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2016

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Articles 23101 - 23130 of 29046

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Intrabone Marrow Injection Enhances Placental Mesenchymal Stem Cellmediated Support Of Hematopoiesis In Mice, Ya Hong Yuan, Chun Fang Zhou, Zhi Yong Lu, Xiao Li Wang, Yan Ding, Dongsheng Li Jan 2016

Intrabone Marrow Injection Enhances Placental Mesenchymal Stem Cellmediated Support Of Hematopoiesis In Mice, Ya Hong Yuan, Chun Fang Zhou, Zhi Yong Lu, Xiao Li Wang, Yan Ding, Dongsheng Li

Turkish Journal of Medical Sciences

Background/aim: In order to determine the synergistic effects of human placental mesenchymal stem cells (PMSCs) on hematopoiesis in vivo, we compared the intrabone marrow injection (IBMI) with the conventional intravenous injection (IVI). Materials and methods: C57BL/6 recipient mice conditioned with lethal doses of irradiation were transplanted with bone marrow mononuclear cells (MNCs) and bone marrow-derived mesenchymal stem cells (BMSCs) from BALB/c mice by IBMI or IVI. NOD/SCID recipient mice conditioned with sublethal doses of irradiation were transplanted with human umbilical cord blood MNCs (UCB-MNCs) and PMSCs by IBMI or IVI. Results: The number of hematopoietic cells was significantly higher in …

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The Effect Of Proanthocyanidin On Formaldehyde-Induced Toxicity In Rat Testes, Eni̇s Uluçam, Elvan Bakar Jan 2016

The Effect Of Proanthocyanidin On Formaldehyde-Induced Toxicity In Rat Testes, Eni̇s Uluçam, Elvan Bakar

Turkish Journal of Medical Sciences

Background/aim: This study investigated the effect of proanthocyanidin (PA) against formaldehyde (FA)-induced lipid peroxidation damage and morphological changes in rat testes. Materials and methods: Twenty-one Wistar albino rats were randomized into 3 groups: control, FA, and FA + PA groups. Plasma and tissue malondialdehyde (MDA) and total sialic acid (TSA) levels were measured. Testes tissues were observed by light and electron microscopy. Results: TSA (plasma and tissue) levels decreased and MDA (plasma) significantly increased (P < 0.05) in rats treated with FA compared to the controls. Tissue MDA levels were not significantly different. Several necrotic changes were observed in testes tissues by light and electron microscopy. Disordering in epithelia of seminiferous tubules, vacuolization between germinal epithelium cells, and separated basement membranes were observed by light microscope. Immunopositivity in Leydig cells decreased in the FA group (P < 0.05). In the FA + PA group there were more immune Leydig cells reacting immune-positively than in the FA group (P < 0.05). Ultrastructurally, FA also caused disorganization and loss of mitochondrial cristae, and dilatation in endoplasmic reticulum in testes. Conclusion: The results suggest that PA has a protective effect on FA toxicity in testes.

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Apitherapy Products Enhance The Recovery Of Ccl4-Induced Hepatic Damages In Rats, Özlem Saral, Oktay Yildiz, Rezzan Ali̇yazicioğlu, Esi̇n Yuluğ, Si̇nan Canpolat, Ferhat Öztürk, Sevgi̇ Kolayli Jan 2016

Apitherapy Products Enhance The Recovery Of Ccl4-Induced Hepatic Damages In Rats, Özlem Saral, Oktay Yildiz, Rezzan Ali̇yazicioğlu, Esi̇n Yuluğ, Si̇nan Canpolat, Ferhat Öztürk, Sevgi̇ Kolayli

Turkish Journal of Medical Sciences

Background/aim: Our objective was to identify the antioxidant properties of honeybee products from Turkey, chestnut honey, pollen, propolis, and royal jelly, and their hepatoprotective activity against CCl4-induced hepatic damage in rats. Materials and methods: Animals were fed with honeybee products for 7 days following CCl4 injection. Development of liver damage and oxidative stress were monitored by measuring the activities of the enzymes alanine transaminase, aspartate transaminase, malondialdehyde, superoxide dismutase, and catalase. Antioxidant capacities of the bee products were identified using FRAP and DPPH assays, as well as by measuring total phenolic and flavonoid contents. Results: The antioxidant activities of the …

