Digital Commons Network^™

Efficacy Of Psychosocial Interventions In Inducing And Maintaining Alcohol Abstinence In Patients With Chronic Liver Disease: A Systematic Review, A Khan, A Tansel, Dl White, Wt Kayani, Wt Bano, J Lindsay, Hb El-Serag, F Kanwal

Faculty, Staff and Students Publications

BACKGROUND & AIMS: We conducted a systematic review of efficacy of psychosocial interventions in inducing or maintaining alcohol abstinence in patients with chronic liver disease (CLD) and alcohol use disorder (AUD). METHODS: We performed structured keyword searches in PubMed, PsychINFO, and MEDLINE for original research articles that were published from January 1983 through November 2014 that evaluated the use of psychosocial interventions to induce or maintain alcohol abstinence in patients with CLD and AUD. RESULTS: We identified 13 eligible studies that comprised 1945 patients; 5 were randomized controlled trials (RCTs). Delivered therapies included motivational enhancement therapy, cognitive behavioral therapy (CBT), …

Early Rescue Of Interneuron Disease Trajectory In Developmental Epilepsies, Ms Siehr, Jl Noebels

Faculty, Staff and Students Publications

The discovery of over 150 monogenic epilepsies and advances in early genetic diagnoses have launched a search for molecular strategies and developmental timetables to reverse or even prevent the course of these debilitating brain disorders. Orthologous rodent models of key disease genes are providing important examples of the range of targets, and serve as valuable test systems for perinatal therapeutic approaches. While gene-specific analyses of single rare 'orphan' diseases are each narrow in scope, they illuminate downstream pathways converging onto interneurons, and treatments that strengthen inhibition during cortical maturation may provide broad protection against these seemingly disparate gene errors. Several …

Genome-Wide Linkage On Chromosome 10q26 For A Dimensional Scale Of Major Depression, Emma E. M. Knowles, Jack W. Kent Jr., D. Reese Mckay, Emma Sprooten, Samuel R. Mathias, Joanne E. Curran, Melanie A. Carless, Marcio A.A. De Almeida, Harald H. H. Goring, Thomas D. Dyer, Rene L. Olvera, Peter T. Fox, Ravindranath Duggirala, Laura Almasy, John Blangero, David C. Glahn

School of Medicine Publications

Major depressive disorder (MDD) is a common and potentially life-threatening mood disorder. Identifying genetic markers for depression might provide reliable indicators of depression risk, which would, in turn, substantially improve detection, enabling earlier and more effective treatment. The aim of this study was to identify rare variants for depression, modeled as a continuous trait, using linkage and post-hoc association analysis. The sample comprised 1221 Mexican–American individuals from extended pedigrees. A single dimensional scale of MDD was derived using confirmatory factor analysis applied to all items from the Past Major Depressive Episode section of the Mini-International Neuropsychiatric Interview. Scores on this …

Biodiversity And You., Garth Woodruff

Faculty Publications

No abstract provided.

The Mosaic Mitral Valve Bioprosthesis: A Long-Term Clinical And Hemodynamic Follow-Up, Michele Celiento, Stefania Blasi, Andrea De Martino, Stefano Pratali, Aldo D Milano, Uberto Bortolotti

The Texas Heart Institute Journal

We reviewed the cases of 100 patients (mean age, 73 ± 10 yr; 64 men) who had mitral valve replacement with a Medtronic Mosaic porcine bioprosthesis from 1995 through 2011. The mean New York Heart Association (NYHA) class was 3 ± 0.7, and 52 patients were in atrial fibrillation. Prosthetic sizes were chiefly 27 mm (50 patients) and 29 mm (40 patients). Follow-up ended in December 2012 and is 97% complete, with a cumulative duration of 611 patient-years (mean duration, 6 ± 4.6 yr; maximum, 17.7 yr). The early mortality rate was 10% (6% in elective patients); late deaths occurred …

Down-Regulation Of Placental Neuropilin-1 In Fetal Growth Restriction., Dev Maulik, Alok De, Louis Ragolia, Jodi Evans, Dmitry Grigoryev, Kamani Lankachandra, David Mundy, Jolene Muscat, Mary M. Gerkovich, Shui Qing Ye

