Digital Commons Network^™

Comparative Use Of A Caribbean Mesophotic Coral Ecosystem And Association With Fish Spawning Aggregations By Three Species Of Shark, Alexandria E. Pickard, Jeremy J. Vaudo, Bradley M. Wetherbee, Richard S. Nemeth, Jeremiah B. Blondeau, Elizabeth A. Kadison, Mahmood S. Shivji

Biological Sciences Faculty Publications

Understanding of species interactions within mesophotic coral ecosystems (MCEs; ~ 30–150 m) lags well behind that for shallow coral reefs. MCEs are often sites of fish spawning aggregations (FSAs) for a variety of species, including many groupers. Such reproductive fish aggregations represent temporal concentrations of potential prey that may be drivers of habitat use by predatory species, including sharks. We investigated movements of three species of sharks within a MCE and in relation to FSAs located on the shelf edge south of St. Thomas, United States Virgin Islands. Movements of 17 tiger (Galeocerdo cuvier), seven lemon (Negaprion …

Advancing Crop Transformation In The Era Of Genome Editing, Fredy Altpeter, Nathan M. Springer, Laura E. Bartley, Ann E. Blechl, Thomas P. Brutnell, Vitaly Citovsky, Liza J. Conrad, Stanton B. Gelvin, David P. Jackson, Albert P. Kausch, Peggy G. Lemaux, June I. Medford, Martha L. Orozco-Cárdenas, David M. Tricoli, Joyce Van Eck, Daniel F. Voytas, Virginia Walbot, Kan Wang, Zhanyuan J. Zhang, C. Neal Stewart Jr.

Cell and Molecular Biology Faculty Publications

Plant transformation has enabled fundamental insights into plant biology and revolutionized commercial agriculture. Unfortunately, for most crops, transformation and regeneration remain arduous even after more than 30 years of technological advances. Genome editing provides novel opportunities to enhance crop productivity but relies on genetic transformation and plant regeneration, which are bottlenecks in the process. Here, we review the state of plant transformation and point to innovations needed to enable genome editing in crops. Plant tissue culture methods need optimization and simplification for efficiency and minimization of time in culture. Currently, specialized facilities exist for crop transformation. Single-cell and robotic techniques …

Comparative Structural And Computational Analysis Supports Eighteen Cellulose Synthases In The Plant Cellulose Synthesis Complex, B. Tracey Nixon, Katayoun Mansouri, Abhishek Singh, Juan Du, Jonathan K. Davis, Jung-Goo Lee, Erin Slabaugh, Venu Gopal Vandavasi, Hugh O'Neill, Eric M. Roberts, Alison W. Roberts, Yaroslava G. Yingling, Candace H. Haigler

Biological Sciences Faculty Publications

A six-lobed membrane spanning cellulose synthesis complex (CSC) containing multiple cellulose synthase (CESA) glycosyltransferases mediates cellulose microfibril formation. The number of CESAs in the CSC has been debated for decades in light of changing estimates of the diameter of the smallest microfibril formed from the β-1,4 glucan chains synthesized by one CSC. We obtained more direct evidence through generating improved transmission electron microscopy (TEM) images and image averages of the rosette-type CSC, revealing the frequent triangularity and average cross-sectional area in the plasma membrane of its individual lobes. Trimeric oligomers of two alternative CESA computational models corresponded well with individual …

Biogeography Of A Plant Invasion: Genetic Variation And Plasticity In Latitudinal Clines For Traits Related To Herbivory, Ganesh P. Bharrarai, Laura A. Meyerson, Jack Anderson, David Cummings, Warwick J. Allen, James T. Cronin

Natural Resources Science Faculty Publications

The juxtaposition of plant‐species invasions with latitudinal gradients in herbivore pressure is an important yet mostly unexplored issue in invasion biology. Latitudinal clines in defense and palatability to herbivores are expected to exist in native plant species but the evolution of these clines may lag behind for invasive plant species resulting in non‐parallel latitudinal clines that may impact invasion success. Our study focused on a native and European invasive lineages of the common reed Phragmites australis in North America. Using native and invasive genotypes of P. australis collected across a 17° latitudinal range, we performed experiments in replicate northern and …

