Digital Commons Network^™

Implementing Kentucky’S College Readiness Agenda: An Organizational Perspective Of Policy Implementation, Todd Baldwin

Theses and Dissertations--Education Sciences

Nearly two-thirds of undergraduate college students within the United States fail to graduate within six years because they are unprepared for postsecondary education. Thus, many states have embarked on policy reform movements centered on college and career readiness for all high school graduates. This study focused on Kentucky’s efforts to implement four key initiatives—accelerated learning, secondary interventions, college and career readiness advising, and persistence to graduation—resulting from sweeping reform policies enacted in 2009 by the Kentucky General Assembly. The study considers policy implementation from an organizational perspective and explores the structural characteristics associated with effective policy implementation at the school …

Closed-Loop Afferent Nerve Electrical Stimulation For Rehabilitation Of Hand Function In Subjects With Incomplete Spinal Cord Injury, Christopher J. Schildt

Theses and Dissertations--Biomedical Engineering

Peripheral nerve stimulation (PNS) is commonly used to promote use-dependent cortical plasticity for rehabilitation of motor function in spinal cord injury. Pairing transcranial magnetic stimulation (TMS) with PNS has been shown to increase motor evoked potentials most when the two stimuli are timed to arrive in the cortex simultaneously. This suggests that a mechanism of timing-dependent plasticity (TDP) may be a more effective method of promoting motor rehabilitation. The following thesis is the result of applying a brain-computer interface to apply PNS in closed-loop simultaneously to movement intention onset as measured by EEG of the sensorimotor cortex to test whether …

Biomedical Word Sense Disambiguation With Neural Word And Concept Embeddings, Akm Sabbir

Theses and Dissertations--Computer Science

Addressing ambiguity issues is an important step in natural language processing (NLP) pipelines designed for information extraction and knowledge discovery. This problem is also common in biomedicine where NLP applications have become indispensable to exploit latent information from biomedical literature and clinical narratives from electronic medical records. In this thesis, we propose an ensemble model that employs recent advances in neural word embeddings along with knowledge based approaches to build a biomedical word sense disambiguation (WSD) system. Specifically, our system identities the correct sense from a given set of candidates for each ambiguous word when presented in its context (surrounding …

Surface-Initiated Polymerizations For The Rapid Sorting Of Rare Cancer Cells, Jacob L. Lilly

Theses and Dissertations--Chemical and Materials Engineering

Cancer metastasis directly accounts for an estimated 90% of all cancer related deaths and is correlated with the presence of malignant cells in systemic circulation. This observed relationship has prompted efforts to develop a fluid biopsy, with the goal of detecting these rare cells in patient peripheral blood as surrogate markers for metastatic disease as a partial replacement or supplement to tissue biopsies. Numerous platforms have been designed, yet these have generally failed to support a reliable fluid biopsy due to poor performance parameters such as low throughput, low purity of enriched antigen positive cells, and insufficiently low detection thresholds …

The Role Of Sox4 In Regulating Choroid Fissure Closure And Retinal Neurogenesis, Wen Wen

Theses and Dissertations--Biology

The development of the vertebrate eye is tightly controlled by precise genetic regulations. From a single ocular primordium to bilateral eyes with complex structures and cell types, it requires intensive proliferation and migration for cells in both the ectoderm and mesoderm to accomplish ocular morphogenesis, and during this process cell differentiation and interaction takes place to establish the complex composition of ocular cell types and cellular connections. Genetic defects can lead to severe abnormalities in eye morphogenesis and cell differentiation during ocular development. A tremendous amount of work has been done to identify both intrinsic and extrinsic factors that regulate …

Role Of Hairy-Related (Her) Genes During Vertebrate Retinal Development And Regeneration, Stephen G. Wilson

Theses and Dissertations--Biology

Development and regeneration of the vertebrate eye are the result of complex interactions of regulatory networks and spatiotemporally controlled gene expression events. During embryonic retinal development, the coordination of cell signaling and transcriptional regulation allows for a relatively homogenous sheet of neuroepithelial cells to proliferate and differentiate in-to a multilayered, light sensitive retinal tissue. Following injury, the retinas of many cold-blooded vertebrates, such as the zebrafish, undergo a proliferative response that results not only in new retinal cells of the correct type in the correct location, but also functional integration of these cells and restoration of vision. In order for …

