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Daily Eastern News: January 21, 2016, Eastern Illinois University

January

No abstract provided.

H2ax Deficiency Is Associated With Erythroid Dysplasia And Compromised Haematopoietic Stem Cell Function, Baobing Zhao, Timothy L. Tan, Yang Mei, Jing Yang, Yiting Yu, Amit Verma, Ying Liang, Juehua Gao, Peng Ji

Toxicology and Cancer Biology Faculty Publications

Myelodysplastic syndromes (MDS) are clonal disorders of haematopoiesis characterised by dysplastic changes of major myeloid cell lines. However, the mechanisms underlying these dysplastic changes are poorly understood. Here, we used a genetically modified mouse model and human patient data to examine the physiological roles of H2AX in haematopoiesis and how the loss of H2AX contributes to dyserythropoiesis in MDS. H2AX knockout mice showed cell-autonomous anaemia and erythroid dysplasia, mimicking dyserythropoiesis in MDS. Also, dyserythropoiesis was increased in MDS patients with the deletion of chromosome 11q23, where H2AX is located. Although loss of H2AX did not affect the early stage of …

Hepatic Transcriptomic And Metabolic Responses Of Hybrid Striped Bass (Morone Saxatilis × Morone Chrysops) To Acute And Chronic Hypoxic Insult, Benjamin H. Beck, S. Adam Fuller, Bartholomew W. Green, Honggang Zhao, Steven D. Rawles, Carl D. Webster, Eric Peatman

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Striped bass (Morone saxatilis), white bass (Morone chrysops), and their hybrid are an important group of fish prized for recreational angling in the United States, and there and abroad as a high-value farmed fish. Regardless of habitat, it is not uncommon for fish of the genus Morone to encounter and cope with conditions of scarce oxygen availability. Previously, we determined that hybrid striped bass reared under conditions of chronic hypoxia exhibited reduced feed intake, lower lipid and nutrient retention, and poor growth. To better understand the molecular mechanisms governing these phenotypes, in the present study, we examined the …

Hepatic Transcriptomic And Metabolic Responses Of Hybrid Striped Bass (Morone Saxatilis × Morone Chrysops) To Acute And Chronic Hypoxic Insult, Benjamin H. Beck, S. Adam Fuller, Chao Li, Bartholomew W. Green, Honggang Zhao, Steven D. Rawles, Carl D. Webster, Eric Peatman

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Striped bass (Morone saxatilis), white bass (Morone chrysops), and their hybrid are an important group of fish prized for recreational angling in the United States, and there and abroad as a high-value farmed fish. Regardless of habitat, it is not uncommon for fish of the genus Morone to encounter and cope with conditions of scarce oxygen availability. Previously, we determined that hybrid striped bass reared under conditions of chronic hypoxia exhibited reduced feed intake, lower lipid and nutrient retention, and poor growth. To better understand the molecular mechanisms governing these phenotypes, in the present study, we …

State V. Crosland Appellant's Brief Dckt. 43377

Not Reported

No abstract provided.

Continuous Processing Of Liposomes To Control And Predict Physical Properties, Antonio P. Costa

Doctoral Dissertations

Archival abstract submitted

The Bg News January 21, 2016, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. January 21, 2016. Volume 95-Issue 37.

The George-Anne, Georgia Southern University

The George-Anne

• Puzzles
• News
• Opinions
• Features
• Sports

2016-01-21 Faculty Senate Newsletter, Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate Newsletter for January 21, 2016.

Cross-Platform Normalization Of Microarray And Rna-Seq Data For Machine Learning Applications, Jeffrey A. Thompson, Jie Tan, Casey S. Greene

Dartmouth Scholarship

Large, publicly available gene expression datasets are often analyzed with the aid of machine learning algorithms. Although RNA-seq is increasingly the technology of choice, a wealth of expression data already exist in the form of microarray data. If machine learning models built from legacy data can be applied to RNA-seq data, larger, more diverse training datasets can be created and validation can be performed on newly generated data. We developed Training Distribution Matching (TDM), which transforms RNA-seq data for use with models constructed from legacy platforms. We evaluated TDM, as well as quantile normalization, nonparanormal transformation, and a simple log …

The 40-Residue Insertion In Vibrio Cholerae Fadr Facilitates Binding Of An Additional Fatty Acyl-Coa Ligand, Wei Shi, Gabriela Kovacikova, Wei Lin, Ronald. K. Taylor, Karen Skorupski, F. Jon Kull