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Quantitative Comparison Of Immunohistochemical And Pcr Analysis Of Midkine Expression In Breast Cancer Types And Serum Midkine Level, Hülya Çeti̇n Sorkun, Meti̇n Akbulut, Yaşar Enli̇, Emre Tepeli̇, Sevgi̇ Özkan, Ergün Erdem Jan 2016

Quantitative Comparison Of Immunohistochemical And Pcr Analysis Of Midkine Expression In Breast Cancer Types And Serum Midkine Level, Hülya Çeti̇n Sorkun, Meti̇n Akbulut, Yaşar Enli̇, Emre Tepeli̇, Sevgi̇ Özkan, Ergün Erdem

Turkish Journal of Medical Sciences

Background/aim: Midkine (MK), a heparin-binding growth factor, has an important role in cancer progression. The aim of this study was to determine MK expression in breast tissue and the preoperative and postoperative serum levels of patients with breast cancer. Materials and methods: Sixty-one patients with breast cancer participated in our study. The MK serum levels were measured pre- and postoperatively for these patients. We also analyzed breast tissues of the 61 patients immunohistochemically. We examined serum midkine levels in 49 healthy volunteers. Results: MK expression was observed in 44 (72.1%) of 61 breast cancer patients. In breast cancer patients the …

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Macrolide And Lincosamide Resistance In Staphylococcal Clinical Isolates In Nablus, Palestine, Motasem Almasri, Nael Abu Hasan, Naela Sabbah Jan 2016

Macrolide And Lincosamide Resistance In Staphylococcal Clinical Isolates In Nablus, Palestine, Motasem Almasri, Nael Abu Hasan, Naela Sabbah

Turkish Journal of Medical Sciences

Background/aim: Macrolide and lincosamide antibiotics are used for the treatment of staphylococcal infections, especially for penicillin-allergic patients. In the present study, we evaluate the prevalence of resistance to macrolide and lincosamide antibiotics among staphylococci isolates. Materials and methods: A total of 200 staphylococcal clinical isolates were collected from January 2012 to April 2013. Minimal inhibitory concentrations of erythromycin and clindamycin were determined by agar dilution method. An erythromycin-clindamycin induction test was performed for isolates that were only resistant to erythromycin. Representative erythromycin-resistant isolates were examined for erythromycin resistance genes using PCR. Results: Among staphylococci isolates, resistance frequencies of erythromycin and …

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An Analysis Of The Incidence Of Measles In Turkey Since 1960, Deni̇z Çalişkan, Bi̇rgül Pi̇yal, Recep Akdur, Mi̇ne Esi̇n Ocaktan, Ceylan Yozgatligi̇l Jan 2016

An Analysis Of The Incidence Of Measles In Turkey Since 1960, Deni̇z Çalişkan, Bi̇rgül Pi̇yal, Recep Akdur, Mi̇ne Esi̇n Ocaktan, Ceylan Yozgatligi̇l

Turkish Journal of Medical Sciences

Background/aim: The aims of this study were to evaluate measles incidence and the effect of elimination strategy interventions on the disease from 1960 to 2014 in Turkey. The administration of measles vaccine started in the rural regions in 1970; it was carried out as a campaign along with the National Vaccine Campaign in 1985, and it has been employed as combined measles, mumps, and rubella under the scope of the Measles Elimination Program (MEP) since 2006 in Turkey. While a dramatic decrease in the reporting of measles was observed between 2000 and 2010, the number of the cases has increased …

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N-Terminal-Pro Brain Natriuretic Peptide Levels In Children With Allergic Rhinitis, Hasi̇be Artaç, Hüsametti̇n Vatansev, Derya Çi̇men, Derya Arslan, Fatma Kaya, Seyi̇t Ali̇ Kayiş, Bülent Oran Jan 2016

N-Terminal-Pro Brain Natriuretic Peptide Levels In Children With Allergic Rhinitis, Hasi̇be Artaç, Hüsametti̇n Vatansev, Derya Çi̇men, Derya Arslan, Fatma Kaya, Seyi̇t Ali̇ Kayiş, Bülent Oran

Turkish Journal of Medical Sciences

Background/aim: Persistent upper airway obstruction may lead to increased pulmonary arterial pressure (PAP). The aim of this study was to evaluate N-terminal pro brain natriuretic peptide (NT-proBNP) concentrations and PAP values in children with allergic rhinitis. Materials and methods: Sixty-six patients with allergic rhinitis and 22 healthy children were prospectively enrolled in this study. Plasma NT-proBNP levels were measured at first admission and after treatment. Simultaneously, echocardiography was done to assess pulmonary arterial hypertension, and rhinitis symptom scores were recorded. Results: The median age of the study group was 9.0 (5.0?17.0) years; 26 were female. PAP was found to be …

