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2016

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The Role Of Mirnas In Niche Regulation Of All Phenotype, Blake Stephen Moses Jan 2016

The Role Of Mirnas In Niche Regulation Of All Phenotype, Blake Stephen Moses

Graduate Theses, Dissertations, and Problem Reports (ETD)

While modern acute lymphoblastic leukemia (ALL) treatment regimens have dramatically improved the survival of ALL patients, disease relapse still occurs in approximately 20% of cases. ALL relapse is, in part, due to the inability of traditional chemotherapeutic agents to efficiently target quiescent, non-dividing tumor cells. The number of viable remaining leukemia cells in patients after initial treatment, termed minimal residual disease (MRD), is directly correlated with likelihood of disease relapse. This reflects the proliferative potential of these refractory cells, consistent with the ability of their healthy hematopoietic progenitor pro- and pre-B cell counterparts. Developing novel therapies to combat refractory disease …

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Phenotypic And Genotypic Characterization Of Lumbosacral Stenosis In Labrador Retrievers, Meenakshi Mukherjee Jan 2016

Phenotypic And Genotypic Characterization Of Lumbosacral Stenosis In Labrador Retrievers, Meenakshi Mukherjee

Graduate Theses, Dissertations, and Problem Reports (ETD)

Lumbosacral stenosis (LS) is a structural narrowing of the spinal canal in the canine lumbosacral spine. Large-sized working and sporting dog breeds such as Labrador retrievers are predisposed for reasons that are incompletely understood. Early diagnosis is essential for maximizing the quality of life, and minimizing the likelihood of early retirement in working dogs. Lumbosacral stenosis is usually considered to be a condition associated with degenerative changes observed with normal aging, however presence of the disease in young and middle aged working dogs has also been reported. This leads to the probable theory that some dogs in large breeds like …

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Characteristics Of Bubble Behavior In Microgravity Conditions, Thilanka Munasinghe Jan 2016

Characteristics Of Bubble Behavior In Microgravity Conditions, Thilanka Munasinghe

Graduate Theses, Dissertations, and Problem Reports (ETD)

The main objective of this thesis is to study the characteristics of bubbles in pool boiling under microgravity conditions with and without the influence of a magnetic field. In order to create microgravity conditions, the parabolic path of an aircraft was used for a period of 20-30 seconds, during which time the experiment was conducted. Two cylindrical tanks were used for the boiling process in the experiment. One tank had a permanent magnet attached at the bottom, and the other one was kept as the control. MnCl2 was dissolved in distilled water to make a paramagnetic liquid, and which used …

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Gender Estimation From Fingerprints Using Dwt And Entropy, Sneha Nagabhyru Jan 2016

Gender Estimation From Fingerprints Using Dwt And Entropy, Sneha Nagabhyru

Graduate Theses, Dissertations, and Problem Reports (ETD)

Gender estimation from fingerprints have wide range of applications, especially in the field of forensics where identifying the gender of a criminal can reduce the list of suspects significantly. Although there have been quite a few research papers in the field of gender estimation from fingerprints most of those experiments used a lot of features but were only able to achieve poor classification results. That being the motivation behind the study we successfully proposed two different approaches for gender estimation from fingerprints and achieved high classification accuracy.;In this study we have developed two different approaches for gender estimation from fingerprints. …

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The Regulation Of Alternative Pre-Mrna Splicing In Photoreceptor Cells., Daniel P. Murphy Jan 2016

The Regulation Of Alternative Pre-Mrna Splicing In Photoreceptor Cells., Daniel P. Murphy

Graduate Theses, Dissertations, and Problem Reports (ETD)

Alternative pre-mRNA splicing provides an important mechanism for generating the diverse array of proteins required to generate complex tissue and cell types from a limited genome. Therefore, the proper regulation of alternative splicing is vital to shape cellular identity and function. As consequence, defects in alternative splicing are associated with disease phenotypes that can range from systemic syndromes to the dysfunction of single cell types. For example, heterozygous mutations in ubiquitously expressed components of the spliceosome lead to photoreceptor specific cell death. This suggests that the topography of alternative splicing in photoreceptors cells may be unique, a notion which is …

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Development Of Polyvinyl Alcohol/Wood-Derived Carbon Thin Films: Influence Of Processing Parameters On Mechanical, Thermal, And Electrical Properties, Nan Nan Jan 2016