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Fetal growth restriction (FGR) is associated with adverse outcomes extending from fetal to adult life, and thus, constitutes a major health care challenge. Fetuses with progressive growth restriction show increasing impedance in the umbilical artery flow, which may become absent during end-diastole. Absent end-diastolic flow (AEDF) is associated with adverse perinatal outcomes including stillbirths and perinatal asphyxia. Placentas from such pregnancies demonstrate deficient fetoplacental vascular branching. Current evidence, moreover, indicates an antiangiogenic state in maternal circulation in several pregnancy complications including preeclampsia, small-for-gestational-age births, fetal death, and preterm labor. The angiogenic mediators in maternal circulation are predominantly of placental …

Pharmacogenetic Allele Nomenclature: International Workgroup Recommendations For Test Result Reporting., L V. Kalman, Jag Agúndez, M Lindqvist Appell, J L. Black, G C. Bell, S Boukouvala, C Bruckner, E Bruford, K Caudle, S A. Coulthard, A K. Daly, Al Del Tredici, J T. Den Dunnen, K Drozda, R E. Everts, D Flockhart, R R. Freimuth, Andrea Gaedigk, H Hachad, T Hartshorne, M Ingelman-Sundberg, T E. Klein, V M. Lauschke, D R. Maglott, H L. Mcleod, G A. Mcmillin, U A. Meyer, D J. Müller, D A. Nickerson, W S. Oetting, M Pacanowski, V M. Pratt, M V. Relling, A Roberts, W S. Rubinstein, K Sangkuhl, M Schwab, S A. Scott, S C. Sim, R K. Thirumaran, L H. Toji, R F. Tyndale, Rhn Van Schaik, M Whirl-Carrillo, Ktj Yeo, U M. Zanger

Manuscripts, Articles, Book Chapters and Other Papers

This article provides nomenclature recommendations developed by an international workgroup to increase transparency and standardization of pharmacogenetic (PGx) result reporting. Presently, sequence variants identified by PGx tests are described using different nomenclature systems. In addition, PGx analysis may detect different sets of variants for each gene, which can affect interpretation of results. This practice has caused confusion and may thereby impede the adoption of clinical PGx testing. Standardization is critical to move PGx forward.

Genetic Loci Associated With Renal Function Measures And Chronic Kidney Disease In Children: The Pediatric Investigation For Genetic Factors Linked With Renal Progression Consortium., Matthias Wuttke, Craig S. Wong, Elke Wühl, Daniel Epting, Li Luo, Anselm Hoppmann, Anke Doyon, Yong Li, Gkdgen Consortium, Betül Sözeri, Daniela Thurn, Martin Helmstädter, Tobias B. Huber, Tom D. Blydt-Hansen, Albrecht Kramer-Zucker, Otto Mehls, Anette Melk, Uwe Querfeld, Susan L. Furth, Bradley A. Warady, Franz Schaefer, Anna Köttgen

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Chronic kidney disease (CKD) in children is characterized by rapid progression and a high incidence of end-stage renal disease and therefore constitutes an important health problem. While unbiased genetic screens have identified common risk variants influencing renal function and CKD in adults, the presence and identity of such variants in pediatric CKD are unknown.

METHODS: The international Pediatric Investigation for Genetic Factors Linked with Renal Progression (PediGFR) Consortium comprises three pediatric CKD cohorts: Chronic Kidney Disease in Children (CKiD), Effect of Strict Blood Pressure Control and ACE Inhibition on the Progression of CRF in Pediatric Patients (ESCAPE) and Cardiovascular …

Surprise And The Aesthetic Experience Of University Students: A Design Experiment, Ofer Marmur, Boris Koichu

Journal of Humanistic Mathematics

Little is known about instructional means by which the aesthetic experience of mathematics can be enhanced for undergraduate learners. This paper presents and discusses an iterative lesson design process towards creating an opportunity for students to appreciate the beauty of an unexpected solution to a challenging calculus problem. The lesson design draws on insights from both mathematics education research on aesthetics and research on aesthetic appreciation in music. The data were collected over the course of five lessons with different groups of calculus students in which the intended problem was presented in two different ways. In addition, stimulated-recall interviews were …

Passion And Purpose: One Student's Journey To Medical School, Christa Brown

Honorable Mention

In a creative essay, a student describes her passion for science and finding a greater purpose in serving people through science—leading her to pursue a medical career.

