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2016

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Physicochemical Modulation Of Huntingtin Aggregation On Lipid Membranes: Implications For Huntington's Disease, Maxmore Chaibva Jan 2016

Physicochemical Modulation Of Huntingtin Aggregation On Lipid Membranes: Implications For Huntington's Disease, Maxmore Chaibva

Graduate Theses, Dissertations, and Problem Reports (ETD)

Huntington disease is a genetic, neurodegenerative disease caused by an expanded polyglutamine (polyQ) in the first exon of the huntingtin (htt) protein, facilitating its aggregation, leading to the formation of a diverse population of potentially toxic aggregate species, such as oligomers, fibrils, and annular aggregates. Htt interacts with a variety of membranous structures within the cell, and the first seventeen amino acids (Nt17) of htt directly flanking the polyQ domain is an amphipathic alpha-helix (AH) lipid-binding domain. AHs are also known to detect membrane curvature. Nt17 also promotes diverse aggregate species of htt and undergoes a number of posttranslational modifications …

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Comparative Analysis Of Uninhibited And Constrained Avian Wing Aerodynamics, Jordan A. Cox Jan 2016

Comparative Analysis Of Uninhibited And Constrained Avian Wing Aerodynamics, Jordan A. Cox

Graduate Theses, Dissertations, and Problem Reports (ETD)

The flight of birds has intrigued and motivated man for many years. Bird flight served as the primary inspiration of flying machines developed by Leonardo Da Vinci, Otto Lilienthal, and even the Wright brothers. Avian flight has once again drawn the attention of the scientific community as unmanned aerial vehicles (UAV) are not only becoming more popular, but smaller. Birds are once again influencing the designs of aircraft. Small UAVs operating within flight conditions and low Reynolds numbers common to birds are not yet capable of the high levels of control and agility that birds display with ease. Many researchers …

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Endocannabinoid Modulation Of Secretory And Inflammatory Causes Of Gastric Pathology, Molly S. Crowe Jan 2016

Endocannabinoid Modulation Of Secretory And Inflammatory Causes Of Gastric Pathology, Molly S. Crowe

Graduate Theses, Dissertations, and Problem Reports (ETD)

Non-steroidal anti-inflammatory drugs (NSAIDs) are common analgesic drugs that also cause well-known, negative gastrointestinal (GI) side effects. The specific physiological mechanism(s) of NSAID-induced GI damage are unknown, and are likely due to multiple causes. The most studied components include: increased gastric acid secretions, inflammation of the gastric epithelium, and increased gastric motility. Currently, proton pump inhibitor (PPI) antacids are used by chronic NSAID users, with the expectation that decreasing gastric acid output will reduce gastric epithelial irritation. However, PPIs are associated with side effects like infection, gastric polyps, and dementia. Therefore, new gastroprotective treatments that prevent NSAID-induced gastropathy are needed. …

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Young Adult Daughters And Their Parents: Communication About Workcareer And Family, Rita Daniels Jan 2016

Young Adult Daughters And Their Parents: Communication About Workcareer And Family, Rita Daniels

Graduate Theses, Dissertations, and Problem Reports (ETD)

Employing adult daughters' (N = 254) perspectives of their communication, relational quality, and identities with and surrounding their relationships with parents, I bridge organizational and family communication's scholarship realms to address family socialization regarding work/career and family. Specifically, I examine: (a) the content and context of memorable messages about work and/or family; (b) the connection between daughters' closeness to parents and daughters' likelihood to transmit these messages; and (c) the impact of mothers' socialization messages about work/career and family on daughters' personal, relational, and enacted identities (identity layers within the Communication Theory of Identity (CTI; Hecht (1993)). Using both online …

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Synergistic Modeling Of In-Vitro And In-Vivo Data Via Stochastic Kriging With Qualitative Factors (Skq), Behnam Dehghan Jan 2016

Synergistic Modeling Of In-Vitro And In-Vivo Data Via Stochastic Kriging With Qualitative Factors (Skq), Behnam Dehghan

