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Integrin Α6Β4 Promotes Pancreatic Cancer Invasion By Altering Dna Repair-Mediated Epigenetics, Brittany L. Carpenter

Theses and Dissertations--Molecular and Cellular Biochemistry

Integrin α6β4 is upregulated in pancreatic carcinoma, where signaling promotes metastatic properties, in part by altering the transcriptome. Such alterations can be accomplished through DNA demethylation of specific promoters, as seen with the pro-metastatic gene S100A4. I found that signaling from integrin α6β4 dramatically upregulates expression of amphiregulin (AREG) and epiregulin (EREG), ligands for the epidermal growth factor receptor (EGFR), and that these ligands promote pancreatic carcinoma invasion. To determine if AREG and EREG are regulated by DNA methylation, pancreatic cancer cells with low AREG and EREG expression were treated with the DNA methyltransferase inhibitor 5-aza-2’-deoxycytidine (5-Aza-CdR), resulting in stable …

Elucidating Binding, Fusion And Entry Of Human Metapneumovirus, Edita M. Klimyte

Theses and Dissertations--Molecular and Cellular Biochemistry

Human metapneumovirus (HMPV) is a respiratory pathogen in the Paramyxoviridae family that infects nearly 100% of the world population. This enveloped RNA virus causes severe viral respiratory disease in infants, the elderly, and immunocompromised patients worldwide. Despite its prevalence and importance to human health, no therapies are available against this pathogen. Entry of paramyxoviruses into host cells generally requires the coordinated activity of the attachment glycoprotein, G, which interacts with a cell receptor, and the fusion glycoprotein, F, which promotes subsequent fusion of viral and cellular membranes. However, HMPV F is the primary viral protein mediating both binding and fusion …

Calcineurin: From Activation To Inhibition, Erik C. Cook

Theses and Dissertations--Molecular and Cellular Biochemistry

Calcineurin is a Ser/Thr phosphatase whose function is implicated in critical physiological processes such as immune system activation, fetal heart development, and long-term depression in neurons. Calcineurin has been implicated in the progression of Alzheimer’s disease and cardiac hypertrophy. It is not well understood how calcineurin is activated on a molecular level by Ca²⁺ and its activating protein calmodulin. Previous data from our lab show that calmodulin interaction induces the folding of the intrinsically disordered regulatory domain of calcineurin in two discrete and distant regions into α-helical conformations and that this folding is critical for complete activation of calcineurin. …

Late Events Of Human Metapneumovirus Infection: Insights Into Viral Spread Within The Respiratory Epithelium, Farah El Najjar

Theses and Dissertations--Molecular and Cellular Biochemistry

Human metapneumovirus (HMPV) is a leading cause of respiratory tract infections worldwide across all age groups, and is particularly devastating in the pediatric, elderly and immunocompromised populations. Despite its high prevalence and burden on human health, there are currently no treatments or vaccines against HMPV infections. HMPV is an enveloped virus that belongs to the paramyxovirus family. Paramyxoviruses in general form by assembly of virus components at the plasma membrane followed by budding and release of virus particles into the extracellular matrix to spread infection. The process of forming new virus particles requires complex interactions between viral and cellular components …

Grandparent Support And Juvenile Delinquent Youth, Anita Marie Taboh

Walden Dissertations and Doctoral Studies

Juvenile delinquency is a social issue which has been shown to have a significant cost to society in a variety of ways which include community safety, the cost of arrest, charges, and court processes, as well as the damage done in families and to the youth through the label of juvenile delinquent or Person in Need of Supervision (PINs). One important area in treatment and discharge planning for youth designated as either juvenile delinquent or Persons in Need of Supervision is the inclusion of supports to help youth change the trajectory from these behaviors into more socially acceptable activities and …

Small Learning Communities And High School Academic Success, Jeremy Eugene Warren

Walden Dissertations and Doctoral Studies

Thousands of students drop out of high school every day in the United States and the repercussions affect more than just the individual. Research on smaller learning communities (SLC) reveals increased student achievement, as well as improved teacher perception of student engagement. Student attendance, grade point average, and standardized test scores have been seen to improve within the SLC. In addition, graduation rates for students enrolled in a SLC have revealed increases, but this research focuses on the SLC as an intervention for any student. The current research targets at-risk students in an educational climate of sparse resources, and an …