Laboratory Studies Of The Biodegradation Of Chemically Dispersed Oil: Effect Of Droplet Size And Nutrient Amendment, Christopher D'Ambrose

Dissertations

Oil spills could have devastating effects on the shorelines, and for this reason, chemical dispersants are commonly used to disperse the oil slick in the water column, preventing it from reaching the shorelines. However, the long term fate of dispersed oil depends on its biodegradation by indigenous microorganisms, which in turn depends on the concentration of nutrients in water and on the droplet size distribution.

Using water from the shorelines of Atlantic City, we placed the water with oil and dispersant inside EPA Baffled Flasks and placed them on rotatory shakers. We selected two speeds: high (250 rpm) and low …

Verification Of Emotion Recognition From Facial Expression, Yanjia Sun

Dissertations

Analysis of facial expressions is an active topic of research with many potential applications, since the human face plays a significant role in conveying a person’s mental state. Due to the practical values it brings, scientists and researchers from different fields such as psychology, finance, marketing, and engineering have developed significant interest in this area. Hence, there are more of a need than ever for the intelligent tool to be employed in the emotional Human-Computer Interface (HCI) by analyzing facial expressions as a better alternative to the traditional devices such as the keyboard and mouse.

The face is a window …

Terahertz Wireless Communication Through Atmospheric Atmospheric Turbulence And Rain, Jianjun Ma

Dissertations

This dissertation focusses on terahertz (THz) wireless communication technology in different weather conditions. The performance of the communication links is mainly studied under propagation through atmospheric turbulence and rain. However, as real outdoor weather conditions are temporally and spatially varying, it is difficult to obtain reproducible atmospheric conditions to verify results of independent measurements making it a challenge to measure and analyze the impact of outdoor atmospheric weather on communication links. Consequently, dedicated indoor weather chambers are designed to produce controllable weather conditions to emulate the real outdoor weather as closely as possible. To emulate turbulent air conditions, an enclosed …

The University Of San Francisco Fact Book And Almanac 2016, Alan Ziajka

USF Fact Book and Almanac

No abstract provided.

Current Status Of Direct Pulp-Capping Materials For Permanent Teeth, Takashi Komabayashi, Qiang Zhu, Robert Eberhart, Yohji Imai

Dental Medicine Faculty Publications

Direct pulp-capping is a method for treating exposed vital pulp with dental material to facilitate the formation of reparative dentin and to maintain vital pulp. Two types of pulp-capping materials, calcium hydroxide and mineral trioxide aggregate, have been most commonly used in clinics, and an adhesive resin has been considered a promising capping material. However, until now, there has been no comprehensive review of these materials. Therefore, in this paper, the composition, working mechanisms and clinical outcome of these types of pulp-capping materials are reviewed.

Medical School Watercooler Newsletter - January 31, 2016, Lindsey Lyle

Watercooler Newsletter

This is the January 31, 2016 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Three USA Medical Students Match in Military Programs
• Dr. Rizk Announced President Elect of Middle East Fertility Society
• Patients Needed for Colonoscopy Sedation Drug Study
• Feb. 4 DSS to Feature Dr. John Zhang

Admissions Report - Detailed Data - January 2016, Office Of Institutional Research & Effectiveness, Wright State University

Admissions Reports

Detailed report of applicants to Wright State including data on county of residency, intended major, and ethnicity for Fall Semester 2015.

A Preliminary Investigation Of The Sterile-Filterability Of Bcs Class Ii Drug Nanosuspensions Prepared Via Wet Stirred Media Milling, Parul Ohri

Theses

Drug nanoparticles can achieve targeting capabilities, enhanced dissolution rates and improved bioavailability when injected intravenously. Sterile filtration of drug nanoparticle suspensions (nanosuspensions) is critically needed for administration by intravenous delivery route. Avoiding gamma irradiation and high temperatures, sterile filtration could be an effective process to sterilize drug nanosuspensions. On the other hand, two major challenges must be tackled: drug particles must at least be smaller than the filter pore size and minimum amount of non-toxic stabilizers must be used to prevent side effects like pain on the injection site. The aim of this study is to prepare naproxen (NPX) nanosuspensions …

Moths Fight Back: Arms Race In The Cloud Forest, Diana Pamela Rivera

Theses

Moths and bats engage in a coevolutionary arm race, where the same signals bats use to find moths are being used by moths to avoid bats. Moths evolve not only behavioral but acoustic responses to avoid predation by bats. This research examines one small component of a complex, multispecies arm race between moths and bats. In this study we found that the moth Amastus hyalina displayed both flight and acoustic responses to ultrasonic stimuli.