Graduate Theses, Dissertations, and Problem Reports (ETD)

The objective of this study is to model in-vivo propranolol plasma concentration after administrating oral propranolol extended-release (ER) tablets. In-vivo data are typically expensive and scarce. To save time and cost needed to achieve high-quality in- vivo profile, this work utilizes both in-vitro and in-vivo data.;The ensemble of in-vitro and in-vivo data is modeled by stochastic kriging with qualitative factors (SKQ). It treats in-vivo and in-vitro as the two distinct levels of a qualitative factor. By synergistically modeling both types of data, SKQ is able to provide fitted in-vivo profiles whose quality is much higher than those obtained from modeling …

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Four Days That Transformed Spain 11-M Impact On Memory Recovery Examined Through The Lens Of Duality, Thomas J. Divins Jan 2016

Four Days That Transformed Spain 11-M Impact On Memory Recovery Examined Through The Lens Of Duality, Thomas J. Divins

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis studies the controversial aftermath of the Madrid terrorist attack of March 11, 2004 and how it impacted the history of memory and silence in Spain since the Spanish Civil War. The terrorist attack had surprising and significant short-term political impacts, which have been well documented by historians, political scientists, and journalists. However, surveying the attack aftermath through the lens of the history of duality in Spain has been less studied. The "lens of duality" is the viewpoint that Spain's history in the twentieth and twenty-first centuries can be explained as a clash between deeply-divided sectors within society which …

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Elucidating Mechanisms Of Canonical Wnt - Ephrin-B Crosstalk, William Tyler Koch Jan 2016

Elucidating Mechanisms Of Canonical Wnt - Ephrin-B Crosstalk, William Tyler Koch

Graduate Theses, Dissertations, and Problem Reports (ETD)

Throughout development, canonical Wnt signaling contributes to the formation and maintenance of a wide array of cells, tissues, and organs. Dys-regulated Wnt signaling during embryonic development is implicated in developmental defects known as neurochristopathies, including craniofacial and heart defects, as well as defects in neural development. Due to its roles in stem cell maintenance and self-renewal, tissue homeostasis, and regeneration, aberrant Wnt signaling in adult tissues can result in various forms of cancer, including colorectal cancer, breast cancer, lung cancer, and gastro-intestinal cancer, among others. Dys-regulated Wnt signaling is also implicated in other pathologies including bone disease, and metabolic diseases, …

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Assessment Of Molecular Action Of Direct Gating And Allosteric Modulatory Effects Of Meprobamate (Miltownrtm) On Gaba A Receptors, Manish Kumar Jan 2016

Assessment Of Molecular Action Of Direct Gating And Allosteric Modulatory Effects Of Meprobamate (Miltownrtm) On Gaba A Receptors, Manish Kumar

Graduate Theses, Dissertations, and Problem Reports (ETD)

Meprobamate (tradenames Miltown, Equanil) is a schedule IV anxiolytic and the primary metabolite of the muscle relaxant carisoprodol. Meprobamate modulates GABAA (gamma-aminobutyric acid type A) receptors, and has been described as having barbiturate-like activity. A thorough understanding of its mechanism remains ill-defined, however. To gain insight into its actions, we have conducted a series of studies using recombinant GABAA receptors. In alphaxbetazgamma2 GABAA receptors (where x = 1-6 and z = 1-3), the ability to enhance GABA-mediated current was evident for all alpha subunit isoforms, with the largest effect observed in alpha5-expressing receptors. Direct gating was comparable with all alpha …

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Development And Application Of Quantitative Gene Expression Assays In Wild-Caught, Non-Model Fish Species, Cassidy Megan Hahn Jan 2016

Development And Application Of Quantitative Gene Expression Assays In Wild-Caught, Non-Model Fish Species, Cassidy Megan Hahn

