Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2016

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 26701 - 26730 of 29042

Full-Text Articles in Entire DC Network

The Effects Of Perceived Stress, Sleep, And Stress Response On Cancer Related Fatigue In 8- To 12-Year-Old Central Nervous System Cancer Survivors, Ann Johnson Jan 2016

The Effects Of Perceived Stress, Sleep, And Stress Response On Cancer Related Fatigue In 8- To 12-Year-Old Central Nervous System Cancer Survivors, Ann Johnson

All ETDs from UAB

Survivors of childhood cancer are a growing population, and knowledge of persistent cancer related fatigue (CRF) is integral to survivorship. CRF in central nervous system (CNS) cancer is multifactorial and may be unique based on treatment and stage of survival. There is a gap in evidence for school-age survivors, especially during early survivorship. Aims: The aim of this study was to examine factors that influence CRF in child CNS cancer survivors at least 6 months and less than 6 years post treatment. The purpose of this study was to examine relationships between select factors and CRF and to determine effect …

Go to article

Plasma Enhanced Chemical Vapor Deposition Of Metal-Boride Interfacial Layers As Diffusion Barriers For Nanostructured Diamond Growth On Cobalt Containing Alloys Cocrmo And Wc-Co, Jamin Michael Johnston Jan 2016

Plasma Enhanced Chemical Vapor Deposition Of Metal-Boride Interfacial Layers As Diffusion Barriers For Nanostructured Diamond Growth On Cobalt Containing Alloys Cocrmo And Wc-Co, Jamin Michael Johnston

All ETDs from UAB

This work is a compilation of theory, finite element modeling and experimental research related to the use of microwave plasma enhanced chemical vapor deposition (MPECVD) of diborane to create metal-boride surface coatings on CoCrMo and WC-Co, including the subsequent growth of nanostructured diamond (NSD). Motivation for this research stems from the need for wear resistant coatings on industrial materials, which require improved wear resistance and product lifetime to remain competitive and satisfy growing demand. Nanostructured diamond coatings are a promising solution to material wear but cannot be directly applied to cobalt containing substrates due to graphite nucleation. Unfortunately, conventional pre-treatment …

Go to article

Resveratrol And Pterostilbene: A Novel Combinatorial Epigenetic Therapy In Targeting Triple-Negative Breast Cancer, Rishabh Kala Jan 2016

Resveratrol And Pterostilbene: A Novel Combinatorial Epigenetic Therapy In Targeting Triple-Negative Breast Cancer, Rishabh Kala

All ETDs from UAB

Although the majority of breast cancers are estrogen receptor (ER)-positive, progesterone receptor (PGR)-positive and/or HER2 positive, approximately 20% of them are triple-negative and lack ER, PGR and HER2 protein expression. These cancers are robust and hard to treat with conventional hormone therapies. The plant-based dietary compounds resveratrol and pterostilbene (a dimethyl derivative of resveratrol) have been shown to modulate the growth of cancer cells individually via affecting genetic and epigenetic profiles, but none of the studies to date have addressed the effects of these two compounds in combination in targeting triple-negative breast cancers (TNBC). We have discovered a synergistic effect …

Go to article

Beyond Just Sea-Level Rise: Considering Macroclimatic Drivers Within Coastal Wetland Vulnerability Assessments To Climate Change, Michael J. Osland, Nicholas M. Enwright, Richard H. Day, Christopher A. Gabler, Camille L. Stagg, James B. Grace Jan 2016

Beyond Just Sea-Level Rise: Considering Macroclimatic Drivers Within Coastal Wetland Vulnerability Assessments To Climate Change, Michael J. Osland, Nicholas M. Enwright, Richard H. Day, Christopher A. Gabler, Camille L. Stagg, James B. Grace

