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Academics: The Newsletter Of The Swosu College Of Arts And Sciences, Peter Grant

aCAdemicS: The Newsletter of the SWOSU College of Arts & Sciences

No abstract provided.

Watkins, Arnold Clayton, Collection, 1942-1945, Special Collections, Leonard H. Axe Library

Finding Aids

Collection of Arnold Clayton Watkins, Corporal in the Tenth Air Corp of the Army Air Force. The collection consists of scrapbooks, photographs, and miscellaneous materials pertaining to World War II.

Rose And Rauk Papers, Circa 1885-1999, Special Collections, Leonard H. Axe Library

Finding Aids

Photographs and biographical materials relating to the Cordes, Lahmann, Gebo, Coerlin and related families collected by Rose Cordes Gebo and Lembit Rauk. The families were originally from the Axstedt-Harrendorf area of Germany and emigrated to America during the late 19th century and early 20th centuries. Members of the Cordes, Lahmann, and Coerlin families have either visited or lived in Pittsburg, Kansas.

Eurydice Club Records, 1903-1929, Special Collections, Leonard H. Axe Library

Finding Aids

Records of the Eurydice Club, at Pittsburg State University, a women's music organization, that became a chapter of Sigma Alpha Iota fraternity in 1930. The records include a constitution and bylaws, a club history, a scrapbook of photographs, clippings, performance programs, and general information about the University and its music department.

Patton On How A Prehistoric Appalachian Food, May Hold Answers To Regional Food Insecurity, Feb 12, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Pbio Colloquium | Alum On Embryology In Cardiopteris, Feb 12, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Celebration Of Faculty Scholarship 2015, Olin Library

Celebration of Faculty Scholarship

No abstract provided.

Daily Eastern News: Feburary 01, 2016, Eastern Illinois University

February

No abstract provided.

Single Fluorescence Probes Along The Reactive Center Loop Reveal Site-Specific Changes During The Latency Transition Of Pai-1, Tihami Qureshi, Cynthia B. Peterson

Faculty Publications

© 2015 The Protein Society The serine protease inhibitor (serpin), plasminogen activator inhibitor-1 (PAI-1), is an important biomarker for cardiovascular disease and many cancers. It is therefore a desirable target for pharmaceutical intervention. However, to date, no PAI-1 inhibitor has successfully reached clinical trial, indicating the necessity to learn more about the mechanics of the serpin. Although its kinetics of inhibition have been extensively studied, less is known about the latency transition of PAI-1, in which the solvent-exposed reactive center loop (RCL) inserts into its central β-sheet, rendering the inhibitor inactive. This spontaneous transition is concomitant with a large translocation …

Does Corticosterone Regulate The Onset Of Breeding In Free-Living Birds?: The Cort-Flexibility Hypothesis And Six Potential Mechanisms For Priming Corticosteroid Function, Christine R. Lattin, Creagh W. Breuner, L. Michael Romero

Faculty Publications

© 2015 Published by Elsevier Inc. For many avian species, the decision to initiate breeding is based on information from a variety of environmental cues, including photoperiod, temperature, food availability, and social interactions. There is evidence that the hormone corticosterone may be involved in delaying the onset of breeding in cases where supplemental cues, such as low food availability and inclement weather, indicate that the environment is not suitable. However, not all studies have found the expected relationships between breeding delays and corticosterone titers. In this review, we present the hypothesis that corticosterone physiology mediates flexibility in breeding initiation (the …

Distinct Encounter Complexes Of Pai-1 With Plasminogen Activators And Vitronectin Revealed By Changes In The Conformation And Dynamics Of The Reactive Center Loop, Tihami Qureshi, Sumit Goswami, Carlee S. Mcclintock, Matthew T. Ramsey, Cynthia B. Peterson

