Digital Commons Network^™

Pt-Mal-Lhrh Mediates Breast Cancer Cell Cytotoxicity Through Increased Apoptosis, Kendall E. Collins

Posters-at-the-Capitol

In the United States one in eight women will be afflicted with breast cancer. It is estimated that in 2016 there will be approximately 246,600 new invasive breast cancer cases and 61,000 new non-invasive cases. Triple negative breast cancers account for 15% of all breast cancers and are significantly more aggressive than other subtypes. Treatment options for triple negative breast cancer are limited due to the cancers not expressing the estrogen, progestogen, or herceptin receptors making them unresponsive to hormonal therapy. Our recent work centers around developing a novel chemotherapeutic agent that will direct therapy selectively to triple negative (4T1) …

Using Fundamental Chemistry To Make Functional Materials For Solar Energy Conversion Applications, Kylie N. Heupel, Haley M. Sizemore, Judith L. Jenkins

Posters-at-the-Capitol

Population growth and rapidly increasing energy consumption necessitate innovative materials for energy conversion and storage. Gains in solar electricity and battery technologies are evidenced by the availability of commercial products. However viable solar fuel platforms—where the energy in sunlight is used to form storable fuels such as hydrogen gas—have not yet been realized, motivating the work presented here. In order to produce hydrogen gas from sunlight and water, a photocatalyst is required. The ideal photocatalyst for hydrogen gas generation absorbs solar photons (sunlight), producing high-energy electrons necessary for the reduction of hydrogen ions in water. The host nanocrystal studied here, …

Development Of A Risk Assessment Framework To Predict Invasive Species Establishment For Multiple Taxonomic Groups And Vectors Of Introduction, Alisha D. Davidson, Abigail J. Fusaro, Rochelle A. Sturtevant, Edward S. Rutherford, Donna R. Kashian

Biological Sciences Faculty Research Publications

A thorough assessment of aquatic nonindigenous species’ risk facilitates successful monitoring and prevention activities. However, species- and vector-specific information is often limited and difficult to synthesize across a single risk framework. To address this need, we developed an assessment framework capable of estimating the potential for introduction, establishment, and impact by aquatic nonindigenous species from diverse spatial origins and taxonomic classification, in novel environments. Our model builds on previous approaches, while taking on a new perspective for evaluation across species, vectors and stages to overcome the limitations imposed by single species and single vector assessments. We applied this globally-relevant framework …

Consultative Minutes 11/08/2016, Consultative Committee

Consultative Committee

No abstract provided.

What Can Social Networks Tell Us About Learning Ecologies?, Caroline A. Haythornthwaite

School of Information Studies - Faculty Scholarship

The ecology metaphor is drawn from the biological sciences and refers to the “scientific study of the distribution, abundance and dynamics of organisms, their interactions with other organisms and with their physical environment” (British Ecological Society, 2016). In recent decades, the metaphor has become useful for tackling the complexity of new information and learning environments, particularly as driven by the increasing quantity of information, the growing number of available media and means of communicating, the extended reach of information technologies, and the new practices arising from these configurations. This paper brings to the discussion of learning ecologies the research and …

Glucose-6-Phosphate Dehydrogenase Deficiency And Physical And Mental Health Until Adolescence, Man Ki Kwok, Gabriel M. Leung, C. Mary Schooling

Publications and Research

Background: To examine the association of glucose-6-phosphate dehydrogenase (G6PD) deficiency with adolescent physical and mental health, as effects of G6PD deficiency on health are rarely reported.

Methods: In a population-representative Chinese birth cohort: ªChildren of 1997º (n = 8,327), we estimated the adjusted associations of G6PD deficiency with growth using generalized estimating equations, with pubertal onset using interval censored regression, with hospitalization using Cox proportional hazards regression and with size, blood pressure, pubertal maturation and mental health using linear regression with multiple imputation and inverse probability weighting.

