by

Cindy Noble

The purpose of this study was to determine the feasibility of a rural health clinic in the Adair, Oklahoma area. A mixed-mode survey was sent to 2,890 households within a certain zip code for the Adair community and surrounding area. A link for the survey was also included so the survey could be accessed on line. The total number of surveys returned was 88. The respondents of the survey did show a willingness to use healthcare clinic if one were available in Adair, Oklahoma. The surveying also showed that the majority …

Advances And Perspectives In Genetics Of Congenital Thyroid Disorders Associated With Thyroglobulin Gene Mutations, Héctor M. Targovnik, Cintia E. Citterio, Sofi Siffo, Carina M. Rivolta

Pharmacy Faculty Articles and Research

Dyshormonogenesis due to thyroglobulin (TG) gene mutations is a rare cause of congenital hypothyroidism with an estimated incidence of approximately 1 in 100,000 newborns. The TG gene is organized in 48 exons, spanning over 270 kb on human chromosome 8q24. The human TG mRNA is 8.5 Kb long and the preprotein monomer is composed of a 19 amino acids signal peptide followed by a 2749 residues polypeptide. Until now, one hundred seventeen deleterious mutations in the human TG gene have been identified and characterized, originating structural changes in the protein that alter the normal protein folding, assembly and …

A Mineralized Alga And Acritarch Dominated Microbiota From The Tully Formation (Givetian) Of Pennsylvania, Usa, John A. Chamberlain Jr., Rebecca B. Chamberlain, James O. Brown

Publications and Research

Sphaeromorphic algal cysts, most probably of the prasinophyte Tasmanites, and acanthomorphic acritarch vesicles, most probably Solisphaeridium, occur in a single 20 cm thick bed of micritic limestone in the lower part of the Middle Devonian (Givetian) Tully Formation near Lock Haven, Pennsylvania. Specimens are composed of authigenic calcite and pyrite crystals about 5–10 µm in length. Some specimens are completely calcitic; some contain both pyrite and calcite; and many are composed totally of pyrite. The microfossils are about 80 to 150 µm in diameter. Many show signs of originally containing a flexible wall composed of at least two layers. Some …

The Vibrio Cholerae Minor Pilin Tcpb Initiates Assembly And Retraction Of The Toxin- Coregulated Pilus, Dixon Ng, Tony Harn, Tuba Altindal, Subramania Kolappan, Jarrad M. Marles, Rajan Lala, Ingrid Spielman, Yang Gao, Caitlyn A. Hauke, Gabriela Kovacikova, Zia Verjee, Ronald K. Taylor, Nicolas Biais, Lisa Craig

Publications and Research

Type IV pilus (T4P) systems are complex molecular machines that polymerize major pilin proteins into thin filaments displayed on bacterial surfaces. Pilus functions require rapid extension and depolymerization of the pilus, powered by the assembly and retraction ATPases, respectively. A set of low abundance minor pilins influences pilus dynamics by unknown mechanisms. The Vibrio cholerae toxin-coregulated pilus (TCP) is among the simplest of the T4P systems, having a single minor pilin TcpB and lacking a retraction ATPase. Here we show that TcpB, like its homolog CofB, initiates pilus assembly. TcpB co-localizes with the pili but at extremely low levels, equivalent …

A Neuronal Network Of Mitochondrial Dynamics Regulates Metastasis., M. Cecilia Caino, Jae Ho Seo, Angeline Aguinaldo, Eric Wait, Kelly G. Bryant, Andrew V. Kossenkov, James E. Hayden, Valentina Vaira, Annamaria Morotti, Stefano Ferrero, Silvano Bosari, Dmitry I. Gabrilovich, Lucia R. Languino, Andrew R. Cohen, Dario C. Altieri