Patriarchal Trauma In Appalachian Literature, Michelle Justus

Theses and Dissertations--English

Patriarchal Trauma in Appalachian Literature examines the effects of subjugation on women as it is represented in three novels set in Appalachia. I define patriarchal trauma as an act causing mental anguish to a woman and perpetrated against her because she is a woman. I use the term to encompass violent, catastrophic harms but more particularly to pinpoint the traumatic effects of the quotidian, systemic deprivation of women’s autonomy. Reconsidering classic texts such as James Still’s River of Earth and Robert Morgan’s Gap Creek: The Story of a Marriage as narratives of women’s trauma establishes a lineage on the subject, …

The Geopolitics Of Reproductive Healthcare: Latina Immigrants’ Experiences As Non-Citizens And Biological Citizena In Atlanta, Ga, Rebecca E. Lane

Theses and Dissertations--Geography

This dissertation examines the experiences of Latina immigrants in Atlanta, GA in accessing and receiving reproductive healthcare. Although Atlanta is a new destination city for immigrant labor, the state of Georgia has passed anti-immigrant legislation, including a 2011 law that allows local police to check immigrants’ documentation while investigating unrelated violations. This localization of immigration policing heightens immigrants’ risk of detention and deportability. In combination with media discourses of illegality, local immigration policing instills fear in immigrants, which deters them from going out in public in order to perform everyday tasks such as seeing a doctor. Latinas immigrants’ ascribed illegality …

Come Together: Desire, Literature, And The Law Of The Sexual Revolution, Eir-Anne E. Edgar

Theses and Dissertations--English

While some scholars have viewed the Sexual Revolution as a “war” with winners and losers, this project finds that all Americans were subject to the fantasy of liberation. This fantasy takes different forms during the era, including relaxed sexual strictures against pre-marital sex, the availability of birth control, and an increased focus on sexual pleasure. However, the seemingly liberatory quickly becomes conservative, coming into focus through the analysis of court cases and legal mandates that protected the declining structures of marriage and heteronormativity. Beginning with widespread fears about interracial mixing in the early 1950’s, escalated by the end of segregation …

Epidemic And Opportunity: American Perceptions Of The Spanish Influenza Epidemic, Jonathan Chilcote

Theses and Dissertations--History

During the final months of the Great War, the loss of human life was not confined to the battlefields of Western Europe. The Spanish influenza virus was rapidly spreading around the globe¸ and would ultimately leave millions dead in its wake. Some American groups, both public and private, saw the pandemic as a blessing in disguise. They interpreted the pandemic as a sign that their work, whether religious, political, commercial, or health, was more vital to the world than ever before. Influenza reinforced their existing beliefs in the rightness and necessity of their causes, and used the pandemic as a …

The Language Of Race In Revolutionary France And Saint-Domingue, 1789-1792, Jeffery L. Stanley

Theses and Dissertations--History

This project studies the historical development of racialist language during the French Revolution as politicians, free people of color, and colonial whites debated the political status of France’s free people of color population. It examines the negotiation of a racialist language that bolstered colonial racial hierarchies with an egalitarian language that sought to level the corporate structures of the Old Regime. I look especially at the ways that language served as a management device to articulate and legitimize new relationships of power in the political culture of the French Revolution. I connect developments in France to the colonies by showing …

An Internal Dilemma: Different Approaches To Handling Melancholia In Early Modern Spanish Religious Orders, Jesse T. Nau

Theses and Dissertations--History

This study argues that religious orders in early modern Spain developed informal sets of procedures to handle the consequences of melancholia in their communities. It also argues that three influential members of these orders, San Ignacio de Loyola of the Jesuits, and San Teresa de Avila and San Juan de la Cruz of the Discalced Carmelites, tailored these protocols according to their own private concerns and experience with the disease. The changing discourse surrounding melancholia and similar diseases during the early modern period, alongside the unique environmental concerns of these newly founded orders, created a need for new methods of …

The Normative Architecture Of Reality: Towards An Object-Oriented Ethics, Justin L. Harmon

