Digital Commons Network^™

Steps Towards Personalized Learning Using Online Asynchronous Technology: A Study Of 7th, 10th And 12th Graders At A Small Rural School In Massachusetts, Michael Raymond Farmer

Educational Studies Dissertations

Adolescents’ use of technology is an integral part of their lives. They use it for communicating, archiving, socialization, identity exploration, and a range of other purposes. As a tool for adolescent academic learning, contemporary technologies target the brain’s recognition, strategic, and affective networks. Synthesizing adolescents’ affinity for technology with proven educational practices, knowledge of the brain’s workings, and an understanding of contemporary technologies’ capabilities, leads to the conclusion that technology-enabled personalized learning approaches can result in successful outcomes for students. This dissertation outlines findings from a 6-week mixed-methods study of 7th-, 10th-, and 12th-grade students attending a small rural school …

Understanding Students' Chosen Literacy Practices During Non-Academic Times: An Ethnographic Teacher-Research Inquiry, Justin Robert Moyer

Educational Studies Dissertations

This dissertation aims to illuminate the literacy practices that a group of “struggling” students undertake during unstructured times of the school day. The study aims to extend prior theoretical work on literacy (Street, 1984; Weil, 1993; Luttrell & Parker, 2001; Kinloch, 2010; among others) to identify the ways these students engage in literacy practices for deeply personal reasons. Further, this dissertation intends to dispel some of the many myths that surround students in special education settings and, in the case of the focal students in this study, alternative schools. Students reveal: (1) the literacy practices in which they participate, (2) …

Genotoxic Effects Of Magnesium Deficiency In The Cardiovascular System And Their Relationships To Cardiovascular Diseases And Atherogenesis, Burton M. Altura, Nilank C. Shah, Gatha J. Shah, Bella T. Altura

The School of Health Sciences Publications and Research

The authors present evidence for a novel, new hypothesis whereby magnesium deficiency (MgD) acts as a genotoxic agent which probably causes numerous, hertofore, unrecognized consequences, even over a short-term, on the physiological, molecular and biochemical machinery of cardiovascular tissues and cells. The end result of these genotoxic effects of MgD probably plays important roles in the etiology and generation of diverse cardiovascular diseases, atherosclerosis, inflammation, and strokes via alterations in the epigenome of cardiovascular tissues and cells. The importance of adequate water-borne and dietary levels of Mg is emphasized.

The Expression Of Platelet-Activating Factor Is Induced By Low Extracellular Mg2+ In Aortic, Cerebral And Neonatal Coronary Vascular Smooth Muscle; Cross Talk With Ceramide Production, Nf–Kb And Proto-Oncogenes: Possible Links To Atherogenesis And Sudden Cardiac Death In Children And Infants, And Aging: Hypothesis, Review And Viewpoint, Burton M. Altura, Wenyan Li, Aimin Zhang, Tao Zheng, Nilank C. Shah, Gatha J. Shah, Bella T. Altura

The School of Health Sciences Publications and Research

An attempt is made, herein, to reconcile, and integrate, various phenomena associated with magnesium deficiency (MgD) in cardiovascular health, disease, and aging as well as reasons for the high incidence of sudden cardiac death in infants and young adults. With new experiments, we demonstrate, for the first time, that very low concentrations of platelet-activating factor (PAF), when added to primary cultured cerebral, neonatal coronary, and aortic vascular smooth muscle (VSM) cells (from three different mammals) promote rapid rises in free intracellular Ca2+ ions and a significant, concomitant reduction in free intracellular Mg2+ ions; these actions of PAF being curtailed with …

Magnesium Deficiency Results In Oxidation And Fragmentation Of Dna, Down Regulation Of Telomerase Activity, And Ceramide Release In Cardiovascular Tissues And Cells: Potential Relationship To Atherogenesis, Cardiovascular Diseases And Aging, Burton M. Altura, Nilank C. Shah, Gatha J. Shah, Jose Luis Perez-Albela, Bella T. Altura

The School of Health Sciences Publications and Research

The authors discuss the potential relationship between magnesium, cardiovascular diseases, and aging.

