Digital Commons Network^™

Ultrafast Spectroscopy And Energy Transfer In An Organic/Inorganic Composite Of Zinc Oxide And Graphite Oxide, Jeff A. Secor

Dissertations, Theses, and Capstone Projects

The energy transfers and nature of defect levels of an organic/inorganic composite of Zinc Oxide and Graphite are studied with multidimensional spectroscopy. The edge and surface states of each composite are uncovered using excitation emission experiments showing which defect states are mediating the energy transfer from the metal oxide to the graphite oxide. Multidimensional time resolved spectroscopy further describes the effect of the carbon phase on the energy transfer pathways in the material.

Messenger Rna Transport And Translation Regulated By The 3' Utrs Of Dendritic Mrnas And Abnormal Alternative Splicing Of Neuroligin1 In The Fmr1 Ko Mouse Hippocampus, Tianhui Zhu

Dissertations, Theses, and Capstone Projects

Fragile X Syndrome (FXS) is one of the most commonly inherited mental retardations. It is caused by the loss of functional fragile X mental retardation protein (FMRP). Loss of functional FMRP is the most widespread single-gene cause of autism. The most prominent phenotype of FXS patients is an IQ ranging from 20 to 70. FMRP is an RNA binding protein, widely expressed in almost all tissues and highly expressed in brain. As a RNA binding protein, 85-90 % of FMRP in the brain is associated with polyribosomes. Approximately 4 % of total mRNA is associated with FMRP, which functions in …

The Sciences Of The Soul: The Emergence Of Psy-Sciences And The Modern State In Turkey, Kutlughan Soyubol

Dissertations, Theses, and Capstone Projects

This dissertation examines the epistemological and conceptual formation and articulations of madness, mental health, and selfhood in the context of creating a modern Turkish nation (1923-1960). Three inter-related themes run through the study. First, the emergence of new and often contested medical discourses on mental health that engaged with and participated in the construction of healthy secular subjects within the imaginary milieu of the Kemalist nationalist project. Second, the processes through which psy-sciences, armed with scientific rationality, came to engage with and appropriate the language and the terrain once occupied by religion. And third, the intricate discursive fluctuations over the …

Lim Protein Ajuba Participates In The Repression Of Atr-Mediated Dna Damage Response In Human Cells, Sampada Kalan

Dissertations, Theses, and Capstone Projects

LIM proteins constitute a superfamily characterized by the presence of specialized domains called LIM. LIM domain is a unique double-zinc finger motif found in a variety of proteins and is mainly involved in protein-protein interactions. Previous work has implicated that members of the Zyxin subfamily of LIM proteins, namely TRIP6 and LPP are involved in the repression of the DNA damage response (DDR) at telomeres. We further explore if another member from this family has an influence on DDR prevention in the cells. Here, we describe a novel role for Ajuba, a Zyxin family LIM protein, in repressing inappropriate activation …

Role Of Bec-1/Beclin 1 And Autophagy Genes In C.Elegans Germline Cell Proliferation, Kristina Ames

Dissertations, Theses, and Capstone Projects

Autophagy is an evolutionary conserved process involved in the cellular adaptation to stress and basal levels of autophagy are crucial for cellular metabolism and homeostasis. Cellular recycling by autophagy is characterized by the formation of distinctive double-membrane vesicles (autophagosomes) that engulf unnecessary cytoplasmic components, such as organelles and long-lived proteins. Failure to remove protein aggregates and/or damaged organelles, via autophagy, has been implicated in various medical conditions such as liver disease, neurodegenerative diseases and cancer. Autophagy may suppress or promote cellular proliferation in tumors, depending on the type and metabolic state of the cell, where autophagy is generally believed to …

The Effect Of Community And Individual Differences On College Students' Attitudes And Behaviors Towards Transgender Individuals, Laura Hackimer

Dissertations, Theses, and Capstone Projects

For transgender adolescents in an environment consisting largely of non-transgender (cisgender) individuals, whether adults and their peers in school are rejecting or accepting of their gender identity can have a large impact on their immediate and future outcomes. As college students will go on to form the social environment for the next generation of transgender adolescents, it is important to assess their beliefs and behaviors regarding this population. The present study sought to investigate the impact of individual and community factors on cisgender college students’ attitudes and behaviors towards transgender individuals. Using a sample of 302 cisgender college students from …

