Digital Commons Network^™

Research Advance On Antioxidant Active Composition And Antioxidant Mechanisms Of Edible Fungi, Xiao Xingning, Yuan Ya, Liao Xia, Wang Liying, Shi Fang, Ming Jian

Food and Machinery

Edible fungi are tasty as well as full of all kinds of biological activity, and the antioxidation is one of the most important activities among them. Polysaccharides, polyphenols, terpenoids,and selenium are the major antioxidants of edible fungi. In this paper, it was reviewed the research advance of antioxidant substances and the antioxidant mechanism of edible fungi, and the future research direction was also summarized, aiming to develop and utilize edible and medicinal values of the polysaccharides in the futher, and improve its application in the fields of food and medicine.

Effects Of Extraction Methods On The Biological Activity Of Plant Polysaccharides, Huang Rengui, Liu Jia

Food and Machinery

Plant polysaccharides are natural biological active substances, and possess a series of biological activities, including anti-tumor, immune regulation, lowering blood fat, lowering blood sugar, anti oxidation, anti-fatigue. The activities of polysaccharides are influenced by their species, parts, extraction methods and other factors. In order to provide a theoretical reference for the development and utilization of plant polysaccharides, the research status of them and the effects of extraction methods on their biological activities were reviewed in this paper.

University Student-Athletes’ Experiences Of Facilitators And Barriers To Contribution: A Narrative Account, Colin J. Deal, Martin Camiré

The Qualitative Report

University student-athletes’ contributions in the form of volunteering, community engagement, and civic engagement have been the subject of recent research; however, no studies have specifically examined the factors that facilitate or serve as barriers to contribution in this population. As such, the purpose of this study is to explore the facilitators and barriers relating to university student-athletes’ contributions. Individual semi-structured interviews were conducted with eight university student-athletes (two males, six females) between 18 and 21 years of age (M = 19.25) from two Canadian universities. The analysis led to the identification of two qualitatively distinct profiles regarding how facilitators and …

Direct Evidence For Microbial-Derived Soil Organic Matter Formation And Its Ecophysiological Controls, Cynthia M. Kallenbach, Serita D. Frey, A. Stuart Grandy

Faculty Publications

Soil organic matter (SOM) and the carbon and nutrients therein drive fundamental submicron- to global-scale biogeochemical processes and influence carbon-climate feedbacks. Consensus is emerging that microbial materials are an important constituent of stable SOM, and new conceptual and quantitative SOM models are rapidly incorporating this view. However, direct evidence demonstrating that microbial residues account for the chemistry, stability and abundance of SOM is still lacking. Further, emerging models emphasize the stabilization of microbial-derived SOM by abiotic mechanisms, while the effects of microbial physiology on microbial residue production remain unclear. Here we provide the first direct evidence that soil microbes produce …

Modern Critiques Of Judicial Empathy: A Revised Intellectual History, Brenner M. Fissell

Faculty Publications

The role of “empathy” haunts recent debates about how judges make decisions. Remarkably, however, the intellectual origins of scholarly resistance to empathic judging remain poorly understood. This Article fills that gap. Through historical and theoretical study, it reveals the ways in which the modern anti-emphatic consensus can be seen as a mutated descendent of late-nineteenth century formalism. This Article also marks an irony with significant implications for the empathy debate: Although the anti-empathic view was born of formalism, it has drifted from its source such that it would almost certainly be condemned by the very formalist scholars from whom it …

Grain-Size Distributions On High Energy Sandy Beaches And Their Relation To Wave Dissipation, Sam Prodger, Paul Russell, Mark Davidson

School of Biological and Marine Sciences

No abstract provided.