Potential Roles Of Magnesium Deficiency In Inflammation And Atherogenesis: Importance And Cross-Talk Of Platelet-Activating Factor And Ceramide, Burton M. Altura, Asefa Gebrewold, Nilank C. Shah, Gatha J. Shah, Bella T. Altura

The School of Health Sciences Publications and Research

Epidemiologic studies in North America and Europe have shown that people consuming Western-type diets are low in magnesium (Mg) content (i.e., < 30 - 65% of the RDA for Mg); most such diets in the USA show that 60 - 80% of Americans are consuming only 185 - 235 mg/day of Mg. Low Mg content in areas of soft-water, and Mg-poor soil, is associated with high incidences of ischemic heart disease (IHD), coronary artery disease, hypertension, and sudden cardiac death (SCD). It is clear that the leading underlying cause of death worldwide is atherosclerosis. Importantly, both animal and human studies have shown an inverse relationship between dietary intake of Mg and atherosclerosis. The myocardial level of Mg has consistently been observed to be lower in subjects dying from IHD and SCD in soft-water areas than those in hard-water areas. Over the past 20 years, our laboratories, using several types of primary cultured vascular smooth muscle (VSM) cells, and myocardial cells, demonstrated that declining levels of extracellular Mg ([Mg2+]0) activated several enzymatic pathways to produce increases in cellular sphingolipids, particularly ceramides which are known to exert numerous types of cardiovascular manifestations including inflammatory effects; the latter play important roles in atherogenesis and cardiovascular diseases. Approximately 20 years ago, we reported that low [Mg2+]0 caused formation of platelet-activating factor (PAF) as well as other types of PAF-like molecules and suggested that these molecules might be causative agents in low Mg2+- induced IHD and SCD. Herein, we review results and data from our labs which strongly support roles for ceramides, PAF and PAF-like lipids in low [Mg2+]0-induced IHD and SCD.

Sudden Cardiac Death In Infants, Children And Young Adults: Possible Roles Of Dietary Magnesium Intake And Generation Of Platelet-Activating Factor In Coronary Arteries, Burton M. Altura, Wenyan Li, Aimin Zhang, Tao Zheng, Nilank C. Shah, Gatha J. Shah, Bella T. Altura

The School of Health Sciences Publications and Research

Magnesium (Mg) is a co-factor for more than 500 enzymes, and is the second most abundant intracellular cation after potassium. It is vital in numerous physiological, cellular and biochemical functions and systems necessary for life. Approximately 35 years ago, our laboratory suggested that a progressive, dietary deficiency and/or metabolic induced loss of Mg from the body, beginning early in life, particularly during development of the coronary arteries, could lead to coronary arterial vasospasm, ischemic heart disease, and sudden-cardiac death (SCD). Herein, we review evidence for a brand-new, novel hypothesis which combines knowledge suggesting a combined role for hypomagnesemia and platelet-activating …

Development And Implementation Of A Medication Adherence Protocol In A Community Free Clinic, Angela L. Caires

Doctor of Nursing Practice (DNP)

Medication adherence occurs when patients take prescribed medications as directed by their healthcare provider and is critical to patient outcomes in clinical settings. Nonadherence has been linked to disease progression, increased hospitalizations, and poor quality of life. This scholarly project was developed to improve patient adherence with prescribed medications in a community free clinic setting. A review of current literature demonstrated that delivery of patient education regarding medications by using more than one teaching format may improve patient adherence. Project participants were selected from current patients of the Community Free Clinic in Huntsville, Alabama. Thirty patients participated in the project, …

Social Media And Credibility Indicator: The Effects Of Bandwagon And Identity Cues Within Online Health And Risk Contexts, Xialing Lin

