Digital Commons Network^™

Regulating Secrecy, W. Nicholson Price Ii

Articles

Inventors face a stark choice between two intellectual property systems of protecting innovative ideas: patents and trade secrecy. But accounts of this choice underexplore the role of the regulators that dominate some areas of innovation. Regulation interacts with intellectual property exclusivity in socially problematic ways by encouraging secrecy at the expense of innovation, efficiency, and competition. This Article theorizes how regulation empowers intellectual property generally, explains why this strengthening is problematic for trade secrecy but not for patents, and offers the solution of regulator-enforced disclosure. When a regulator defines a product or a process, it becomes much harder to successfully …

Leveraging Lexical Link Analysis (Lla) To Discover New Knowledge, Ying Zhao, Douglas J. Mackinnon, Shelley P. Gallup, Joseph L. Billingsley

Military Cyber Affairs

Lexical Link Analysis (LLA) is a form of text mining in which word meanings represented in lexical terms (e.g., word pairs) are treated as if they are in a community of a word network. LLA can provide automated awareness for analyzing text data and reveal previously unknown, data-driven themed connections. We applied LLA to develop authentic archetypes and conversely determine potential imposters of that same archetype. We use publically available social media data to develop a cyber professional as an example. This paper reports the development of the algorithm, the collection and labeling of data, as well as the results …

An Urban Institute Community Outreach Program: The Changing Faces Of Pharmacy - A Student Enrichment Program, Manouchkathe Cassagnol, Vibhuti Arya, John Conry

Journal of Vincentian Social Action

Pharmacists serve as important resources for health and medication-related questions to many communities across various demographics, races and ethnicities throughout the U.S. This is particularly true for a place as diverse as New York City (NYC). The Changing Faces of Pharmacy-Student Enrichment Program has provided mentoring services and education to a growing cohort of high school students through the active participation of our Pharm.D. students. We will look to create strategic alliances that will provide broader services and support to this group of students, including financial and academic aspects. We will also look to develop partnerships to find STEM focused …

Preparing Teachers Of English Learners: How Field Reports Bridge The Gap Between Theory And Practice, Judy Lombardi

TAPESTRY

Preservice teachers of English learners need practical experience in real classrooms to supplement the rich strategies learned in college methods classes. In classes of preservice teachers in secondary education at California State University Northridge, state course standards require teacher candidates to complete not only classwork but also field observation reports. The field observation reports help teacher candidates bridge theory and practice, making connections between university course strategies and public school classroom applications. With access to the largest number of English learners in any school district in the nation, candidates are able to observe and report on the diverse needs, strategies, …

Essay Review: Implications For Educators Of Daniel Everett’S Language: The Cultural Tool, Christopher W. Johnson

TAPESTRY

This essay review discusses Everett (2012), Language: The Cultural Tool, with particular emphasis on implications for educators. While Everett does not belong to the discourse of pedagogy and policy for classrooms, his findings and arguments resonate powerfully with the contemporary challenges of PK-12 classrooms and teacher preparation.

Disrupting Poverty: The Impact Of Academic Optimism And Organizational Citizenship Behaviors On Student Achievement In California High-Poverty Secondary Charter Schools, Derek King

Dissertations

ABSTRACT

Disrupting Poverty: The Impact of Academic Optimism and Organizational Citizenship Behaviors on Student Achievement in California High-Poverty Secondary Charter Schools

by Derek King

One of the byproducts of the Civil Rights Act of 1964 was the commissioning of a study by the United States Department of Health, Education and Welfare to better understand the disposition of the nation’s educational system. By 1966, the most comprehensive educational study to date was completed, the Equality of Educational Opportunity (Coleman et al., 1966). The findings shocked the nation by concluding that familial poverty restricted a student’s academic achievement, rendering all school-based interventions …

Auditory Fatigue Model Applications To Predict Noise Induced Hearing Loss In Human And Chinchilla, Pengfei Sun, Daniel Fox, Kathleen Campbell, Jun Qin