Coastal Ocean And Shelf-Sea Biogeochemical Cycling Of Trace Elements And Isotopes: Lessons Learned From Geotraces, Matthew A. Charette, Phoebe J. Lam, Maeve C. Lohan, Eun Young Kwon, Vanessa Hatje, Catherine Jeandel, Alan M. Shiller, Gregory A. Cutter, A Thomas, Philip W. Boyd, William B. Homoky, Angela Milne, H Thomas, Per S. Andersson, Don Porcelli, Takahiro Tanaka, Walter Geibert, Frank Dehairs, Jordi Garcia-Orellana

School of Geography, Earth and Environmental Sciences

Continental shelves and shelf seas play a central role in the global carbon cycle. However, their importance with respect to trace element and isotope (TEI) inputs to ocean basins is less well understood. Here, we present major findings on shelf TEI biogeochemistry from the GEOTRACES programme as well as a proof of concept for a new method to estimate shelf TEI fluxes. The case studies focus on advances in our understanding of TEI cycling in the Arctic, transformations within a major river estuary (Amazon), shelf sediment micronutrient fluxes and basin-scale estimates of submarine groundwater discharge. The proposed shelf flux tracer …

Medical School Watercooler Newsletter - November 27, 2016, Lindsey Lyle

Watercooler Newsletter

This is the November 27, 2016 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Latest Issue of CURRents Available Now
• University Physicians Group Recognized
• USA Welcomes Dr. Katie Malozzi
• USA Medical Student Serves as Representative at American Academy of Pediatrics Conference

Gruber Explores The Living Lights Of The Oceans., Aldemaro Romero Jr.

Publications and Research

The ocean waters are full of creatures that produce light, from microscopic organisms to sharks and marine turtles. Sometimes human vision is not prepared to detect it, but that does not mean such phenomena, known as bioluminescence and biofluorescence, are unimportant.

“There’s so many different ways in which life perceives light, and trying to get inside these animals, to get behind their eyes, is almost like walking in someone else’s shoes,” says Dr. David Gruber, an associate professor of biology at Baruch College in New York City. “It’s like being someone else for a day.”

Husserl’S Concept Of Position-Taking And Second Nature, Alejandro Arango

Philosophy Faculty Scholarship

I argue that Husserl’s concept of position-taking, Stellungnahme, is adequate to understand the idea of second nature as an issue of philosophical anthropology. I claim that the methodological focus must be the living subject that acts and lives among others, and that the notion of second nature must respond to precisely this fundamental active character of subjectivity. The appropriate concept should satisfy two additional desiderata. First, it should be able to develop alongside the biological, psychological, and social individual development. Second, it should be able to underlie the vast diversity of human beings within and across communities. As possible candidates, …

Diminished Quality Of Life Among Women Affected By Ebola, Jessi Hanson, Alexis Decosimo, Megan Quinn

Journal of Social, Behavioral, and Health Sciences

This article analyzes data collected from Liberian women afflicted by the Ebola virus disease, survivors of the virus and noninfected persons living in Ebola-affected homes. This research is one of the first statistical analyses examining factors diminishing quality of life: negative experiences, stigma, and psychosocial symptoms among females affected by the virus after the outbreak. The research presents a thorough literature review, including research related to other infectious diseases like HIV/AIDS, to inform the gap in studies on Ebola’s effects on quality of life. Women who are Ebola virus disease survivors demonstrate significant differences in stigma and psychosocial stress when …

Quantifying An Aquifer Nitrate Budget And Future Nitrate Discharge Using Field Data From Streambeds And Well Nests, Troy E. Gilmore, David P. Genereux, Kathleen M. Farrell, Helena Mitasova

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Novel groundwater sampling (age, flux, and nitrate) carried out beneath a streambed and in wells was used to estimate (1) the current rate of change of nitrate storage, dS_NO3 /dt, in a contaminated unconfined aquifer, and (2) future [NO₃^–]_FWM (the flow-weighted mean nitrate concentration in groundwater discharge) and f_NO3 (the nitrate flux from aquifer to stream). Estimates of dS_NO3 /dt suggested that at the time of sampling (2013) the nitrate storage in the aquifer was decreasing at an annual rate (mean = –9 mmol/m²yr) equal …

Desidero Ergo Sum (I Desire Therefore I Am): Towards A Psychoanalytic Reading Of The Advertising Of Perfume, Eugene O'Brien

Irish Communication Review

No abstract provided.