Development Of Polyvinyl Alcohol/Wood-Derived Carbon Thin Films: Influence Of Processing Parameters On Mechanical, Thermal, And Electrical Properties, Nan Nan

Graduate Theses, Dissertations, and Problem Reports (ETD)

The first goal of this research was to explore the potential value of hardwood-derived carbon materials as fillers for reinforcing polymer materials, and investigate the effect of filler content on various properties of reinforced composites. Three loading levels of biochar particles, 2wt%, 6wt%, and 10wt% (by weight) were added to a 10wt% polyvinyl alcohol (PVA) solution (by weight) and composites were formed via the film-casting method. The morphological, tensile, thermal, and dynamic mechanical properties of PVA/biochar composite films were tested and analyzed. Tensile tests indicated that the addition of biochar reduced the tensile strength and elongation at break of the …

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Hydroclimatic Assessment Of Changing Climate On Diarrheal Diseases With Reference To Cholera, Fariborz Nasr Azadani Jan 2016

Hydroclimatic Assessment Of Changing Climate On Diarrheal Diseases With Reference To Cholera, Fariborz Nasr Azadani

Graduate Theses, Dissertations, and Problem Reports (ETD)

The association of cholera with the climatic processes is well documented. However the effects of changing climate on occurrence of cholera is not yet evaluated, perhaps due to unavailability of geophysical data and their quantitative linkages with cholera. Global climate models (GCMs) outputs are available at coarse resolution of 200-300km, but the diseases usually occur at 10-15 km, therefore, it is rather challenging to link any GCM outputs with a disease. The goal of this research is to develop algorithms that can link diarrheal diseases with changing climatic conditions. Within this context, cholera is used as a model disease due …

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Associations Among Task Self-Efficacy, Physical Activity And Subjective Wellbeing, Abigail M. Nehrkorn Jan 2016

Associations Among Task Self-Efficacy, Physical Activity And Subjective Wellbeing, Abigail M. Nehrkorn

Graduate Theses, Dissertations, and Problem Reports (ETD)

The physical and psychological health benefits resulting from physical activity engagement have been documented in previous literature, including the connection between physical activity and subjective wellbeing (SWB). Associations have also been found between task-related self-efficacy and physical activity, connecting these concepts to Bandura's Social Cognitive Theory (SCT; Bandura, 1982, 1997), such that retaining a higher belief in one's physical activity abilities has been associated with successful physical activity engagement. Previous literature has documented these separate associations, but not as much focus has been placed on examining task self-efficacy, physical activity, and SWB in one model, especially during the time of …

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How College Instructors Use Social Media For Instruction, Benson Njoroge Jan 2016

How College Instructors Use Social Media For Instruction, Benson Njoroge

Graduate Theses, Dissertations, and Problem Reports (ETD)

The use of social media has increased tremendously in recent years with many sectors using it for the purpose of communicating, sharing ideas, gathering information and stating opinions. The use of social media has trickled down into education with instructors using it for teaching and learning. This study used Gagne's Nine Events of Instruction as a framework to investigate the types of social media applications used, and how they are specifically used for instructional purpose in colleges. The study used both qualitative and quantitative methods to analyze data. Results indicated that about 31% of instructors use different social media types …

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Pretreating Underutilized Woody Biomass For Value-Added Biofuels And Bioproducts, Amy K. Falcon Jan 2016

Pretreating Underutilized Woody Biomass For Value-Added Biofuels And Bioproducts, Amy K. Falcon

Graduate Theses, Dissertations, and Problem Reports (ETD)

Biomass pretreatment is a key techno-economic factor affecting the yield and economics of bioenergy or bioproduct production. The cost of pretreatment significantly increases if the sugars cannot be efficiently recovered once they are removed from the complex wood structure. Separation of the liquid extract from the solid particulates is important, especially in cellulose and hemicellulose recovery. A urea pretreatment of woody biomass was studied in this paper due to the ability of urea to decompose into ammonia molecules and carbon dioxide. Glucose separation from woody biomass was analyzed as an indication of pretreatment efficiency using three separation techniques: Whatman 113 …

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Grainyhead-Like 2 Reverses The Metabolic Changes Induced By The Oncogenic Epithelialmesenchymal Transition: Effects On Anoikis, Joshua C. Farris Jan 2016

Grainyhead-Like 2 Reverses The Metabolic Changes Induced By The Oncogenic Epithelialmesenchymal Transition: Effects On Anoikis, Joshua C. Farris

Graduate Theses, Dissertations, and Problem Reports (ETD)