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Great Lakes Basin is the most significant freshwater resource in North America. It is a central location for diverse anthropogenic enterprises and consequently has been heavily impacted by the release of toxic substances. Environmental studies increasingly identify the presence of both contaminants of emerging concern (CECs) and legacy contaminants in aquatic environments; however, the biological effects of these compounds on resident fishes remain largely unknown. To address this issue, the U.S. Fish and Wildlife Service Environmental Contaminants Programs initiated a multiagency, collaborative study which included chemical analysis of water and benthic sediment, assessment of caged fathead minnows and assessment …

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Distribution And Efficacy Of Chemotherapeutics In The Treatment Of Preclinical Brain Metastases Of Breast Cancer, Tori Terrell Hall Jan 2016

Distribution And Efficacy Of Chemotherapeutics In The Treatment Of Preclinical Brain Metastases Of Breast Cancer, Tori Terrell Hall

Graduate Theses, Dissertations, and Problem Reports (ETD)

Brain metastases are a critical, life-threatening problem for women with advanced metastatic breast cancer. Approximately 80% of women with disseminated central lesions are unable to survive the first year after diagnosis. Despite the breakdown of the blood-brain barrier, chemotherapeutics have limited penetration and distribution into brain metastases and are unable to induce cytotoxicity in the tumor. Limiting the development of new treatments for brain metastases of breast cancer, there are no commercially available in vitro models available that accurately model, and mimic the functionality of, the in vivo blood-tumor barrier (BTB). In an attempt to address the aforementioned problem, the …

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Modulation Of Coronary Reactive Hyperemia Through Soluble Epoxide Hydrolase: Role Of Oxylipins And Ppargamma, Ahmad Mahmoud Hanif Jan 2016

Modulation Of Coronary Reactive Hyperemia Through Soluble Epoxide Hydrolase: Role Of Oxylipins And Ppargamma, Ahmad Mahmoud Hanif

Graduate Theses, Dissertations, and Problem Reports (ETD)

Ischemic heart disease (IHD) continues to be a leading cause of morbidity and mortality in increasingly more countries. Function and structural damage to the heart are likely consequences of ischemic insults and may even lead to death. The body's physiological response to ischemia is by increasing nourishment or perfusion to the deprived organ in an attempt to decrease the potential ischemia-induced damage and achieve faster recovery. This reaction to ischemia is termed reactive hyperemia (RH), and in the heart, it is coronary reactive hyperemia (CRH). Epoxyeicosatrienoic acids (EETs) are oxylipins derived from arachidonic acid (AA) and possess distinct cardiovascular benefits, …

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The Influence Of Dams On Downstream Larval And Juvenile Fish And Benthic Macroinvertebrate Community Structure And Associated Physicochemical Variables, R. Daniel Hanks Jan 2016

The Influence Of Dams On Downstream Larval And Juvenile Fish And Benthic Macroinvertebrate Community Structure And Associated Physicochemical Variables, R. Daniel Hanks

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Influence of Dams on Downstream Larval and Juvenile Fish and Benthic Macroinvertebrate Community Structure and Associated Physicochemical Variables R. Daniel Hanks The influence of dams on downstream biotic and abiotic components of aquatic ecosystems has been largely studied within the context of the River Continuum (RCC) and Serial Discontinuity Concepts (SDC). Few of these studies have sufficiently studied how these variables change along the longitudinal gradient below the impoundments in a systematic manner, comparing equal distances below both epilimnetic and hypolimnetic dams to a reference condition. This is especially true of early life stages of fish (i.e., larval and …

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The Effect Of Chemotherapy On Stromal Components Of The Bone Marrow, Ian Woodrow Hare Jan 2016

The Effect Of Chemotherapy On Stromal Components Of The Bone Marrow, Ian Woodrow Hare

Graduate Theses, Dissertations, and Problem Reports (ETD)

The cells comprising the stromal compartment of the bone marrow microenvironment are critical to the maintenance of several homeostatic processes of the body. For example, mesenchymal stem cells (MSCs) and osteoblasts are vital to the regulation of differentiation and quiescence of hematopoietic cells, maintaining the skeletal system, and regulating tumor microenvironments. In addition to contributing to these processes, MSCs display several properties that make them favorable for the use in transplantation therapies. The work described herein summarizes the means by which chemotherapy damages these cells, and potential consequences of such damage with regard to their function.;Previously, our laboratory has investigated …