It's Just One Of Those Gender Role Things: The Woman Does The Shopping, And The Man Fixes The Doors: Irish Advertising Students And Postfeminist Gendered Discourses, Aileen O'Driscoll

Irish Communication Review

In 2010 the European Commission published a report outlining its official position on ‘Breaking gender stereotypes in Media’ thereby explicitly recognising that advertising’s dissemination of images that depict gender stereotyping works to uphold gender inequalities. In addition, the European Coalition against Media Sexism (WECAMS) has engaged with the European Parliament and the European Advertising Standards Alliance in a bid to open up discussion on the possibility for standardising guidelines aimed at tackling and preventing sexism and gender stereotyping in advertising. Furthermore, over a more than forty-year history feminist media research has consistently pointed to problematic gendered imagery in advertising texts …

Biliverdin Reductase A Attenuates Hepatic Steatosis By Inhibition Of Glycogen Synthase Kinase (Gsk) 3Β Phosphorylation Of Serine 73 Of Peroxisome Proliferator-Activated Receptor (Ppar) Α, Terry D. Hinds, Katherine A. Burns, Peter Hosick, Lucien Mcbeth, Andrea Nestor-Kalinoski, Heather A. Drummond, Abdulhadi A. Alamodi, Michael W. Hankins, John P. Vanden Heuvel, David E. Stec

Department of Exercise Science and Physical Education Scholarship and Creative Works

Non-alcoholic fatty liver disease is the most rapidly growing form of liver disease and if left untreated can result in non-alcoholic steatohepatitis, ultimately resulting in liver cirrhosis and failure. Biliverdin reductase A (BVRA) is a multifunctioning protein primarily responsible for the reduction of biliverdin to bilirubin. Also, BVRA functions as a kinase and transcription factor, regulating several cellular functions. We report here that liver BVRA protects against hepatic steatosis by inhibiting glycogen synthase kinase 3β (GSK3β) by enhancing serine 9 phosphorylation, which inhibits its activity. We show that GSK3β phosphorylates serine 73 (Ser(P)73) of the peroxisome proliferator-activated receptor α (PPARα), …

Temporary Nerve Block At Selected Digits Revealed Hand Motor Deficits In Grasping Tasks, Aude Cateron, Kerry Mcpartlan, Christina Gioeli, Emily Reid, Matt Turturro, Barry Hahn, Cynthia Benson, Wei Zhang

Publications and Research

Peripheral sensory feedback plays a crucial role in ensuring correct motor execution throughout hand grasp control. Previous studies utilized local anesthesia to deprive somatosensory feedback in the digits or hand, observations included sensorimotor deficits at both corticospinal and peripheral levels. However, the questions of how the disturbed and intact sensory input integrate and interact with each other to assist the motor program execution, and whether the motor coordination based on motor output variability between affected and non-affected elements (e.g., digits) becomes interfered by the local sensory deficiency, have not been answered. The current study aims to investigate the effect of …

Interfaith-Cross-Cultural Improvisation: Music And Meaning Across Boundaries Of Faith And Culture, Gerard J. Yun

Consensus

This article explores the social value and meaning of interfaith-cross-cultural improvisation (musical improvisation between people from differing cultural and faith traditions) and its unique quality of engaging widely different cultural and faith-based groups. It draws concepts from evolutionary biology, ethnomusicology, religious experience, the emerging field of community music, and the insight of first-hand participants. Interfaith-cross-cultural improvisation can be seen as a form of “deep play” with the ability to signal and evoke empathy across participants who identify with divergent beliefs, cultures, and practices. The article attempts to illuminate the process of interfaith-cross-cultural improvisation as a meaningful undertaking of interfaith and …

5-Hydroxymethylcytosine Localizes To Enhancer Elements And Is Associated With Survival In Glioblastoma Patients, Kevin C. Johnson, E. Andres Houseman, Jessica E. King, Katharine M. Von Herrmann, Camilo E. Fadu, Brock C. Christensen