School of Earth, Environmental, & Marine Sciences Faculty Publications

Due to their position at the land-sea interface, coastal wetlands are vulnerable to many aspects of climate change. However, climate change vulnerability assessments for coastal wetlands generally focus solely on sea-level rise without considering the effects of other facets of climate change. Across the globe and in all ecosystems, macroclimatic drivers (e.g., temperature and rainfall regimes) greatly influence ecosystem structure and function. Macroclimatic drivers have been the focus of climate change-related threat evaluations for terrestrial ecosystems, but largely ignored for coastal wetlands. In some coastal wetlands, changing macroclimatic conditions are expected to result in foundation plant species replacement, which would …

Go to article

Separate But Equal: A Phenomenological Study Of Teachers' Experiences With African American Males In Gender-Specific Classrooms In An Urban School Setting, Hamidah Elmore Jan 2016

Separate But Equal: A Phenomenological Study Of Teachers' Experiences With African American Males In Gender-Specific Classrooms In An Urban School Setting, Hamidah Elmore

All ETDs from UAB

The purpose of this phenomenological study was to illuminate teachers’ experiences with African American males in gender-specific classrooms in an urban school setting in an inner-city school system in Alabama. The central question, “What is it like to be a teacher of African American males within a gender-specific classroom?” guided this qualitative study. This question spawned several sub-questions: (1) “What characteristics are common in an African-American male gender-specific instructor?”, (2) “What strategies do successful African-American male gender specific instructors use in their teaching?”, (3) “What types of administrative support are useful for African-American male gender-specific instructors?”, and (4) “What types …

Go to article

Mechanical Properties Of The Growth Plate In A Rat Model Of Obesity, Patrick Neil Estep Jan 2016

Mechanical Properties Of The Growth Plate In A Rat Model Of Obesity, Patrick Neil Estep

All ETDs from UAB

The other group (group 2) of 50 women received the same intervention with heel QUS

Go to article

Electrospun Polycaprolactone Scaffolds: Mechanical Properties, Alignment Quantification, And Topology Induced Gene Expression, Timothy John Fee Jan 2016

Electrospun Polycaprolactone Scaffolds: Mechanical Properties, Alignment Quantification, And Topology Induced Gene Expression, Timothy John Fee

All ETDs from UAB

Producing tissue engineering scaffolds which mimic the structure and mechanical properties of the native extracellular matrix (ECM) is an important challenge in developing synthetic tissue replacements. Electrospinning is a frequently used technique to fabricate 3D nanofibrous scaffolds which match the dimensions of the fibrous elements of ECM. However, the mechanical behavior of electrospun materials is complex and challenging to predict. To aid in understanding the mechanical properties of electrospun materials, a microtensile testing platform was developed. This platform was used to quantify the mechanical properties of arrays of individual electrospun nanofibers. Additionally, this device permitted optical strain recording to visualize …

Go to article

The Role Of Ppar-Delta In Regulating Cardiomyocyte Proliferation And Angiogenesis In Post-Myocardial Infarction Adult Heart, Yishu Ding Jan 2016

The Role Of Ppar-Delta In Regulating Cardiomyocyte Proliferation And Angiogenesis In Post-Myocardial Infarction Adult Heart, Yishu Ding

All ETDs from UAB

immediately before, soon after, and one month after intervention. Average daily calcium

Go to article

Examination Of 4-Hydroxy Tamoxifen- And Bh3 Mimetic-Induced Cell Death Pathways In Glioblastoma And Malignant Peripheral Nerve Sheath Tumor Cells, Christopher Dillon Graham Jan 2016

Examination Of 4-Hydroxy Tamoxifen- And Bh3 Mimetic-Induced Cell Death Pathways In Glioblastoma And Malignant Peripheral Nerve Sheath Tumor Cells, Christopher Dillon Graham

All ETDs from UAB

Glioblastoma (GBM) is the most common and aggressive human primary malignant brain tumor with a 5-year survival rate of less than 5%. GBM is highly invasive, rendering complete surgical resection impossible. Additionally, this tumor type is relatively insensitive to radiotherapy. Thus, effective chemotherapeutic options present the last line of defense for GBM patients. Unfortunately, nearly 50% of all GBM tumors are resistant to the current chemotherapeutic standard, temozolomide (TMZ). TMZ is a DNA alkylating agent that promotes apoptosis via DNA damage. Resistance to TMZ-induced cell death is attributed to expression of the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) resultant from …