Theses and Dissertations--Communication

Three studies were conducted to investigate how social media affordances influence individuals’ source credibility perceptions in risk situations. The MAIN model (Sundar, 2008), warranting theory (Walther & Parks, 2002), and signaling theory (Donath, 1999) served as the theoretical framework to examine the effects of bandwagon cues and identity cues embedded in retweets and users’ profile pages for health and risk online information processing. Study One examines whether bandwagon heuristics triggered by retweets would influence individuals’ source credibility judgments. Study Two investigates how bandwagon heuristics interact with different identity heuristics in credibility heuristics on an individual level. Study Three explores bandwagon …

The Idea Model: Designing Earthquake Early Warning Messages Using Instructional Risk Communication, Nigel D. Haarstad

Theses and Dissertations--Communication

The goal of risk communication is to inform people about the risks they face and to encourage them to take appropriate action in response to that threat. To achieve this goal, risk communication scholars continuously examine the messages surrounding crises and disasters, and engage in message-testing to evaluate theory-driven message designs. Recent communication scholarship recommends that messages should including instructing information (Coombs, 2012), and should take into consideration established pedagogy based on instructional communication research (Sellnow & Sellnow, 2010). This dissertation continues to build on research which applies instructional communication scholarship to risk communication messaging. Using message-testing, this dissertation examined …

Chaos Theory And Emergent Behavior: How Ephemeral Organizations Function As Strange Attractors Through Information Communication Technologies, Morgan C. Getchell

Theses and Dissertations--Communication

Chaos theory holds that systems act in unpredictable nonlinear ways and that their behavior can only be observed, never predicted. This is an informative model for an organization in crisis. The West Virginia water contamination crisis, which began on January 9, 2014, fits the criteria of a system in chaos. Given the lack of appropriate response from the established organizations involved, many emergent organizations formed to help fill unmet informational and physical needs of the affected population. Crisis researchers have observed these ephemeral organizations for decades, but the recent proliferation of information communication technologies (ICT’s) have made their activities more …

Do Black Lives Matter In American Mainstream News Media? Two Case Studies Of Police-Involved Shootings Of Black Men Explaining A Racist Media Environment, Alfred J. Cotton Iii

Theses and Dissertations--Communication

This dissertation examines two cases of fatal police-involved shootings of Black men in order to expose the power structures perpetuated through racist media narratives assuming the officers’ behavior was justified and the unarmed men the officers killed somehow were complicit in their death. In reporting on police-involved shootings, mainstream media practices that privilege elites and officials as primary sources of information may produce a dominant media narrative that masks the marginalization and mistreatment of minorities at the hands of these officials and their institutions. The two cases under consideration here examine the “floating signifier” of race in media coverage of …

Communicating Social Support: Understanding Complexities Of Breastfeeding Communication Among African American Mothers, Nicole Rachael Peritore

Theses and Dissertations--Communication

Breast milk is the best choice for meeting the nutritional needs for an infant whenever possible. Despite the knowledge that this nutritional choice is the best choice for an infant, data demonstrates that there is a sharp decline in the rates of breastfeeding mothers. Among African Americans, breastfeeding rates are significantly lower than the national averages. Despite many of the applications of social support in communication research, there is a gap in knowledge on the social support systems in the context of breastfeeding, especially for African Americans. With the social ecological model as a framework, social support theory provides understanding …

The Global Struggle For Lgbtq Rights: Legal, Political, And Social Dimensions, Macarena Saez

Scholarly Articles in Law Reviews & Journals

No abstract provided.