Dartmouth Scholarship

Glioblastomas exhibit widespread molecular alterations including a highly distorted epigenome. Here, we resolve genome-wide 5-methylcytosine and 5-hydroxymethylcytosine in glioblastoma through parallel processing of DNA with bisulfite and oxidative bisulfite treatments. We apply a statistical algorithm to estimate 5-methylcytosine, 5-hydroxymethylcytosine and unmethylated proportions from methylation array data. We show that 5-hydroxymethylcytosine is depleted in glioblastoma compared with prefrontal cortex tissue. In addition, the genomic localization of 5-hydroxymethylcytosine in glioblastoma is associated with features of dynamic cell-identity regulation such as tissue-specific transcription and super-enhancers. Annotation of 5-hydroxymethylcytosine genomic distribution reveal significant associations with RNA regulatory processes, immune function, stem cell maintenance and …

Combating Ebola With Repurposed Therapeutics Using The Cando Platform, Gaurav Chopra, Sashank Kaushik, Peter L. Elkin, Ram Samudrala

Department of Chemistry Faculty Publications

Ebola virus disease (EVD) is extremely virulent with an estimated mortality rate of up to 90%. However, the state-of-the-art treatment for EVD is limited to quarantine and supportive care. The 2014 Ebola epidemic in West Africa, the largest in history, is believed to have caused more than 11,000 fatalities. The countries worst affected are also among the poorest in the world. Given the complexities, time, and resources required for a novel drug development, finding efficient drug discovery pathways is going to be crucial in the fight against future outbreaks. We have developed a Computational Analysis of Novel Drug Opportunities (CANDO) …

Development Of Metal Matrix Composite Gridlines For Space Photovoltaics, Omar K. Abudayyeh

Chemical and Biological Engineering ETDs

Space vehicles today are primarily powered by multi-junction photovoltaic cells due to their high efficiency and high radiation hardness in the space environment. While multi-junction solar cells provide high efficiency, microcracks develop in the crystalline semiconductor due to a variety of reasons, including: growth defects, film stress due to lattice constant mismatch, and external mechanical stresses introduced during shipping, installation, and operation. These microcracks have the tendency to propagate through the different layers of the semiconductor reaching the metal gridlines of the cell, resulting in electrically isolated areas from the busbar region, ultimately lowering the power output of the cell …

Palmitoylation Of Desmoglein 2 Is A Regulator Of Assembly Dynamics And Protein Turnover., Brett J. Roberts, Robert A. Svoboda, Andrew M. Overmiller, Joshua D. Lewis, Andrew P. Kowalczyk, My G. Mahoney, Keith R. Johnson, James K. Wahl

Department of Dermatology and Cutaneous Biology Faculty Papers

Desmosomes are prominent adhesive junctions present between many epithelial cells as well as cardiomyocytes. The mechanisms controlling desmosome assembly and remodeling in epithelial and cardiac tissue are poorly understood. We recently identified protein palmitoylation as a mechanism regulating desmosome dynamics. In this study, we have focused on the palmitoylation of the desmosomal cadherin desmoglein-2 (Dsg2) and characterized the role that palmitoylation of Dsg2 plays in its localization and stability in cultured cells. We identified two cysteine residues in the juxtamembrane (intracellular anchor) domain of Dsg2 that, when mutated, eliminate its palmitoylation. These cysteine residues are conserved in all four desmoglein …

Carryover Of Scanning Behaviour Affects Upright Face Recognition Differently To Inverted Face Recognition, Peter J. Hills, Mila Mileva, Catherine Thompson, J. Michael Pake

School of Psychology

No abstract provided.