Go to article

Genome-Wide Transcription And Dna Methylation Profiling In An App Mouse Model Of Alzheimer’S Disease, Mikael C. Guzman Karlsson Jan 2016

Genome-Wide Transcription And Dna Methylation Profiling In An App Mouse Model Of Alzheimer’S Disease, Mikael C. Guzman Karlsson

All ETDs from UAB

The ability to encode information for long-term behavioral adaptation relies on experience-dependent alterations in neuronal plasticity. Neuronal plasticity encompasses the cellular and molecular changes that modulate synaptic communication between neurons as well as intrinsic electrophysiological properties within neurons. Epigenetic mechanisms, including DNA cytosine methylation and histone post-translational modifications, are powerful regulators of neuronal gene expression, allowing for dynamic, bidirectional regulation of transcriptional signatures necessary for neuronal plasticity. Emerging evidence using candidate-gene and microarray-based approaches suggest that the deficits in neuronal plasticity and cognitive impairment observed in Alzheimer’s disease (AD) is attributable, in part, to aberrant cytosine methylation and transcription of …

Go to article

Elucidating The Role Of The Pro-Survival To Pro-Death Molecular Switch In The Ire1a Signaling Pathway In Arabidopsis Thaliana, Marie Vollmer Alexander Jan 2016

Elucidating The Role Of The Pro-Survival To Pro-Death Molecular Switch In The Ire1a Signaling Pathway In Arabidopsis Thaliana, Marie Vollmer Alexander

All ETDs from UAB

In eukaryotic cells, the accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) results in ER stress that induces a cascade of reactions termed the unfolded protein response (UPR). The most conserved UPR sensor amongst eukaryotes, Inositol-Requiring Enzyme 1 (IRE1), responds to ER stress by activating a pathway that, under normal conditions, would up-regulate the cellular pro-survival pathway. However, under extreme conditions the infected portion of the plant will ultimately “switch” from pro-survival to pro-death in order to avoid further unfavorable circumstances for the plant as a whole. Arabidopsis possesses two homologs of the major UPR sensor, IRE1a …

Go to article

Novel Biomarkers For Parkinson Disease, Kyle Bradley Fraser Jan 2016

Novel Biomarkers For Parkinson Disease, Kyle Bradley Fraser

All ETDs from UAB

Parkinson disease (PD) is the most common neurodegenerative movement disorder for which no treatments exist capable of slowing progression of the disease. One obstacle slowing the development of novel therapies is the lack of molecular biomarkers for PD prognosis, tracking of disease progression, and assessing efficacious target engagement of compounds that do reach clinical trials. Missense mutations in LRRK2 account for between 1-5% of late onset PD and lead to increases in LRRK2 kinase activity and LRRK2 autophosphorylation. This thesis characterizes the secretion of LRRK2 into extracellularly secreted microvesicles called exosomes. We find that kinase-active LRRK2 is secreted within exosomes …

Go to article

Detection And Str Profiling Of Saliva Remaining In Water Bottles, Brittany Kriz Jan 2016

Detection And Str Profiling Of Saliva Remaining In Water Bottles, Brittany Kriz

All ETDs from UAB

As instruments for detecting DNA have become more sensitive and reagents for amplifying DNA become more effective, forensic DNA analysts have obtained short tandem repeat (STR) profiles from evidence containing a small amount of DNA. Sources, such as dandruff, sweat, and saliva, which were once thought to be inadequate for STR profiling, can now be analyzed to effectively establish a profile. These low quantities of DNA can be recovered from liquid samples, such as saliva, or extracted and concentrated from large volumes of buffer, then amplified to give a DNA profile. This study focused on recovering saliva from drinking containers. …

