Digital Commons Network^™

Aging Assessment Of High Voltage Single Component Room Temperature Vulcanized Silicone Rubber (Rtv-1) Subjected To Aqueous Salt, Monika Bleszynski

Electronic Theses and Dissertations

Single component room temperature vulcanized (RTV-1) silicone based caulk used in high voltage insulators and other applications is frequently subjected to environmental pollutants. Aging of RTV-1 silicone rubber is the result of various stressors, including environmental aging conditions such as UV, acid, and salt exposure from ocean mist. Loss of hydrophobicity due to damage of the hydrophobic methyl groups, as well as loss of mechanical strength due to depolymerization via hydrolysis as a result of aqueous salt exposure were the two main factors of material aging assessed in this work. Multiple RTV-1 formulations were initially assessed for resistance to aging …

Creating Rhetorical Subjectivities: Negotiating The Precarity Of The Homo Oeconomicus In The Neoliberal Workplace, Leslie Lynne Rossman

Electronic Theses and Dissertations

The ubiquitous impact of the neoliberal economy on our everyday life leads to questions of rhetorical significance. This project strives to incorporate service labor experience as a source as well as an effect of rhetoric thereby embodying materialist notions of the body at the site of production. I explore neoliberal discourses through the phenomena of outsourcing and offshoring by interviewing service industry employees that have experienced job uncertainty within a Fortune 500 corporation. By studying narratives, this project explores how the material effects of rhetoric are able to determine discourses of power relating to production. Thus, this study questions the …

The Role Of P38 Mapk In Protein Homeostasis And Aging, Sarah Mae Ryan

Electronic Theses and Dissertations

Aging is characterized by a failure to maintain proper protein homeostasis, potentially leading to tissue dysfunction. Though a variety of genes have been found to regulate lifespan and age-related behaviors how these genetic factors contribute to protein homeostasis has not been fully explored. Here, we report that the evolutionarily conserved aging gene p38 MAPK (p38Kb) regulates age-dependent protein homeostasis. Over-expression of p38Kb results in reduced protein aggregation, while knockout of p38Kb leads to increased protein aggregation. Furthermore, we find that p38Kb regulates protein homeostasis, lifespan, and age-dependent locomotor functions through an interaction with the Chaperone Assisted Selective Autophagy complex; a …

The Neuroprotective And Therapeutic Effects Of Anthocyanins And Their Metabolites In Vitro And In A Mouse Model Of Amyotrophic Lateral Sclerosis, Aimee Nicole Winter

Electronic Theses and Dissertations

Anthocyanins, a unique class of flavonoid compounds, have recently come to the forefront of investigative research aimed at evaluating the potential applications of natural products to human health. Evidence demonstrating the beneficial effects of anthocyanin consumption has been reported for a myriad of conditions including cancer, cardiovascular disease, and lately, neurodegenerative disease. Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) are characterized by the death of specific neuronal populations within the brain and spinal cord, leading to cognitive and/or motor impairment. While the etiology of many of these diseases is largely unknown, several factors have …

Adaptive Divergence Despite Strong Genetic Drift: Genomic Analysis Of The Evolutionary Mechanisms Causing Genetic Differentiation In The Island Fox (Urocyon Littoralis), W. Chris Funk, Robert E. Lovich, Paul A. Hohenlohe, Courtney A. Hofman, Scott A. Morrison, T. Scott Sillett, Cameron K. Ghalambor, Jesus E. Maldonado, Torben C. Rick, Mitch D. Day, Nicholas R. Polato, Sarah W. Fitzpatrick, Timothy J. Coonan, Kevin R. Crooks, Adam Dillon, David K. Garcelon, Julie L. King, Christina L. Boser, Nicholas Gould, William F. Andelt

United States Navy: Publications

The evolutionary mechanisms generating the tremendous biodiversity of islands have long fascinated evolutionary biologists. Genetic drift and divergent selection are pre- dicted to be strong on islands and both could drive population divergence and specia- tion. Alternatively, strong genetic drift may preclude adaptation. We conducted a genomic analysis to test the roles of genetic drift and divergent selection in causing genetic differentiation among populations of the island fox (Urocyon littoralis). This species consists of six subspecies, each of which occupies a different California Chan- nel Island. Analysis of 5293 SNP loci generated using Restriction-site Associated DNA (RAD) sequencing …

Altitudinal Shifts Of The Native And Introduced Flora Of California In The Context Of 20th-Century Warming, A. Wolf, Naupaka B. Zimmerman, W. R. Anderegg, P. E. Busby, J. Christensen

Biology Faculty Publications

Aim: The differential responses of plant species to climate change are of great interest and grave concern for scientists and conservationists. One underexploited resource for better understanding these changes are the records held by herbaria. Using these records to assess the responses of different groups of species across the entire flora of California, we sought to quantify the magnitude of species elevational shifts, to measure differences in shifts among functional groups and between native and introduced species, and to evaluate whether these shifts were related to the conservation of thermal niches.