Articles

Noise induced hearing loss (NIHL) remains a severe health problem worldwide. Current noise metrics and models have assessment limitations on gradually developing NIHL (GDNIHL). In this study, we apply a complex velocity level (CVL) auditory fatigue model to quantitatively assess the impact of basilar membrane (BM) movement on GDNIHL. The transfer functions of chinchilla and human auditory systems, including the triple-path nonlinear (TRNL) filters to simulate the inner ear responses, are applied to obtain BM velocity distribution. Chinchilla and human experimental hearing loss data are used to validate the proposed CVL model’s effectiveness. The results reveal that the developed CVL …

Boosting Student Retention Rates, Alex Burchfield

College of Arts and Sciences Newsroom

The University of Dayton has seen a nearly 8 percent increase in student retention rates after launching a course to provide undeclared first-year students with skills and resources for academic success.

Equivalent Representations Of Non-Exponential Discounting Models, James A. Feigenbaum

Economics and Finance Faculty Publications

I characterize the entire class of consumption rules for finite-horizon models in which consumption is proportional to lifetime wealth. Any such rule can be obtained from a preference model with CRRA period utility. In a steady state with constant interest rates, a proportional consumption rule can be derived from a model with time-consistent preferences or from a model with possibly time-inconsistent preferences in which a household continually reoptimizes future utility discounted relative to the present instant. These two preference models will only coincide for the special case when the discount function is exponential. More generally, there will be two distinct …

Career Corner: Apply Now For Nih Summer Internships, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

New Open Conformation Of Smyd3 Implicates Conformational Selection And Allostery, Nicholas Spellmon, Xiaonan Sun, Wen Xue, Joshua Holcomb, Srinivas Chakravarthy, Weifeng Shang, Brian Fp Edwards, Nualpun Sirinupong, Chunying Li, Zhe Yang

Biochemistry and Molecular Biology Faculty Publications

SMYD3 plays a key role in cancer cell viability, adhesion, migration and invasion. SMYD3 promotes formation of inducible regulatory T cells and is involved in reducing autoimmunity. However, the nearly “closed” substrate-binding site and poor in vitro H3K4 methyltransferase activity have obscured further understanding of this oncogenically related protein. Here we reveal that SMYD3 can adopt an “open” conformation using molecular dynamics simulation and small-angle X-ray scattering. This ligand-binding-capable open state is related to the crystal structure-like closed state by a striking clamshell-like inter-lobe dynamics. The two states are characterized by many distinct structural and dynamical differences and the conformational …

Are New Hampshire’S Bobcats Well-Connected?, Lori Wright

UNH Today Archive

No abstract provided.

A New Benzoyl Compound Isolated From The Endophytic Fungi Of Kandis Gajah (Garcinia Griffithii) And Asam Kandis (Garcinia Cowa), Elfita, Munawar, Muharni, Gusti Pratiwi, Rahmadania

Makara Journal of Science

Garcinia griffithii and Garcinia cowa belong to the genus Garcinia. The genus Garcinia has been known to be a rich source of secondary metabolites, such as xanthones, benzophenones, flavonoids, steroids, terpenoids, and other phenolic derivatives. Previous investigations of endophytic fungi from G. griffithii revealed the presence of three compounds not found in the host. In order to the continue the phytochemical work on endophytic fungi of G. griffithii, the constituent of the endophytic fungi of G. griffithii was re-examined. In this study, a benzoyl compound similar to that found in the endophytic fungus of G. cowa was observed. The same …

The Quantum Biology Of Reactive Oxygen Species Partitioning Impacts Cellular Bioenergetics, Robert J. Usselman, Cristina Chavarriaga, Pablo R. Castello, Maria Procopio, Thorsten Ritz, Edward A. Dratz, David John Singel, Carlos F. Martino

Biomedical Engineering and Sciences Faculty Publications

Quantum biology is the study of quantum effects on biochemical mechanisms and biological function. We show that the biological production of reactive oxygen species (ROS) in live cells can be influenced by coherent electron spin dynamics, providing a new example of quantum biology in cellular regulation. ROS partitioning appears to be mediated during the activation of molecular oxygen (O2) by reduced flavoenzymes, forming spin-correlated radical pairs (RPs). We find that oscillating magnetic fields at Zeeman resonance alter relative yields of cellular superoxide (O2•−) and hydrogen peroxide (H2O2) ROS products, indicating coherent singlet-triplet mixing at the point of ROS formation. Furthermore, …

Attractive Drug Candidate Identified To Target Glioma Brain Tumors, Jeff Hansen

Browse All News

No abstract provided.