Go to article

The Matricellular Protein Ccn1 Potentiates Fibrogenic Responses To Lung Injury, Ashish Kurundkar Jan 2016

The Matricellular Protein Ccn1 Potentiates Fibrogenic Responses To Lung Injury, Ashish Kurundkar

All ETDs from UAB

Normal wound healing is a well-coordinated reparative response to injury aimed at restoring the normal tissue function. The dynamic interactions between cells and ex-tracellular matrix (ECM) regulate and dictate the fate of tissue repair process. Fibrosis is a dysregulated wound healing with excessive deposition of ECM and loss of tissue func-tion. Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic disease of lung with no cure. Matricellular proteins are non-structural matrix proteins which regulates the cellular functions by directly binding to cell surface integrins and/or indirectly modulating growth factor signaling. Matricellular proteins are emerging as critical mediators of tissue injury …

Go to article

Sea Urchins Under Predicted Near-Future Ocean Conditions: The Effects Of Ocean Warming And Acidification On Physiology And Behavior, Cecilia Joy Brothers Jan 2016

Sea Urchins Under Predicted Near-Future Ocean Conditions: The Effects Of Ocean Warming And Acidification On Physiology And Behavior, Cecilia Joy Brothers

All ETDs from UAB

Sea urchins (Class Echinoidea) play important economic and ecological roles in the marine ecosystems they inhabit. However, climate change is causing seawater temperatures to increase and pH and the saturation state of polymorphs of calcium calcite to decrease at unprecedented rates, and these changes may have serious implications for the fitness and survival of sea urchin populations. The purpose of the present dissertation was to determine the effects of ocean warming and acidification on the physiology and behavior of sea urchins. This research was conducted on three sea urchin taxa (Lytechinus variegatus, Heliocidaris erythrogramma, and Sterechinus spp.) representing species that …

Go to article

Elementary Photoreceptor Signaling In Human Vision, Kady Scarlett Bruce Jan 2016

Elementary Photoreceptor Signaling In Human Vision, Kady Scarlett Bruce

All ETDs from UAB

To perceive a spot of light at photopic threshold, a minimum number of photons must be absorbed by cone photoreceptors. While many factors affecting psychophysical threshold have been studied, few have been examined at the single-cone level. Here we reveal how variation in synaptic weighting and signal integration among cones in the human retina occurs in vivo. Using an adaptive optics scanning laser ophthalmoscope (AOSLO) equipped with stimulation capabilities, we targeted cone-sized stimuli to single cones. Perceptual increment thresholds were measured from individual cones and cone pairs in 7 subjects using a Bayesian-based staircase method of threshold estimation. In 42 …

Go to article

Development And Evaluation Of Formulations For Transdermal Drug Delivery Systems, Carlos Arturo Carmona-Moran Jan 2016

Development And Evaluation Of Formulations For Transdermal Drug Delivery Systems, Carlos Arturo Carmona-Moran

All ETDs from UAB

Delivering drugs through the skin reduces side effects and avoids first pass drug metabolism. This is especially advantageous for drugs with associated side effects due to oral administration such as the case of diclofenac sodium; a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of symptomatic pain of joints due to osteoarthritis. However, transdermal delivery of diclofenac relies on the use of topical formulations that require constant application and are inconvenient for daily activities. These factors reduce patient compliance and diminish the efficacy of transdermal delivery of diclofenac. Improving transdermal delivery of diclofenac in joints or extremities requires developing novel …

Go to article

Expanding Pulmonary Rehabilitation Access With Technology, Erica Mccarron Anderson Jan 2016

Expanding Pulmonary Rehabilitation Access With Technology, Erica Mccarron Anderson