Location: California.

Methods: To characterize these shifts in California, …

Behavioral And Neural Indices Of Metacognitive Sensitivity In Preverbal Infants, Louise Goupil, Sid Kouider

Biology Faculty Publications

Humans adapt their behavior not only by observing the consequences of their actions but also by internally monitoring their performance. This capacity, termed metacognitive sensitivity [1 ; 2], has traditionally been denied to young children because they have poor capacities in verbally reporting their own mental states [3; 4 ; 5]. Yet, these observations might reflect children’s limited capacities for explicit self-reports, rather than limitations in metacognition per se. Indeed, metacognitive sensitivity has been shown to reflect simple computational mechanisms [1; 6; 7 ; 8], and can be found in various …

The High Cost Of Reproduction In Sea Otters Necessitates Unique Physiological Adaptations, Nicole Thometz, T. L. Kendall, B. P. Richter, T. M. Williams

Biology Faculty Publications

Resting Superimposed on inherently high basal metabolic demands, the additional energetic requirements of reproduction can push female sea otters beyond physiological limits. Indeed, the resulting energy imbalance contributes to disproportionately high rates of mortality at the end of lactation in this species. To examine and quantify metabolic changes associated with reproduction, we measured the resting metabolic rate (RMR) of a female sea otter across gestation, lactation and non-reproductive periods. Concurrently, measurements were made on a non-breeding control female. Our results suggest that RMR declines during gestation. Conversely, RMR increases during lactation, reaches a peak at 3–4 months postpartum, and remains …

Ten Simple Rules For Digital Data Storage, E. M. Hart, P. Barmby, D. Lebauer, F. Michonneau, S. Mount, P. Mulrooney, T. Poisot, K. H. Woo, Naupaka B. Zimmerman, J. W. Hollister

Biology Faculty Publications

No abstract provided.

Role-Playing In A Vaccination Debate Strengthens Student Scientific Debate Skills For Various Audiences, Gianne Souza, P. F. Mixter

Biology Faculty Publications

Students are surrounded by strongly-held viewpoints on scientific topics and frequently discuss news reports with their classmates. We developed the vaccination debate exercise to leverage this interest and develop core higher-order cognitive skills (HOCS), including, but not limited to, the ability to critique public media or primary research sources and create arguments for defending multiple viewpoints. Students prepared to debate different sides of the topic and then randomly assumed one of the roles: “Physician” (pro-vaccine), “Activist” (anti-vaccination), or “Parent-on-the-fence” (undecided). Students reported an increase in their abilities to discuss scientific topics with diverse audiences and an increased awareness of importance …

Neural And Neuroendocrine Processing Of A Non-Photic Cue In An Opportunistically Breeding Songbird, Darcy K. Ernst, G. E. Bentley

Biology Faculty Publications

Recent studies of the onset of breeding in long-day photoperiodic breeders have focused on the roles of type 2 and 3 iodothyronine deiodinases (DIO2 and DIO3) in the conversion of thyroxine (T4) to triiodothyronine (T3) and subsequent activation of the reproductive axis. It has been hypothesized that an increase in DIO2 and a reciprocal decrease in DIO3 causes the release of gonadotropinreleasing hormone (GnRH) from the hypothalamus, setting off a reproductive cascade, and that this DIO mechanism for GnRH release is conserved across vertebrate taxa. We sought to test whether social cues that are known to stimulate reproductive behaviors can …

Competitive Mothers: Comparing Competitiveness In Spheres That Matter, Alessandra Cassar, F Wordofa, Y J. Zhang

Economics Faculty Publications

Recent advances have highlighted the evolutionary significance of female competition, with the sexes pursuing different competitive strategies and females reserving their most intense competitive behaviors for the benefit of offspring (1-3). Influential economic experiments using cash incentives, however, have found evidence suggesting that women have a lower desire to compete than men (4-7). We hypothesize that the estimated gender differences critically depend on how we elicit them, especially on the incentives used. We test this hypothesis through an experiment with adults in China (n=358). Data show that, once the incentives are switched from monetary to childbenefitting, gender differences disappear. This …

Hexokinase Ii Localization Is Independent Of Ampk Activation In Hela Cells, Alyssa Brown

