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A Future For A Forgotten Predator: Assessment Of The Global And Regional Legal Frameworks For Protection And Recovery Of The Caribbean Sawfishes Pristis Pristis And Pristis Pectinata And Recommendations For The Course Forward, Olga Koubrak

LLM Theses

Two species of sawfish, Pristis pristis and Pristis pectinata, used to be common in the coastal waters of the Caribbean Region. However, due to direct and incidental fishing pressures, national and international trade in body parts, and habitat loss, the populations of these ecologically and culturally significant species have drastically declined. This thesis identifies and reviews global and regional, binding and non-binding legal instruments in effect in the Caribbean Region that encourage states to protect biodiversity in general or address identified threats to sawfishes specifically. Despite the presence of obligations that call upon states to adopt sawfish conservation and habitat …

This Is What We Do: Annual Report 2016, Tennessee. Department Of Environment And Conservation

TDEC Annual Reports

This annual report highlights the accomplishments of the Tennessee Department of Environment and Conservation over the fiscal year.

Crispr/Cas9 As A Therapeutic Approach To Duchenne Muscular Dystrophy, Abraham Daniel Levitman

The Science Journal of the Lander College of Arts and Sciences

Transhumanism, designer babies, gene therapy, and super-soldiers are founded upon the same concept—genetic engineering. Clustered Regularly-Interspersed Short Palindromic Repeats (CRISPR) is a natural bacterial immune response method that takes advantage of gene manipulation to prevent an infection from mobile genetic elements. Since Mojica et al. (2005) first suggested the relationship between the CRISPR/Cas system and prokaryotic immunity, significant advancements have been made in understanding the mechanism and subsequent applications of CRISPR. CRISPR, has three main subtypes based on unique proteins and interference pathways and serves as an accurate and effective method for gene editing. Its mechanism consists of spacer acquisition, …

Development Of A Novel Renal Activity Index Of Lupus Nephritis In Children & Young Adults, H. I. Brunner, M. Bennett, K. Abulaban, M. Klein-Gitelman, K. O'Neil, L. Tucker, S. Ardoin, K. Rouster-Stevens, B. A. Eberhard, P. Devarajan, +8 Additional Authors

Journal Articles

BACKGROUND: Noninvasive estimation of the degree of inflammation seen on kidney biopsy with lupus nephritis (LN) remains difficult. The objective of this study was to develop a Renal Activity Index for Lupus (RAIL) that, based solely on laboratory measures, accurately reflects histological LN activity. METHODS: We assayed traditional LN laboratory tests and 16 urine biomarkers (UBMs) in children (n=47) at the time of kidney biopsy. Histological LN activity was measured by the NIH Activity Index (NIH-AI) and the Tubulointerstitial Activity Index (TIAI). High LN-activity status (vs. moderate/low) was defined as NIH-AI scores > 10 (vs.5 (vs.92% accuracy and LN-activityTIAI status with …

Prioritizing Management And Protection Of The Colorado River's Environmental Resources, Colorado River Research Group

Books, Reports, and Studies

4 pages.

Improving Irrigation Water Uses For Agricultural And Environmental Benefits, Anne Castle, Amy Beattie, Zach Smith, Drew Peternell, Ted Kowalski

Books, Reports, and Studies

37 pages : color pictures, color maps.

Introduction -- Agricultural and environmental enhancements -- An ag and environmental enhancement program for Colorado -- Appendix A: Conservation case studies in Colorado -- Appendix B: Related Colorado water law -- Appendix C: Relevant laws from other states -- Appendix D: Legislative attempts to statutorily recognize conserved water -- Appendix E: The problem of vocabulary

Increased Hepcidin In Transferrin-Treated Thalassemic Mice Correlates With Increased Liver Bmp2 Expression And Decreased Hepatocyte Erk Activation, H. Chen, T. Choesang, H. Li, S. Sun, P. Pham, W. Bao, M. Feola, M. Westerman, L. Blanc, Y. Z. Ginzburg, +4 Additional Authors

Journal Articles

Iron overload results in significant morbidity and mortality in beta-thalassemic patients. Insufficient hepcidin is implicated in parenchymal iron overload in beta-thalassemia and approaches to increase hepcidin have therapeutic potential. We have previously shown that exogenous apo-transferrin markedly ameliorates ineffective erythropoiesis and increases hepcidin expression in Hbb(th1/th1) (thalassemic) mice. We utilize in vivo and in vitro systems to investigate effects of exogenous apo-transferrin on Smad and ERK1/2 signaling, pathways that participate in hepcidin regulation. Our results demonstrate that apo-transferrin increases hepcidin expression in vivo despite decreased circulating and parenchymal iron concentrations and unchanged liver Bmp6 mRNA expression in thalassemic mice. Hepatocytes …