Cerebellar Nuclei Neurons Show Only Small Excitatory Responses To Optogenetic Olivary Stimulation In Transgenic Mice: In Vivo And In Vitro Studies, Huo Lu, Bo Yang, Dieter Jaeger

PCOM Scholarly Works

BACKGROUND: To study the olivary input to the cerebellar nuclei (CN) we used optogenetic stimulation in transgenic mice expressing channelrhodopsin-2 (ChR2) in olivary neurons. We obtained in vivo extracellular Purkinje cell (PC) and CN recordings in anesthetized mice while stimulating the contralateral inferior olive (IO) with a blue laser (single pulse, 10 - 50 ms duration). Peri-stimulus histograms were constructed to show the spike rate changes after optical stimulation. Among 29 CN neurons recorded, 15 showed a decrease in spike rate of variable strength and duration, and only 1 showed a transient spiking response. These results suggest that direct olivary …

Immune Complex-Induced, Nitric Oxide-Mediated Vascular Endothelial Cell Death By Phagocytes Is Prevented With Decoy Fcyreceptors, Ramanjaneya V. R. Mula, Deepa Machiah, Lauren Holland, Xinyu Wang, Harish Parihar, Avadhesh Sharma, Periasamy Selvaraj, Rangaiah Shashidharamurthy

PCOM Scholarly Works

Autoimmune vasculitis is an endothelial inflammatory disease that results from the deposition of immune-complexes (ICs) in blood vessels. The interaction between Fcgamma receptors (FcyRs) expressed on inflammatory cells with ICs is known to cause blood vessel damage. Hence, blocking the interaction of ICs and inflammatory cells is essential to prevent the IC-mediated blood vessel damage. Thus we tested if uncoupling the interaction of FcyRs and ICs prevents endothelium damage. Herein, we demonstrate that dimeric FcyR-Igs prevented nitric oxide (NO) mediated apoptosis of human umbilical vein endothelial cells (HUVECs) in an in vitro vasculitis model. Dimeric FcyR-Igs significantly inhibited the IC-induced …

Apocynin Exerts Dose-Dependent Cardioprotective Effects By Attenuating Reactive Oxygen Species In Ischemia/Reperfusion, Qian Chen, Woodworth C. Parker, Issachar Devine, Regina Ondraskik, Tsion Habtamu, Kyle Bartol, Brendan Casey, Harsh Patel, William Chau, Tarah Kuhn

PCOM Scholarly Works

Ischemia/reperfusion results in cardiac contractile dysfunction and cell death partly due to increased reactive oxygen species and decreased endothelial-derived nitric oxide bioavailability. NADPH oxidase normally produces reactive oxygen species to facil

Metformin Represses Bladder Cancer Progression By Inhibiting Stem Cell Repopulation Via Cox2/Pge2/Stat3 Axis, Q. Liu, W. Yuan, D. Tong, G. Liu, W. Lan, Diangzheng Zhang, H. Xiao, Y. Zhang, J. Yang, J. Zhang

PCOM Scholarly Works

Cancer stem cells (CSCs) are a sub-population of tumor cells playing essential roles in initiation, differentiation, recurrence, metastasis and development of drug resistance of various cancers, including bladder cancer. Although multiple lines of evidence suggest that metformin is capable of repressing CSC repopulation in different cancers, the effect of metformin on bladder cancer CSCs remains largely unknown. Using the N-methyl-N-nitrosourea (MNU)-induced rat orthotropic bladder cancer model, we demonstrated that metformin is capable of repressing bladder cancer progression from both mild to moderate/severe dysplasia lesions and from carcinoma in situ (CIS) to invasive lesions. Metformin also can arrest bladder cancer cells …

Pharmacological Activity Of Costus Spicatus In Experimental Bothrops Atrox Envenomation, Leide Caroline Dos Santos Picanço, José Adolfo Homobono Machado Bittencourt, Shayanne Vanessa Correia Henriques, Juliane Silva Da Silva, Juliana Maria Da Silva Oliveira, José Renato Ribeiro, Antony-Babu Sanjay, José Carlos Tavares Carvalho, Didier Stien, Jocivânia Oliveira Da Silva

Department of Food Science and Technology: Faculty Publications

Context: Medicinal plants encompass a rich source of active compounds that can neutralize snake venoms or toxins. Costus spicatus (Jacq.) Sw. (Costaceae) is used by the Amazonian population to treat inflammation, pain and other pathological manifestations.