Results: Among 5,520 screened adolescents (66% follow-up), 4.8% boys and 0.5% girls had …

Selection Of Reference Genes For Rt-Qpcr Analysis In Coccinella Septempunctata< To Assess Un-Intended Effects Of Rnai Transgenic Plants, Chunxiao Yang, Evan L. Preisser, Hongjun Zhang, Yong Liu, Liangying Dai, Huipeng Pan, Xuguo Zhou

Biological Sciences Faculty Publications

The development of genetically engineered plants that employ RNA interference (RNAi) to suppress invertebrate pests opens up new avenues for insect control. While this biotechnology shows tremendous promise, the potential for both non-target and off-target impacts, which likely manifest via altered mRNA expression in the exposed organisms, remains a major concern. One powerful tool for the analysis of these un-intended effects is reverse transcriptase-quantitative polymerase chain reaction, a technique for quantifying gene expression using a suite of reference genes for normalization. The seven-spotted ladybeetle Coccinella septempunctata, a commonly used predator in both classical and augmentative biological controls, is a …

Detritus Quality And Locality Determines Survival And Mass, But Not Export, Of Wood Frogs At Metamorphosis, Joseph Milanovich, Kyle Barrett, John A. Crawford

Biology: Faculty Publications and Other Works

Single-site experiments have demonstrated detritus quality in wetlands can have strongly negative, neutral, and even positive influences on wildlife. However, an examination of the influence of detritus quality across several regions is lacking and can provide information on whether impacts from variation in detritus quality are consistent across species with wide ranges. To address this gap in regional studies we examined effects of emergent and allochthonous detritus of different nutrient qualities on amphibians and assessed a mechanism that may contribute to potential impacts. We used aquatic mesocosms to raise wood frogs (Rana sylvatica) from two regions of the …

Investigating Error-Related Processing In Incarcerated Adolescents With Elevated Psychopathic Traits, James M. Maurer

Psychology ETDs

Adult psychopathic offenders show an increased propensity towards violence, impulsivity, and recidivism. For a subsample of youth with elevated psychopathic traits, the disorder appears to remain stable throughout development. Such youth represent a particularly severe subgroup characterized by their extreme behavioral problems and comparable neurocognitive deficits as their adult counterparts, including perseveration deficits. Here, we investigated error-related processing using two distinct neuroimaging methodologies in response-locked event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI) in two samples of incarcerated juvenile male offenders who performed a response inhibition Go/NoGo task. Adolescent psychopathic traits were assessed using the Hare Psychopathy Checklist: Youth …

The Parthenon, November 8, 2016, Lexi Browning

The Parthenon

The Parthenon, Marshall University’s student newspaper, was published by students Monday through Friday during the regular semester and weekly on Thursdays during the summer. Due to budgetary constraints, beginning with the 2016 Fall semester, the newspaper is only published two days a week. Physical issues are printed on Tuesdays and Fridays. The editorial staff is responsible for the news and the editorial content.

The Current Volume 27 : Issue 12, Nova Southeastern University

Student Newspapers

No abstract provided.

Daily Eastern News: November 08, 2016, Eastern Illinois University

November

No abstract provided.

Method And System For Producing Triterpenes, Joe Chappell, Thomas D. Niehaus, Shigeru Okada, Timothy P. Devarenne, David Watt

Pharmaceutical Sciences Faculty Patents

A method and system are provided for the production of triterpene including methylated triterpenes. The method and system include isolated nucleic acid sequences encoding triterpene methyltransferases such as triterpene methyltransferases 1, 2, 3. Advantageously, the method and system includes transgenic plant cells via an expression vector for triterpene methyltransferase and optionally various triterpene synthase and prenyltransferase all with tags directing these enzymes to the chloroplast of the transgenic plant cells for using the chloroplast methyl erythritol phosphate (MEP) pathway in the triterpene biogenesis.