The Role Of Auctions In University Intellectual Property Transactions, Daniel R. Cahoy, Anthony M. Kwasnica, Luis A. Lopez

Duquesne Law Review

Reflecting the trend in the business community, universities are increasingly investing in intellectual property rights. But they are often unsuccessful in realizing licensing revenues that provide adequate return on investment. This paper considers how auctions could potentially increase licensing efficiency and make university intellectual property transactions more productive. The paper begins by placing the auction in the universe of possible transaction forms and considers how well it aligns to the unique nature of university rights. Penn State's recent patent auctions provide useful context. The paper then provides recommendations to modify the auction structure for maximum benefit in university intellectual property …

Isu Today - January 27, 2016, Indiana State University, Communications And Marketing

University Announcements - ISU Today

No abstract provided.

Use Of Chromatin Remodeling Atpases As Rnai Targets For Parental Control Of Western Corn Rootworm (Diabrotica Virgifera Virgifera) And Neotropical Brown Stink Bug (Euschistus Heros), Elane Fishilevich, Ana María Vélez, Chitvan Khajuria, Meghan L.F. Frey, Ronda L. Hamm, Haichuan Wang, Greg A. Schulenberg, Andrew J. Bowling, Heather E. Pence, Premchand Gandra, Kanika Arora, Nicholas P. Storer, Kenneth E. Narva, Blair D. Siegfried

Department of Entomology: Faculty Publications

RNA interference (RNAi) is a gene silencing mechanism that is present in animals and plants and is triggered by double stranded RNA (dsRNA) or small interfering RNA (siRNA), depending on the organism. In the western corn rootworm (WCR), Diabrotica virgifera virgifera LeConte (Coleoptera: Chrysomelidae), RNAi can be achieved by feeding rootworms dsRNA added to artificial diet or plant tissues transformed to express dsRNA. The effect of RNAi depends on the targeted gene function and can range from an absence of phenotypic response to readily apparent responses, including lethality. Furthermore, RNAi can directly affect individuals that consume dsRNA or the effect …

Suffolk University Law School Alumni Magazine, Winter 2016, Suffolk University Law School

Suffolk Law School Alumni Magazine

No abstract provided.

Stakeholder Perceptions Of Ecosystem Services Of The Wami River And Estuary, Catherine G. Mcnally, Arthur J. Gold, Richard B. Pollnac, Halima R. Kiwango

Natural Resources Science Faculty Publications

Management of riverine and coastal ecosystems warrants enhanced understanding of how different stakeholders perceive and depend upon different kinds of ecosystem services. Employing a mixed methods approach, this study compares and contrasts the use and perceptions of upstream residents, downstream residents, tourism officials, and conservation organizations regarding the value of 30 ecosystem services provided by the Wami River and its estuary in Tanzania, and investigates their perceptions of the main threats to this system. Our findings reveal that all of the stakeholder groups place a high value on the provision of domestic water, habitat for wild plants and animals, tourism, …

Feedbackly – A Tool For Collecting Real-Time Feedback On The Student Experience., Steve Meaney

Teaching Fellowships

In higher education institutes feedback is collected via various formal (e.g. quality assurance processes) and informal (e.g. one-to-one discussion) methods. A core distinction between these approaches is the immediacy of informal feedback set against a slower, but potentially more powerful, formal feedback mechanism. This project aimed to explore a real-time mechanism to explore the student experience, using a simple data entry point connected to a webaccessible dashboard which summarises the data. A prototype was successfully developed and deployed, and collected feedback from students across the College of Sciences and Health. The system was broadly used by students, with more than …

Dit Teaching Fellowships Reports 2015-2016., Learning And Teaching Technology Centre Dublin Institute Of Technology

Annual Reports

No abstract provided.