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Spatial Redistribution Of Organic Phosphorus In Hay And Grass Pastures Of Eastern West Virginia Following Longterm Animal Manure Applications, Michael B. Harman Jan 2016

Spatial Redistribution Of Organic Phosphorus In Hay And Grass Pastures Of Eastern West Virginia Following Longterm Animal Manure Applications, Michael B. Harman

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study was conceived to investigate the fate of organic P (Po) in typical hay and grass pasture of eastern West Virginia. It is not uncommon in this region of West Virginia for hay and grass pastures to receive annual applications of animal manure, often on a nitrogen basis. As P management has evolved, many farms in the region have begun to use management tools such as a P index to continue use of animal manure as N fertilizer. However, many hay and grass pastures in the region already have a high degree of P saturation. There are reasonable expectations …

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The Relationship Between Plasma Osmolarity And Feed Efficiency In Beef Cattle And Effect Of Feeding Cows Medicated Feed Through Mineral Containing Altosidrtm Igr On The Growth Of Beef Calves, Taylor Diane Harrison Jan 2016

The Relationship Between Plasma Osmolarity And Feed Efficiency In Beef Cattle And Effect Of Feeding Cows Medicated Feed Through Mineral Containing Altosidrtm Igr On The Growth Of Beef Calves, Taylor Diane Harrison

Graduate Theses, Dissertations, and Problem Reports (ETD)

Dietary cation-anion modification in cattle has effects on productivity through various means. Alterations of dietary cation-anion balances has been shown to affect plasma osmolarity. Plasma osmolarity is directly related to renal function and metabolism in all animals. In a feeding operation with a single diet fed to a similar population of animals, plasma osmolarity should fall within a somewhat normal range (approximately 270-310 mOsm). However, subtle, yet very distinguishable differences will exist between animals. In theory, variances in osmolarity may reflect differences in metabolism and as such, efficiency of feed utilization. Many researchers believe that utilizing residual feed intake (RFI) …

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Molecular Characterization Of Lhx8, An Oocyte-Specific Transcription Factor, And Its Interacting Proteins In Rainbow Trout And Cattle, Liyuan Fu Jan 2016

Molecular Characterization Of Lhx8, An Oocyte-Specific Transcription Factor, And Its Interacting Proteins In Rainbow Trout And Cattle, Liyuan Fu

Graduate Theses, Dissertations, and Problem Reports (ETD)

LIM homeobox 8 (Lhx8) is an important transcription factor that is preferentially expressed in germ cells. Lhx8 null mice are infertile due to lack of oocytes and impairment of the transition from primordial follicles to primary follicles. Lhx8 deficiency also affects the expression of many important oocyte-specific genes. To date, no attempts have been made to investigate the existence of any cellular factors that might interact with Lhx8 protein in oocytes and early embryos. In this study, we report the characterization of rainbow trout and bovine Lhx8 genes and identification of important germ cell-specific nuclear factors that interact with Lhx8 …

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Feeding Soy Protein Isolate Andor Omega-3 Polyunsaturated Fatty Acids On The Spleen-Liver Axis In A Female Rat Model Of Autosomal Recessive Polycystic Kidney Disease With Liver Steatosis, Lauren Gibson Jan 2016

Feeding Soy Protein Isolate Andor Omega-3 Polyunsaturated Fatty Acids On The Spleen-Liver Axis In A Female Rat Model Of Autosomal Recessive Polycystic Kidney Disease With Liver Steatosis, Lauren Gibson