When deprived of connections to their extracellular matrix, normal epithelial cells trigger a process of programmed cell death referred to as anoikis. The transcriptional reprogramming event known as Epithelial-Mesenchymal transition (EMT) confers anoikis resistance and ultimately, increased metastatic potential. Distant metastatic disease contributes to the majority of deaths occurring in many cancer types, especially those originating in breast tissue. The ability to metastasize depends critically upon a cancer cell's ability to evade anoikis. Heterogeneity of tumors containing anoikis, therapy resistant populations likely explains the tendency of disease to reappear in distant locations after a period of apparent remission. The wound …

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The Effects Of Six Weeks Of High Intensity Interval Training (Hiit) Or Moderate Intensity Training (Mit) On Antioxidant Capacity And Metabolic Health In Obese/Overweight Males, Samuel Pierce Cauffman Jan 2016

The Effects Of Six Weeks Of High Intensity Interval Training (Hiit) Or Moderate Intensity Training (Mit) On Antioxidant Capacity And Metabolic Health In Obese/Overweight Males, Samuel Pierce Cauffman

All ETDs from UAB

Background: Obesity is an independent risk factor for type 2 diabetes and cardiovascular disease. Oxidative stress or low total antioxidant capacity has been shown to be associated with decreased insulin sensitivity (SI) in overweight/obese individuals. Exercise training has been shown to improve systemic antioxidant capacity (TAC) and SI; however whether or not correlations between SI and TAC observed under untrained conditions are associated following exercise training is less clear. PURPOSE: The purpose of this study was twofold: 1) to determine if SI was correlated with serum TAC in a cohort of overweight/obese men at baseline and following six-weeks of exercise …

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Cultural Competence Practices Implemented In Hospitals And Health Systems By Minority Executives On The Top Management Team, John H. Cunningham Jan 2016

Cultural Competence Practices Implemented In Hospitals And Health Systems By Minority Executives On The Top Management Team, John H. Cunningham

All ETDs from UAB

The study examined whether hospital implementation of cultural competence practices was influenced by the racial/ethnic composition of top management. With one-third of the U.S. population identifying with a racial or ethnic group other than non-Hispanic White, and that population continuing to grow increasingly diverse, racial and ethnic minorities are increasingly accessing health care services. Yet they represent less than 1% of the top management teams (TMT) of health care organizations. The study sought to determine the extent to which health care organizations with TMTs that are representative of the racial and ethnic compositions of the communities in which they serve …

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Human Cytosolic Sulfotransferase (Sult) 1b1 Half-Site Reactivity And The Identification And Characterization Of A Novel Variant Sult1b1 Isoform (L145v), Zachary Evan Tibbs Jan 2016

Human Cytosolic Sulfotransferase (Sult) 1b1 Half-Site Reactivity And The Identification And Characterization Of A Novel Variant Sult1b1 Isoform (L145v), Zachary Evan Tibbs

All ETDs from UAB

The human cytosolic sulfotransferases (hSULTs) are a fourteen-member family of phase II drug-metabolizing enzymes that catalyze the transfer of a sulfonate moiety from 3’-phosphoadenosine 5’-phosphosulfate (PAPS) to a recipient substrate. SULT-mediated sulfation serves to deactivate physiological hormones and detoxify xenobiotics. SULT1B1 is primarily resident to the gastrointestinal tract, liver, and possibly peripheral white blood cells (WBCs), whereby it performs its supposed physiological role. The iso-form has the capacity to sulfate thyroid hormones, small phenols, and polyaromatic hy-drocarbons resulting in their inactivation, detoxification, and bioactivation/detoxification, respectively. Immunohistochemistry was used to show hSULT1B1 protein is present in periph-eral lymphocytes and neutrophils. Further, …

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Microglia Orchestrate The Inflammatory Response To Alpha-Synuclein In Parkinson Disease Models, Aaron Thome Jan 2016

Microglia Orchestrate The Inflammatory Response To Alpha-Synuclein In Parkinson Disease Models, Aaron Thome

All ETDs from UAB

Parkinson disease (PD) is the most common neurodegenerative movement disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and widespread aggregates of the protein alpha-synuclein (α-syn). Increasing evidence points to inflammation as a chief mediator of PD with many of the inflammatory manifestations of human PD cases recapitulated in animal models of PD. We began by examining the inflammatory potential of α-syn fibrils, a newly characterized α-syn conformation that is neurotoxic and prion-like in its endogenous α-syn recruitment and cellular transmission. Our studies provide evidence that the α-syn fibrils evoke a pro-inflammatory response …