Dartmouth Scholarship

FadR is a master regulator of fatty acid metabolism and influences virulence in certain members of Vibrionaceae. Among FadR homologues of the GntR family, the Vibrionaceae protein is unusual in that it contains a C-terminal 40-residue insertion. Here we report the structure of Vibrio cholerae FadR (VcFadR) alone, bound to DNA, and in the presence of a ligand, oleoyl-CoA. Whereas Escherichia coli FadR (EcFadR) contains only one acyl-CoA-binding site in each monomer, crystallographic and calorimetric data indicate that VcFadR has two. One of the binding sites resembles that of EcFadR, whereas the other, comprised residues from the insertion, has not …

Processes Controlling Carbon Cycling In Antarctic Glacier Surface Ecosystems, Elizabeth A. Bagshaw, Martyn Tranter, Jemma L. Wadham, Andrew G. Fountain, A. Dubnick, S. Fitzsimons

Geology Faculty Publications and Presentations

Glacier surface ecosystems, including cryoconite holes and cryolakes, are significant contributors to regional carbon cycles. Incubation experiments to determine the net production (NEP) of organic matter in cryoconite typically have durations of 6-24 hours, and produce a wide range of results, many of which indicate that the system is net heterotrophic. We employ longer term incubations to examine the temporal variation of NEP in cryoconite from the McMurdo Dry Valleys, Antarctica to examine the effect of sediment disturbance on system production, and to understand processes controlling production over the lifetimes of glacier surface ecosystems. The shorter-term incubations have durations of …

Development Of Cad-Related Items For A Concept Inventory For Engineering Graphics, Steven Nozaki, Nancy Study, Heidi Steinhauer, Sheryl Sorby, Mary Sadowski, Ron Miller

ASEE EDGD Midyear Conference

This research paper describes the development of a concept inventory for Engineering Graphics. As instructional methods continue to evolve in the area of graphics, there is a need for a concept inventory instrument that is able to measure the students’ misconceptions of important graphical concepts. In a Delphi study, CAD was identified as an important component of the graphics curriculum to be included in the concept inventory. There have been unanticipated challenges in the creation of multiple-choice items designed to assess the understanding of the concepts in the CAD construct. This paper is a work-in-progress describing the evolution of possible …

Models For Hsv Shedding Must Account For Two Levels Of Overdispersion, Amalia Magaret

UW Biostatistics Working Paper Series

We have frequently implemented crossover studies to evaluate new therapeutic interventions for genital herpes simplex virus infection. The outcome measured to assess the efficacy of interventions on herpes disease severity is the viral shedding rate, defined as the frequency of detection of HSV on the genital skin and mucosa. We performed a simulation study to ascertain whether our standard model, which we have used previously, was appropriately considering all the necessary features of the shedding data to provide correct inference. We simulated shedding data under our standard, validated assumptions and assessed the ability of 5 different models to reproduce the …

Easterner, Vol. 67, No. 13, January 20, 2016, Associated Students Of Eastern Washington University

Student Newspapers

This issue of the Easterner contains articles about plans to remodel the original Cheney high school building, the impact of Tapingo on food service lines, a Spokane rally in protest of the shooting of African American youth Tamir Rice, a joint campus rally and march for Martin Luther King, Jr. Day, the Pride Center, challenges brought by large amounts of snow on campus, the men's and women's basketball seasons, and a preview of a track meet at the University of Washington.

The Lumberjack, January 20, 2016, The Lumberjack Staff

2016

The student newspaper of Humboldt State University

Hyaluronidase And Hyaluronan Oligosaccharides Promote Neurological Recovery After Intraventricular Hemorrhage, Govindaiah Vinukonda, Preeti Dohare, Arslan Arshad, Muhammad T. Zia, Sanjeet Panda, Ritesh Korumilli, Praveen Ballabh

NYMC Faculty Publications

Intraventricular hemorrhage (IVH) in premature infants results in inflammation, arrested oligodendrocyte progenitor cell (OPC) maturation, and reduced myelination of the white matter. Hyaluronan (HA) inhibits OPC maturation and complexes with the heavy chain (HC) of glycoprotein inter-α-inhibitor to form pathological HA (HC-HA complex), which exacerbates inflammation. Therefore, we hypothesized that IVH would result in accumulation of HA, and that either degradation of HA by hyaluronidase treatment or elimination of HCs from pathological HA by HA oligosaccharide administration would restore OPC maturation, myelination, and neurological function in survivors with IVH. To test these hypotheses, we used the preterm rabbit model of …

Reversible Recruitment Of A Homeostatic Reserve Pool Of Synaptic Vesicles Underlies Rapid Homeostatic Plasticity Of Quantal Content, Xueyong Wang, Martin J. Pinter, Mark M. Rich