Il-15 Activates The Jak3/Stat3 Signaling Pathway To Mediate Glucose Uptake In Skeletal Muscle Cells, James E. Krolopp, Shantaé M. Thornton, Marcia J. Abbott

Health Sciences and Kinesiology Faculty Articles

Myokines are specialized cytokines that are secreted from skeletal muscle (SKM) in response to metabolic stimuli, such as exercise. Interleukin-15 (IL-15) is a myokine with potential to reduce obesity and increase lean mass through induction of metabolic processes. It has been previously shown that IL-15 acts to increase glucose uptake in SKM cells. However, the downstream signals orchestrating the link between IL-15 signaling and glucose uptake have not been fully explored. Here we employed the mouse SKM C2C12 cell line to examine potential downstream targets of IL-15-induced alterations in glucose uptake. Following differentiation, C2C12 cells were treated overnight with 100 …

A Bounded Affinity Theory Of Religion And The Paranormal, Joseph O. Baker, Christoper Bader, F. Carson Mencken

Sociology Faculty Articles and Research

We outline a theory of bounded affinity between religious experiences and beliefs and paranormalism, which emphasizes that religious and paranormal experiences and beliefs share inherent physiological, psychological, and ontological similarities. Despite these parallels, organized religious groups typically delineate a narrow subset of experiences and explanatory frames as acceptable and True, banishing others as either false or demonic. Accordingly, the theory provides a revised definition of the “paranormal” as beliefs and experiences explicitly rejected by science and organized religions. To demonstrate the utility of the theory, we show that, after controlling for levels of conventional religious practice, there is a strong, …

Roots And Repercussions Of Romantic Feeling: Sensation And Affect In The Poetry Of Samuel Taylor Coleridge And William Wordsworth, Mary K. Cotter

Theses and Dissertations

Enlightenment emphasis on rationalism in philosophy and the arts prefigures Samuel Taylor Coleridge’s and William Wordsworth’s Romantic recovery of a subject’s empirical relationship to nature and the phenomenal world. Coleridge and Wordsworth respond to philosophical precedents that emphasize rationalism and the autonomy of a subject while introducing empiricism and sensation as primary components of the speaker’s experience. The poets delineate a fluid shift from the Enlightenment to Romanticism through an interchangeable reliance on Kantian and Burkean philosophical methods. The philosophy of Immanuel Kant follows the Cartesian cogito toward a similar end of reducing human experience to circumstance bereft of empirical …

Current And Evolving Approaches For Improving The Oral Permeability Of Bcs Class Iii Or Analogous Molecules, Vivek S. Dave, Deepak Gupta, Monica Yu, Phong Nguyen, Sheeba Varghese Gupta

Pharmacy Faculty/Staff Publications

The Biopharmaceutics Classification System (BCS) classifies pharmaceutical compounds based on their aqueous solubility and intestinal permeability. The BCS Class III compounds are hydrophilic molecules (high aqueous solubility) with low permeability across the biological membranes. While these compounds are pharmacologically effective, poor absorption due to low permeability becomes the rate-limiting step in achieving adequate bioavailability. Several approaches have been explored and utilized for improving the permeability profiles of these compounds. The approaches include traditional methods such as prodrugs, permeation enhancers, ion-pairing, etc., as well as relatively modern approaches such as nanoencapsulation and nanosizing. The most recent approaches include a combination/hybridization of …

Effects Of Temperature On Transcriptome And Cuticular Hydrocarbon Expression In Ecologically Differentiated Populations Of Desert Drosophila, William J. Etges, Cassia De Oliveira, Sub Hash Rajpurohit, Allen G. Gibbs