Modification Of Expanded Nk Cells With Chimeric Antigen Receptor Mrna For Adoptive Cellular Therapy, Yaya Chu, Allyson Flower, Mitchell S. Cairo

NYMC Faculty Publications

NK cells are bone marrow-derived cytotoxic lymphocytes that play a major role in the rejection of tumors and cells infected by viruses. The regulation of NK activation vs inhibition is regulated by the expression of a variety of NK receptors (NKRs) and specific NKRs' ligands expressed on their targets. However, factors limiting NK therapy include small numbers of active NK cells in unexpanded peripheral blood and lack of specific tumor targeting. Chimeric antigen receptors (CAR) usually include a single-chain Fv variable fragment from a monoclonal antibody, a transmembrane hinge region, and a signaling domain such as CD28, CD3-zeta, 4-1BB (CD137), …

Parents And Teachers’ Perceptions And Clinical Diagnosis Of Autism Among White And Non-White Groups, Margaret Gopaul

Walden Faculty and Staff Publications

The pervasiveness of autism has significantly increased over the past 2 decades with the 2014 Center for Disease Control and Prevention report indicating 1 in 68 children are diagnosed with Autism Spectrum Disorder (ASD). Early intervention is recommended as the most effective treatment approach. Nevertheless, previous research has indicated that White children are diagnosed with ASD about 1.5 years earlier than are Non-White children. A current gap remains in literature regarding ASD and different racial groups, and evidence has been inconclusive regarding disparities in identifying and diagnosing ASD. To fill this gap, this study investigated the relationship between child race, …

Pregnancy With Psoriasis: What New Parents Need To Know, Debra Henline Sullivan, Deborah Weatherspoon, Christopher Weatherspoon

Walden Faculty and Staff Publications

Psoriasis is a common, chronic, autoimmune inflammatory disease that affects a substantial number of women annually during pregnancy and childbirth. Some of these women will need and seek guidance before or during their pregnancies and during lactation. The childbirth educator needs a basic knowledge base and ability to answer questions that may arise regarding psoriasis during the childbirth experience. This article will define psoriasis and its effects on pregnancy and childbirth, consider genetic concerns, and explore treatment options.

Temporal Variability In Aboveground Plant Biomass Decreases As Spatial Variability Increases, Devan Allen Mcgranahan, Torre J. Hovick, R. Dwayne Elmore, David M. Engle, Samuel D. Fuhlendorf, Stephen L. Winter, James R. Miller, Diane M. Debinski

School of Natural Resources: Faculty Publications

Ecological theory predicts that diversity decreases variability in ecosystem function. We predict that, at the landscape scale, spatial variability created by a mosaic of contrasting patches that differ in time since disturbance will decrease temporal variability in aboveground plant biomass. Using data from a multi-year study of seven grazed tallgrass prairie landscapes, each experimentally managed for one to eight patches, we show that increased spatial variability driven by spatially patchy fire and herbivory reduces temporal variability in aboveground plant biomass. This pattern is associated with statistical evidence for the portfolio effect and a positive relationship between temporal variability and functional …

Temporal Variability In Aboveground Plant Biomass Decreases As Spatial Variability Increases, Devan Allen Mcgranahan, Torre J. Hovick, R. Dwayne Elmore, David M. Engle, Samuel D. Fuhlendorf, Stephen L. Winter, James R. Miller, Diane M. Debinski

School of Natural Resources: Faculty Publications

Ecological theory predicts that diversity decreases variability in ecosystem function. We predict that, at the landscape scale, spatial variability created by a mosaic of contrasting patches that differ in time since disturbance will decrease temporal variability in aboveground plant biomass. Using data from a multi-year study of seven grazed tallgrass prairie landscapes, each experimentally managed for one to eight patches, we show that increased spatial variability driven by spatially patchy fire and herbivory reduces temporal variability in aboveground plant biomass. This pattern is associated with statistical evidence for the portfolio effect and a positive relationship between temporal variability and functional …

Traces Volume 44, Number 4, Kentucky Library Research Collections

Traces, the Southern Central Kentucky, Barren County Genealogical Newsletter

Traces, the South Central Kentucky Genealogical Society's quarterly newsletter, was first published in 1973. The Society changed its name in 2016 to the Barren County Historical Society. The publication features compiled genealogies, articles on local history, single-family studies and unpublished source materials related to this area.