Association Analysis Of Copy Numbers Of Fc-Gamma Receptor Genes For Rheumatoid Arthritis And Other Immune-Mediated Phenotypes, L. Franke, H. El Bannoudi, D. T. Jansen, K. Kok, G. Trynka, D. Diogo, M. Swertz, K. Fransen, P. K. Gregersen, A. Zhernakova, +16 Additional Authors

Journal Articles

Segmental duplications (SDs) comprise about 5% of the human genome and are enriched for immune genes. SD loci often show copy numbers variations (CNV), which are difficult to tag with genotyping methods. CNV in the Fcgamma receptor region (FCGR) has been suggested to be associated with rheumatic diseases. The objective of this study was to delineate association of FCGR-CNV with rheumatoid arthritis (RA), coeliac disease and Inflammatory bowel disease incidence. We developed a method to accurately quantify CNV in SD loci based on the intensity values from the Immunochip platform and applied it to the FCGR locus. We determined the …

Dense Genotyping Of Immune-Related Loci In Idiopathic Inflammatory Myopathies Confirms Hla Alleles As The Strongest Genetic Risk Factor And Suggests Different Genetic Background For Major Clinical Subgroups, S. Rothwell, R. G. Cooper, I. E. Lundberg, F. W. Miller, P. K. Gregersen, J. Bowes, J. Vencovsky, K. Danko, V. Limaye, J. A. Lamb, +26 Additional Authors

Journal Articles

OBJECTIVES: The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare autoimmune diseases characterised by muscle weakness and extramuscular manifestations such as skin rashes and interstitial lung disease. We genotyped 2566 IIM cases of Caucasian descent using the Immunochip; a custom array covering 186 established autoimmune susceptibility loci. The cohort was predominantly comprised of patients with dermatomyositis (DM, n=879), juvenile DM (JDM, n=481), polymyositis (PM, n=931) and inclusion body myositis (n=252) collected from 14 countries through the Myositis Genetics Consortium. RESULTS: The human leucocyte antigen (HLA) and PTPN22 regions reached genome-wide significance (p

Loci Associated With N-Glycosylation Of Human Igg Are Not Associated With Rheumatoid Arthritis: A Mendelian Randomisation Study, A. Yarwood, S. Viatte, Y. Okada, R. Plenge, K. Yamamoto, A. Barton, D. Symmons, S. Raychaudhuri, P. Gregersen, S. Eyre, +2 Additional Authors

Journal Articles

OBJECTIVES: A recent study identified 16 genetic variants associated with N-glycosylation of human IgG. Several of the genomic regions where these single nucleotide polymorphisms (SNPs) reside have also been associated with autoimmune disease (AID) susceptibility, suggesting there may be pleiotropy (genetic sharing) between loci controlling both N-glycosylation and AIDs. We investigated this by testing variants associated with levels of IgG N-glycosylation for association with rheumatoid arthritis (RA) susceptibility using a Mendelian randomisation study, and testing a subset of these variants in a less well-powered study of treatment response and severity. METHODS: SNPs showing association with IgG N-glycosylation were analysed for …

Lower Omega-3 Fatty Acids Are Associated With The Presence Of Anti-Cyclic Citrullinated Peptide Autoantibodies In A Population At Risk For Future Rheumatoid Arthritis: A Nested Case-Control Study, R. W. Gan, K. A. Young, G. O. Zerbe, M. K. Demoruelle, M. H. Weisman, J. H. Buckner, P. K. Gregersen, T. R. Mikuls, J. R. O'Dell, J. M. Norris, +4 Additional Authors

Journal Articles

OBJECTIVE: The aim of this study was to investigate omega-3 fatty acid (FA) supplement use and omega-3 FAs in erythrocyte membranes [omega-3 FA % in erythrocyte membranes (RBC)] and their association with anti-CCP autoantibodies in a population without RA, but who are at genetic risk for RA. METHODS: The multicentre Studies of the Etiology of RA (SERA) cohort includes RA-free subjects who are first-degree relatives of RA probands or are enriched with the HLA-DR4 allele. In a nested case-control study, 30 SERA cases were identified who were anti-CCP2 antibody positive. We further identified 47 autoantibody negative controls, frequency matched to …