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT Feeding Soy Protein Isolate and/or Omega-3 Polyunsaturated Fatty Acids on the Spleen-Liver Axis in a Female Rat Model of Autosomal Recessive Polycystic Kidney Disease with Liver Steatosis Lauren Brooke Gibson Autosomal recessive polycystic kidney disease (ARPKD) is a congenital hepatorenal fibrocystic syndrome with a mortality rate of 30% during the first year of life. The most common extra-renal manifestation of ARPKD is liver disease with a greater rate in females due to their higher estrogen levels. Abnormal spleen enlargement (splenomegaly) has been found to occur in 60% of ARPKD patients. In the absence of effective medications to treat the …

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A Cbct Evaluation Of Root Position Within Bone, Long Axis Inclination, And The Wala Ridge, Timothy R. Glass Jan 2016

A Cbct Evaluation Of Root Position Within Bone, Long Axis Inclination, And The Wala Ridge, Timothy R. Glass

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background and Objectives: Correct tooth position in all planes of space while respecting the boundaries of the underlying bone has been proposed as a necessary hallmark to providing a foundation of stability for the teeth as well as the supporting periodontium. The aim of this study was to determine 1) If teeth centeredness over basal bone improves when teeth are more upright or approach WALA Ridge norms 2) If teeth centeredness in alveolar bone improves when teeth are more upright or approach WALA Ridge norms 3) If the WALA ridge is located at or near the estimated center of resistance …

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Spatial And Temporal Distribution Of The Brown Marmorated Stink Bug (Hemiptera: Pentatomidae), Jakob Goldner Jan 2016

Spatial And Temporal Distribution Of The Brown Marmorated Stink Bug (Hemiptera: Pentatomidae), Jakob Goldner

Graduate Theses, Dissertations, and Problem Reports (ETD)

An obstacle to efficient management of the brown marmorated stink bug, Halyomorpha halys (Hemiptera: Pentatomidae), is the lack of knowledge of its seasonal movements at the landscape level. H. halys is highly mobile and utilizes various commodities throughout the growing season and winter, making it difficult to manage. We hypothesized that H. halys displayed an annual spatial pattern at the farm scale and as they moved into overwintering habitats. To test for a spatial pattern at the farm scale, we conducted a two-year spatial study on three organic farms in West Virginia and New Jersey. A total of 92-127 sample …

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Development Of A Cobinamide-Based Optical Sensor For Hydrogen Cyanide And Hydrogen Sulfide, Lee Ann Greenawald Jan 2016

Development Of A Cobinamide-Based Optical Sensor For Hydrogen Cyanide And Hydrogen Sulfide, Lee Ann Greenawald

Graduate Theses, Dissertations, and Problem Reports (ETD)

In an occupational or military environment, a personal air-purifying respirator must be provided when breathing-air is contaminated by harmful dust, fumes, gases, aerosols, or vapors. Too often, a respirator user does not have enough information to know when to change his/her cartridge/canister and thus is potentially exposed to toxic gases. Currently, there is no definitive way to determine when respirators' carbon beds have begun to fail. When an end-of-service-life indicator (ESLI) is incorporated into the carbon bed, it informs one, in real-time, when imminent breakthrough is occurring and to replace the cartridge/canister. ESLIs are a more reliable and safer way …

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Beyond High And Lonesome: A Comparative Analysis Of Early Male And Contemporary Female Bluegrass Vocal Styles, Hillary C. Kay Jan 2016

Beyond High And Lonesome: A Comparative Analysis Of Early Male And Contemporary Female Bluegrass Vocal Styles, Hillary C. Kay

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis is a comparative analysis of the bluegrass vocal styles of early male performers of the 1940s and 50s and contemporary female performers actively performing between 2001 and 2016. Four songs were selected from the standard bluegrass repertoire, each one having been recorded by both an early male performer and a contemporary female performer. The three body chapters of the study draw comparisons between the male performers, between the female performers, and then between the two groups. The aims of this study are to better understand 1) How bluegrass singing, which is rooted in male vocal production, is performed …

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Imaging Ductal Carcinoma Using A Hyperspectral Imaging System, Yasser M. Khouj Jan 2016

Imaging Ductal Carcinoma Using A Hyperspectral Imaging System, Yasser M. Khouj

Graduate Theses, Dissertations, and Problem Reports (ETD)