Clemmer College Extramural Funding Research Impact Report - 2016, Clemmer College, East Tennessee State University

Clemmer College Research Impact Reports

No abstract provided.

Undergraduate Review, Vol. 12, 2015/2016

Undergraduate Review

No abstract provided.

Through My Great-Grandfather’S Eyes: The Environmental History Of Hilo, Carmen Garson-Shumway

Gateway Prize for Excellent Writing

No abstract provided.

Differential Rna Expression Profile Of Skeletal Muscle Induced By Experimental Autoimmune Myasthenia Gravis In Rats, Henry J. Kaminski, Keiichi Himuro, Jumana Alshaikh, Bendi Gong, Georgiama Cheng, Linda L. Kusner

Neurology Faculty Publications

The differential susceptibility of skeletal muscle by myasthenia gravis (MG) is not well understood. We utilized RNA expression profiling of extraocular muscle (EOM), diaphragm (DIA), and extensor digitorum (EDL) of rats with experimental autoimmune MG (EAMG) to evaluate the hypothesis that muscles respond differentially to injury produced by EAMG. EAMG was induced in female Lewis rats by immunization with acetylcholine receptor purified from the electric organ of the Torpedo. Six weeks later after rats had developed weakness and serum antibodies directed against the AChR, animals underwent euthanasia and RNA profiling performed on DIA, EDL, and EOM. Profiling results were validated …

Protective Role Of Dietary Curcumin In The Prevention Of The Oxidative Stress Induced By Chronic Alcohol With Respect To Hepatic Injury And Antiatherogenic Markers, Ravi Varatharajalu, Mamatha Garige, Leslie C Leckey, Karina Reyes-Gordillo, Ruchi Shah, M. Raj Lakshman

Biochemistry and Molecular Medicine Faculty Publications

No abstract provided.

Potential Role Of P21 Activated Kinase 1 (Pak1) In The Invasion And Motility Of Oral Cancer Cells., Muraleedharan Parvathy, Sreeharshan Sreeja, Rakesh Kumar, M. Radhakrishna Pillai

Biochemistry and Molecular Medicine Faculty Publications

Background

Oral cancer malignancy consists of uncontrolled division of cells primarily in and around the floor of the oral cavity, gingiva, oropharynx, lower lip and base of the tongue. According to GLOBOCAN 2012 report, oral cancer is one of the most common cancers among males and females in India. Even though significant advancements have been made in the field of oral cancer treatment modalities, the overall prognosis for the patients has not improved in the past few decades and hence, this demands a new thrust for the identification of novel therapeutic targets in oral cancer. p21 Activated Kinases (PAKs) are …

Socially Supported Transition: How Transgender Individuals Use The Internet To Navigate Medical Transition, Katy A. Ross, Juliann C. Scholl

Iowa Journal of Communication

Transgender individuals use the Internet, especially social media, to help establish and confirm their gender identity and to discover information which could be beneficial during medical transition. Transgender individuals often need to seek social support, because traditional health environments can be a personally negative experience, can be unequipped to address their particular needs, and can be a place of potential discrimination. Using Gottlieb's (1978) framework of social support, the purpose of this study was to better understand the use of social media by transgender individuals seeking social support related to medical transition. Qualitative analysis of in-depth interviews produced three themes: …

T Cell/Histiocyte-Rich Large B Cell Lymphoma Of The Thymus: A Diagnostic Pitfall., Jie Xu, Xiaojun Wu, Vishnu Reddy