Interfictional Identities: Transformation And Dissimulation In The Early Modern Period, Yael Nezer Lavender-Smith

Dissertations, Theses, and Capstone Projects

Interfictional Identities develops the concept of interfictional transformations. In these transformations, characters in early modern texts adopt new identities rooted in previous literature. Specifically, Interfictional Identities explores how four early modern moments of interfictional transformation—of Nick Bottom in Shakespeare’s A Midsummer Night’s Dream, of Pyrocles in Sidney’s New Arcadia, of Uriel da Costa in A Specimen of Human Life, and of Don Quixote in Cervantes’ novel—produce both literary and literal hybridity. One wonders why, in these works, writers and playwrights such as Shakespeare, Sidney, Da Costa, and Cervantes favor interfictional transformations over mere allusions to classical literature, …

Climate, Ecology, And Human Evolution During The Plio-Pleistocene, Scott Adam Blumenthal

Dissertations, Theses, and Capstone Projects

A major goal of paleoanthropology is to identify the selective pressures associated with hominin biological and behavioral evolution, yet establishing cause-effect relationships between climate, ecology, and human evolution remains problematic. This dissertation seeks to investigate hominin paleoecology in eastern Africa by reconstructing aspects of climate and ecology using stable isotope analysis.

The first part of this dissertation is focused on the ecology of primates and hominins. Modern tropical African ecosystems provide a useful model for understanding the ecological correlates of isotopic variation in the fossil record, and living primates provide a useful model for understanding the ecological significance of isotopic …

The Conflicts Of Coexistence: Contested Meanings Of Carnivore Management And Conservation In The Greater Yellowstone Ecosystem, Hannah F. Jaicks

Dissertations, Theses, and Capstone Projects

The Greater Yellowstone Ecosystem (GYE) encompasses urbanizing areas adjacent to essential conservation habitat with an inimitable capacity to support carnivore populations, including grizzly bears, wolves, and cougars. This geography has resulted in divisive social conflicts about these animals’ management as well as physical conflicts when they come into contact with people over the course of daily life in the region. Employing a qualitative methodology with semi-structured interviews, participant observation, wilderness treks, and archival work, this study examines the context, social processes, and decision-making processes that underlie the predator conflicts and produce management challenges in the GYE. This approach integrates theory …

The Impact Of Affect On Neural Mechanisms Underlying Orientation Perception, Michelle L. Fowler

Dissertations, Theses, and Capstone Projects

The underlying mechanisms used to process 2D visual information to form a unified 3D percept of the world remain largely unknown. Previous work in our lab has shown that accurate 3D perception of textured surfaces depends on the presence of specific patterns of orientation flows in the retinal image. Recent research has shown that affective state may influence the visual perception of oriented patterns. Relative to neutral face stimuli, fearful face stimuli have been shown to increase sensitivity to orientation of low spatial frequency patterns and decrease sensitivity to orientation of high spatial frequency patterns. How affective state influences the …

Novel Electrolytes For Use In New And Improved Batteries: An Nmr Study, Marc B. Berman

Dissertations, Theses, and Capstone Projects

This thesis focuses on the use of nuclear magnetic resonance (NMR) spectroscopy in order to study materials for use as electrolytes in batteries. The details of four projects are described in this thesis as well as a brief theoretical background of NMR. Structural and dynamics properties were determined using several NMR techniques such as static, MAS, PFG diffusion, and relaxation to understand microscopic and macroscopic properties of the materials described within. Nuclei investigate were 1H, 2H, 7Li, 13C, 19F, 23Na, and 27Al. The first project focuses on an exciting new material to be used as a solid electrolyte membrane. T. …

The Impact Of Foster Care On Depression: An Examination Of Placement Type And Mental Health Service Utilization Among Children And Adolescents, Kisha Cummings

Dissertations, Theses, and Capstone Projects

Background: Children and adolescents in foster care with a history of complex trauma such as neglect, emotional, physical, and sexual abuse have a greater odds of being clinically diagnosed with depression in adulthood compared to children and adolescents without such a history. The current study examines the prevalence of depression in a national sample of children and adolescents aged 7 to 17 years. This study asks whether a) foster care is associated with a greater prevalence of depression among children and adolescents in foster care compared to children and adolescents not in foster care; b) there is an association between …

Millets From The Margins: Value, Knowledge And The Subaltern Practice Of Biodiversity In Uttarakhand, India, Priya R. Chandrasekaran

Dissertations, Theses, and Capstone Projects

Millets from the Margins: Value, Knowledge and the Subaltern Practice of Biodiversity in Uttarakhand, India analyzes what is at stake for small-scale, predominantly women, farmers as local varieties of rainfed food grains such as finger millet are being newly commodified and valued as a biodiversity resource. With support from a Doctoral Dissertation Improvement Grant from the National Science Foundation, I conducted seventeen months of ethnographic research with farmers, activists, scientists, NGO leaders, government officials, transnational functionaries and agribusiness representatives in segregated yet interconnected realms ranging from a village in the Himalayan foothills to transnational institutions in Rome.