All ETDs from UAB

ii EXPANDING PULMONARY REHABILITATION WITH TECHNOLOGY ERICA MCCARRON ANDERSON COMMUNITY HEALTH & HUMAN SERVICES ABSTRACT Chronic Obstructive Pulmonary Disease (COPD) is a major cause of mortality and morbidity in the United States. COPD is a chronic, progressive lung disease characterized by irreversible airway obstruction. Symptoms include fatigue, chronic cough, excess mucus production and shortness of breath. These symptoms often impair quality-of-life. There are many interventions aimed at improving health related qualityof- life for patients living with COPD. Pulmonary rehabilitation is a multidisciplinary program exercise, education and psychosocial support. Pulmonary rehabilitation is well established to decrease symptoms in all stages of …

Go to article

Regulation Of Vibrio Cholerae Biofilm Formation By H-Ns Repression And Anti-Repression, Julio Cesar Ayala-Figueredo Jan 2016

Regulation Of Vibrio Cholerae Biofilm Formation By H-Ns Repression And Anti-Repression, Julio Cesar Ayala-Figueredo

All ETDs from UAB

The diarrheal disease cholera is caused by the Gram-negative and motile bacterium Vibrio cholerae of serogroups O1 and O139. V. cholerae can switch between planktonic (motile) and sessile (biofilm) lifestyles. Biofilms are sessile communities encased in a self-produced extracellular matrix mainly composed of exopolysaccharide, proteins and extracellular DNA. Biofilm formation enhances the capacity of V. cholerae to persist in environmental waters and increases its infectivity. The bacterial second messenger cyclic diguanylic acid (c-di-GMP) regulates the transition between motile and biofilm lifestyles in V. cholerae. At low cell density, two c-di-GMP receptors, the LuxR-type regulator VpsT and the NtrC-type regulator VpsR …

Go to article

Cleaning Protocol For Implant Abutment Screws, Rocio Barocio Torano Jan 2016

Cleaning Protocol For Implant Abutment Screws, Rocio Barocio Torano

All ETDs from UAB

Aim: To develop a time and cost effective cleaning protocol for implant abutment screws that are used throughout the fabrication of an implant restoration in the dental laboratory. Materials and Methods: Ninety (90) implant abutment screws (Biohorizons PXAS®) were collected from different dental laboratories after abutment milling and restoration fabrication. Seventy five (75) of these screws were randomly divided into 5 groups (n=15). Each group was cleaned for 1, 5, and 10 minutes in an ultrasonic cleaner and all screws were observed under 40x magnification before and after cleaning. Any debris was collected and weighed by using paper filters. The …

Go to article

Evaluating Driving Performance Of Adolescents And Young Adults With Autism Spectrum Disorders Around Social And Non-Social Hazards, Haley Johnson Bishop Jan 2016

Evaluating Driving Performance Of Adolescents And Young Adults With Autism Spectrum Disorders Around Social And Non-Social Hazards, Haley Johnson Bishop

All ETDs from UAB

The leading cause of death among adolescents is motor vehicle collisions, which may be due to a number of factors including inexperience and incomplete brain development. These risks may be even more prominent for young drivers with Autism Spectrum Disorders (ASD) because of additional impairments in processing speed, social communication and emotional regulation. Despite elevated safety risks, little research has considered the impacts of ASD on driving. This study aimed to characterize driving performance and hazard perception of drivers with ASD, specifically various types of hazards (e.g., pedestrians or other cars). The study also aimed to investigate factors that predict …

Go to article

Ribosomal Protein L12 (Rpl12) As A Novel Target In Cystic Fibrosis, Kathryn E. Oliver Jan 2016

Ribosomal Protein L12 (Rpl12) As A Novel Target In Cystic Fibrosis, Kathryn E. Oliver

All ETDs from UAB

Approximately 1,000 new cases of cystic fibrosis (CF) are diagnosed in the United States every year. The disease is caused by over 1,700 naturally occurring variants in the CF transmembrane conductance regulator (CFTR). Defects in the CFTR coding sequence contribute to variable disease severity in the patient population. The majority of individuals born with CF harbor at least one specific mutation in CFTR termed F508del. Clinical manifestations of CF include severe damage of multiple exocrine tissues, including the lungs, intestine, pancreas, reproductive and other organ systems. An overarching goal of our work is to identify cellular targets that contribute to …