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Ilp-2 Modeling And Virtual Screening Of An Fda-Approved Library:A Possible Anticancer Therapy, Saeed Khalili, Hemn Mohammadpour, Mahideh Shokrollahi Barough, Parviz Kokhaei Jan 2016

Ilp-2 Modeling And Virtual Screening Of An Fda-Approved Library:A Possible Anticancer Therapy, Saeed Khalili, Hemn Mohammadpour, Mahideh Shokrollahi Barough, Parviz Kokhaei

Turkish Journal of Medical Sciences

Background/aim: The members of the inhibitors of apoptosis protein (IAP) family inhibit diverse components of the caspase signaling pathway, notably caspase 3, 7, and 9. ILP-2 (BIRC-8) is the most recently identified member of the IAPs, mainly interacting with caspase 9. This interaction would eventually lead to death resistance in the case of cancerous cells. Therefore, structural modeling of ILP-2 and finding applicable inhibitors of its interaction with caspase 9 are a compelling challenge. Materials and methods: Three main protein modeling approaches along with various model refinement measures were harnessed to achieve a reliable 3D model, using state-of-the-art software. Thereafter, …

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The Inhibitory Effect Of Bacteriocin Produced By Lactobacillus Acidophilusatcc 4356 And Lactobacillus Plantarum Atcc 8014 On Planktonic Cells And Biofilms Of Serratia Marcescens, Roya Vahedi Shahandashti, Rouha Kasra Kermanshahi, Parinaz Ghadam Jan 2016

The Inhibitory Effect Of Bacteriocin Produced By Lactobacillus Acidophilusatcc 4356 And Lactobacillus Plantarum Atcc 8014 On Planktonic Cells And Biofilms Of Serratia Marcescens, Roya Vahedi Shahandashti, Rouha Kasra Kermanshahi, Parinaz Ghadam

Turkish Journal of Medical Sciences

Background/aim: The spread of antibiotic-resistant pathogens has resulted in the need for new treatments. The aim of the present study is to investigate the effect of bacteriocin from Lactobacillus acidophilus ATCC 4356 and Lactobacillus plantarum ATCC 8014 on planktonic and biofilm forms of Serratia marcescens strains. Materials and methods: The direct antagonism of the L. plantarum and L. acidophilus cell-free supernatant on S. marcescens cultures was determined using an optical density assay. The bacteriocin was partial purified by ammonium sulfate precipitation. Its molecular weight was analyzed with sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The effect of bacteriocins on the biofilm …

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Effects Of Resveratrol And Cigarette Smoking Onbone Healing: Histomorphometric Evaluation, Özge Kolkesen Şahi̇n, Müge Çina Aksoy, Mustafa Ci̇hat Avunduk Jan 2016

Effects Of Resveratrol And Cigarette Smoking Onbone Healing: Histomorphometric Evaluation, Özge Kolkesen Şahi̇n, Müge Çina Aksoy, Mustafa Ci̇hat Avunduk

Turkish Journal of Medical Sciences

Background/aim: The aim of the present study is to investigate the effects of cigarette smoke (CS) and simultaneous application of resveratrol on bone healing histomorphometrically and to evaluate the effects of resveratrol on negative effects of CS. Materials and methods: For 4 weeks, Sprague Dawley rats were exposed to cigarette smoke at the equivalent of 6 cigarettes per day. After this period, monocortical defects were created in femurs by a trephine bur on day 28. Starting from the day of defect creation to the 28th postoperative day, rats were given 20 mg/kg body weight resveratrol. Histomorphometric examination of the number …

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The Effect Of Low-Dose Methotrexate On Autologous Fat Graft Survival, Eli̇f Sari, Bülent Bakar, Bahram Sarkarati, Önder Bozdoğan, Tarik Çavuşoğlu Jan 2016

The Effect Of Low-Dose Methotrexate On Autologous Fat Graft Survival, Eli̇f Sari, Bülent Bakar, Bahram Sarkarati, Önder Bozdoğan, Tarik Çavuşoğlu