African American Women Stem Majors' Lived Experiences In Community College, Loretta D. Westry

Walden Dissertations and Doctoral Studies

The United States economy has an accelerating demand for science, technology, engineering, and mathematics (STEM)-related degrees and programs that makes it essential for members of minority populations to achieve degrees in these fields. African American women are underrepresented in STEM fields, suggesting a need to better understand their development and needs while attending community college. This hermeneutical, phenomenological research study investigated the lived experiences and perspectives of African American women enrolled in STEM majors at community colleges. The conceptual framework used to interpret data for this study was derived from Maslow, Erikson, and Rogers's humanist theories of social learning, and …

Prescribing Hiv Prep And The Need For Education Among Care Providers, Martin Kokou Logo

Walden Dissertations and Doctoral Studies

Preexposure prophylaxis (PrEP) is an innovative biomedical approach that has been used over the past 6 years to avert the spread of human immunodeficiency virus (HIV). Under-prescribing of PrEP could increase the probability of HIV exposure among serodiscordant couples/partners and those who do not practice safe sex. Previous PrEP research has not assessed the association between awareness of PrEP, years of experience of providers, provider types, and the frequency of PrEP prescription among physicians. Precaution adoption model framed this study, which aimed to evaluate the bond between the independent variables relating to awareness of PrEP, years of experience, and provider …

High Wire, No Net: Emergence From Generational Poverty Without Higher Education, Corey Alan Caugherty

Walden Dissertations and Doctoral Studies

Existing literature indicates that education is vital to overcoming poverty, yet educational prospects for those in persistent, generational poverty (GP) are often limited. This qualitative phenomenological study centered on the emergence from GP of individuals without formal education beyond 12th grade or a high school equivalency certificate, and explored how those who have done it perceived their experiences. Rutter's resilience theory was the conceptual framework for examining this phenomenon and its challenges and processes. A sample of five adult participants from the United States were recruited using a snowball method, completed a screening survey, and then participated in in-depth interviews. …

Differences In Treatment-Seeking And Treatment-Adherence Factors For Tuberculosis In Armenian Versus Non-Armenian Populations Of Los Angeles County, Tanya Marie Ferguson

Walden Dissertations and Doctoral Studies

Tuberculosis (TB) is a deadly, yet curable, infectious disease that continues to be a global health threat. Armenia suffers from rising TB incidence and mortality rates. Armenians living in Los Angeles (LA) County, where TB incidence is higher than national averages, is the second largest Armenian community in the world; therefore implications are that many TB cases are attributed to this group. Using the social ecological model as a theoretical framework, this concurrent, mixed-methods study compared Armenians to non-Armenians in LA County about their knowledge of TB and perceived barriers to seeking and adhering to treatment. Bivariate chi-square analysis from …

Perceived Impact Of Prevention And Relationship Enhancement Program (Prep) On Marital Satisfaction, Angel Shantella Pierce

Walden Dissertations and Doctoral Studies

Married couples often face serious issues that require them to make difficult decisions in their relationships. Many couples turn to marital counseling as a means to improve the marriage. The purpose of this phenomenological study was to understand and describe the experiences of heterosexual married individuals who participated in the Prevention and Relationship Enhancement Program (PREP) and how they felt their participation had influenced their perceived satisfaction in their marriages. The theoretical framework that guided this study was social exchange theory, which is a basis for thinking about the influence individuals have on each other in personal relationships. The research …

How Social Presence On Twitter Impacts Student Engagement And Learning In A Grade 8 Mathematics Classroom, Shelly Vohra

Walden Dissertations and Doctoral Studies

Social media for personal use has evolved rapidly among adolescents, changing the way they communicate with each other. However, little research has been conducted about how teachers use social media in the classroom to improve student learning. The purpose of this qualitative study was to describe how social presence on Twitter impacts student engagement and learning when a mathematics teacher integrates this social media tool into an instructional unit. The conceptual framework was based on social presence theory developed by Short, Williams, and Christie. This qualitative study used a single case study design. Participants included 6 students and 1 classroom …