Ocean Sprawl: Challenges And Opportunities For Biodiversity Management In A Changing World, Louise B. Firth, Antony M. Knights, Danielle Bridger, Ally J. Evans, Nova Mieszkowska, Pippa J. Moore, Nessa E. O'Connor, Emma V. Sheehan, Richard C. Thompson, Stephen J. Hawkins

School of Biological and Marine Sciences

The last few decades have seen rapid proliferation of hard artificial structures (e.g., energy infrastructure, aquaculture, coastal defences) in the marine environment: ocean sprawl. The replacement of natural, often sedimentary, substrata with hard substrata has altered the distribution of species, particularly non-indigenous species, and can facilitate the assisted migration of native species at risk from climate change. This has been likened to urbanization as a driver of global biotic homogenization in the marine environment-the process by which species invasions and extinctions increase the genetic, taxonomic, or functional similarity of communities at local, regional, and global scales. Ecological engineering research showed …

Regulatory Ecotoxicity Testing Of Nanomaterials – Proposed Modifications Of Oecd Test Guidelines Based On Laboratory Experience With Silver And Titanium Dioxide Nanoparticles, K Hund-Rinke, A Baun, D Cupi, Tf Fernandes, R Handy, Jh Kinross, Jm Navas, W Peijnenburg, K Schlich, Bj Shaw, Jj Scott-Fordsmand

School of Biological and Marine Sciences

No abstract provided.

Respective Contributions Of Single And Compound Granule Fusion To Secretion By Activated Platelets, Anita Eckly, Jean-Yves Rinckel, Fabienne Proamer, Neslihan Ulas, Smita Joshi, Sidney W. Whiteheart, Christian Gachet

Molecular and Cellular Biochemistry Faculty Publications

Although granule secretion is pivotal in many platelet responses, the fusion routes of α and δ granule release remain uncertain. We used a 3D reconstruction approach based on electron microscopy to visualize the spatial organization of granules in unstimulated and activated platelets. Two modes of exocytosis were identified: a single mode that leads to release of the contents of individual granules and a compound mode that leads to the formation of granule-to-granule fusion, resulting in the formation of large multigranular compartments. Both modes occur during the course of platelet secretion. Single fusion events are more visible at lower levels of …

Wetland Invasion By Typha×Glauca Increases Soil Methane Emissions, Beth A. Lawrence, Shane Lishawa, Nancy Tuchman, Nia Hurst, Buck T. Castillo

School of Environmental Sustainability: Faculty Publications and Other Works

Wetland invasion by monotypic dominant plants can alter the physicochemical and biological properties of soils that affect methane emissions, a potent greenhouse gas. We examined the effects of Typha × glauca invasion on soil methane using laboratory incubation and controlled mesocosm experiments. Typha-invaded soils collected from three Midwestern (USA) wetlands had greater methane production potential during laboratory incubation than soils dominated by native wet meadow vegetation. Ten years post-invasion of native plant-dominated mesocosms, Typha increased methane emissions at least three-fold (native: 15.0 ± 10.5 mg CH₄-C m⁻² h⁻¹, median: 6.1 mg CH₄-C …

Lncrnas: The Bridge Linking Rna And Colorectal Cancer., Yanfei Yang, Linjie Zhao, Lingzi Lei, Wayne Bond Lau, Bonnie Lau, Qilian Yang, Xiaobing Le, Huiliang Yang, Chenlu Wang, Zhongyue Luo, Yu Xuan, Yi Chen, Xiangbing Deng, Lian Xu, Min Feng, Tao Yi, Xia Zhao, Yuquan Wei, Shengtao Zhou

Department of Emergency Medicine Faculty Papers

Long noncoding RNAs (lncRNAs) are transcribed by genomic regions (exceeding 200 nucleotides in length) that do not encode proteins. While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, lncRNAs control pleiotropic cancer phenotypes through interactions with other cellular molecules including DNA, protein, and RNA. Recent studies have demonstrated that dysregulation of lncRNAs is influential in proliferation, angiogenesis, metastasis, invasion, apoptosis, stemness, and genome instability in colorectal cancer (CRC), with consequent clinical implications. In this review, we explicate the roles of different lncRNAs in CRC, and the potential implications for their clinical application.