Turkish Journal of Medical Sciences

Background/aim: The survival of autologous fat graft tissue is dependent on various factors such as vascularization and inflammation. The aim of the present study was to evaluate the possible beneficial effects of low-dose methotrexate (LD-MTX) on fat graft volume and survival. Materials and methods: A total of 13 male Wistar albino rats were divided into two groups, a control group and an LD-MTX group. An autologous fat graft obtained from the inguinal region of each rat was transferred to its back. LD-MTX was administered intraperitoneally in the LD-MTX group once a week for 4 weeks after the surgical procedure. The …

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The Beneficial Effects Of Almond (Prunus Amygdalus Batsch) Hull On Serum Lipid Profile And Antioxidant Capacity In Male Rats, Soheil Safarian, Yadollah Azarmi, Ali Jahanban-Esfahlan, Hasan Jahanban-Esfahlan Jan 2016

The Beneficial Effects Of Almond (Prunus Amygdalus Batsch) Hull On Serum Lipid Profile And Antioxidant Capacity In Male Rats, Soheil Safarian, Yadollah Azarmi, Ali Jahanban-Esfahlan, Hasan Jahanban-Esfahlan

Turkish Journal of Medical Sciences

Background/aim: Almond hull is produced in high amounts and mostly used as livestock feed. This study was designed to examine the impact of almond hull powder (AHP) administration on lipid profile and antioxidant activities in plasma and liver in hyperlipidemic rats. Materials and methods: As the first step, the antioxidant capacity and radical scavenging activity of AHP were determined using calorimetric methods. Then 36 adult male Wistar rats were randomly divided into 6 groups: group 1 with oral administration of 10% AHP, group 2 with oral administration of 20% AHP, group 3 with oral administration of 30% AHP, group 4 …

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The Consequences Of Aluminium Intake On Reproductive Function In Male Rats:A Three-Generation Study, Florin Muselin, Romeo Teodor Cristina, Violeta Igna, Eugenia Dumitrescu, Diana Brezovan, Alexandra Trif Jan 2016

The Consequences Of Aluminium Intake On Reproductive Function In Male Rats:A Three-Generation Study, Florin Muselin, Romeo Teodor Cristina, Violeta Igna, Eugenia Dumitrescu, Diana Brezovan, Alexandra Trif

Turkish Journal of Medical Sciences

Background/aim: The effects of aluminium exposure on reproductive biomarkers in male rats were followed in a three-generation study. Materials and methods: Forty Wistar male rats (F0) were divided into the following groups: control (C), receiving only tap water, and three experimental (E) groups, receiving aluminium sulphate (AS) (E1: 200 ppb, E2: 400 ppb, and E3: 1000 ppb) in drinking water for a 6-month exposure period. To obtain F1, three males from each group were mated with previously unexposed females (1:2 sex ratios) that during gestation and lactation were exposed to the same AS levels as males. The F1 generation male …

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Effectiveness Of A Single Versus Repeated Administration Of Trimetazidine In The Protection Against Warm Ischemia/Reperfusion Injury Of Rat Liver, Asma Mahfoudh Boussaid, Rabi Selmi, Mohamed Bejaoui, Kaouther Hadj Ayed, Mohamed Amine Zaouali, Hassen Ben Abdennebi Jan 2016

Effectiveness Of A Single Versus Repeated Administration Of Trimetazidine In The Protection Against Warm Ischemia/Reperfusion Injury Of Rat Liver, Asma Mahfoudh Boussaid, Rabi Selmi, Mohamed Bejaoui, Kaouther Hadj Ayed, Mohamed Amine Zaouali, Hassen Ben Abdennebi

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to compare the effects of single and repeated trimetazidine (TMZ) administration against warm hepatic ischemia/reperfusion (I/R) injury and to explore the possible mechanisms affected by TMZ. Materials and methods: Wistar rats were divided into 4 groups (n = 6). Sham: rats were subjected to dissection. I/R: rats were subjected to 60 min of partial hepatic ischemia followed by 24 h of reperfusion. TMZ1: Same as I/R group but rats were pretreated with a single dose of TMZ (10 mg/kg, intraperitoneal injection) 30 min before warm ischemia. TMZ3: Same as I/R but rats were …

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An Investigation On The Prevalence And Efficiency Of Immunochromatographic Testing In Suspected Malarial Patients Of Rawalpindi And Islamabad, Pakistan, Saima Jabeen, Sobia Kanwal, Mazhar Qayyum, Umair Farrukh, Shahzad Abdul Hameed Jan 2016