Objective: To evaluate the influence of C. spicatus aqueous extract on edema, peritonitis, nociception, coagulation, haemorrhage and indirect haemolytic activity induced by Bothrops atrox venom (BAV).

Materials and methods: Dried and pulverized leaves were extracted with distilled water. Envenoming was induced by administration of B. atrox snake venom in Swiss Webster mice. The experimental groups consisted of BAV (at the minimum dose to induce …

Fibronectin Deposition Participates In Extracellular Matrix Assembly And Vascular Morphogenesis, Abigail Hielscher, Kim Ellis, Connie Qiu, Josh Porterfield, Sharon Gerecht

PCOM Scholarly Works

The extracellular matrix (ECM) has been demonstrated to facilitate angiogenesis. In particular, fibronectin has been documented to activate endothelial cells, resulting in their transition from a quiescent state to an active state in which the cells exhibit enhanced migration and proliferation. The goal of this study is to examine the role of polymerized fibronectin during vascular tubulogenesis using a 3 dimensional (3D) cell-derived de-cellularized matrix. A fibronectin-rich 3D de-cellularized ECM was used as a scaffold to study vascular morphogenesis of endothelial cells (ECs). Confocal analyses of several matrix proteins reveal high intra- and extra-cellular deposition of fibronectin in formed vascular …

The Link Between Smoking, Lung Cancer And Socioeconomic Factors In Kentucky, Shreya Berlia

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Background and Purpose

Lung cancer is the leading cause of cancer death and the second most diagnosed cancer in both men and women in the United States. An estimated 158,080 deaths from lung cancer are expected to occur in 2016, which will account for approximately 1 in 4 of all cancer deaths. The 1- and 5-year relative survival rates for lung cancer are 44% and 17%, respectively. The incidence rate for lung cancer has been declining since the mid-1980s in men, but only since the mid-2000s in women. Tobacco smoke is the leading cause of preventable disease and death in …

Prospects Of Genomic Prediction In The Usda Soybean Germplasm Collection: Historical Data Creates Robust Models For Enhancing Selection Of Accessions, Diego Jarquin, James Specht, Aaron Lorenz

Department of Agronomy and Horticulture: Faculty Publications

The identification and mobilization of useful genetic variation from germplasm banks for use in breeding programs is critical for future genetic gain and protection against crop pests. Plummeting costs of next-generation sequencing and genotyping is revolutionizing the way in which researchers and breeders interface with plant germplasm collections. An example of this is the high density genotyping of the entire USDA Soybean Germplasm Collection. We assessed the usefulness of 50K SNP data collected on 18,480 domesticated soybean (G. max) accessions and vast historical phenotypic data for developing genomic prediction models for protein, oil, and yield. Resulting genomic prediction models explained …

Corn (Zea Mays L.) Seeding Rate Optimization In Iowa, Usa, Mark A. Licht, Andrew W. Lenssen, Roger W. Elmore

Department of Agronomy and Horticulture: Faculty Publications

Collecting soil, topography, and yield information has become more feasible and reliable with advancements in precision technologies. Combined with the accessibility of precision technologies and services to farmers, there has been increased interest and ability to make site-specific crop management decisions. The objective of this research was to develop procedures to optimize corn seeding rates and maximize yield using soil and topographic parameters. Experimental treatments included five seeding rates (61 750; 74 100; 86 450; 98 800; and 111 150 seeds ha^-1) in a randomized complete block design in three central Iowa fields from 2012 to 2014 (nine …