Regional Variation In Ascaris Lumbricoides And Trichuris Trichiura Infections By Age Cohort And Sex: Effects Of Market Integration Among The Indigenous Shuar Of Amazonian Ecuador, Theresa E. Gildner, Tara J. Cepon-Robins, Melissa A. Liebert, Samuel S. Urlacher, Felicia C. Madimenos, J. Josh Snodgross, Lawrence S. Sugiyama

Publications and Research

Background: Soil-transmitted helminth (STH) infection peaks during childhood and varies by sex. The impact of market integration (MI) (increasing production for and consumption from a market-based economy) on these infection patterns, however, is unclear. In this study, STH infection is examined by sex and age among indigenous Shuar inhabiting two regions of Amazonian Ecuador: (1) the modestly market-integrated Upano Valley (UV) and (2) the more traditional Cross-Cutucú (CC) region.

Methods: Kato-Katz fecal smears were examined for parasite presence and infection intensity. Factorial ANOVAs and post hoc simple effects analyses were performed by sex to compare infection intensity between regions and …

Nucleoside-Diphosphate-Kinase Of P. Gingivalis Is Secreted From Epithelial Cells In The Absence Of A Leader Sequence Through A Pannexin-1 Interactome, Kalina Atanasova, Jungnam Lee, Joann Roberts, Kyulim Lee, David M. Ojcius, Özlem Yilmaz

All Dugoni School of Dentistry Faculty Articles

Nucleoside-diphosphate-kinases (NDKs) are leaderless, multifunctional enzymes. The mode(s) of NDK secretion is currently undefined, while extracellular translocation of bacterial NDKs is critical for avoidance of host pathogen clearance by opportunistic pathogens such as Porphyromonas gingivalis. P. gingivalis-NDK during infection inhibits extracellular-ATP (eATP)/P2X7-receptor mediated cell death in gingival epithelial cells (GECs) via eATP hydrolysis. Furthermore, depletion of pannexin-1-hemichannel (PNX1) coupled with P2X7-receptor blocks the infection-induced eATP release in GECs, and P. gingivalis-NDK impacts this pathway. Ultrastructural and confocal microscopy of P. gingivalis-co-cultured GECs or green-fluorescent-protein (GFP)-P. gingivalis-NDK transfected GECs revealed a perinuclear/cytoplasmic localization of NDK. eATP stimulation induced NDK recruitment to …

A Trial Of Unrelated Donor Marrow Transplantation For Children With Severe Sickle Cell Disease., Shalini Shenoy, Mary Eapen, Julie A. Panepinto, Brent R. Logan, Juan Wu, Allistair Abraham, Joel Brochstein, Sonali Chaudhury, Kamar Godder, Ann E. Haight, Kimberly A. Kasow, Kathryn Leung, Martin Andreansky, Monica Bhatia, Jignesh Dalal, Hilary Haines, Jennifer Jaroscak, Hillard M. Lazarus, John E. Levine, Lakshmanan Krishnamurti, David Margolis, Gail C. Megason, Lolie C. Yu, Michael A. Pulsipher, Iris Gersten, Nancy Difronzo, Mary M. Horowitz, Mark C. Walters, Naynesh Kamani

Manuscripts, Articles, Book Chapters and Other Papers

Children with sickle cell disease experience organ damage, impaired quality of life, and premature mortality. Allogeneic bone marrow transplant from an HLA-matched sibling can halt disease progression but is limited by donor availability. A Blood and Marrow Transplant Clinical Trials Network (BMT CTN) phase 2 trial conducted from 2008 to 2014 enrolled 30 children aged 4 to 19 years; 29 were eligible for evaluation. The primary objective was 1-year event-free survival (EFS) after HLA allele-matched (at HLA-A, -B, -C, and -DRB1 loci) unrelated donor transplant. The conditioning regimen included alemtuzumab, fludarabine, and melphalan. Graft-versus-host disease (GVHD) prophylaxis included calcineurin inhibitor, …