Faculty Publications

© 2015 The Protein Society Plasminogen activator inhibitor-1 (PAI-1) is a biologically important serine protease inhibitor (serpin) that, when overexpressed, is associated with a high risk for cardiovascular disease and cancer metastasis. Several of its ligands, including vitronectin, tissue-type and urokinase-type plasminogen activator (tPA, uPA), affect the fate of PAI-1. Here, we measured changes in the solvent accessibility and dynamics of an important unresolved functional region, the reactive center loop (RCL), upon binding of these ligands. Binding of the catalytically inactive S195A variant of tPA to the RCL causes an increase in fluorescence, indicating greater solvent protection, at its C-terminus, …

Mathematical Model Of The Firefly Luciferase Complementation Assay Reveals A Non-Linear Relationship Between The Detected Luminescence And The Affinity Of The Protein Pair Being Analyzed, Renee Dale, Yuki Ohmuro-Matsuyama, Hiroshi Ueda, Naohiro Kato

Faculty Publications

© 2016 Dale et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The firefly luciferase complementation assay is widely used as a bioluminescent reporter technology to detect protein-protein interactions in vitro, in cellulo, and in vivo. Upon the interaction of a protein pair, complemented firefly luciferase emits light through the adenylation and oxidation of its substrate, luciferin. Although it has been suggested that kinetics of light production in the firefly luciferase complementation assay …

Dna Methylation Variation Of Human-Specific Alu Repeats, Mark A. Batzer, Arundhati Bakshi, Scott W. Herke, Joomyeong J. Kim

Faculty Publications

DNA methylation is the major repression mechanism for human retrotransposons, such as the Alu family. Here, we have determined the methylation levels associated with 5238 loci belonging to 2 Alu subfamilies, AluYa5 and AluYb8, using high-throughput targeted repeat element bisulfite sequencing (HT-TREBS). The results indicate that »90% of loci are repressed by high methylation levels. Of the remaining loci, many of the hypomethylated elements are found near gene promoters and show high levels of DNA methylation variation. We have characterized this variation in the context of tumorigenesis and interindividual differences. Comparison of a primary breast tumor and its matched normal …

Dna Methylation Variation Of Human-Specific Alu Repeats, Arundhati Bakshi, Scott W. Herke, Mark A. Batzer, Joomyeong Kim

Faculty Publications

© 2016 Taylor & Francis Group, LLC. ABSTRACT: DNA methylation is the major repression mechanism for human retrotransposons, such as the Alu family. Here, we have determined the methylation levels associated with 5238 loci belonging to 2 Alu subfamilies, AluYa5 and AluYb8, using high-throughput targeted repeat element bisulfite sequencing (HT-TREBS). The results indicate that ∼90% of loci are repressed by high methylation levels. Of the remaining loci, many of the hypomethylated elements are found near gene promoters and show high levels of DNA methylation variation. We have characterized this variation in the context of tumorigenesis and interindividual differences. Comparison of …

Msh1 Is A Plant Organellar Dna Binding And Thylakoid Protein Under Precise Spatial Regulation To Alter Development, Kamaldeep S S. Virdi, Yashitola Wamboldt, Hardik Kundariya, John D D. Laurie, Ido Keren, K. R. Sunil Kumar, Anna Block, Gilles Basset, Steve Luebker, Christian Elowsky, Philip M M. Day, Johnna L L. Roose, Terry M M. Bricker, Thomas Elthon, Sally A A. Mackenzie

Faculty Publications

© 2016 The Authors As metabolic centers, plant organelles participate in maintenance, defense, and signaling. MSH1 is a plant-specific protein involved in organellar genome stability in mitochondria and plastids. Plastid depletion of MSH1 causes heritable, non-genetic changes in development and DNA methylation. We investigated the msh1 phenotype using hemi-complementation mutants and transgene-null segregants from RNAi suppression lines to sub-compartmentalize MSH1 effects. We show that MSH1 expression is spatially regulated, specifically localizing to plastids within the epidermis and vascular parenchyma. The protein binds DNA and localizes to plastid and mitochondrial nucleoids, but fractionation and protein–protein interactions data indicate that MSH1 also …