Effect Of Dietary Supplementation With Different Levels Of Inulin-Typefructans On Renal Expression Of Aquaporin 2 Of Growing Piglets, Katarzyna Michalek, Marta Grabowska, Mariusz Skowronski, Adam Lepczynski, Agnieszka Herosimczyk, Maria Laszczynska

Turkish Journal of Veterinary & Animal Sciences

The purpose of this study was to identify and investigate the expression of aquaporin 2 (AQP2) in the renal tubules of growing piglets fed with different levels of inulin-type fructans. The experiment was performed on five groups of PIC x Penarlan P76 crossbred piglets fed with the following diets: standard diet (control group) and standard diet supplemented with 1% (group I), 2% (group II), and 3% (group III) of water extract of chicory root inulin-type fructans. The animals from the group IV were fed with standard diet supplemented with 4% dried chicory roots. To analyze immunolocalization and expression of AQP2 …

A Comparison Of Rule-Based Analysis With Regression Methods In Understanding The Risk Factors For Study Withdrawal In A Pediatric Study, Mona Haghighi, Suzanne B. Johnson, Xiaoning Qian, Kristian F. Lynch, Kendra Vehik, Shuai Huang, The Teddy Study Group

Industrial and Management Systems Engineering Faculty Publications

Regression models are extensively used in many epidemiological studies to understand the linkage between specific outcomes of interest and their risk factors. However, regression models in general examine the average effects of the risk factors and ignore subgroups with different risk profiles. As a result, interventions are often geared towards the average member of the population, without consideration of the special health needs of different subgroups within the population. This paper demonstrates the value of using rule-based analysis methods that can identify subgroups with heterogeneous risk profiles in a population without imposing assumptions on the subgroups or method. The rules …

Metapopulation Viability Of Swamp Rabbits In Southern Illinois: Potential Impacts Of Habitat Change, Christopher D. Robinson, Joanne C. Crawford, Lyann Corcoran, Eric M. Schauber, Clayton K. Nielsen

Publications

Swamp rabbits (Sylvilagus aquaticus) in southern Illinois exist as a metapopulation due to fragmentation of the bottomland hardwood forests in which they live. This fragmentation makes their persistence in Illinois uncertain. We used population viability analysis (PVA) to estimate the probability of persistence of the swamp rabbit metapopulation in Illinois, using a habitat suitability map we created and life history parameters drawn from the literature. We varied the parameters used in our PVA from 50% to 150% of the initial value to compare their effects on extinction risk and to direct future management and research. We tested the …

Enhanced Cognition And Hypoglutamatergic Signaling In A Growth Hormone Receptor Knockout Mouse Model Of Successful Aging., Kevin N Hascup, Mary K Lynn, Patrick J Fitzgerald, Shari Randall, John J Kopchick, Heather A Boger, Andrzej Bartke, Erin R Hascup

Articles

Growth hormone receptor knockout (GHR-KO) mice are long lived with improved health span, making this an excellent model system for understanding biochemical mechanisms important to cognitive reserve. The purpose of the present study was to elucidate differences in cognition and glutamatergic dynamics between aged (20- to 24-month-old) GHR-KO and littermate controls. Glutamate plays a critical role in hippocampal learning and memory and is implicated in several neurodegenerative disorders, including Alzheimer's disease. Spatial learning and memory were assessed using the Morris water maze (MWM), whereas independent dentate gyrus (DG), CA3, and CA1 basal glutamate, release, and uptake measurements were conducted in …

2016-2017 Southern Illinois University Bulletin Carbondale Campus (Graduate Catalog), Southern Illinois University Carbondale

SIU Bulletins and Course Catalogs Archives

No abstract provided.

2016-2017 Southern Illinois University Bulletin Carbondale Campus (Undergraduate Catalog), Southern Illinois University Carbondale

SIU Bulletins and Course Catalogs Archives

No abstract provided.

Asbury Theological Seminary Academic Catalog : 2016-2017, Asbury Theological Seminary

Academic Catalogs

No abstract provided.