An Investigation On The Prevalence And Efficiency Of Immunochromatographic Testing In Suspected Malarial Patients Of Rawalpindi And Islamabad, Pakistan, Saima Jabeen, Sobia Kanwal, Mazhar Qayyum, Umair Farrukh, Shahzad Abdul Hameed

Turkish Journal of Medical Sciences

Background/aim: The prevalences of Plasmodium falciparum and Plasmodium vivax are increasing rapidly in Pakistan, but recent data on the epidemiology of malaria are not properly reported with scarce diagnostic methods for quick diagnosis. This study was designed to determine the current prevalence and distribution of Plasmodium species in the vicinity of Rawalpindi and Islamabad and report on the validity of the immunochromatographic test (ICT) in diagnosing malarial infections. Materials and methods: A total of 1500 blood samples obtained from a local hospital were screened during the course of this study via microscopic examination and ICT. Results: It was seen that …

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The Association Of Vaspin Rs2236242 And Leptin Rs7799039 Polymorphism With Metabolic Syndrome In Egyptian Women, Amina Alnory, Hoda Gad, Gehan Hegazy, Olfat Shaker Jan 2016

The Association Of Vaspin Rs2236242 And Leptin Rs7799039 Polymorphism With Metabolic Syndrome In Egyptian Women, Amina Alnory, Hoda Gad, Gehan Hegazy, Olfat Shaker

Turkish Journal of Medical Sciences

Background/aim: Genetic predisposition is implicated in the etiology of metabolic syndrome. This study aimed to investigate the1397645907association of vaspin rs2236242 and leptin rs7799039 polymorphisms with their serum levels and with the risk of developing metabolic syndrome in Egyptian women.1397645907 Materials and methods: This case control study included 100 Egyptian women with metabolic syndrome and 100 without metabolic syndrome. The genotypes of vaspin rs2236242 and leptin rs7799039 were detected by a methodology based on PCR-RFLP. Serum vaspin and leptin levels were determined by ELISA. Results: The metabolic syndrome group was associated with higher serum vaspin and leptin levels when compared to …

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Interlukine-17 And Tgf-Ss Levels In Patients With Acute Brucellosisbefore And After Treatment, Masoomeh Sofian, Amitis Ramezani, Alia Mousavi, Mohammad Banifazl, Shima Cherei, Ali Cherei, Arezoo Aghakhani Jan 2016

Interlukine-17 And Tgf-Ss Levels In Patients With Acute Brucellosisbefore And After Treatment, Masoomeh Sofian, Amitis Ramezani, Alia Mousavi, Mohammad Banifazl, Shima Cherei, Ali Cherei, Arezoo Aghakhani

Turkish Journal of Medical Sciences

Background/aim: T-helper cell type 1 (Th1)/Th2 cytokine balance is involved in the resistance or susceptibility to Brucella infection. The analysis of cytokine levels is valuable to determine the role of the immune system in Brucella prognosis. The aim of this study was to investigate the levels of serum interleukin-17 (IL-17) and transforming growth factor beta (TGF-β) and their alterations with treatment in patients with acute brucellosis. Materials and methods: TGF-β was tested in 33 acute brucellosis patients and 19 controls and IL-17 was analyzed in 40 patients and 12 controls. Cytokine levels were tested in controls and patients before and …

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Serum Procalcitonin And C-Reactive Protein Kinetics As Indicators Of Treatmentoutcome In Hospitalized Patients With Community-Acquired Pneumonia, Mehmet Sezai̇ Taşbakan, Canan Gündüz, Abdullah Sayiner, Aykut Çi̇lli̇, Burcu Çelenk Karaboğa, Ayşin Şakar Coşkun, Feri̇de Durmaz Yaman, Oğuz Kilinç, Öznur Kiliç Soylar Jan 2016

Serum Procalcitonin And C-Reactive Protein Kinetics As Indicators Of Treatmentoutcome In Hospitalized Patients With Community-Acquired Pneumonia, Mehmet Sezai̇ Taşbakan, Canan Gündüz, Abdullah Sayiner, Aykut Çi̇lli̇, Burcu Çelenk Karaboğa, Ayşin Şakar Coşkun, Feri̇de Durmaz Yaman, Oğuz Kilinç, Öznur Kiliç Soylar