An Adenovirus-Derived Protein: A Novel Candidate For Anti-Diabetic Drug Development, Vijay Hegde, Ha Na Na, Olga Dubuisson, Susan J. Burke, J. Jason Collier, David Burk, Tamra Mendoza, Nikhil V. Dhurandhar

Faculty Publications

© 2015 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). Aims Exposure to human adenovirus Ad36 is causatively and correlatively linked with better glycemic control in animals and humans, respectively. Although the anti-hyperglycemic property of Ad36 may offer some therapeutic potential, it is impractical to use an infectious agent for therapeutic benefit. Cell-based studies identified that Ad36 enhances cellular glucose disposal via its E4orf1 protein. Ability to improve glycemic control in vivo is a critical prerequisite for further investigating the therapeutic potential of E4orf1. Therefore, the aim of this study was to determine the ability of E4orf1 …

Balance Of Threat, Balance Of Mind: Nuclear Rivalry And Arms Control, Benjamin Joseph Bonin

Political Science ETDs

Under what conditions will rivals choose to accept mutual constraints, limitations, and even reductions on their capabilities for waging war? Contemporary political science lacks a strong theoretical basis for understanding this behavior, despite the fact that states in the modern era continue to negotiate and enter into arms control arrangements. This study contributes a theoretical framework and empirical analysis identifying the conditions under which nuclear-armed rivals might choose to curb their deadly arsenals. Traditional theories grounded in classical deterrence theory suggest arms control serves to preserve a deterrent status quo and prevent expensive and destabilizing arms competition; it should therefore …

Faculty Senate Monthly Packet February 2016, Portland State University Faculty Senate

Faculty Senate Monthly Packets

The February 2016 Monthly packet includes the February agenda and appendices and the Faculty Senate minutes and attachments from the meeting held January 2016.

Analogous Cellular Contribution And Healing Mechanisms Following Digit Amputation And Phalangeal Fracture In Mice, Lindsay A. Dawson, Jennifer Simkin, Michelle Sauque, Maegan Pela, Teresa Palkowski, Ken Muneoka

Biology Faculty Publications

Regeneration of amputated structures is severely limited in humans and mice, with complete regeneration restricted to the distal portion of the terminal phalanx (P3). Here, we investigate the dynamic tissue repair response of the second phalangeal element (P2) post amputation in the adult mouse, and show that the repair response of the amputated bone is similar to the proximal P2 bone fragment in fracture healing. The regeneration-incompetent P2 amputation response is characterized by periosteal endochondral ossification resulting in the deposition of new trabecular bone, corresponding to a significant increase in bone volume; however, this response is not associated with bone …

Inefficient Dmn Suppression In Schizophrenia Patients With Impaired Cognitive Function But Not Patients With Preserved Cognitive Function, Li Zhou, Weidan Pu, Jingjuan Wang, Haihong Liu, Guowei Wu, Chang Liu, Tumbwene Mwansisya, Haojuan Tao, Xudong Chen, Dongsheng Lv

School of Nursing & Midwifery, East Africa

Previous studies have observed reduced suppression of the default mode network (DMN) during cognitive tasks in schizophrenia, suggesting inefficient DMN suppression is critical for the cognitive deficits of schizophrenia. Cognitive function in schizophrenia patients, however, varies from relatively intact to severely impaired. This study, which compared the DMN suppression patterns between first-episode schizophrenia patients with (SZ-Imp) and without (SZ-Pre) impaired cognitive function, may provide further insight into the role of DMN dysfunction in cognitive deficits of schizophrenia. Independent component analysis (ICA) was applied to resting-state fMRI data to identify the DMN in each subject, and then general linear modeling based …