What Is Damaging The Kidney In Lupus Nephritis?, A. Davidson

Journal Articles

Despite marked improvements in the survival of patients with severe lupus nephritis over the past 50 years, the rate of complete clinical remission after immune suppression therapy is

Whole-Exome Sequencing In Relapsing Chronic Lymphocytic Leukemia: Clinical Impact Of Recurrent Rps15 Mutations, V. Ljungstrom, D. Cortese, E. Young, T. Pandzic, L. Mansouri, K. Plevova, S. Ntoufa, P. Baliakas, N. Chiorazzi, R. Rosenquist, +24 Additional Authors

Journal Articles

Fludarabine, cyclophosphamide and rituximab (FCR) is first-line treatment for medically fit chronic lymphocytic leukemia (CLL) patients, however despite good response rates many patients eventually relapse. Whilst recent high-throughput studies have identified novel recurrent genetic lesions in adverse-prognostic CLL, the mechanisms leading to relapse after FCR therapy are not completely understood. To gain insight into this issue, we performed whole-exome sequencing of sequential samples from 41 CLL patients who were uniformly treated with FCR but relapsed after a median of 2 years. In addition to mutations with known adverse-prognostic impact (TP53, NOTCH1, ATM, SF3B1, NFKBIE, BIRC3) a large proportion of cases …

Interview With Janice Booker, 1998, Columbia College Chicago

An Oral History of Columbia College Chicago, 1998 -2004

At the time of the interview, Janice Booker was Administrative Services manager.

Interview With Charles Cannon, 2004, Columbia College Chicago

An Oral History of Columbia College Chicago, 1998 -2004

At the time of the interview, Charles Cannon was chair of the Science and Math department.

Interview With Zafra Lerman, 1998, Columbia College Chicago

An Oral History of Columbia College Chicago, 1998 -2004

At the time of the interview, Zafra Lerman was director of the Science Institute.

Interview With Sara Livingston, 2001, Columbia College Chicago

An Oral History of Columbia College Chicago, 1998 -2004

At the time of the interview, Sara Livingston was acting associate dean of the School of Media Arts.

Interview With John Moore, 1998, Columbia College Chicago

An Oral History of Columbia College Chicago, 1998 -2004

At the time of the interview, John Moore was associate dean of Student Affairs.

Interview With Dominic Pacyga, 2001, Columbia College Chicago

An Oral History of Columbia College Chicago, 1998 -2004

At the time of the interview, Dominic Pacyga was Liberal Education department faculty.

Development Of Elisa Assay For D1327 Adenovirus, Christopher Peterson, Yohichi Kumaki, Dale L. Barnard

Biology Posters

Adenoviruses are a common cause of upper respiratory tract infections in children and the source of acute respiratory disease outbreaks among military recruits. Named after the human adenoid tissue it was first isolated in, the adenoviridae are non-enveloped, double-stranded DNA viruses with over 50 serotypes1. Yet to date vaccines have been developed for only two serotypes, and no adenovirus antiviral drugs have been approved by the FDA, highlighting the need for more research. In virus research, detection the presence of a particular virus is of especial interest when developing animal or cell models. As human pathogens often do not infect …

The Identification And Characterization Of Bacterial Endosymbionts In The Planthopper Family, Caliscelidae (Sternorrhyncha: Fulgoroidea, Ghazal Abu-Salim, Kathryn Weglarz

Biology Posters

Plant-sap sucking insects with deficient nutritional diets contain symbiotic microorganisms in a specific organ in the abdomen (bacteriome). Such symbionts were discovered to belong to various bacterial lineages. Ongoing genomic research concluded that these symbiotic organisms provide the essential nutrients that are absent in the insect’s diets such as amino acids and vitamins. While the identities and functions of several sap-sucking lineages have been studied, some lineages such as Fulgoroidea are not understood because recent results failed to confirm the presence of the symbiotic microbes even though older microscopy studies identified microbes in the bacteriomes. The objective of this research …

Upic Magazine, Issue 5, Center For Career And Professional Development

UPIC Magazine

Every semester, undergraduate students from every major and staff from every part of Clemson University join together through UPIC internships. These paid internships grant students real, on the job experience in professional fields and offer staff a chance to mentor some of Clemson’s most brilliant students.