The Aftermath Of Violence: The Lived Experience Phenomena Of Assault In Nursing, Kathleen Clark

Walden Dissertations and Doctoral Studies

Despite the high incidence of violence directed at registered nurses while on duty, there is limited qualitative data that explores the lived experience of returning to the workplace after an assaultive incident. This phenomenological study sought to explore and analyze the phenomena of registered nurses who are employed in high-risk settings. The research questions considered the detailed descriptions of the experiences of nurses returning to the workplace. The conceptual framework was resiliency, as these participants continued to survive and thrive after the adverse assaultive events. Data were collected using in-depth interviews from purposeful sampling. Registered nurses working in the high …

Exploring Transition Factors Among Female Veterans Of Operation Enduring Freedom/Operation Iraqi Freedom (Oif/Oef), Myra Robinson

Walden Dissertations and Doctoral Studies

Many transitional challenges have affected female veterans after returning from serving in the war in Iraq and Afghanistan. The number of females joining the military and becoming involved in combat has increased within the past 10 years. Research exists on the transitional challenges of male veterans. However, little research exists on the reintegration challenges faced by female veterans. As these females become veterans, they are more visible in the Veterans Affairs Health Care System. Given this increase in number of female veterans, it is important to address transitional challenges experienced by females who served in Operations Enduring Freedom and Operation …

Factors Impacting Older Adults' Adoption Of Mobile Technology In Emergency Communications, William A. Scerra

Walden Dissertations and Doctoral Studies

An increasing number of older adults must continue working, which requires that they maintain their competencies and work skills, including use of mobile technology (MT). However, little is known about older adult adoption of MT in relation to work. This study used Rogers's diffusion of innovation theory and Davis's technology acceptance model as a framework. The purpose of this exploratory sequential mixed methods study was to examine the experiences of older adults' who adopted MT in the emergency communications (EC) field. Participants came from an emergency services LinkedIn group. Data sources included surveys completed by 85 respondents and interviews of …

Decoding Metacommunication Patterns From African American Single Mothers To Sons, Michael-Kamau Henderson

Walden Dissertations and Doctoral Studies

With a significant number of African American single-parent families responsible for raising a generation of male children, the focus of this qualitative case study was on exploring the African American single mother-son dyad to identify metacommunicative signals delivered from mothers to sons. This study was grounded in a theoretical framework combining attachment theory and social learning theory. The research questions focused on identifying metacommunication messages passed from mothers to sons and how metacommunication patterns influence the youth's social identity. Four single mothers with adolescent sons and 4 unrelated adult sons of single mothers participated in semistructured interviews. Data were collected …

Biological Markers For Pulpal Inflammation: A Systematic Review., Dan-Krister Rechenberg, Johnah C. Galicia, Ove A. Peters

All Dugoni School of Dentistry Faculty Articles

BACKGROUND AND OBJECTIVE: Pulpitis is mainly caused by an opportunistic infection of the pulp space with commensal oral microorganisms. Depending on the state of inflammation, different treatment regimes are currently advocated. Predictable vital pulp therapy depends on accurate determination of the pulpal status that will allow repair to occur. The role of several players of the host response in pulpitis is well documented: cytokines, proteases, inflammatory mediators, growth factors, antimicrobial peptides and others contribute to pulpal defense mechanisms; these factors may serve as biomarkers that indicate the status of the pulp. Therefore, the aim of this systematic review was to …

Poverty, Food Insecurity, And Obesity Among Urban And Rural Populations, Tameka Ivory Walls

Walden Dissertations and Doctoral Studies

Over 17 million food-insecure households are associated with increasing obesity rates across the United States. Although food insecurity and obesity are distinct social concerns, the two are linked and may be influenced by poverty and geographic location. Public health authorities and state leaders responsible for the health and nutrition of rural populations in particular would benefit from this information. The purpose of this quantitative cross-sectional study was to examine whether poverty mediated the relationship between food insecurity and obesity among urban and rural adults. The study was guided by the poverty, food insecurity, and obesity conceptual framework. The study addressed …

Socioeconomic Status As A Predictor Of Chronic Obstructive Pulmonary Disease, Hilaire Saint-Pierre