In tethered flight the tiger moth Amastus hyalina (Arctiinae) exhibits a complex array of reactions to ultrasonic tones that includes changes in flight and production of …

Pre-Settlement Vegetation Of Greene, Jersey And Macoupin Counties Along The Prairie/Forest Border In Illinois, Richard B. Brugam Ph.D., Paul D. Kilburn Ph.D., Laura Luecking Ma

SIUE Faculty Research, Scholarship, and Creative Activity

The US Federal Government established the Public Land Survey (PLS) to survey federal land before sale to settlers in the early 1800’s. We used a Geographic Information System (GIS) and the PLS to explore the relationship among forests, fire frequency, topography, and soils in Greene, Jersey and Macoupin Counties in Illinois. The PLS data was digitized from microfiche copies of the survey in the Lovejoy Library at Southern Illinois University Edwardsville. The floodplains along the Illinois River supported a fire-intolerant forest of Salix sp., Populus deltoides, Acer spp., and Fraxinus spp. The floodplain is bordered by a line of …

Legitimising The Illegitimate : Extending Interpretation Beyond Reality. The Shrimp Fairytale And Its Implications, Mervyn Martin

Indonesian Journal of International Law

The challenges of liberalization of international trade; Firstly was the realization that in the past there was a tendency to be satisfied with sweeping, unspecific statements on best principles, which always led to often a meaningless outcome without hard and fast commitments. The second was their episodic character. The notion of dispute settlement involves conflicting assertions as to the rights and obligations of the parties involved. Disputes arise from freely entered relationships between parties that create expectations as to their future conduct. there existed a three-pronged objective of the negotiating plan indicated from the Negotiating Group on Dispute Settlement for …

Realizing The Dream: African American Males’ Narratives That Encouraged The Pursuit Of Doctoral Education, Ted N. Ingram

Journal of Research Initiatives

This article used personal narratives to discover factors affecting the decision of African American males to consider doctoral education. This study was based on qualitative interviews with 18 African American male doctoral students enrolled at predominantly white institutions as they reflected on their reasons for pursuing an advanced degree. The following were found to influence their decision: (a) need for faculty encouragement, (b) motivation to pursue a doctorate, and (c) their personal motivations. Recommendations are offered for increasing the numbers of African American male doctoral students.

Peluang Dan Tantangan Undang-Undang Desa Dalam Upaya Demokratisasi Tata Kelola Sumber Daya Alam Desa: Perspektif Agraria Kritis, Mohamad Shohibuddin

Masyarakat: Jurnal Sosiologi

Law Number 6 of 2014 on Village—apart from its political contribution in democratizing statevillage relation—has a fundamental limitation on natural resource issues in the village in the light of agrarian and ecological crises. This Law offers a minor elaboration on natural resource issues and provides limited authority to the village on this field, while no reference is made to the problem of inequality in community’s access to local natural resources. Confronted with such structural challenges, it is argued that “struggle for village autonomy” will hardly lead to significant social transformation without involving attempts to establish just and sustainable natural resource …

Direct And Indirect Effects Of Pro-Poor Growth, Maria Piotrowska

Bulletin of Monetary Economics and Banking

Balancing sustainable growth requires poverty to be reduced. The paper is aimed at determining under which conditions growth can be considered pro-poor. Own approaching to the definition of pro-poor growth is suggested. It allows identifying the growth factors, which directly reduce poverty. Furthermore, it analyses two transmission mechanisms through which growth can reduce poverty; a labor market and local redistribution. It reveals barriers in poverty reduction thus pointing at necessary state intervention. It also helps to evaluate if the sectors of strongest foreign direct investments contribute to poverty reduction. The hypotheses suggested in the paper are verified on a base …