Theses and Dissertations--Philosophy

The fact-value distinction has structured and still structures ongoing debates in metaethics, and all of the major positions in the field (expressivism, cognitivist realism, and moral error theory) subscribe to it. In contrast, I claim that the fact-value distinction is a contingent product of our intellectual history and a prime object for questioning. The most forceful reason for rejecting the distinction is that it presupposes a problematic understanding of the subject-object divide whereby one tends to view humans as the sole source of normativity in the world. My dissertation aims to disclose the background against which human ethical praxis is …

Anthropocentrism As Environmental Ethic, Kyle L. Burchett

Theses and Dissertations--Philosophy

Ever since the environment and nonhumanity became major ethical topics, human-centered worldviews have been blamed for all that is morally wrong about our dealings with nature. Those who consider themselves nonanthropocentrists typically assume that the West’s anthropocentric axiologies and ontologies underlie all of the environmental degradations associated with our species. On the other hand, a handful of environmental philosophers argue that anthropocentrism is perfectly acceptable as a foundation for environmental ethics. According to Bryan Norton’s convergence hypothesis, "If reasonably interpreted and translated into appropriate policies, a nonanthropocentric ethic will advocate the same [environmental] policies as a suitably broad and long-sighted …

Becoming What We Are: Virtue And Practical Wisdom As Natural Ends, Keith Buhler

Theses and Dissertations--Philosophy

This dissertation is about ethical naturalism. Philippa Foot and John McDowell both defend contemporary neo-Aristotelian ethics but each represents a rival expression of the same. They are united in the affirmation that virtue is ‘natural goodness’ for human beings. Nevertheless, they are divided in their rival conceptions of ‘nature.’ McDowell distinguishes second nature or the "space of reasons" from first nature or the “realm of law.” Foot rejects this division.

On Foot's naturalism, natural goodness is just as much a feature of first nature as health is, even though human practical reasoning is unique in the biological world. I defend …

Forget Not The Whip! Nietzsche, Perspectivism, And Feminism: A Non-Apologist Interpretation Of Nietzsche’S Polemical Axiology, Jennifer L. Hudgens

Theses and Dissertations--Philosophy

The nineteenth-century German philosopher Friedrich Nietzsche is notoriously a misogynist according to many feminists. In parallel, Nietzsche’s theory of value, perspectivism, is relativist according to many philosophers. However, I propose a counter-reading of both Nietzsche’s comments regarding women and his comments regarding perspective in which I interpret Nietzsche as neither misogynistic nor relativistic. I adopt a stance which is non-apologist, in that I do not merely wash my hands of Nietzsche’s apparently sexist remarks about women as Walter Kaufmann does, for example. Rather I demonstrate that Nietzsche is performing a polemical attack on a particular kind of naïve feminism which …

Expectancy-Value In The Enrollment Factor Of Agricultural Education Youth, Morgan Schafbuch

Theses and Dissertations--Community & Leadership Development

This quantitative study considers the motivating factors for enrollment in secondary agricultural education courses from students whose home background is not from a farm. This study utilizes expectancy-value theory, and looks at students (n=211) from different agricultural backgrounds and the impact on their ability beliefs, expectancies for success, and usefulness, importance, and interest for enrollment in agricultural education courses. The results indicate that students who have no affiliation to a farm have the highest ability beliefs and expectancies for success towards agricultural education in relation to students who are from traditional agricultural backgrounds.

Comprehensive Sexuality Education In Kentucky, Luciana D. Hockersmith

Theses and Dissertations--Community & Leadership Development

Discussions of sex education of any kind can be controversial in a given setting. Traditional approaches to sex education prompt debate regarding effectiveness. Key indicators central to the effectiveness of sex education continue to be rates of teen pregnancy and transmission of sexually transmitted diseases (STDs). With discontentment surrounding the effectiveness of “traditional approaches,” a more wide-ranging method is worthy of being explored. The curriculum approach of Comprehensive Sexuality Education (CSE) includes six key concepts, and subsequent sub-concepts, intended to provide a broad and even all-inclusive range of topics for a similarly broad and even all-inclusive range of ages of …

Effectiveness Of Biochar Addition In Reducing Concentrations Of Selected Nutrients And Bacteria In Runoff, Rachel Williams