This work demonstrates …

Richard A. Posner: A Study In Judicial Entrepreneurship, Sean J. Shannon

Dissertations, Theses, and Capstone Projects

This dissertation analyzes the role of Richard Posner, one of the most prolific and innovative legal thinkers over the past forty years, as a judicial entrepreneur in his efforts to persuade the legal academy and judiciary to incorporate economic principles into the judicial decision making process in market and non-market areas of the law and legal discourse and thereby to re-examine the role of the judge. Though political scientists have explored the entrepreneurial activities of policy makers and political actors, they have given little attention to the role of judges as judicial entrepreneurs. This dissertation develops a comprehensive theoretical understanding …

Effect Of Temporal Onset Of Mechanical Loading On Tendon To Bone Healing, Determined With A Novel In-Vivo Device, Mark E. Stasiak

Dissertations, Theses, and Capstone Projects

Background: Exposure to tensile loading has been shown to maintain tendon/ligament homeostasis, with the tensile modulus of the tissue increasing in response to greater loading frequency, and even decreasing in the absence of load. However after injury or surgical repair the effect of tensile load is controversial, with many studies implicating mechanical loading with impaired healing. It is currently unknown when the tensile loading imparted during rehabilitation exercise, can be safely reintroduced after surgical tendon repair or ligament reconstruction, and at what time point it can most benefit the remodeling process. To investigate the effect of tensile loading protocols on …

The Fictions Of Whiteness: Transatlantic Race Science, Gender, Nationalism, And The Construction Of Race In Nineteenth-Century American Fiction (1823-1867), Philip E. Kadish

Dissertations, Theses, and Capstone Projects

Fictions of Whiteness argues that political beliefs preceded and determined the race science theories which nineteenth century American white novelists applied or invoked in their work, the inverse of the current critical consensus. For issues ranging from Indian removal to slavery and Reconstruction, and utilizing theories from of Condorcet, Buffon, Camper, Louis Agassiz, James Pritchard, Johannes Blumenbach, and George Borrow these authors shifted allegiances to divergent race theories between and within works, applied those theories selectively to white, black, and Indians characters, and applied the same scientific race theories to politically divergent rhetorical ends. By analyzing shifting application of different …

The Interaction Between Eukaryotic Translation Initiation Factor Eif4g And 3’ Cap Independent Translation Element Of Barley Yellow Dwarf Virus Is Affected By Multiple Initiation Factors, Pei Zhao

Dissertations, Theses, and Capstone Projects

Barley Yellow Dwarf Virus (BYDV) lacks a 5’ (7-methyl guanosine) cap as well as a 3’poly A tail. Like many plant viruses, BYDV contains a cap independent translation element (CITE) in the 3’ untranslated region of the viral mRNA. BTE (Barley Yellow Dwarf Virus like cap-independent translation element) is one of the well characterized CITEs. BTE mediated translation primarily depends on eukaryotic initiation factor eIF4G. BTE binds to eIF4G; however, the details of BTE initiated translation are still unclear. Three eIF4G deletion mutants with different domain organization were used to investigate BTE interaction with eIF4G: eIF4G601-1196 is the eIF4G fragment …

The Implications Of Chromatin Remodelers' Acetylation In Ino1 Activation, Michelle M. Esposito

Dissertations, Theses, and Capstone Projects

It is known that histone acetylases (HATs) regulate gene expression, but only recently have new functional implications about remodelers’ acetylation emerged. For instance, the HAT, Gcn5p, is capable of acetylating the catalytic subunit of the nucleosome remodeling complex SWI/SNF, Snf2p, which results in the dissociation of the complex from chromatin. The implications of this acetylation and subsequent dissociation have yet to be explored with regard to transcriptional regulation and other possible mechanisms. To further understand the implications of remodeler acetylation, I used a yeast model system examining the expression of the inositol-3-phosphate synthase gene INO1. Through chromatin immunoprecipitation (ChIP) …