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Polycomb Repressive Complex 2 And Heterochromatin Protein 1 Beta Regulate Neural And Neural Crest Development, Chih-Liang Tien Jan 2016

Polycomb Repressive Complex 2 And Heterochromatin Protein 1 Beta Regulate Neural And Neural Crest Development, Chih-Liang Tien

All ETDs from UAB

Epigenetic factors control gene expression via modulating chromatin conformation. Current studies on epigenetics mainly focus on biochemical mechanisms or functions of epigenetic factors in cancer or neurobiology. The underlying mechanism for epigenetic regulation in early embryonic development, particularly neural and neural crest development, is not well understood. In this thesis, the model organism, Xenopus laevis, is used to study epigenetic factors – polycomb repressive complex 2 (PRC2) and heterochromatin protein 1 beta (HP1β) in neural and neural crest development. In chapter one, the processes of neural and neural crest development are described, and the concepts of epigenetic mechanisms, such as …

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Methods For Analysis Of Genetic Differences In Sex And Ethnicity For Complex Human Traits, Yogasudha Veturi Veturi Jan 2016

Methods For Analysis Of Genetic Differences In Sex And Ethnicity For Complex Human Traits, Yogasudha Veturi Veturi

All ETDs from UAB

In the last two decades, thousands of genome-wide association (GWA) analyses have been published. These studies have been primarily conducted using data from Caucasians and many of the reported findings have not been replicated in other populations, perhaps reflecting that the underlying architecture of effects may vary across ethnically diverse groups. Similarly, the possibility that the genetic architecture of traits may vary between males and females has also been overlooked. We propose a methodology for estimation and testing of effect heterogeneity between groups such as sex or ethnicity that involves modeling genotype-by-group random interactions. Using simulations, we show that the …

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Germline Restriction Of B Cell Receptor Repertoire Influences Antigenic Epitope Recognition And Primary Antibody Deficiency Pathogenesis, Yuge Wang Jan 2016

Germline Restriction Of B Cell Receptor Repertoire Influences Antigenic Epitope Recognition And Primary Antibody Deficiency Pathogenesis, Yuge Wang

All ETDs from UAB

Part I. Mouse Studies Complementarity determining region 3 of the immunoglobulin (Ig) H chain (CDR-H3) lies at the center of the antigen binding site where it often plays a decisive role in antigen recognition and binding. Amino acids encoded by the diversity (DH) gene segment are the main component of CDR-H3. Each DH has the potential to rearrange into one of six DH reading frames (RFs), each of which exhibits a characteristic amino acid hydrophobicity signature that has been conserved among jawed vertebrates by natural selection. A preference for use of RF1 promotes the incorporation of tyrosine into CDR-H3 while …

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Cell Signaling Pathways As Targets For Precision Medicine In Head And Neck Squamous Cell Carcinoma, Alice Weaver Jan 2016

Cell Signaling Pathways As Targets For Precision Medicine In Head And Neck Squamous Cell Carcinoma, Alice Weaver

All ETDs from UAB

Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease with high rates of recurrence and mortality. Unlike other cancer types, genome sequencing studies have failed to produce clinically actionable targets to improve HNSCC management. Therefore, alternative methods are needed to study the molecular mechanisms responsible for disease progression and response to therapy. The focus of this research was to determine how dysregulation of cell signaling pathways affects outcomes in HNSCC. In HPV-positive HNSCCs, we hypothesized that HPV induces dysregulation of the DNA damage response which mediates differences in therapeutic sensitivity and survival. We identified a defect in DNA …

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Paper Me, Matthew David Whitehurst Jan 2016

Paper Me, Matthew David Whitehurst

All ETDs from UAB

Paper Me is an autobiographical collage. It contains memoir essays, personal essays and comedic essays. Dark humor and sarcasm are the vehicle for the narrative voice throughout the collage. The narrative is arranged in a pseudo-chronological order, and traces a line through dotted memories: from the first memory as a child in pre-school, to the death of a friend after college. Addiction, Paternal Relationships, Politics, Absurdity/Humor, Poverty, Sociology and Philosophy are recurring themes in this collection. This is the author’s attempt to concretize a world view, as informed by personal experience, and to impart that experiential knowledge on the larger …