Theses and Dissertations--Biosystems and Agricultural Engineering

Land application and storage of horse manure and municipal sludge can increase nutrient and bacteria concentrations in runoff. Biochar increases soil nutrient retention when used as a soil amendment. The objectives of this study were to determine if biochar, when mixed with horse manure or sludge, affects runoff concentrations of total Kjehldahl nitrogen (TKN), ammonia-nitrogen (NH3-N), nitrate (NO3-N), total phosphorus (TP), dissolved phosphorus (DP), total suspended solids (TSS), chemical oxygen demand (COD), and fecal coliforms (FC). Horse manure and sludge were applied to 2.4 x 6.1 m fescue plots (six each), with three plots of each material amended with 5-8% …

Recirculating Calcium Hydroxide Solution: A Practical Choice For On-Farm High Solids Lignocellulose Pretreatment, William S. Sympson Jr.

Theses and Dissertations--Biosystems and Agricultural Engineering

Pretreatment is a necessary step in the utilization of lignocellulosic biomass for biochemical conversion to higher value products. There are multiple chemical choices for industrial settings, however on-farm choices are constrained to near ambient conditions with minimal specialized equipment, training, and limited waste disposal. Calcium hydroxide (lime) is suitable for on-farm use. This work presents the novel idea of pretreating biomass by recirculating a filtered, saturated lime solution in an up-flow, high solids (14-16% w/w) configuration at ambient conditions. In this system, lime solids were efficiently consumed, post-pretreatment washing of substrate did not significantly improve glucose yields, and energy and …

Heat And Mass Transfer In Baled Switchgrass For Storage And Bioconversion Applications, Drew F. Schiavone

Theses and Dissertations--Biosystems and Agricultural Engineering

The temperature and moisture content of biomass feedstocks both play a critical role in minimizing storage and transportation costs, achieving effective bioconversion, and developing relevant postharvest quality models. Hence, this study characterizes the heat and mass transfer occurring within baled switchgrass through the development of a mathematical model describing the relevant thermal and physical properties of this specific substrate. This mathematical model accounts for the effect of internal heat generation and temperature-induced free convection within the material in order to improve prediction accuracy. Inclusion of these terms is considered novel in terms of similar biomass models.

Two disparate length scales, …

Long-Term Effects Of Forestry Best Management Practices On Hydrology And Water Chemistry In Three Appalchian Headwater Catchments, Kameryn I. Wright

Theses and Dissertations--Biosystems and Agricultural Engineering

In 1982, a study was initiated in the Field Branch watershed, in the University of Kentucky’s Robinson Forest, to evaluate forestry best management practice (BMP) effectiveness after intensive harvesting. The study utilized a paired watershed approach on three adjacent Field Branch subcatchments. One subcatchment was left as the control, one had BMPs implemented (including a 50-ft undisturbed buffer along the stream), and one was clear-cut to the stream’s banks without the use of BMPs (i.e. logger’s choice). Prior research has shown that logging can negatively impact watershed functions by altering stream hydrology, geomorphology, water quality, and instream habitat. Thus, the …

Induction Of Cellulase In High Solids Cultivation Of Trichoderma Reesei For Enhanced Enzymatic Hydrolysis Of Lignocellulose, Danielle Empson

Theses and Dissertations--Biosystems and Agricultural Engineering

This project aimed investigated cellulase in-situ production for large-scale on-farm production of lignocellulosic biofuel. Cellulase activity and glucose released by T. reesei with corn stover and wheat bran as co-substrates for solid state cultivation (SSC) were examined. Co-cultivation has previously increased T. reesei cellulase, but corn stover and wheat bran have not been co-cultivated (Dhillon, Oberoi et al. 2011). This work compared cellulase activity and glucose concentration of corn stover co-cultivated with 0-40% wheat bran in high solids. Samples with at least 20% wheat bran exhibited increased cellulase activity. However, the average glucose concentration without wheat bran was 3.29 g/L …

Development Of Regional And Hydraulic Geometry Curves For The Eastern Kentucky Coalfields, Ashlan Berry

Theses and Dissertations--Biosystems and Agricultural Engineering

Regional curves and hydraulic geometry curves relate bankfull channel dimensions to drainage area and bankfull discharge, respectively. These curves are used in the natural channel design process to help identify bankfull and to estimate bankfull dimensions of the design channel. Nineteen streams were surveyed to determine their bankfull parameters (cross-sectional area, width, mean depth, discharge, slope, and Manning’s n), along with 27 streams previously surveyed in other studies. The data were used to create regional and hydraulic geometry curves for three hydrologic landscape regions (HLR 9, HLR 11, and HLR 16, individually) in the Eastern Kentucky Coalfields (EKC) as well …