Advances In Nursing Doctoral Education & Research [Complete Issue: February 2016 Vol 5, No 1], Sonja Mcilfatrick

International Network for Doctoral Education in Nursing - ANDER

Advances in Nursing Doctoral Education & Research

Official Journal for the International Network for Doctoral Education in Nursing (INDEN)

The file attached to this record is the February 2016 issue of ANDER, INDEN's peer-reviewed journal. This journal evolved from the INDEN Newsletter which served the organization well for many years. Since 2013 the journal has acknowledged the excellence of submitted manuscripts by having them peer-reviewed. Submissions are warmly invited and the relevant guidelines can be found at http://nursing.jhu.edu/excellence/inden/ander-journal.html

This edition of the journal continues to explore key issues in nursing doctoral education and showcase its diversity. In the peer-reviewed section …

Continental Carbonate Facies Of A Neoproterozoic Panglaciation, North-East Svalbard, Ian J. Fairchild, Edward J. Fleming, Huiming Bao, Douglas I. Benn, Ian Boomer, Yuri V. Dublyansky, Galen P. Halverson, Michael J. Hambrey, Chris Hendy, Emily A. Mcmillan, Christoph Spötl, Carl T.E. Stevenson, Peter M. Wynn

Faculty Publications

© 2016 International Association of Sedimentologists. The Marinoan panglaciation (cα 650 to 635 Ma) is represented in north-east Svalbard by the 130 to 175 m thick Wilsonbreen Formation which contains syn-glacial carbonates in its upper 100 m. These sediments are now known to have been deposited under a CO2-rich atmosphere, late in the glaciation, and global climate models facilitate testing of proposed analogues. Precipitated carbonates occur in four of the seven facies associations identified: Fluvial Channel (including stromatolitic and intraclastic limestones in ephemeral stream deposits); Dolomitic Floodplain (dolomite-cemented sand and siltstones, and microbial dolomites); Calcareous Lake Margin (intraclastic dolomite and …

New Loci For Body Fat Percentage Reveal Link Between Adiposity And Cardiometabolic Disease Risk, Yingchang Lu, Felix R. Day, Stefan Gustafsson, Martin L. Buchkovich, Jianbo Na, Veronique Bataille, Diana L. Cousminer, Zari Dastani, Alexander W. Drong, Toñu Esko, David M. Evans, Mario Falchi, Mary F. Feitosa, Teresa Ferreira, Åsa K. Hedman, Robin Haring, Pirro G. Hysi, Mark M. Iles, Anne E. Justice, Stavroula Kanoni, Vasiliki Lagou, Rui Li, Xin Li, Adam Locke, Chen Lu, Reedik Mägi, John R.B. Perry, Tune H. Pers, Qibin Qi, Marianna Sanna, Ellen M. Schmidt, William R. Scott, Dmitry Shungin

Faculty Publications

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (Po5108), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and …

A Dose-Schedule Finding Design For Phase I-Ii Clinical Trials, Beibei Guo, Yisheng Li, Ying Yuan

Faculty Publications

Summary: Dose finding methods aiming at identifying an optimal dose of a treatment with a given schedule may be at a risk of misidentifying the best treatment for patients. We propose a phase I-II clinical trial design to find the optimal dose-schedule combination. We define schedule as the method and timing of administration of a given total dose in a treatment cycle. We propose a Bayesian dynamic model for the joint effects of dose and schedule. The model proposed allows us to borrow strength across dose-schedule combinations without making overly restrictive assumptions on the ordering pattern of the schedule effects. …

Quantifying Demographic Uncertainty: Bayesian Methods For Integral Projection Models, Bret D. Elderd, Tom E.X. Miller

Faculty Publications

© 2016 by the Ecological Society of America. Integral projection models ( IPM s) are a powerful and popular approach to modeling population dynamics. Generalized linear models form the statistical backbone of an IPM . These models are typically fi t using a frequentist approach. We suggest that hierarchical Bayesian statistical approaches offer important advantages over frequentist methods for building and interpreting IPM s, especially given the hierarchical nature of most demographic studies. Using a stochastic IPM for a desert cactus based on a 10- year study as a worked example, we highlight the application of a Bayesian approach for …