Turkish Journal of Medical Sciences

Background/aim: There has been growing interest in the use of serum procalcitonin (PCT) and C-reactive protein (CRP) in patients with community-acquired pneumonia (CAP). The aim of this study was to investigate whether an assessment of fever, leukocyte count, and serum CRP and PCT levels on admission and during follow-up (day 3) provides any information about the clinical outcome in hospitalized patients with CAP. Materials and methods: Patients with a diagnosis of CAP who were admitted to and followed at four university hospitals were evaluated retrospectively using the Turkish Thoracic Society Pneumonia Database. Results: A total of 103 hospitalized CAP patients …

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Factors Affecting Treatment Success In Community-Acquired Pneumonia, Canan Gündüz, Mehmet Sezai̇ Taşbakan, Abdullah Sayiner, Aykut Çi̇lli̇, Oğuz Kilinç, Ayşin Şakar Coşkun Jan 2016

Factors Affecting Treatment Success In Community-Acquired Pneumonia, Canan Gündüz, Mehmet Sezai̇ Taşbakan, Abdullah Sayiner, Aykut Çi̇lli̇, Oğuz Kilinç, Ayşin Şakar Coşkun

Turkish Journal of Medical Sciences

Background/aim: Treatment failure in hospitalized patients with community-acquired pneumonia is a major cause of mortality. The aim of this study was to evaluate the factors affecting treatment success in community-acquired pneumonia. Materials and methods: A total of 537 patients (mean age: 66.1 ± 15.8 years, 365 males) registered to the Turkish Thoracic Society Pneumonia Database were analyzed. Of these, clinical improvement or cure, defined as treatment success, was achieved in 477, whereas 60 patients had treatment failure and/or died. Results: Lower numbers of neutrophils (5989.9 ± 6237.3 vs. 8495.6 ± 7279.5/mm3), higher blood urea levels (66.1 ± 42.1 vs. 51.2 …

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Genotypic Analysis Of Escherichia Coli Strains That Cause Urosepsis In The Aegean Region, Betül Gi̇ray, Füsun Bahri̇ye Uçar, Sabi̇re Şöhret Aydemi̇r Jan 2016

Genotypic Analysis Of Escherichia Coli Strains That Cause Urosepsis In The Aegean Region, Betül Gi̇ray, Füsun Bahri̇ye Uçar, Sabi̇re Şöhret Aydemi̇r

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to characterize strains genotypically, to determine their phylogenetic relationships, to investigate the presence of the papG gene, and to compare their antibiotic susceptibility test results. Materials and methods: Seventy pathogenic E. coli strains were isolated from both urine and blood cultures of patients with the preliminary diagnosis of urosepsis who were referred to the Ege University Faculty of Medicine, Bacteriology Laboratory of Medical Microbiology Department in İzmir. All of these strains were examined for the papG gene and phylogenetic groups with the multiplex polymerase chain reaction technique. Pulsed-field gel electrophoresis and multilocus sequence …

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The Combined Effects Of Proteasome Inhibitor Bortezomib With Topoisomerase I And Ii Inhibitors On Topoisomerase Enzymes, Emi̇ne Öksüzoğlu, Çi̇ydem Tirinoğlu, Bariş Keri̇moğlu Jan 2016

The Combined Effects Of Proteasome Inhibitor Bortezomib With Topoisomerase I And Ii Inhibitors On Topoisomerase Enzymes, Emi̇ne Öksüzoğlu, Çi̇ydem Tirinoğlu, Bariş Keri̇moğlu

Turkish Journal of Medical Sciences

Background/aim: DNA topoisomerases are ubiquitous enzymes that regulate conformational changes in DNA topology during essential cellular processes, and, for this reason, have been characterized as the cellular targets of a number of anticancer drugs. Bortezomib is a powerful proteasome inhibitor used in the treatment of hematological malignancies. In this study, we investigated the inhibitory effects of bortezomib on human topoisomerase I and II enzymes both alone and in combination modes with camptothecin and etoposide. Materials and methods: The interactions of these drugs with topoisomerase enzymes were evaluated by relaxation assay in cell-free systems. IC50 values of the drugs on topoisomerase …

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Virulence Factors, Biofilm-Forming Ability, And Antimicrobial Resistance Of Urinary Escherichia Coli Strains Isolated From Hospitalized Patients, Barbara Kot, Jolanta Wicha, Agata Gruzewska, Malgorzata Piechota, Katarzyna Wolska, Maria Obrebska Jan 2016