Pathology Faculty Publications

T cell/histiocyte-rich large B cell lymphoma (THRLBCL) is predominantly a nodal disease, with extranodal involvement, such as bone marrow, spleen, and liver. However, primary THRLBCL has never been reported in the thymus in the English literature. Here we report a case of THRLBCL presenting as mediastinal mass and lymphadenopathy. Based on the frozen section diagnosis of "thymoma," a 12 cm mass was excised. A year later she developed multiple enlarged lymph nodes and pulmonary nodules. Consultant review of the excised mediastinal mass showed scattered large atypical cells that were CD20+ and PAX-5+ and negative for pan-cytokeratin, AE1, and AE3, compatible …

Mitosis In Circulating Tumor Cells Stratifies Highly Aggressive Breast Carcinomas., Daniel L. Adams, Diane K. Adams, Steingrimur Stefansson, Christian Haudenschild, Stuart S. Martin, Monica Charpentier, Saranya Chumsri, Massimo Cristofanilli, Cha-Mei Tang, R Katherine Alpaugh

Pathology Faculty Publications

BACKGROUND: Enumeration of circulating tumor cells (CTCs) isolated from the peripheral blood of breast cancer patients holds promise as a clinically relevant, minimally invasive diagnostic test. However, CTC utility has been limited as a prognostic indicator of survival by the inability to stratify patients beyond general enumeration. In comparison, histological biopsy examinations remain the standard method for confirming malignancy and grading malignant cells, allowing for cancer identification and then assessing patient cohorts for prognostic and predictive value. Typically, CTC identification relies on immunofluorescent staining assessed as absent/present, which is somewhat subjective and limited in its ability to characterize these cells. …

Smallpox And Dracunculiasis: The Scientific Value Of Infectious Diseases That Have Been Eradicated Or Targeted For Eradication. Is Schistosomiasis Next?, Michael H. Hsieh, Margaret M. Mentink-Kane

Urology Faculty Publications

No abstract provided.

Examination Of Reticulocytosis Among Chronically Transfused Children With Sickle Cell Anemia., Megha Kaushal, Colleen Byrnes, Zarir Khademian, Natalie Duncan, Naomi L.C. Luban, Jeffery L Miller, Ross M. Fasano, Emily Riehm Meier

Pediatrics Faculty Publications

Sickle cell anemia (SCA) is an inherited hemolytic anemia with compensatory reticulocytosis. Recent studies have shown that increased levels of reticulocytosis during infancy are associated with increased hospitalizations for SCA sequelae as well as cerebrovascular pathologies. In this study, absolute reticulocyte counts (ARC) measured prior to transfusion were analysed among a cohort of 29 pediatric SCA patients receiving chronic transfusion therapy (CTT) for primary and secondary stroke prevention. A cross-sectional flow cytometric analysis of the reticulocyte phenotype was also performed. Mean duration of CTT was 3.1 ± 2.6 years. Fifteen subjects with magnetic resonance angiography (MRA) -vasculopathy had significantly higher …

The Role Of Self-Disclosure In Buffering Negative Feelings Within Adolescent Friendships, Nicholaas David W. Smith, Mandy B. Medvin

Modern Psychological Studies

Friendship serves a variety of functions throughout development and can buffer the effects of negative experiences through self-disclosure, the communication of emotions. Participants were 140 adolescents (51% male, M =12.95 years old) that completed surveys examining the buffering of negative life events, global self-worth, and relationships with their best friend in a correlational design. It was hypothesized that buffered feelings from negative experiences would mediate the relationship between self-disclosure and global self-worth, particularly for girls. Findings indicated levels of self-disclosure and buffered feelings from negative experiences were not associated with increased global self-worth. Gender differences were found between ratings of …

Milestone 2016, Hope College

Milestone

Milestone, the Hope College yearbook, is an annual publication of Hope College. The first yearbook was published in 1905 as a single edition and was titled The Hope College Annual. The yearbooks became an annual publication in 1916, which was also when it was titled Milestone.