Go to article

Machine Learning Of Composite Concepts And The Alleviation Of The Content Completeness Problem In Text Mention Normalization, John David Osborne Jan 2016

Machine Learning Of Composite Concepts And The Alleviation Of The Content Completeness Problem In Text Mention Normalization, John David Osborne

All ETDs from UAB

A critical area in the field of information extraction is the assignment of ontological categories (meaning) to fragments of natural language. These fragments are termed ``utterances'' when referring to a continuous fragment or ``mentions'' when the fragment may be discontinuous. In text, most approaches to ontological assignment use named entity recognition (NER) to first discover mention boundaries. This can then be followed by a concept recognition or normalization process to assign a more precise conceptual category to the NER discovered mention. Typically this semantic assignment is represented by only a single identifier from an ontology. If the provided semantic categories …

Go to article

Targeting The Tumor-Promoting Microenvironment With Inhibitors Of Pro-Hgf Activation, Benjamin Yaw Owusu Jan 2016

Targeting The Tumor-Promoting Microenvironment With Inhibitors Of Pro-Hgf Activation, Benjamin Yaw Owusu

All ETDs from UAB

The tumor microenvironment plays a key role in tumor progression and therapeutic resistance. Hepatocyte growth factor (HGF), commonly expressed by cancer-associated fibroblasts, mediates signaling via its receptor, MET, and promotes survival, proliferation, migration and invasion of cancer cells. In addition, HGF dependence has emerged as a hallmark of therapeutic resistance. HGF is secreted as an inactive precursor, pro-HGF, which requires proteolytic cleavage and processing to form the mature, active HGF. This is the rate-limiting step in the HGF/MET signaling pathway and it is achieved by one of the serine proteases, matriptase, hepsin and HGF activator (HGFA). At Southern Research, we …

Go to article

Joint Intervention In Opposing Pathways, Pi3k/Akt And Tgf-Beta, With Px-866 And Raloxifene, To Alter Gene Expression And Suppress Estrogen Receptor-Positive Breast Cancer Cell Proliferation, Gregory William Peek Jan 2016

Joint Intervention In Opposing Pathways, Pi3k/Akt And Tgf-Beta, With Px-866 And Raloxifene, To Alter Gene Expression And Suppress Estrogen Receptor-Positive Breast Cancer Cell Proliferation, Gregory William Peek

All ETDs from UAB

For each regulatory pathway implementing environmental or internal messages, there is at least one additional pathway to relay a message to override or modify the original message, in the event of new or conflicting input. The opposing pathway may also be an instrument for negative feedback or redundancy as well as for transmission of additional encountered conditions or considerations. Because the multiple disease conditions based on aberrant cell cycle proliferation often require a level of correction independent of opposing feedback, selection of opposing pathways for complementary joint input is a practical approach to cancer and related proliferation-associated diseases. Accordingly, I …

Go to article

Regulation Of The Mitochondrial Thiol Network With Targeted Electrohpiles, Matthew Ryan Smith Jan 2016

Regulation Of The Mitochondrial Thiol Network With Targeted Electrohpiles, Matthew Ryan Smith

All ETDs from UAB

Cells possess a remarkable plasticity to alter their metabolism and change their function based on stimuli within their resident microenvironment. The mitochondria within these cells utilize a variety of sources such as pyruvate, glutamine, or fatty acids in order to generate metabolites, amino acids, and reducing equivalents needed for cellular proliferation.Many mitochondrial enzymes possess contain a cysteine which possesses a thiol group, a unique redox-signaling moiety that can be activated under specific circumstances by bio-reactive compounds forming a network of mitochondrial proteins which are responsible for mitochondrial respiration. However, it is unknown whether targeting these reactive thiol groups present a …

Go to article

Factors Of Evidence-Based Coaching Practices Used By Pre-K Coaches In Alabama And How They Relate To Pre-K Children’S Scores In The Areas Of Social-Emotional, Physical, Language, Cognitive, Literacy, And Mathematics In A State Funded Pre-K: A Quantitative Study, Tracye Cutts Strichik Jan 2016