Life Sciences Faculty Research

We assessed the effects of temperature differences on gene expression using whole-transcriptome microarrays and cuticular hydrocarbon variation in populations of cactophilic Drosophila mojavensis. Four populations from Baja California and mainland Mexico and Arizona were each reared on two different host cacti, reared to sexual maturity on laboratory media, and adults were exposed for 12 hr to 15, 25, or 35°C. Temperature differences influenced the expression of 3,294 genes, while population differences and host plants affected >2,400 each in adult flies. Enriched, functionally related groups of genes whose expression changed at high temperatures included heat response genes, as well as genes …

Liver Enzymes And Risk Of Ischemic Heart Disease And Type 2 Diabetes Mellitus: A Mendelian Randomization Study, Junxi Liu, Shiu Lun Au Yeung, Gabriel M. Leung, C. Mary Schooling

Publications and Research

We used Mendelian randomization to estimate the causal effects of the liver enzymes, alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma glutamyltransferase (GGT), on diabetes and cardiovascular disease, using genetic variants predicting these liver enzymes at genome wide significance applied to extensively genotyped case-control studies of diabetes (DIAGRAM) and coronary artery disease (CAD)/myocardial infarction (MI) (CARDIoGRAMplusC4D 1000 Genomes). Genetically higher ALT was associated with higher risk of diabetes, odds ratio (OR) 2.99 per 100% change in concentration (95% confidence interval (CI) 1.62 to 5.52) but ALP OR 0.92 (95% CI 0.71 to 1.19) and GGT OR 0.88 (95% CI 0.75 …

Wound Healing Post-Mesh Repair ― An Observational Study, Lebbe M.N, Kularajasingham J, Dioso P

ASEAN Journal on Science and Technology for Development

This study identified the best surgical mesh repair techniques for inguinal hernia and prevalence of wound healing post-mesh repair. The cross-sectional study design used cluster sampling for data collection. Of the 120 respondents, 48.3% preferred anterior tension-free mesh repair and 49.2% Lichtenstein mesh repair, both identified as the common surgical techniques in eastern Sri Lanka. About 82.5% of the respondents (n = 99) healed while 17% (n = 21) had recurrence of hernia after one month. Nevertheless, 2.5% of the total respondents said that the hernia repaired after one month but less than two months; and 97.5% of the interviewees …

A Clinical Audit On The Compliance Of Ultrasound Users To The Standard Operating Procedure Of Ultrasonography In A Private Radiologic Academy, Yuliawati Y, Dioso P

ASEAN Journal on Science and Technology for Development

This clinical audit identified the compliance rate of ultrasound users to the standard operating procedures (SOP); and identified the factors that led to a compliance rate of ultrasound human users. The review was conducted for six days in a private radiologic academy in Indonesia. Only 23 subjects selected randomly were audited. Of the 23 participants, there were 11 males and 12 females. Of the 11 males, seven were compliant, and three were non-compliant. Of the 12 females, eight were compliant, and four were non-compliant. The factors that affect the compliance to the SOP were based on the skills of the …

Immunogenicity And Protective Efficacy Of The Dar-901 Booster Vaccine In A Murine Model Of Tuberculosis, Timothy Lahey, Dominick Laddy, Krystal Hill, Jacqueline Schaeffer

Dartmouth Scholarship

The development of a novel tuberculosis vaccine is a leading global health priority. SRL172, an inactivated, whole-cell mycobacterial vaccine, was safe, immunogenic and reduced the incidence of culture-confirmed tuberculosis in a phase III trial in HIV-infected and BCG immunized adults in Tanzania. Here we describe the immunogenicity and protective efficacy of DAR-901, a booster vaccine against tuberculosis manufactured from the same seed strain using a new scalable method.