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Temporal Co-Expression Network Construction, Leading Sub-Network Identification, And Time Point Alignment In The Integration Of Phase Transition Theory And Systems Biology And The Application To Human Type 1 Diabetes, Nathaniel Wolanyk Jan 2016

Temporal Co-Expression Network Construction, Leading Sub-Network Identification, And Time Point Alignment In The Integration Of Phase Transition Theory And Systems Biology And The Application To Human Type 1 Diabetes, Nathaniel Wolanyk

All ETDs from UAB

Systems biology is a rapidly expanding field used to tackle a wide range of biological problems. Systems biology arose to explain areas that detailed biological analysis, such as genetics and biopsies, struggled with. Systems biology is the study of the complexity within a biological system of multiple units that is due to the interaction among the units. In this dissertation systems biology will be combined with phase transition theory from physics to create a new analysis method for complex diseases and apply this new method to a longitudinal dataset on Type 1 Diabetes (T1D) to identify the key contributing molecules …

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For Love Or Money? The Economic Consequences Of Delayed Marriage, Jason S. Carroll Jan 2016

For Love Or Money? The Economic Consequences Of Delayed Marriage, Jason S. Carroll

Faculty Publications

It has been well documented that over the last few decades we have seen a substantial increase in the median age of marriage in the United States. In fact, we are currently at all-time historic highs in these trends. According to the Current Population Survey from the U.S. Census, the median age of marriage right now is nearly 29 years of age for men and 27 years of age for women. Given the trajectory of this trend over the last several years, we are quickly approaching a time in our culture where half of marriages will occur for individuals after …

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Influence Of Maternal Age On The Effects Of Organic Selenium In The Animal Model Daphnia Pulex, Jordan E. Roberts Jan 2016

Influence Of Maternal Age On The Effects Of Organic Selenium In The Animal Model Daphnia Pulex, Jordan E. Roberts

All ETDs from UAB

As a necessary micronutrient, seleno-L-methionine (SeMet) exhibits a U-shaped dose-response with deficiency and toxicity leading to adverse health outcomes. Some studies suggest dietary selenium may offer protection against toxicity from other metals, but excessive dietary levels can also lead to toxicity. In addition, increased maternal age has been shown to increase the risk of adverse developmental outcomes. We hypothesize that older maternal age will increase susceptibility in offspring exposed to toxic concentrations of SeMet. The goal of this project was to evaluate the effects of SeMet treatment on lifespan and determine if the effects are altered by maternal age using …

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Altering Metabolism In The Tumor Microenvironment To Enhance Anti-Tumor Immunity For Lung Cancer, Cara Schafer Jan 2016

Altering Metabolism In The Tumor Microenvironment To Enhance Anti-Tumor Immunity For Lung Cancer, Cara Schafer

All ETDs from UAB

Overcoming cancer cell immune escape represents a fundamental obstacle in the treatment of cancer. Indoleamine 2,3-dioxygenase (IDO)-expressing myeloid-derived suppressor cells (MDSCs) are known to induce oxidative stress and alter amino acid metabolism within the tumor microenvironment (TME). The tryptophan (Trp)-catabolizing action of IDO not only promotes T cell tolerance and evasion but is also associated with impaired quality of life in cancer patients. We have previously demonstrated that a novel combination therapy, consisting of MDSC-depleting gemcitabine and a superoxide dismutase mimetic, prolonged survival of tumor-bearing mice by enhancing CD8+ memory T cell metabolism. We identify that combination therapy inhibits IDO …

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Handcrafted Microwire Regenerative Peripheral Nerve Interfaces With Wireless Neural Recording And Stimulation Capabilities, Ali Ajam, Ridwan Hossain, Nishat Tasnim, Luis Castanuela, Raul Ramos, Dong-Chul Kim, Yoonsu Choi Jan 2016

Handcrafted Microwire Regenerative Peripheral Nerve Interfaces With Wireless Neural Recording And Stimulation Capabilities, Ali Ajam, Ridwan Hossain, Nishat Tasnim, Luis Castanuela, Raul Ramos, Dong-Chul Kim, Yoonsu Choi

Computer Science Faculty Publications

A scalable microwire peripheral nerve interface was developed, which interacted with regenerated peripheral nerves in microchannel scaffolds. Neural interface technologies are envisioned to facilitate direct connections between the nervous system and external technologies such as limb prosthetics or data acquisition systems for further processing. Presented here is an animal study using a handcrafted microwire regenerative peripheral nerve interface, a novel neural interface device for communicating with peripheral nerves. The neural interface studies using animal models are crucial in the evaluation of efficacy and safety of implantable medical devices before their use in clinical studies. 16- electrode microwire microchannel scaffolds were …