Neuroscience, Cell Biology & Physiology Faculty Publications

Homeostatic regulation is essential for the maintenance of synaptic strength within the physiological range. The current study is the first to demonstrate that both induction and reversal of homeostatic upregulation of synaptic vesicle release can occur within seconds of blocking or unblocking acetylcholine receptors at the mouse neuromuscular junction. Our data suggest that the homeostatic upregulation of release is due to Ca²⁺-dependent increase in the size of the readily releasable pool (RRP). Blocking vesicle refilling prevented upregulation of quantal content (QC), while leaving baseline release relatively unaffected. This suggested that the upregulation of QC was due to mobilization …

Food Studies Book Club Reads Cumin Camels And Caravans A Spice Odyssey, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Can The National Park Service Regulate Navigable Waters In Alaska’S National Parks?, Richard Henry Seamon

Articles

No abstract provided.

Science Café | Spread Of Contagions Diseases Rumors And Mathematical Models, Jan 20, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Daily Eastern News: January 20, 2016, Eastern Illinois University

January

No abstract provided.

Hyperfine Rather Than Spin Splittings Dominate The Fine Structure Of The B 4Σ-–X 4Σ- Bands Of Aic, Dennis J. Clouthier, Aimable Kalume

Chemistry Faculty Publications

Laser-induced fluorescence and wavelength resolved emission spectra of the B ⁴Σ⁻–X ⁴Σ⁻ band system of the gas phase cold aluminum carbide free radical have been obtained using the pulsed discharge jet technique. The radical was produced by electron bombardment of a precursor mixture of trimethylaluminum in high pressure argon. High resolution spectra show that each rotational line of the 0-0 and 1-1 bands of AlC is split into at least three components, with very similar splittings and intensities in both the P- and R-branches. The observed structure was reproduced by assuming b …

Volume 53, Number 23: January 20, 2016, University Of North Dakota

University Letter Archive

No abstract provided.

Modeling Postpartum Depression In Rats: Theoretic And Methodological Issues, Ming Li, Shinn-Yi Chou

Department of Psychology: Faculty Publications

The postpartum period is when a host of changes occur at molecular, cellular, physiological and behavioral levels to prepare female humans for the challenge of maternity. Alteration or prevention of these normal adaptions is thought to contribute to disruptions of emotion regulation, motivation and cognitive abilities that underlie postpartum mental disorders, such as postpartum depression. Despite the high incidence of this disorder, and the detrimental consequences for both mother and child, its etiology and related neurobiological mechanisms remain poorly understood, partially due to the lack of appropriate animal models. In recent decades, there have been a number of attempts to …

Spectator 2016-01-20, Editors Of The Spectator

The Spectator

No abstract provided.

Does Dark-Spot Syndrome Experimentally Transmit Among Caribbean Corals?, Carly J. Randall, Adán Guillermo Jordán-Garza, Erinn M. Muller, Robert Van Woesik

Ocean Engineering and Marine Sciences Faculty Publications

Over the last half-century, coral diseases have contributed to the rapid decline of coral populations throughout the Caribbean region. Some coral diseases appear to be potentially infectious, yet little is known about their modes of transmission. This study experimentally tested whether dark-spot syndrome on Siderastrea siderea was directly or indirectly transmissible to neighboring coral colonies.We also tested whether open wounds were necessary to facilitate disease transmission. At the completion of the experiments, we sampled bacterial communities on diseased, exposed, and healthy coral colonies to determine whether bacterial pathogens had transmitted to the susceptible colonies.We saw no evidence of either direct …

Understanding The Interaction Between Ulk1 And Atg9 And Autophagy, Ryan Hyatt, Joshua L. Andersen

Journal of Undergraduate Research

Autophagy is an adaptive catabolic process of self-digestion, a process by which the cell recycles aged organelles and other structures. Interestingly, changes in the regulation of autophagy have been linked to infections, cancers, neurodegeneration, aging, and heart disease (Arroyo, Daniela S. et al. 2014). Understanding the mechanisms which control autophagy will aid in better treatment of those diseases, specifically in the development of effective pharmaceuticals.

The Winonan, Winona State University

The Winonan - 2010s

No abstract provided.

The Parthenon, January 20, 2016, Megan Osborne

The Parthenon

The Parthenon, Marshall University’s student newspaper, was published by students Monday through Friday during the regular semester and weekly on Thursdays during the summer. Due to budgetary constraints, beginning with the 2015 Fall semester, the newspaper is only published four days a week. There is no issue on Mondays, physical issues are printed on Tuesdays and Fridays, and online issues only are published on Wednesdays and Thursdays. The editorial staff is responsible for the news and the editorial content.