Antifungal Activity Of (+)-2,2’-Epicytoskyrin A And Its Membrane-Disruptive Action, Dewi Wulansari, Praptiwi, Heddy Julistiono, Arif Nurkanto, Andria Agusta

Makara Journal of Science

(+)-2,2’-Epicytoskyrin A, a bis-anthraquinone isolated from fungal endophyte Diaporthe sp. GNBP-10 associated with Uncaria gambir Roxb., was investigated for its antifungal activity. The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) against 22 yeast strains and three filamentous fungi. The MICs of (+)-2,2’-epicytoskyrin A ranged from 16 to 128 µg/mL, which exhibited lower activity than the antifungal nystatin. A study of the mechanism of action revealed similar effects of (+)-2,2’-epicytoskyrin A and nystatin on Candida tropicalis at their MICs (16 and 8 µg/mL, respectively) and 2 times of the MIC. Both compounds caused cytoplasmic material and …

Variable Patterns Of Ectopic Mineralization In Enpp1asj-2j Mice, A Model For Generalized Arterial Calcification Of Infancy., Sarah Y. Siu, Nathaniel A. Dyment, David W. Rowe, John P. Sundberg, Jouni Uitto, Qiaoli Li

Department of Dermatology and Cutaneous Biology Faculty Papers

Generalized arterial calcification of infancy (GACI) is an autosomal recessive disorder characterized by early onset of extensive mineralization of the cardiovascular system. The classical forms of GACI are caused by mutations in the ENPP1 gene, encoding a membrane-bound pyrophosphatase/phosphodiesterase that hydrolyzes ATP to AMP and inorganic pyrophosphate. The asj-2J mouse harboring a spontaneous mutation in the Enpp1 gene has been characterized as a model for GACI. These mutant mice develop ectopic mineralization in skin and vascular connective tissues as well as in cartilage and collagen-rich tendons and ligaments. This study examined in detail the temporal ectopic mineralization phenotype of connective …

Teaching The First: A Phenomenological Study Of Southeastern Community College Instructors Communicating With First-Generation College Students, Tanyanika Mattos

All Theses And Dissertations

This phenomenological research study explored eight Southeastern community college instructors communicating with first-generation college students, specifically the lived experiences of community college instructors as they taught developmental education. The participated included a lawyer, health care executive, and engineer, psychologist, bookkeeper, health sciences professional, and education specialist and computer information systems professional. Pre-interviews, interviews and an electronic survey were utilized to obtain the data on the phenomenon. This phenomenological data analysis process offered a structured analysis process that is reflective and grounded in vibrant descriptions. During the interview, all forms were used to document responses of interviewees. The interviews were interpreted …

Comparative Genetic Screens In Human Cells Reveal New Regulatory Mechanisms In Wnt Signaling, Andres M. Lebensohn, Ramin Dubey, Leif Neitzel, Ofelia Tacchelly-Benites

Dartmouth Scholarship

The comprehensive understanding of cellular signaling pathways remains a challenge due to multiple layers of regulation that may become evident only when the pathway is probed at different levels or critical nodes are eliminated. To discover regulatory mechanisms in canonical WNT signaling, we conducted a systematic forward genetic analysis through reporter-based screens in haploid human cells. Comparison of screens for negative, attenuating and positive regulators of WNT signaling, mediators of R-spondin-dependent signaling and suppressors of constitutive signaling induced by loss of the tumor suppressor adenomatous polyposis coli or casein kinase 1α uncovered new regulatory features at most levels of the …

Synthesis And In Vitro Experiment Of Biomaterial Tricalcium Phosphate, Bui X.V

ASEAN Journal on Science and Technology for Development

Calcium phosphate ceramics consist of materials such as hydroxyapatite, tricalcium phosphate (TCP), calcium phosphate cement (CPC), biphasic calcium phosphate, etc. CPCs have been used for filling bone defects in dentistry and orthopedics. Among these materials, β-tricalcium phosphate is suggestedas an ideal candidate for bone graft in hard tissue engineering due to its high biocompatibility, bioactivity and bone bonding. The preparation, as well as the application of this powder material, has been the important topic of research in material science. In this paper, β-tricalcium phosphate (β-TCP), a component that has chemical formulation similar to bone structure, was synthesized by the precipitate …

Editorial Board, Kesmawan Andri Putra

ASEAN Journal on Science and Technology for Development

No abstract provided.