Walden Dissertations and Doctoral Studies

While epidemiological research has generated new knowledge about the treatment and prevention of chronic obstructive pulmonary disease (COPD) through smoking secession, the socioeconomic status (SES) of people with the disease has been under investigated. Thus, the purpose of this study was to determine the predictability of association between SES and COPD. This study was based on the ecological theory, which states that health and disease may have multiple underlying factors. This study was a secondary analysis of archived data from the Inter-University Consortium for Political and Social Research (ICPSR). The dataset was collected for the National Survey of Midlife Development …

Digitally Immigrant Social Work Faculty: Technology Self-Efficacy And Practice Outcomes, Ellen M. Belluomini

Walden Dissertations and Doctoral Studies

The problem addressed in this study was the lack of a model for technology integration in social work education to meet the needs of graduate social workers in the field. Extant research has focused on the efficacy of online or blended learning, but not on social work educators' technology literacy. The purpose of this study was to explore social work educators' self efficacy related to technology use in curriculum and pedagogy. Digitally immigrant educators, defined as those over the age of 35, were studied since this group struggles in adjustment to technology, commonly used by younger students. The conceptual framework …

The Association Of Smoking With Low Back Pain In Adult Americans: Analysis Of The 2012 National Health Interview Survey, Bart Green

Walden Dissertations and Doctoral Studies

Back pain is a chronic disease epidemic and the most common chronic painful condition in Americans. It is associated with human suffering and enormous financial and social burdens. Smoking is a prevalent and harmful health behavior and is the greatest modifiable risk factor for many chronic diseases. Cigarette smoking is associated with back pain, but there is little research on this relationship among adults in the United States. Using biopsychosocial theory, this study examined (a) the prevalence of back pain (dependent variable) among smokers, former smokers, and never smokers (independent variable), and (b) the influence of age, sex, race, body …

Academic Success For The 21st Century Learner: Intrapersonal Intelligence And Resilience, Juanita Lynn Parker

Walden Dissertations and Doctoral Studies

Internal and personal strengths are associated with positive academic outcomes in the higher educational setting and are particularly relevant to the 21st century learner in the modern complex and global society. There is limited research addressing the connection between intrapersonal intelligence, resilience, and academic success. This information is important to better assist students in developing qualities that foster academic success and sustainability. The purpose of this study was to investigate the correlations between intrapersonal intelligence, as measured by the Multiple Intelligences Development Assessment Scales (MIDAS); resilience, as measured by the Connor-Davidson Resilience Scale (CD-RISC); and academic success, as measured by …

Diagnosing Fibromyalgia: Using A Diagnostic Screening Tool In Primary Care, Lilo Fink

Walden Dissertations and Doctoral Studies

Fibromyalgia (FMS) goes undiagnosed in as many as 3 out of 4 people who have the disease. Primary care providers (PCPs) are the first to evaluate patients; therefore, PCPs need to be able to recognize FMS, implement initial treatment, and refer for further consultation. The Fibromyalgia Diagnostic Screening Tool (FDST), a validated instrument to identify FMS, can improve the speed and accuracy of FMS diagnosis. The purpose of this project was to familiarize PCPS with the FDST, evaluate their receptiveness to the tool, and train them in its use. The Leventhal, Diefenbach, and Levanthal, common sense model of illness provided …

Socioeconomic Responsibility And Its Effect On Hypertension Among West African Immigrants In The United States, Chryss Arekhandia Okonofua

Walden Dissertations and Doctoral Studies

Native-born African Americans (NBAA) bear a disproportionate burden of the effect of hypertension (HTN) in comparison to other racial groups in the United States. West African immigrants (Foreign-born African Americans) appear to carry a heavier burden than the NBAA in the United States. Using the social support theory as a guide, this study examined the association between the need to meet socioeconomic responsibility of financial and familial obligations (SERFFO) and perceived stress and the increased likelihood of HTN among West African immigrants, aged 25-54 years, in the United States. In this quantitative, cross-sectional design, self-reported data were collected from a …

African American Clergy's Attitude Toward Professional Mental Health Services, Ebony Gaffney