Graduate School of Biomedical Sciences Theses and Dissertations

In order for a cancer cell to thrive, it must alter its metabolism to produce the energy needed for rapid growth. Cells accomplish this by the Warburg Effect, or switching metabolism to aerobic glycolysis, where a cell can rapidly break down sugar into ATP, lactic acid and additional byproducts. Hexokinase 2, the enzyme that catalyzes the first committed step of glycolysis, may also be upregulated in cancer cells to increase glucose breakdown. Similar proteins for metabolism are found in both S. cerevisiae and mammalian cells. S. cerevisiae regulates metabolism through glucose repression, by Snf1 (mammalian homolog: AMPK) activation, which aids …

The Effect Of Internally Versus Externally Focused Balance Training On Mindfulness, Kathleen J. Pantano, Jeremy E. C. Genovese

International Journal of Transpersonal Studies

The purpose of this study was to determine how alternative types of instruction provided during a 6-week balance exercise program affect mindfulness. A sample of 63 college students was recruited for the study. Group 1 (N = 33) received a 6-week balance exercise intervention instructed with an internal focus of attention (IFA). Group 2 (N = 30) received the same intervention, but exercises were instructed with an external focus of attention (EFA). Mindfulness was measured at baseline and at 6 weeks using the Freiburg Mindfulness Inventory (FMI). Baseline FMI scores between groups were similar (Group 1: 41.6; Group 2: 41.3), …

Harnessing The Placebo Effect: A New Model For Mind-Body Healing Mechanisms, Gabriel Crane

International Journal of Transpersonal Studies

The placebo effect is a phenomenon that has confounded Western medicine and research for over sixty years. While the field has historically and continues to be rife with misconceptions and confusion, recent research aims to reignite the art of medicine by turning the effect's underlying mechanisms to therapeutic benefit. However, researchers may not have the appropriate theoretical framework to do so. While significant progress has been made in identifying a number of the placebo effect's underlying mechanisms, conceptual deficiencies hinder application of advances in the field. In part, this is because the placebo effect unearths a number of problematic philosophical …

A Critical Analysis Of African-Centered Psychology: From Ism To Praxis, A. Ebede-Ndi

International Journal of Transpersonal Studies

The purpose of this article is to critically evaluate what is perceived as shortcomings in the scholarly field of African-centered psychology and mode of transcendence, specifically in terms of the existence of an African identity. A great number of scholars advocate a total embrace of a universal African identity that unites Africans in the diaspora and those on the continent and that can be used as a remedy to a Eurocentric domination of psychology at the detriment of Black communities’ specific needs. Another group of scholars argue for a relative African identity, emphasizing diversity and differences among African people both …

Womanist Preservation: An Analysis Of Black Women’S Spiritual Coping, Angelina Graham

International Journal of Transpersonal Studies

The highly spiritual and religious nature of Black women is fairly established in the social science arena, yet the transpersonal field yields very little discourse on this relevant nexus. This static void resembles the macro and micro aggressions Black women face routinely in the Western world which perpetually diminishes and nullifies their collective character and lived experiences. The ostracism Black women face regularly stems primarily from the triple threat of racism, sexism and socioeconomic status which thereby stimulates the inherent and roused use of spiritual practices as a form of resiliency. By analyzing existing research this investigation exposes the experiences, …

Considerations And Caveats For The Use Of Placebo Responses In Clinical Care: Minding The Matter Of Mechanisms–And Morality– In Medical Treatment, James Giordano

International Journal of Transpersonal Studies

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Imparting Biblical Theology Cross-Culturally For Transformation, Malcolm S. Reid

All Electronic Theses and Dissertations

Moore Theological College’s Preliminary Theological Certificate has been a vehicle to impart an approach to Biblical Theology not only domestically but also outside Australia. Course participation overseas has seen significant growth and this research identifies some of reasons for this as well some principles for imparting Biblical Theology cross-culturally. The first chapter of this study outlines the specific approach of the research. Four specific case studies are identified as being Latin America, India, East Africa and South East Asia. A biblical foundation is laid down in the next chapter. Three themes that affect a Biblical Theology of culture in the …

Hydrogen Production With A Simple And Scalable Membraneless Electrolyzer, Glen O'Neil, Corey D. Christian, David E. Brown, Daniel V. Esposito

Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works

Ion-conducting membranes are essential components in many electrochemical devices, but they often add substantial cost, limit performance, and are susceptible to degradation. This work investigates membraneless electrochemical flow cells for hydrogen production from water electrolysis that are based on angled mesh flow-through electrodes. These devices can be fabricated with as few as three parts (anode, cathode, and cell body), reflecting their simplicity and potential for low-cost manufacture. 3D printing was used to fabricate prototype electrolyzers that were demonstrated to be electrolyte agnostic, modular, and capable of operating with minimal product crossover. Prototype electrolyzers operating in acidic and alkaline solutions achieved …