Department of Cancer Biology Faculty Papers

The role of mitochondria in cancer is controversial. Using a genome-wide shRNA screen, we now show that tumours reprogram a network of mitochondrial dynamics operative in neurons, including syntaphilin (SNPH), kinesin KIF5B and GTPase Miro1/2 to localize mitochondria to the cortical cytoskeleton and power the membrane machinery of cell movements. When expressed in tumours, SNPH inhibits the speed and distance travelled by individual mitochondria, suppresses organelle dynamics, and blocks chemotaxis and metastasis, in vivo. Tumour progression in humans is associated with downregulation or loss of SNPH, which correlates with shortened patient survival, increased mitochondrial trafficking to the cortical cytoskeleton, greater …

A Dynamic Power Grid For A Dynamic Age Introducing Les To A Pricing Mechanism That Assesses Demand, And Changes Every Hour, Marvin Christopher Cunningham

Op-Eds from ENSC230 Energy and the Environment: Economics and Policies

Lets say you knew someone who would buy a whole pizza when they were a little bit hungry, left their sink running when they weren’t using it, maxed out their A/C in their house when they were on vacation, and always kept their stove on just in case they wanted to cook something.

You would probably see this as horribly wasteful, and a terrible drain of money. But every time we pay our power bill, our prices assume we share these wasteful habits. The rate that we pay per kilowatt hour assumes customers are eating the whole pizza, even though …

Week Of December 19, 2016, New York Medical College

InTouch

• Department of Surgery Hosts Thirteenth Annual Louis R.M. DelGuercio, M.D., Distinguished Visiting Professorship and Research Day
• Student Leadership Groups Take Action
• The First Snowman Project Is a Success
• P2P Committee Recognizes Role Models at NYMC

The Effects Of Frequency Of Social Interaction, Social Cohesion, Age, And The Built Environment On Walking, Gretchen Allison Luhr

Dissertations and Theses

The purpose of this dissertation was to explore, through a social ecological framework, the multifaceted effects of the neighborhood environment by investigating how dimensions of both the built environment and the neighborhood social context may interact to influence walking. Aesthetics, land use mix, crime, and pedestrian infrastructure were considered with respect to built environment walkability, and the neighborhood social context was conceptualized using measures of both social cohesion and social interaction with neighbors. This research used data from an Environmental Protection Agency (EPA)-funded study of 748 adults (18 years of age and older) residing in the Lents neighborhood in Portland, …

The Ever-Changing Bogeyman: How Fear Has Driven Immigration Law And Policy, Arthur L. Rizer Iii

Louisiana Law Review

The article explores the relationship between national security and immigration law in the U.S. with the legal framework of immigration law including provisions of the Immigration and Nationality Act and the need of protecting the borders, population control, and the essence of the rule of law.

Gardner-Webb University Awards Degrees During Commencement Exercises Dec. 19, Office Of University Communications

Gardner-Webb NewsCenter Archive

Gardner–Webb University hosted Fall Commencement on Monday, Dec. 19, in the Lutz-Yelton Convocation Center. Nearly 240 graduates were honored during the ceremony. GWU achieved several notable milestones during commencement.

Effect Of Disorder On The Magnetic And Electronic Structure Of A Prospective Spin-Gapless Semiconductor Mncrval, P. Kharel, J. Herran, Pavel Lukashev, Y. Jin, J. Waybright, S. Gilbert, B, Staten, P. Gray, S. Valloppilly, Y. Huh, D. J. Sellmyer

Faculty Work

Recent discovery of a new class of materials, spin-gapless semiconductors (SGS), has attracted considerable attention in the last few years, primarily due to potential applications in the emerging field of spin-based electronics (spintronics). Here, we investigate structural, electronic, and magnetic properties of one potential SGS compound, MnCrVAl, using various experimental and theoretical techniques. Our calculations show that this material exhibits ≈ 0.5 eV band gap for the majority-spin states, while for the minority-spin it is nearly gapless. The calculated magnetic moment for the completely ordered structure is 2.9 µ_B/f.u., which is different from our experimentally measured value of …

Bjc Today

BJC Today

No abstract provided.