Walden Dissertations and Doctoral Studies

Evaluating the attitude of African American clergy toward parishioners seeking professional mental health services for mental illness has important treatment implications. Religion and spirituality are equally important determinants of mental health and can affect African American clergy's attitudes toward professional care for mental illness. Utilizing the health belief model (HBM), this quantitative study examined the role of theological beliefs, education, and personal experience with mental illness as they correlated with clergy's attitudes toward seeking professional mental illness services. Approximately 98 African American Protestant Clergy in the states of Georgia and South Carolina participated in this study. Data were collected using …

Preschool Educators' Roles In Creating Supportive Spaces For Gender Exploration And Expression, Shaun-Adrian Choflã¡

Walden Dissertations and Doctoral Studies

Children begin to develop their understanding of gender in preschool, yet there is a dearth of research focused on understanding how preschool teachers affect the gender identity development of young children. Guided by Rokeach's belief systems theory, this qualitative case study explored the pedagogical strategies and perceptions of 4 Sacramento County, California preschool educators related to the gender identity development of young children. Interview data were collected and coded to derive 12 participant-specific themes and 3 common intersecting themes, which showed that teachers' perspectives on gender identity development were influenced by social rules, biases, and a lack of pedagogical knowledge …

Using International Property Law As A Lever To Evolve Toward Integrative Ocean Governance, Rachael E. Salcido

McGeorge School of Law Scholarly Articles

TABLE OF CONTENTS I. INTRODUCTION .............................................................................................. 254 II. BACKGROUND ............................................................................................... 255 A. Brief Primer on Ocean Jurisdiction ...................................................... 256 B. Dispute Resolution and International Governance ............................... 257 C. The Power of Property .......................................................................... 259 D. Ocean Governance Support for an International Property Law Thesis ..................................................................................................... 260 III. STATE OF OCEAN HEALTH ........................................................................... 261 A. Overfishing ............................................................................................ 262 B. Climate Change ..................................................................................... 263 C. Pollution ................................................................................................ 264 1. Traditional Pollution ...................................................................... 264 2. Special Growing Plastic Pollution Problem ................................... 265 D. Industrialization .................................................................................... 265 1. Marine Renewable Energy .............................................................. 266 2. Aquaculture ..................................................................................... 268 3. Offshore Oil and Gas ...................................................................... 268 …

Ditching Our Innocence: The Clean Water Act In The Age Of The Anthropocene, Rachael Salcido, Karrigan Bork

McGeorge School of Law Scholarly Articles

Humanity has entered the Age of the Anthropocene, a geologic era marked by the emergence of human activity as the single most dominant influence on Earth’s environment. Every ecosystem shows

signs of anthropogenic influence, and the environments we experience everyday are often shaped almost entirely by human actions and decisions. The new discipline of reconciliation ecology recognizes this

reality and suggests that we must manage the new habitats we create in order to protect species diversity and ecosystem services. But the 2015 rule defining the jurisdiction of the Clean Water Act explicitly excludes

many manmade environments, including many artificial lakes, …

Awareness Of Clinical Laboratory Sciences And Shortage Of Clinical Laboratory Scientists In The 21st Century, Cynthia Funnye Doby

Walden Dissertations and Doctoral Studies

Retiring baby boomers and the lack of interest and awareness among college students to enroll in an accredited Clinical Laboratory Science (CLS) program have created a shortage of CLS professionals in the 21st century. The U.S. Bureau of Labor Statistics predicts 18,000 CLS vacancies by 2018. However, only about 5,000 students graduate from accredited CLS programs each year. The purpose of this study was to explore students' perceptions of allied health professions and factors that influenced students and CLS professionals to select CLS as a profession. Bandura's social cognitive career theory served as the theoretical framework for this phenomenological study. …

Understanding A School's Response To Childhood Obesity, April Dawn Goins-Jones

Walden Dissertations and Doctoral Studies

Childhood obesity has become a national epidemic. Although many of the consequences of childhood obesity are known, such as physical, social, emotional, and academic effects on a student's development, there is a lack of literature on the topic of childhood obesity in Native American tribes. The purpose of this case study was to explore how school personnel address the effects of obesity on students' social, emotional, academic, and physical development in an elementary school in the southwest United States where 90% of the students are Native Americans. Bronfenbrenner's socioecological model served as the theoretical foundation. The research questions explored strategies …