Tooth Borne Anchorage: A Comparative Analysis, Shane Hodson

Student Theses, Dissertations and Capstones

Objective: The purpose of this study was to compare two anchorage modalities. Differential mass and differential moments were compared for their anchorage effectiveness in the sagittal and vertical dimensions. Class I patients with maximum anchorage requirements and treated with four first premolar extractions were selected. Background: Due to a severe combination of crowding, incisor proclination and protrusion, and procumbency of the lips, certain patients require extractions and maximum anchorage in orthodontic treatment.8 Two tooth borne anchorage modalities, differential mass and differential moments, have been shown to be able to achieve maximum anchorage requirements.5, 7 Methods: The available digital records of …

Effect Of Ph And Recharge Protocol On Fluoride Release From Orthodontic Band Adhesives, Erica Kader

Student Theses, Dissertations and Capstones

Objective: This study evaluated the release of fluoride from orthodontic band adhesives before and after exposure to fluoride varnish (FV), MI Paste (MIP), MI Paste Plus (MIPP), or no application, in neutral and acidic solutions. Background: White spot lesions (WSLs) occur in 73% of orthodontic patients. WSLs occur as a result of plaque accumulation, which leads to increased acidity of the oral cavity and subsequent enamel demineralization. Topical fluoride is frequently used as therapy for WSLs, in the form of toothpaste, mouth-rinse and varnish. In an effort to reduce demineralization around fixed appliances, fluoride-releasing adhesives have been employed, including glass …

Modelling Proteins’ Hidden Conformations To Predict Antibiotic Resistance, Kathryn M. Hart, Chris M. W. Ho, Supratik Dutta, Michael L. Gross, Gregory R. Bowman

Open Access Publications

No abstract provided.

Chemical Chaperone Tudca Prevents Apoptosis And Improves Survival During Polymicrobial Sepsis In Mice, Marcel Doerflinger, Jason Glab, Christina Nedeva, Irvin Jose, Ann Lin, Lorraine O’Reilly, Cody Allison, Marc Pellegrini, Richard S. Hotchkiss, Hamsa Puthalakath

Open Access Publications

No abstract provided.

Spatially- And Temporally-Controlled Postnatal P53 Knockdown Cooperates With Embryonic Schwann Cell Precursor Nf1 Gene Loss To Promote Malignant Peripheral Nerve Sheath Tumor Formation, Angela C. Hirbe, Sonika Dahiya, Dinorah Friedmann-Morvinski, Inder M. Verma, D. Wade Clapp, David H. Gutmann

Open Access Publications

No abstract provided.

Coa Protects Against The Deleterious Effects Of Caloric Overload In Drosophila, Laura Palanker Musselman, Jill L. Fink, Thomas J. Baranski

Open Access Publications

No abstract provided.

Human Metabolome-Derived Cofactors Are Required For The Antibacterial Activity Of Siderocalin In Urine, Robin R. Shields-Cutler, Jan R. Crowley, Connelly D. Miller, Ann E. Stapleton, Weidong Cui, Jeffery P. Henderson

Open Access Publications

No abstract provided.

The University Of Texas Of The Permian Basin Graduate Studies Catalog 2016-2018, The University Of Texas Of The Permian Basin

Course Catalogs

No abstract provided.

Targeting Multi-Drug Resistant Pathogens With Novel Antimicrobial Peptides, Mohamed F. Mohamed

Open Access Dissertations

The emergence of antibiotic resistance is a notorious problem worldwide. In the United States alone, antibiotic-resistant bacteria infect at least two million people and kill around 23,000 patients each year. Half of these infections are attributed to the bacterial pathogen, methicillin resistant Staphylococcus aureus (MRSA) according to a report published in 2013 by the Centers for Disease Control and Prevention (CDC). Similarly, S. pseudintermedius is a leading cause of opportunistic infections in pet animals and has zoonotic potential. Furthermore, the marked increase in the incidence of infections due to extensively drug-resistant and pandrug-resistant isolates of Pseudomonas aeruginosa and Acinetobacter baumannii …

Quantitative Modeling Of Scaling Of Patterns And Receptor Signaling In Morphogenesis, Md Shahriar Karim

Open Access Dissertations

Organs and tissue development often experience perturbations, but developmental processes seem to replicate a common body template to maintain appropriate proportions and positions. The key signaling factors that guide a number of those processes are known as morphogens. Developing cells sense their respective positional information from a graded morphogen profile, and differentiate into patterns. Remarkably, patterns are highly robust and reproducible among species, and the underlying mechanisms associated with such high degrees of precision are still enigmatic. In addition, details of the signal, such as the Bone Morphogenetic Protein (BMP) signal, that transmit patterning information to a group of homogenous …