To find out more about the UPIC Program, visit career.clemson.edu/internship_programs

UPIC is part of Clemson’s Center for Career and Professional Development

Effects Of Amniotic Fluid Mesenchymal Stem Cells In Carboxymethyl Cellulosegel On Healing Of Spontaneous Pressure Sores: Clinical Outcome In Sevenhospitalized Neonatal Foals, Eleonora Iacono, Aliai Lanci, Barbara Merlo, Francesca Ricci, Alessandro Pirrone, Carlotta Antonelli, Jole Mariella, Carolina Castagnetti

Turkish Journal of Biology

In the present study, an innovative therapy for spontaneously arisen pressure sores in seven hospitalized neonatal foals is described, using mesenchymal stem cells obtained from equine amniotic fluid. Amniotic fluid mesenchymal stem cells (AFMSCs) were isolated from fluid samples recovered at delivery. Heterologous cells, at passage three of in vitro culture, were applied to sores twice a week for four consecutive times in a carboxymethylcellulose (CMC) gel. As a control, a commercial ointment was used. The results showed that the mean sore regression rate with AFMSCs in CMC gel was statistically higher than the mean value recorded in the control …

Direct Shoot Organogenesis And Agrobacterium Tumefaciens Mediated Transformation Of Solanum Trilobatum L., Jayabalan Shilpha, Manoharan Jayashre, Muthiah Joe Virgin Largia, Manikandan Ramesh

Turkish Journal of Biology

Solanum trilobatum L. İs one of the most valued medicinal plants of Indian Ayurveda and Siddha medicine. An efficient protocol for direct shoot organogenesis and Agrobacterium tumefaciens mediated transformation using in vitro derived leaf explants of S. Trilobatum was established for the first time. High frequency direct shoot regeneration (89%) was achieved in MS medium containing 2 mg/L 6-benzylaminopurine and 0.25 mg/L indole-3-acetic acid. The Agrobacterium strain EHA 105 harboring the binary vector pCAMBIA 1301, which contained hygromycin phosphotransferase (hpt) as a selectable marker gene and β-glucuronidase (gus) as a reporter gene, was used for the transformation. The factors that …

Ada News Convention Daily - 2016 Day 1, American Dental Association, Publishing Division

ADA News

The ADA News Daily (also called the ADA News Convention Daily) is a special edition of the ADA News published each day during American Dental Association Annual Sessions.

Analysis Of Rocky Mountain Snail (Oreohelix Sp.) Dietary Preference, Michael R. Bernard, Joseph S. Wilson

Biology Posters

Rocky Mountain snails in the genus Oreohelix go mostly unnoticed beneath layers of leaf litter in the western Mountain ranges. These snails are most common in rocky foothill habitat that consists of high-density deciduous groves of maple and oak. It is in this habitat where a great number of unobserved feeding behaviors occur. While some research indicates that terrestrial snails may prefer to feed on living plants, it is thought that Oreohelix are detritivores, feeding primarily on decomposing plant matter. In this study we investigated Oreohelix diet by designing a food preference experiment. We provided two food sources (Boxelder maple …

Use Of A Mouse Model To Evaluate The Effect Of Statins On The Immune Response To An Influenza Virus Vaccine, Calvin Olsen, Bart Tarbet

Biology Posters

Statins are cholesterol lowering drugs that have shown a profound effect on human health by reducing cardiovascular disease. However, two recent publications in the Journal of Infectious Diseases showed that statin use had a negative impact on the influenza vaccine response in elderly individuals [1, 2]. We propose to evaluate the immune response following vaccination in mice undergoing statin treatment. An initial study will determine the therapeutic window for statin treatment of mice fed a lipid-enriched diet. From the literature this window is expected to be between 21-28 days. That therapeutic window will be used for evaluation of the immune …

The Joint Archives Quarterly, Volume 25.04: Winter 2016, Natalie Fulk, Geoffrey D. Reynolds, Nathan Longfield

The Joint Archives Quarterly

No abstract provided.

Scholarworks Statistics - January 2016, Scholarworks

ScholarWorks Reports

For the month of January 2016, ScholarWorks recorded a total of 29,703 full-text and additional file downloads and 11,624 page views.

Racial And Socioeconomic Disparities In Body Mass Index Among College Students: Understanding The Role Of Early Life Adversity, David S. Curtis, Thomas E. Fuller-Rowell, Stacey N. Doan, Aleksandra E. Zgierska, Carol D. Ryff

CMC Faculty Publications and Research

The role of early life adversity (ELA) in the development of health disparities has not received adequate attention. The current study examined differential exposure and differential vulnerability to ELA as explanations for socioeconomic and racial disparities in body mass index (BMI). Data were derived from a sample of 150 college students (Mage = 18.8, SD = 1.0; 45 % African American; 55 % European American) who reported on parents’ education and income as well as on exposure to 21 early adverse experiences. Body measurements were directly assessed to determine BMI. In adjusted models, African American students had higher …