Role Of The Endocannabinoid System And Medical Cannabis, Sabrina Jarvis, Sean Rasmussen, Blaine Winters

Student Works

Our bodies produce substances called endocannabinoids which attach to receptors within the endocannabinoid system (ECS) impacting physiological processes on a daily basis. The cannabis plant contains over 100 different cannabinoids which also manipulate the ECS. Knowledge about these interactions have led to an increase in cannabis based pharmacological studies. Providers should have a basic understanding about how the ECS works and how cannabis is being used to treat certain illnesses. This article presents what is currently known about the ECS and how cannabis based medicines impact it, as well as the current laws providers need know regarding cannabis use.

We Need A Fracking Baseline, Ryan King

Louisiana Law Review

The article focuses on the theories of liability available to injured landowners and the evidentiary requirements' prevention of an equitable resolution regardless of whether strict liability is imposed on hydraulicfracturing.

Skull Shape Affects Susceptibility To Traumatic Brain Injury, Kashyap Arcot, Guy M. Genin

Mechanical Engineering and Materials Science Independent Study

Rapid deformation of brain matter caused by skull acceleration is one of the most significant causes of concussion and severe traumatic brain injury (TBI). Despite substantial research being conducted in this area of study, very little is understood regarding the mechanics of the brain when exposed to rapid acceleration. As a result, the biomechanics of TBI remain ambiguous. In the present study, we apply a new strain estimation algorithm that enables the tracking of strains on the periphery of an image onto data obtained from tagged gel phantom and human MR-images. We use this new method to quantify strain concentrations …

The Hif/Phf8/Ar Axis Promotes Prostate Cancer Progression., D Tong, Q Liu, G Liu, W Yuan, L Wang, Y Guo, W Lan, Dianzheng Zhang, S Dong, Y Wang, H Xiao, J Mu, C Mao, J Wong, J Jiang

PCOM Scholarly Works

Recent studies provide strong evidence that the androgen receptor (AR) signaling pathway remains active in castration-resistant prostate cancer (CRPC). However, the underlying mechanisms are not well understood. In this study, we demonstrate that plant homeo domain finger protein 8 (PHF8 )interacts with and functions as an essential histone demethylase activity-dependent AR coactivator. Furthermore, we demonstrate that the expression of PHF8 is induced by hypoxia in various prostate cancer cell lines. Knockdown of either hypoxia-inducible factor HIF2α or HIF1α almost completely abolished hypoxia-induced PHF8 expression. Importantly, we observed that PHF8 is highly expressed in clinical androgen deprived prostate cancer samples and …

The Vibrio Cholerae Minor Pilin Tcpb Initiates Assembly And Retraction Of The Toxin-Coregulated Pilus, Dixon Ng, Tony Harn, Tuba Altindal, Subramania Kolappan, Jarrad Marles, Rajan Lala, Ingrid Spielman, Yang Gao, Caitlyn Hauke, Gabriela Kovacikova

Dartmouth Scholarship

Type IV pilus (T4P) systems are complex molecular machines that polymerize major pilin proteins into thin filaments displayed on bacterial surfaces. Pilus functions require rapid extension and depolymerization of the pilus, powered by the assembly and retraction ATPases, respectively. A set of low abundance minor pilins influences pilus dynamics by unknown mechanisms. The Vibrio cholerae toxin-coregulated pilus (TCP) is among the simplest of the T4P systems, having a single minor pilin TcpB and lacking a retraction ATPase. Here we show that TcpB, like its homolog CofB, initiates pilus assembly. TcpB co-localizes with the pili but at extremely low levels, equivalent …

Deep Data Analysis On The Web, Xuanyu Liu

Master's Projects

Search engines are well known to people all over the world. People prefer to use keywords searching to open websites or retrieve information rather than type typical URLs. Therefore, collecting finite sequences of keywords that represent important concepts within a set of authors is important, in other words, we need knowledge mining. We use a simplicial concept method to speed up concept mining. Previous CS 298 project has studied this approach under Dr. Lin. This method is very fast, for example, to mine the concept, FP-growth takes 876 seconds from a database with 1257 columns 65k rows, simplicial complex only …

Caribbean Spiny Lobster Fishery Is Underpinned By Trophic Subsidies From Chemosynthetic Primary Production, Nicholas D. Higgs, Jason Newton, Martin J. Attrill

School of Biological and Marine Sciences

No abstract provided.