Factors Of Evidence-Based Coaching Practices Used By Pre-K Coaches In Alabama And How They Relate To Pre-K Children’S Scores In The Areas Of Social-Emotional, Physical, Language, Cognitive, Literacy, And Mathematics In A State Funded Pre-K: A Quantitative Study, Tracye Cutts Strichik

All ETDs from UAB

The National Association for the Education of Young Children (2011), The National Staff Development Council (2012), and the report released by the U.S. Department of Education (2011), recommends individualizing professional development and emphasizing the application of knowledge to practice. To meet the challenges of educating learners from all levels, teachers need professional development that is ongoing and job embedded (Neuman & Wright, 2010; Ochshorn, 2011). A coach can be a valuable resource in leading this high-quality professional development. Coaching provides educators with authentic opportunities to learn from, and with, one another inside the classroom and improves the classroom experience for …

Go to article

Glycosyltransferases Involved In The Glycosylation Of Serine-Rich Glycoproteins From Streptococci, Fan Zhu Jan 2016

Glycosyltransferases Involved In The Glycosylation Of Serine-Rich Glycoproteins From Streptococci, Fan Zhu

All ETDs from UAB

Serine - rich repeat glycoproteins (SRRPs) play important roles in mediating bac-terial attachment to a variety of host and microbial surfaces. They have been im-plicated in the development of tissue infections such as pneumonia, infective en-docarditis, meningitis and oral infectious diseases. Streptococcus parasanguinis, one of the commensal streptococci present in the oral cavity, utilizes its fimbriae to mediate the initial attachment to the tooth pellicle. Fap1 (Fimbriae-associated-protein 1), the first identified SRRP, is the subunit of the fimbriae which utilizes proteins encoded by an 11-gene cluster (gly-gtf3-dGT1-galT2 and secY2-gap1-gap2-gap3-secA2-gtf1-gtf2) to mediate its glycosylation and secretion. The key enzymes responsible for …

Go to article

Analysis Of The Ciliary Genes Gas8 And Mks6 Reveal Conserved Roles In Cilia Motility And Transition Zone Function, Wesley Robert Lewis Jan 2016

Analysis Of The Ciliary Genes Gas8 And Mks6 Reveal Conserved Roles In Cilia Motility And Transition Zone Function, Wesley Robert Lewis

All ETDs from UAB

Cilia are microtubule based cellular appendages that are present throughout the hierarchy of the animal kingdom. These appendages are utilized for a wide array of functions such as motility in single celled organisms to coordinating complex cellular signaling pathways in more complex organisms. Though these appendages are well conserved, the exact function of cilia in many cell types remains unknown. Recently, cilia are tied to a myriad of developmental diseases and diseases of adult homeostasis collectively referred to as ciliopathies. Dysfunction in cilia results in a wide array of phenotypes ranging from retinal degeneration to polydactyly, cystic kidney disease, and …

Go to article

No Association Between Latent Toxoplasmosis And Multiple Body Measures In U.S. Adults, Bruce L. Brown, Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Dawson W. Hedges Jan 2016

No Association Between Latent Toxoplasmosis And Multiple Body Measures In U.S. Adults, Bruce L. Brown, Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Dawson W. Hedges

Faculty Publications

Toxoplasma gondii (Nicolle et Manceaux, 1908) is an intracellular parasite that can cause ongoing latent infection persisting for the duration of a non-definitive host's life. Affecting approximately one-third of the world's population, latent toxoplasmosis has been associated with neuropsychological outcomes and a previous report suggested an association between latent toxoplasmosis and adult height. Given the large number of people with latent toxoplasmosis and its potential associations with human height, we sought to better understand the association between latent toxoplasmosis and human morphology by evaluating seropositivity for T. gondii and multiple body measures reported in the National Health and Nutrition Examination …

Go to article

First Prev Next Last