Status Signaling And The Characterization Of A Chirp-Like Signal In The Weakly Electric Fish Steatogenys Elegans, Caitlin E. Field

Dissertations, Theses, and Capstone Projects

Sensory systems are critical to both exploratory and communicatory processes, the study of which is critical to our understanding of how animals perceive and respond to their environments. In weakly electric fishes the electrosensory system is utilized for both of these purposes. One type of communication, status signaling, is widespread across taxa and frequently hormonally modulated. This hormonal modulation keeps the signal honest, wherein the status of the sender and the production of the status signal itself are both hormone dependent. We investigated exploratory and communicatory strategies of the electromotor system in pulse-type gymnotiforms, with a focus on status communication …

Exploring Sewage Sludge/Fish Waste-Based Materials As Adsorbents Of Pharmaceuticals From Water Phase, Lilja Nielsen

Dissertations, Theses, and Capstone Projects

In an effort to enable wastewater treatment that is more economical and environmentally friendly, alternative adsorbents composed of sewage sludge and fish waste were tested for the removal of pharmaceuticals from aqueous phase. Sewage sludge, fish waste and their homogenized mixtures (90:10, 75:25, 50:50) were carbonized at two temperatures (650 and 950 °C). The obtained materials were extensively characterized in terms of their chemistry and porosity. Adsorption isotherms were used to determine adsorption capacity for 3 model pharmaceuticals: carbamazepine, sulfamethoxazole, and trimethoprim. To simulate the complex environment in the wastewater treatment plant, the adsorption capacity for a multi-component solution, containing …

Through The Gateway: Marijuana Production, Governance, And The Drug War Détente, Michael Polson

Dissertations, Theses, and Capstone Projects

Since the 1996 voter approval of medical marijuana laws in California, marijuana policy has become increasingly liberalized. Producers, however, have remained in the greyest of grey market zones. Federal anti-drug laws and supply-side tactics have intensively targeted them even as marijuana has become more licit. In this legally unstable environment, marijuana patient-cultivators and underground producers have articulated and asserted themselves politically and economically, particularly as the likelihood of full legalization has increased. This dissertation explores how producers navigated the nebulous zone between underground and medical markets. I argue that even as producers supplied marijuana to a formalizing, regulated medical industry …

When Human-Leopard Conflict Turns Deadly: A Cross-Country Situational Analysis, Julie S. Viollaz

Dissertations, Theses, and Capstone Projects

Habitat destruction and pollution are two of the main causes for the decline of the planet’s biodiversity. Yet environmentalists are now recognizing that illegal wildlife killings, both poaching and retaliatory killings due to human-wildlife conflict, are perhaps the next major threat. Biologists have researched illegal killings and their effect on species conservation, but few researchers have applied criminological principles of crime reduction to them. This research will explore the situational factors that drive retaliatory leopard killings in parts of South Africa, Kenya, and India. These factors, human and environmental, include local expectations from wildlife, sensitivity to environmental issues, communication between …

Healthy Beginnings: Exploring The Impact Of Parental Stress And Relationship Quality On Birth Outcomes, Anna A. Divney

Dissertations, Theses, and Capstone Projects

This dissertation consists of three studies exploring the effects of maternal and paternal experiences of stress and perceptions of relationship quality on length of gestation and birth weight. The first study assessed the association of parental relationship quality with the baby’s length of gestation and birth weight among 2,072 families in the Fragile Families and Child Wellbeing study. Romantic relationships can be a substantial source of social support as well as stress, and have been shown to influence many health outcomes. Beyond crude relationship characteristics, however, few studies have assessed the association of other dimensions of relationship quality, such as …

The Evolution Of The Viral Rna Sensor Oas1 In Old World Monkeys And Cetartiodactyls, Ian Fish

Dissertations, Theses, and Capstone Projects

Animals produce an array of sensors patrolling the intracellular environment poised to detect and respond to viral infection. The oligoadenylate synthetase family of enzymes comprises a crucial part of this innate immune response, directly signaling endonuclease activity responsible for inhibiting viral replication. Oligoadenylate synthetase 1 plays a vital role in animal susceptibility to pathogens including flaviviruses such as dengue, West Nile, and hepatitis c virus. This thesis includes a population level analysis of OAS1 diversity within macaque and baboon species followed by a broader survey of the gene in nineteen Old World monkeys. My research found that at the species …