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Stability Analysis And Hopf Bifurcation Of Density-Dependent Predator-Prey Systems With Beddington-Deangelis Functional Response, Xin Jiang, Zhikun She, Zhaosheng Feng Jan 2016

Stability Analysis And Hopf Bifurcation Of Density-Dependent Predator-Prey Systems With Beddington-Deangelis Functional Response, Xin Jiang, Zhikun She, Zhaosheng Feng

School of Mathematical & Statistical Sciences Faculty Publications

In this article, we study a density-dependent predator-prey system with the Beddington-DeAngelis functional response for stability and Hopf bifurcation under certain parametric conditions. We start with the condition of the existence of the unique positive equilibrium, and provide two sufficient conditions for its local stability by the Lyapunov function method and the Routh-Hurwitz criterion, respectively. Then, we establish sufficient conditions for the global stability of the positive equilibrium by proving the non-existence of closed orbits in the first quadrant R²+. Afterwards, we analyze the Hopf bifurcation geometrically by exploring the monotonic property of the trace of the Jacobean matrix with …

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Aconitic Acid, Glycerol And Cinnamic Acid Polyester Characterization For Bone Tissue Engineering, Katie Joanna Hogan Jan 2016

Aconitic Acid, Glycerol And Cinnamic Acid Polyester Characterization For Bone Tissue Engineering, Katie Joanna Hogan

Honors Capstones

No abstract provided.

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Sensation, Intuition, Space, And Time In Hegel’S Philosophy Of Subjective Spirit, Willem A. Devries Jan 2016

Sensation, Intuition, Space, And Time In Hegel’S Philosophy Of Subjective Spirit, Willem A. Devries

Faculty Publications

The subject of space, time, sensation, and intuition in Hegel is complicated, more so in Hegel than in Kant, and for good reason. Hegel rejected Kant’s Transcendental Idealism; besides the subjective reality Kant attributed to space and time, Hegel also attributed to them a truly objective reality. According to Hegel, space and time qualify finite things as they really are. Moreover, I shall argue, space and time, in Hegel’s view, have two different modes of subjective presence. We can illuminate these distinctive modes of subjective presence by comparing Hegel’s with Wilfrid Sellars’ strikingly similar arguments against Transcendental Idealism.

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"Sleep Tight, Don't Let The Dysfunction Bite!" The Relationship Between Sleep Problems And Behavioral And Emotional Problems In Adolescence, Meredith Ashley Henry Jan 2016

"Sleep Tight, Don't Let The Dysfunction Bite!" The Relationship Between Sleep Problems And Behavioral And Emotional Problems In Adolescence, Meredith Ashley Henry

All ETDs from UAB

The effects of sleep on behavioral and emotional functioning in a low income, urban sample of 84 African American adolescents was investigated over 3 years (mean ages: 13.36, 14.76, and 16.14 years) of parent and child interviews. Results suggest child-reported sleep duration decreased while all other sleep variables remained stable. Substance use increased over time. Physical aggression and conduct problems decreased; depression, emotional problems, and hyperactivity/inattention remained stable until late adolescence and then decreased. Lower duration of sleep and more sleep problems at age 13 predicted more conduct problems at age 15 which, in turn, predicted less sleep duration and …

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What's Up, Dut? Help, Help I'M Being Derepressed; The Great Derepression Of Sapis Or How I Learned To Stop Worrying And Love Mobilization, Rosanne Lorin Lee Hill Jan 2016

What's Up, Dut? Help, Help I'M Being Derepressed; The Great Derepression Of Sapis Or How I Learned To Stop Worrying And Love Mobilization, Rosanne Lorin Lee Hill

All ETDs from UAB

Staphylococcus aureus is known to cause disease in both human and animal populations. Many of the virulence factors important for S. aureus pathogenesis are found on mobile genetic elements known as S. aureus pathogenicity islands (SaPIs). SaPIs can transduce into surrounding cells, giving those cells the ability to produce virulence factors. Derepression allows SaPIs to be excised from S. aureus genome to initiate mobilization. Derepressors have been identified for multiple SaPIs, but it remains unknown if the same SaPI can be derepressed by multiple derepressors. It has been shown that SaPIbov1 can be derepressed by the type 1 dUTPase from …

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