Intraocular Pressure Sensing And Control For Glaucoma Research, Simon Antonio Bello

USF Tampa Graduate Theses and Dissertations

Animal models of ocular hypertension are important for glaucoma research but come with experimental costs. Available methods of intraocular pressure (IOP) elevation are not always successful, the amplitude and time course of IOP changes are unpredictable and irreversible, and IOP measurement by tonometry is laborious. This dissertation focuses on the development and implementation of two novel systems for monitoring and controlling IOP without these limitations. The first device consists of a cannula implanted in the anterior chamber of the eye, a pressure sensor that continually measures IOP, and a bidirectional pump driven by control circuitry that can infuse or withdraw …

Hormone Replacement Therapy (Hrt) Modulates Peripheral And Central Auditory System Processing With Aging, Tanika Williamson

USF Tampa Graduate Theses and Dissertations

After the findings were reported for the Women’s Health Initiative (WHI) study in the past decade, there has been a significant decline in the overall use of hormone replacement therapy (HRT) among women. However, there are still millions of middle-aged, menopausal women in the U.S. who are currently undergoing hormone therapy. Their reasons for continuing treatment include relief of severe menopausal symptoms, aid in the management of osteoporosis and reduction in the risk of colon cancer (Ness et al., 2005). The purpose of the following investigation was to evaluate the impact of HRT on the central and peripheral auditory systems …

Resource Discovery Services: An Overreaching Overview, Athena Hoeppner

Faculty Scholarship and Creative Works

No abstract provided.

Sb 331 - Parent And Child Relationship Generally, Corbin Aiken, Karen Lowell

Georgia State University Law Review

The Act amends provisions of Georgia’s domestic relations statutes to allow a court to deny a biological father’s legitimation petition or to terminate his parental rights when there is clear and convincing evidence that the child was conceived as a result of rape. If the court denies the biological father’s legitimation petition, the child is still capable of inheriting from the father, but the father is not capable of benefiting from the child.

Hb 801 - Postsecondary Education: Hope Scholarship, S. Umarah Ali, Sakinah N. Jones

Georgia State University Law Review

The Act amends provisions of the HOPE scholarship by allowing students who choose to take more rigorous courses to have a weighted grade point average for the evaluation of their HOPE scholarship disbursement.

Passive Electric Field Focus System For In Vivo And In Vitro Applications, Jose I. Rey, Richard Gilbert, Mark J. Jaroszeski, Richard Heller

USF Patents

The present invention provides a system and method of directing, focusing, or concentrating electrical charges within a defined electric field so that these charges can be used to exert forces on cells and tissues in vivo and/or cell cultures in vitro. The present invention reduces and/or eliminates the damage at a target site that would normally be caused by an electrode that acts as a current source or sink to accomplish the same task.

Compositions Including Triciribine And One Or More Platinum Compounds And Methods Of Use Thereof, Jin Q. Cheng, Said M. Sebti

USF Patents

This application encompasses combination therapies including triciribine and related compounds and one or more platinum compounds and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.

The Sun Star Vol 70 No 11 (November 8th, 2016), N/A N/A

Sun Star

No abstract provided.

Cucurbitacin D Exhibits Potent Anticancer Activity In Cervical Cancer, Mohammed Sikander, Bilal B. Hafeez, Shabnam Malik, Abdulrhman Alsayari, Fathi T. Halaweish, Murali M. Yallapu, Subhash C. Chauhan, Meena Jaggi

School of Medicine Publications

In this study, we for the first time, investigated the potential anti-cancer effects of a novel analogue of cucurbitacin (Cucurbitacin D) against cervical cancer in vitro and in vivo. Cucurbitacin D inhibited viability and growth of cervical cancer cells (CaSki and SiHa) in a dose-dependent manner. IC50 of Cucurbitacin D was recorded at 400 nM and 250 nM in CaSki and SiHa cells, respectively. Induction of apoptosis was observed in Cucurbitacin D treated cervical cancer cells as measured by enhanced Annexin V staining and cleavage in PARP protein. Cucurbitacin D treatment of cervical cancer cells arrested the cell cycle in …

Selection Of Reference Genes For Rt-Qpcr Analysis In Coccinella Septempunctata To Assess Un-Intended Effects Of Rnai Transgenic Plants, Chunxiao Yang, Evan L. Preisser, Hongjun Zhang, Yong Liu, Liangying Dai, Huipeng Pan, Xuguo Zhou