Middle School Pedagogical Order: Lecture Or Lab?, Barry R. Thompson, Thomas E. Deering

Journal of Research Initiatives

A study was recently conducted in a suburban middle school regarding two teaching strategies. Ninety-three eighth grade students were administered a pretest regarding plate tectonics. Forty-one of the students conducted an inquiry lab; they participated in a class discussion regarding the material. Forty-two of the students first participated in a class discussion regarding plate tectonics; afterwards they completed the laboratory exercise. A posttest was administered at the conclusion of the unit. Ten students were not in attendance for both the pretest and the posttest. Statistical analysis of the 83 remaining students through the use of t-tests indicates no statistically significant …

Synthesis Of A Renewable Sourced Thermotropic Polyester With 2,5-Furandicarboxylic Acid, Alicia Marie Marguerite Hurst

Theses

With the rapid depletion of non-renewable sourced materials, unpredictable fluctuations in the prices of fossil fuels, and increased environmental awareness the need to develop biobased materials grows ever more desperate. Furan derivatives sourced from hexoses provide a promising solution for replacing petrochemical based materials. One furan derivative in particular, 2,5-furandicarboxylic acid (FDCA), is especially promising due to its structural similarity to terephthalic acid and potential for use in the production of polyesters similar to PET, PPT, and PBT. This study investigated the synthesis, thermal and liquid crystalline properties of a totally renewable sourced thermotropic polyester based on FDCA. Fructose was …

Effects Of Human Development On Aeolian Sediment Transport Rates Within An Adjacent Undeveloped Backshore Enclave, Kayla L. Kaplan

Theses

Sandy backshore enclaves are created where shorefront buildings are lost during high magnitude storms. Subsequent foredune growth in these enclaves is critical to providing protection to landward development. Conditions for foredune growth and sediment flux within an enclave can be influenced by the presence of adjacent buildings. The objectives of this research are to assess the following questions: what is the nature of sediment flux on a beach within an enclave, what are the potential constraints to transport on a beach within an enclave and, are natural processes alone able to sustain a foredune in an enclave. A field investigation …

Computational And Experimental Determination Of The Hydrodynamics In A Stirred Unbaffled Vessel Provided With Angle-Mounted Axial Impellers, Ji Ma

Theses

In most industrial applications, stirred tanks and reactors are typically provided with baffles to improve their mixing characteristics. However, in a number of pharmaceutical production facilities unbaffled vessels are commonly used. The absence of baffles is preferred in such cases because it reduces the potential for contamination and makes cleaning the vessel between batches easier. However, the lack of baffles also has a negative impact on the system’s hydrodynamics since it often results in poor mixing of the batch, especially if the impeller is centrally placed, since the liquid in such a system is subject to a strong tangential flow, …

Triplex Dna Receptor-Gold Nanoparticle Conjugates For Detection Of Oxidized Dna Base, Qingyu Xing

Theses

Oxidations of DNA nucleobases are believed to be one of the sources of aging and some age-dependent disease, such as cancer. Human body have various mechanisms to repair damaged DNA and base-excision-repair is one mechanism for removing those oxidized nucleobases. This mechanism processes in the cells by cutting the oxidized nucleobases from deoxyribose and letting them excrete though urine. Detection of those abnormal nucleobases in urine has been suggested as a convenient way of early cancer diagnosis. 5-OHU (5-hydroxyuracil), the oxidation product of cytosine, is one of those abnormal nucleobases and it potentially forms base pairs with all four DNA …

Opto-Mechanical Design Of Synchrotron Radiation-Based Far-Infrared Spectroscopic Ellipsometer With Strong Magnetic-Field, Ahmad Abbas Chaudhry

Theses

The objective of this dissertation is to present opto-mechanical design of a synchrotron radiation based far-infrared spectroscopic ellipsometer with a strong external magnetic-field capability. Since high magnetic field has enabled major breakthrough in science such instrument will be highly important to the field of condensed matter physics and characterization of advanced electronic materials. This instrument will be installed at the multi-User facility with the most advanced synchrotron light source: Natonal Synchrotron Source (NSLS-II) at Brookhaven National Laboratory (BNL).The proposed here instrument is capable to measure full Mueller matrix spectroscopic ellipsometry spectra in high magnetic fields of up to 9 Tesla. …