Let Fall: Hysteria And The Psychoanalytic Act, Matthew W. Oyer

Dissertations, Theses, and Capstone Projects

This text proposes to examine the contemporary crisis of psychoanalysis by taking seriously feminist critiques of the theory’s phallocentrism, but arguing that the phallus cannot be metaphorically or metonymically replaced by any substitutive term, as most revisionist theories of psychoanalysis have sought to do. Castration is the central psychoanalytic concept, though the theory always seeks to cover it over. In order to develop a psychoanalysis that can confront this castration that is always repressed and yet, in its persistent return, continuously disrupts the continuity of psychoanalytic theory, a detour is proposed, returning to the origins of psychoanalysis and taking hysteria …

Locked In: Melancholia In The Modern American Prison Literature Of R. Dwayne Betts And Jarvis Jay Masters, Johnna Scrabis

Dissertations, Theses, and Capstone Projects

This thesis explores the theme of melancholia in the writing of currently and formerly incarcerated African American men during the late 20^th and early 21^st century. Melancholia, with its rich history in literature from ancient times to the present, is discernable in the works of many people with prison experience. In their writing, melancholia is expressed primarily as a loss and as a disconnection with time, as well as an empowering creative force. The work of Jarvis Jay Masters and R. Dwayne Betts reflects the paradox of melancholia: just as it shows the depressive element of the condition, …

Chamber-Specific Patterns Of Epicardium Formation In Zebrafish, Sana Khan

Dissertations, Theses, and Capstone Projects

The outer cardiac layer, the epicardium, coordinates the final steps of vertebrate heart development. This cardiac tissue arises from cells in the proepicardial organ (PEO) that forms around the base of the inflow tract. Its general location is conserved across species despite morphological differences. Cellular mechanisms of migration differ across species. Three strategies of PEO migration are described: 1) The floating cyst model - PEO cells released into the pericardial cavity are directed by fluid movements to migrate onto the myocardium; 2) Villi transfer - cardiac contractions may mediate multicellular PEO villi contact to the myocardium; and 3) Tissue bridge-mediated …

Creating With Anger: Contemplating Vendetta. An Analysis Of Anger In Italian And Spanish Women Writers Of The Early Modern Era, Luisanna Sardu Castangia

Dissertations, Theses, and Capstone Projects

In the vast gamut of human emotions, anger is one of the most complex, provocative, and enduring. From Greek philosophers working in antiquity to today’s most recent theories on emotions, most scholars agree that anger has a multifaceted nature. This near universal agreement across the barriers of time and geography stems from the following facts: in order to exist, anger involves the participation of other emotions; anger does not have an opposite; anger leads an individual to engage in an act of self-analysis and in an evaluation of other individuals; and, finally, anger inspires action to right a wrong that …

Dying To Learn, Learning To Die, The Craft Of Dying In Early Modern English Drama And The Cultivation Of Dying-Voice Literacy, Simon Gaston Fortin

Dissertations, Theses, and Capstone Projects

DYING TO LEARN, LEARNING TO DIE

THE CRAFT OF DYING IN EARLY MODERN ENGLISH DRAMA

AND THE CULTIVATION OF DYING-VOICE LITERACY

by

SIMON G. FORTIN

Adviser: Professor Mario DiGangi

This dissertation contends that, through their relentless dramatization of agonies, the early modern English dramatists taught their audiences how to die. Attending a play where characters devised, discussed, prepared for, plotted, inflicted, endured and witnessed death, constituted an apprenticeship I demonstrate, akin to going to school, though informal it may have been, where audiences learned about mortality, death as an event, and dying as a process. Thus, this study points to …

Glial Contributions To Neural Function And Disease, Mn Rasband

Faculty, Staff and Students Publications

The nervous system consists of neurons and glial cells. Neurons generate and propagate electrical and chemical signals, whereas glia function mainly to modulate neuron function and signaling. Just as there are many different kinds of neurons with different roles, there are also many types of glia that perform diverse functions. For example, glia make myelin; modulate synapse formation, function, and elimination; regulate blood flow and metabolism; and maintain ionic and water homeostasis to name only a few. Although proteomic approaches have been used extensively to understand neurons, the same cannot be said for glia. Importantly, like neurons, glial cells have …