Virulence Factors, Biofilm-Forming Ability, And Antimicrobial Resistance Of Urinary Escherichia Coli Strains Isolated From Hospitalized Patients, Barbara Kot, Jolanta Wicha, Agata Gruzewska, Malgorzata Piechota, Katarzyna Wolska, Maria Obrebska

Turkish Journal of Medical Sciences

Background/aim: Escherichia coli is the most frequent cause of urinary tract infections. We investigated the possible associations between the origin of strains, antimicrobial resistance, the presence of urovirulence factors, and biofilm-forming ability. Materials and methods: Antibiotic susceptibility of E. coli strains was tested by disk diffusion method. Hemagglutination assays were performed for phenotypic characterization of the cell surface. Multiplex PCR was used for detection of virulence genes and for determination of phylogenetic relationships. Results: The resistance to ampicillin (55.5%) and tetracycline (39.3%) was significantly more frequent than to other antimicrobial agents. The fim gene was present in 92.5% of strains. …

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Radon Concentration Measurements At A University Campus In Turkey, Melekşah Altinsöz, Emel Alğin, Celal Aşici, Haci Soğukpinar Jan 2016

Radon Concentration Measurements At A University Campus In Turkey, Melekşah Altinsöz, Emel Alğin, Celal Aşici, Haci Soğukpinar

Turkish Journal of Physics

In this study we measured radon (222Rn) concentrations in offices at the Meşelik campus of Eskişehir Osmangazi University to estimate the effective dose of 222Rn and its progeny for office occupants. The measurements were performed four times in 2011 over a period of 3 months using solid state nuclear track detectors (LR-115). A total of 381 LR-115 detectors were installed in 110 different offices, choosing three offices on each floor in the same building. 222Rn concentrations obtained in the first, second, third, and fourth measurement periods were 163 (73) Bq m-3, 77 (43) Bq m-3, and 164 (70) Bq m-3 …

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Treatment Of A Periodontic-Endodontic Lesion In A Patient With Aggressive Periodontitis, Mina D. Fahmy, Paul G. Luepke, Mohamed Ibrahim, Arndt Guentsch Jan 2016

Treatment Of A Periodontic-Endodontic Lesion In A Patient With Aggressive Periodontitis, Mina D. Fahmy, Paul G. Luepke, Mohamed Ibrahim, Arndt Guentsch

School of Dentistry Faculty Research and Publications

Case Description: This case report describes the successful management of a left mandibular first molar with a combined periodontic-endodontic lesion in a 35-year-old Caucasian woman with aggressive periodontitis using a concerted approach including endodontic treatment, periodontal therapy, and a periodontal regenerative procedure using an enamel matrix derivate. In spite of anticipated poor prognosis, the tooth lesion healed. This case report also discusses the rationale behind different treatment interventions. Practical Implication. Periodontic-endodontic lesions can be successfully treated if dental professionals follow a concerted treatment protocol that integrates endodontic and periodontic specialties. General dentists can be the gatekeepers in managing …

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An Integrated Analysis For Sustainable Supply Of Remote Winter Tourist Centers - A Future Concept Case Study, Ajla Merzic, Mustafa Music, Mirsad Rascic, Nijaz Hadzimejlic Jan 2016

An Integrated Analysis For Sustainable Supply Of Remote Winter Tourist Centers - A Future Concept Case Study, Ajla Merzic, Mustafa Music, Mirsad Rascic, Nijaz Hadzimejlic

Turkish Journal of Electrical Engineering and Computer Sciences

In every power system there are consumer areas away from traditional power networks. Existing grid expansion can always be treated as one of the ways of powering them over long transmission and distribution lines. This is often characterized by significant transmission losses, as well as significant investments, depending on the distance and the infrastructure development. On the other hand, there are cases when these consumers are not connected to the power system and use alternative methods of supply. For that matter, possible solutions may use locally available energy sources. In this paper, comparative analyses between independent power supply through particular …

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Time Series Adapted Supervised Fuzzy Discretization: An Application To Ecg Signals, Umut Orhan Jan 2016

Time Series Adapted Supervised Fuzzy Discretization: An Application To Ecg Signals, Umut Orhan