Variance Of The Amyloid Beta Peptide As A Metric For The Diagnosis Of Alzheimer's Disease, Christina Beckett

Theses and Dissertations--Medical Sciences

Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder associated with aging. AD is by far the best understood and most studied neurodegenerative disease. Substantial advances have been made over the last decade, however it is debatable how much closer we are to a clinically useful therapy. A long standing goal in the AD field has been to improve the accuracy of early detection, with the assumption that the ability to intervene earlier in the disease process will lead to a better clinical outcome. Major facets of this effort have been the continued development and improvement of AD biomarkers, with …

Evaluating The Use Of Second LifeTm For Virtual Team-Based Learning In An Online Undergraduate Anatomy Course, Christena Gazave

Theses and Dissertations--Medical Sciences

Team-based learning (TBL) is one strategy for improving team-work and critical thinking skills. It has proven to be an engaging teaching pedagogy in face-to-face classes, however, to our knowledge, has never been implemented online in a 3-D virtual world. We implemented virtual TBLs in an online undergraduate anatomy course using Second Life^TM, and evaluated whether it engaged students. This study was conducted over 2 semesters with 39 total students. Surveys and content analysis of transcripts were used to evaluate student engagement. Our results indicate virtual TBLs were engaging for most students. The average engagement score was 7.8 out …

Novel Targets For Mitochondrial Dysfunction Following Traumatic Brain Injury, Heather M. Yonutas

Theses and Dissertations--Neuroscience

Mitochondrial dysfunction is a phenomenon observed in models of Traumatic Brain Injury (TBI). Loss of mitochondrial bioenergetics can result in diminished cellular homeostasis leading to cellular dysfunction and possible cellular death. Consequently, the resultant tissue damage can manifest as functional deficits and/or disease states. Therapeutic strategies to target this mitochondrial dysfunction have been investigated for models TBI and have shown promising effects.

For this project, we tested the hypothesis that mitoNEET, a novel mitochondrial membrane protein, is a target for pioglitazone mediated neuroprotection. To test this, we used a severe Controlled Cortical Impact (CCI) injury model in mitoNEET null and …

Development In Normal Mixture And Mixture Of Experts Modeling, Meng Qi

Theses and Dissertations--Statistics

In this dissertation, first we consider the problem of testing homogeneity and order in a contaminated normal model, when the data is correlated under some known covariance structure. To address this problem, we developed a moment based homogeneity and order test, and design weights for test statistics to increase power for homogeneity test. We applied our test to microarray about Down’s syndrome. This dissertation also studies a singular Bayesian information criterion (sBIC) for a bivariate hierarchical mixture model with varying weights, and develops a new data dependent information criterion (sFLIC).We apply our model and criteria to birth- weight and gestational …

Multi-State Models With Missing Covariates, Wenjie Lou

Theses and Dissertations--Statistics

Multi-state models have been widely used to analyze longitudinal event history data obtained in medical studies. The tools and methods developed recently in this area require the complete observed datasets. While, in many applications measurements on certain components of the covariate vector are missing on some study subjects. In this dissertation, several likelihood-based methodologies were proposed to deal with datasets with different types of missing covariates efficiently when applying multi-state models.

Firstly, a maximum observed data likelihood method was proposed when the data has a univariate missing pattern and the missing covariate is a categorical variable. The construction of the …

Statistical Inference On Dynamical Systems, Hongyuan Wang

Theses and Dissertations--Statistics

The ordinary differential equation (ODE) is one representative and popular tool in modeling dynamical systems, which are widely implemented in physics, biology, economics, chemistry and biomedical sciences, etc. Because of the importance of dynamical systems in scientific studies, they are the main focuses of my dissertation.

The first chapter of the dissertation is introduction and literature review, which mainly focuses on numerical integration algorithms of ODEs that are difficult to solve analytically, as well as derivative-free optimization algorithms for the so-called inverse problem.

The second chapter is on the estimation method based on numerical solvers of differential equations. We start …