Hyperspectral Imaging (HSI) is a non-invasive optical imaging modality that shows the potential to aid pathologists in breast cancer diagnoses cases. In this study, breast cancer tissues from different patients were imaged by a hyperspectral system to detect spectral differences between normal and breast cancer tissues, as well as early and late stages of breast cancer. If the spectral differences in these tissue types can be measured, automated systems can be developed to help the pathologist identify suspect biopsy samples, which will improve sample throughput and assist in making critical treatment decisions. Tissue samples from ten different patients were provided …

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An Integrated Lateral Flow Device For Flow Control And Blood Separation, Veronica Betancur Calle Jan 2016

An Integrated Lateral Flow Device For Flow Control And Blood Separation, Veronica Betancur Calle

Graduate Theses, Dissertations, and Problem Reports (ETD)

Lateral flow devices (LFD) have been used and are promising in many applications, including point-of-care diagnosis in medical, clinical, food and environmental control and monitoring. In particular, disposable paper-based lateral flow strips utilize low-cost materials and do not require expensive fabrication instruments. Many examples of diagnostic tests have been developed using microfluidics paper analytical devices (muPADs), including tests for the detection of total glucose and protein in urine (colorimetric), detection of beta-galactosidase (fluorescence), and liver enzyme tests for monitoring the health of patients been treated with multiple medications for HIV and/or tuberculosis that can cause hepatotoxicity. However, there are constraints …

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Paradoxical Roles Of Nanoparticles In Cancer Therapeutics And Carcinogenesis, Emily Despeaux Jan 2016

Paradoxical Roles Of Nanoparticles In Cancer Therapeutics And Carcinogenesis, Emily Despeaux

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nanoparticles (NPs) are becoming increasingly common in consumer goods and are under investigation for a variety of industrial and biomedical applications. However, challenges in determining NP toxicity may prevent them from reaching their full potential. NPs cannot be treated as single class for toxicity evaluations. Even among particles made from the same material, particle-specific physical properties, including size, shape, surface charge, agglomeration state, and surface modifications have a strong effect on the toxicity. Even so, the obstacles to conclusively and reproducibly evaluating toxicity span all NP classes. NP literature is riddled with confusing and often contradictory reports regarding the biocompatibility …

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Using Tree-Ring Data To Analyze The Effects Of Volcanic Eruptions On Climate In Inner Asia From 500 Bce To Present, Jennie Zhu Jan 2016

Using Tree-Ring Data To Analyze The Effects Of Volcanic Eruptions On Climate In Inner Asia From 500 Bce To Present, Jennie Zhu

Graduate Theses, Dissertations, and Problem Reports (ETD)

Volcanic eruptions have influenced regional and global climate on annual, interannual, decadal, and multi-decadal time scales. However, past studies have largely focused on the response of global temperature to modern eruptions with the aid of satellite records. This approach limits the number of eruptions that can be studied and restricts our knowledge to relatively small events when compared to the volcanic history of the late Holocene. I used modern climate records to evaluate the effect of recent eruptions on Mongolian climate. I then extended my analysis to the last 2500 years by examining existing and new tree-ring data from Mongolia …

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The Effect Of Physicochemical Properties On The Multiwalled Carbon Nanotube-Induced Genotoxicity And Carcinogenesis, Katelyn J. Siegrist Jan 2016

The Effect Of Physicochemical Properties On The Multiwalled Carbon Nanotube-Induced Genotoxicity And Carcinogenesis, Katelyn J. Siegrist

Graduate Theses, Dissertations, and Problem Reports (ETD)

Multiwalled carbon nanotubes (MWCNT) are one of the most exciting industrial materials of our time. They are used in life-saving medical therapeutics and many commercial products that could make day-to-day life seem effortless. However, previous toxicological research has demonstrated this material to be significantly genotoxic in both in vitro and in vivo models and potentially carcinogenic in the lung. The unique physiochemical properties of MWCNT make respiratory exposures likely in workers. Combining the genotoxic effects with the potential for lung deposition in the workplace, MWCNT should be considered as a potential health hazard. Altering the physiochemical properties of MWCNT has …