Entomology Faculty Publications

The development of genetically engineered plants that employ RNA interference (RNAi) to suppress invertebrate pests opens up new avenues for insect control. While this biotechnology shows tremendous promise, the potential for both non-target and off-target impacts, which likely manifest via altered mRNA expression in the exposed organisms, remains a major concern. One powerful tool for the analysis of these un-intended effects is reverse transcriptase-quantitative polymerase chain reaction, a technique for quantifying gene expression using a suite of reference genes for normalization. The seven-spotted ladybeetle Coccinella septempunctata, a commonly used predator in both classical and augmentative biological controls, is a …

The George-Anne, Georgia Southern University

The George-Anne

• Opinions
• News
• Features
• Sports
• Puzzles

Executive Committee - Agenda, 11/8/2016, Academic Senate

Academic Senate Agendas

For meeting minutes, see http://digitalcommons.calpoly.edu/senateminutes/1251/

Critical Role Of The Secondary Binding Pocket In Modulating The Enzymatic Activity Of Dusp5 Toward Phosphorylated Erks, Marat R. Talipov, Jaladhi Nayak, Michael Lepley, Robert D. Bongard, Daniel Sem, Ramani Ramchandran, Rajendra Rathore

Chemistry Faculty Research and Publications

DUSP5 is an inducible nuclear dual-specificity phosphatase that specifically interacts with and deactivates extracellular signal-regulated kinases ERK1 and ERK2, which are responsible for cell proliferation, differentiation, and survival. The phosphatase domain (PD) of DUSP5 has unique structural features absent from other nuclear DUSPs, such as the presence of a secondary anion-binding site in the proximity of the reaction center and a glutamic acid E264 positioned next to the catalytic cysteine C263, as well as a remote intramolecular disulfide linkage. The overall 400 ns molecular dynamics simulations indicate that the secondary binding site of DUSP5 PD acts as an allosteric regulator …

The World Of Finance In Russia, Matthew Thomas

Honors Theses

Russia is currently in an economic crisis the likes of which the Russian people are unfortunately familiar with in their turbulent past. Economic sanctions, paired with a global downturn in oil prices, have stalled any progress that had been occurring after the 2008 global economic meltdown. The Central Bank of Russia, which was founded after the fall of the USSR in the early 1990s, was quick to respond to the sanctions and domestic economic issues by laying out an Anti-Crisis plan along with the aid of the rest of the government. They raised interest rates to over 20%, passed legislation …

Effects Of Antibiotic Mixtures Across Marine Intertidal Trophic Levels: Examining Environmentally-Relevant Contaminant Concentrations, Jaclyn Rebecca Teixeira

Dissertations and Theses

Approximately 48% of Americans use prescription drugs within each 30-day period, and there are signs this trend is increasing. Although many studies track pharmaceuticals’ fates in contaminating waterways, only fairly recent efforts have examined the potential impacts of these drugs on non-target organisms. The antibiotics sulfamethoxazole and trimethoprim, often prescribed together to treat bacterial infections, have been detected worldwide in marine and estuarine environments at concentrations up to 700-800 ng/L each. Toxic effects of these drugs have been identified in freshwater organisms, with synergistic effects observed in short-term studies of mixtures of the two; however, little research has examined possible …

Ucc Minutes, November 8, 2016, University Curriculum Council

UCC Agendas/Minutes

No abstract provided.

Soldier 2.0: Military Human Enhancement And International Law, Heather A. Harrison Dinniss, Jann K. Kleffner

International Law Studies

Advances in technologies that could endow humans with physical or mental abilities that go beyond the statistically normal level of functioning are occurring at an incredible pace. The use of these human enhancement technologies by the military, for instance in the spheres of biotechnology, cybernetics and prosthetics, raise a number of questions under the international legal frameworks governing military technology, namely the law of armed conflict and human rights law. The article examines these frameworks with a focus on weapons law, the law pertaining to the detention of and by “enhanced individuals,” the human rights of those individuals and their …