Turkish Journal of Electrical Engineering and Computer Sciences

In this study, a new method called supervised fuzzy discretization (SFD), which can be used without having expertise on data, is proposed for classifying time series datasets. Because an ECG signal has a partially stationary characteristic, its classification process is more difficult than it would be for completely stationary signals. On the other hand, because the method proposed can be used without having expertise on the data, comprehensive data like ECG signals are enough to introduce one such method. To prove the efficacy of the SFD, RR intervals selected from a common ECG database are used in the classification experiments. …

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An Advanced Optimization Technique For Considering Reliability Issues And Unit Commitment Problems Simultaneously, Ahmad Heidari, Mohammad Reza Alizadeh Pahlavani, Hamid Dehghani Jan 2016

An Advanced Optimization Technique For Considering Reliability Issues And Unit Commitment Problems Simultaneously, Ahmad Heidari, Mohammad Reza Alizadeh Pahlavani, Hamid Dehghani

Turkish Journal of Electrical Engineering and Computer Sciences

This paper presents an advanced optimization technique to solve unit commitment problems and reliability issues simultaneously for thermal generating units. To solve unit commitment, generalized Benders decomposition along with a genetic algorithm are proposed to include minimum up/down time constraints, and for reliability issues consideration, a fuzzy stochastic-based technique is presented. To implement the problem into an optimization program, MATLAB software and CPLEX and KNITRO solvers are applied. To verify the proposed technique and algorithm, two case studies, the IEEE 14- and 118-bus systems, are implemented for optimal generation scheduling and reliability issues. Finally, a comparison with other solution techniques …

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Comparative Performance Evaluation Of Blast Furnace Flame Temperature Prediction Using Artificial Intelligence And Statistical Methods, Yasi̇n Tunçkaya, Etem Köklükaya Jan 2016

Comparative Performance Evaluation Of Blast Furnace Flame Temperature Prediction Using Artificial Intelligence And Statistical Methods, Yasi̇n Tunçkaya, Etem Köklükaya

Turkish Journal of Electrical Engineering and Computer Sciences

The blast furnace (BF) is the heart of the integrated iron and steel industry and used to produce melted iron as raw material for steel. The BF has very complicated process to be modeled as it depends on multivariable process inputs and disturbances. It is very important to minimize operational costs and reduce material and fuel consumption in order to optimize overall furnace efficiency and stability, and also to improve the lifetime of the furnace within this task. Therefore, if the actual flame temperature value is predicted and controlled properly, then the operators can maintain fuel distribution such as oxygen …

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An Application Of Simulated Annealing To Optimal Transcranial Direct Current Stimulation Of The Human Brain, Raheleh Tavakoli, Hamed Sadjedi, Seyyed Mohammad Pourmir Firoozabadi Jan 2016

An Application Of Simulated Annealing To Optimal Transcranial Direct Current Stimulation Of The Human Brain, Raheleh Tavakoli, Hamed Sadjedi, Seyyed Mohammad Pourmir Firoozabadi

Turkish Journal of Electrical Engineering and Computer Sciences

Transcranial direct current stimulation (tDCS) is known as the most effective technique for stimulating deeper brain areas. The capability of tDCS, however, strongly depends on the number of electrodes, their positions, and the amount of injected currents. This paper intends to apply the simulated annealing algorithm for determining optimal stimulation parameters in a multiple electrode scheme. The objective of the presented approach is to maximize the current density delivered to the target area under safety constraints. In order for the skin under the electrodes to be protected against temperature rises that may be caused by the stimulation, current injections are …

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Performance Analysis Of Biogeography-Based Optimization For Automatic Voltage Regulator System, Uğur Güvenç, Ali̇ Hakan Işik, Tuncay Yi̇ği̇t, İbrahi̇m Akkaya Jan 2016

Performance Analysis Of Biogeography-Based Optimization For Automatic Voltage Regulator System, Uğur Güvenç, Ali̇ Hakan Işik, Tuncay Yi̇ği̇t, İbrahi̇m Akkaya

Turkish Journal of Electrical Engineering and Computer Sciences

A self-tuning method to determine the appropriate parameters of a proportional-integral-derivative controller for an automatic voltage regulator (AVR) system using a biogeography-based optimization (BBO) algorithm is proposed in this study. The BBO algorithm was developed based on the theory of biogeography, which describes migration and its results. We propose that the BBO algorithm has a high-quality solution and stable convergence characteristics, and thus it improves the transient response of the controlled system. The performance of the BBO algorithm depends on the transient response, root locus, and Bode analysis. Robustness analysis is done in the AVR system, which is tuned by …

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