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Exercise As A Treatment For Conduit Artery Dysfunction In A Comorbid State Of Metabolic Syndrome And Depressive-Like Symptoms, Chris Skinner Jan 2016

Exercise As A Treatment For Conduit Artery Dysfunction In A Comorbid State Of Metabolic Syndrome And Depressive-Like Symptoms, Chris Skinner

Graduate Theses, Dissertations, and Problem Reports (ETD)

Metabolic Syndrome (Mets) is a clustering of cardiovascular risk factors that results in a three-fold increase in cardiovascular disease. MetS is known to be associated with adverse arterial remodeling, endothelial dysfunction, decreased nitric oxide (NO) bioavailability, increased inflammation, and conduit artery dysfunction. Depression/chronic stress is emerging as a potent contributor to MetS, with MetS also aiding in the progression of depression, and thus increased vascular dysfunction. These bi-directional comorbidities are continually increasing in prevalence, justifying a need for research on their interplay and potential treatments. Aerobic exercise is a widely accepted therapy for the risk factors associated with MetS, mental …

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Bone Marrow Microenvironment Regulation Of Bcl6 In Acute Lymphoblastic Leukemia, William Lee Slone Jan 2016

Bone Marrow Microenvironment Regulation Of Bcl6 In Acute Lymphoblastic Leukemia, William Lee Slone

Graduate Theses, Dissertations, and Problem Reports (ETD)

Acute lymphoblastic leukemia (ALL) is a hematological malignancy with approximately 6000 newly diagnosed cases every year. Although ALL is the most common malignancy in children, it can occur in patients of all ages. Great strides have been made in the treatment of ALL and remission rates are at all-time highs. However, relapse rates have remained relatively consistent, and relapse continues to be correlated with a poor prognosis in patients with ALL. As the site of origin and progression of ALL, the bone marrow microenvironment (BMM) is important in regulating tumor cell quiescence and proliferation. Of clinical relevance is the frequency …

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Geotechnical Testing And Finite Element Modeling Of Geomorphic Landform Design With A Multi-Layer Cap And Cover System, Jeffrey R. Stevens Jan 2016

Geotechnical Testing And Finite Element Modeling Of Geomorphic Landform Design With A Multi-Layer Cap And Cover System, Jeffrey R. Stevens

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research was aimed at implementation of Geomorphic Landform Design (GLD) principles to the Royal Scot abandoned coal refuse disposal facility in Greenbrier County, West Virginia, USA. This facility currently exhibits many undesirable environmental problems including acid-mine drainage and significant erosion and sediment transport.;A multi-layer cap and cover system in conjunction with GLD principles was proposed as a solution to these environmental problems. This cover is proposed to be constructed from the coarse coal refuse material on-site and a short paper fiber material (MGro(TM)) from the MeadWestVaco paper mill in nearby Covington, Virginia, USA. To determine the possible effectiveness of …

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Fabrication Of Nanoelectrode Arrays For Dopamine Detection, Savan Suri Jan 2016

Fabrication Of Nanoelectrode Arrays For Dopamine Detection, Savan Suri

Graduate Theses, Dissertations, and Problem Reports (ETD)

Recent advancements in the semiconductor fabrication technologies have greatly helped in advancing the understanding of electrochemistry at nano scale (10-9 m). Electrodes are being produced at micro (10-6 m) and nano scale with varied materials, designs and for diverse applications. Better electrochemical sensing and detecting capabilities are achieved with nanoelectrodes in comparison with regular macroelectrodes. Lot of theoretical studies of electrochemistry at these nanoelectrodes have been proposed and developed. Despite the theoretical advancements, little has been done in experimental studies of nanoelectrodes. The progress is majorly impeded by lack of reliable fabrication procedures to produce such nanoelectrodes and test them …

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