Change In Obesity Prevalence Across The United States Is Influenced By Recreational And Healthcare Contexts, Food Environments, And Hispanic Populations, Candice A. Myers, Tim Slack, Corby K. Martin, Stephanie T. Broyles, Steven B. Heymsfield

Faculty Publications

Objective To examine change in county-level adult obesity prevalence between 2004 and 2009 and identify associated community characteristics. Methods Change in county-level adult (≥20 years) obesity prevalence was calculated for a 5-year period (2004-2009). Community measures of economic, healthcare, recreational, food environment, population structure, and education contexts were also calculated. Regression analysis was used to assess community characteristics associated (p< 0.01) with change in adult obesity prevalence. Results Mean±SD change in obesity prevalence was 5.1±2.4%. Obesity prevalence decreased in 1.4% (n = 44) and increased in 98% (n = 3,060) of counties from 2004-2009. Results showed that both baseline levels and increases in physically inactive adults were associated with greater increases in obesity prevalence, while baseline levels of and increases in physician density and grocery store/supercenter density were related to smaller increases in obesity rates. Baseline levels of the Hispanic population share were negatively linked to changing obesity levels, while places with greater Hispanic population growth saw greater increases in obesity. Conclusions Most counties in the U.S. experienced increases in adult obesity prevalence from 2004 to 2009. Findings suggest that community-based interventions targeting adult obesity need to incorporate a range of community factors, such as levels of physical inactivity, access to physicians, availability of food outlets, and ethnic/racial population composition.

Transcriptome Profiling Of Beach Morning Glory (Ipomoea Imperati) Under Salinity And Its Comparative Analysis With Sweetpotato, Julio Solis, Niranjan Baisakh, Steven R. Brandt, Arthur Villordon, Don La Bonte

Faculty Publications

The response and adaption to salt remains poorly understood for beach morning glory [Ipomoea imperati (Vahl) Griseb], one of a few relatives of sweetpotato, known to thrive under salty and extreme drought conditions. In order to understand the genetic mechanisms underlying salt tolerance of a Convolvulaceae member, a genome-wide transcriptome study was carried out in beach morning glory by 454 pyrosequencing. A total of 286,584 filtered reads from both salt stressed and unstressed (control) root and shoot tissues were assembled into 95,790 unigenes with an average length of 667 base pairs (bp) and N50 of 706 bp. Putative differentially expressed …

Halobacteriovorax, An Underestimated Predator On Bacteria: Potential Impact Relative To Viruses On Bacterial Mortality, Henry N. Williams, Despoina S. Lymperopoulou, Rana Athar, Ashvini Chauhan, Tamar L. Dickerson, Huan Chen, Edward Laws, Timkhite Kulu Berhane, Adrienne R. Flowers, Nadine Bradley, Shanterial Young, Denene Blackwood, Jacqueline Murray, Oladipupo Mustapha, Cory Blackwell, Yahsuan Tung, Rachel T. Noble

Faculty Publications

Predation on bacteria and accompanying mortality are important mechanisms in controlling bacterial populations and recycling of nutrients through the microbial loop. The agents most investigated and seen as responsible for bacterial mortality are viruses and protists. However, a body of evidence suggests that predatory bacteria such as the Halobacteriovorax (formerly Bacteriovorax), a Bdellovibrio-like organism, contribute substantially to bacterial death. Until now, conclusive evidence has been lacking. The goal of this study was to better understand the contributors to bacterial mortality by addressing the poorly understood role of Halobacteriovorax and how their role compares with that of viruses. The results revealed …

Feedstock Analysis Sensitivity For Estimating Ethanol Production Potential In Switchgrass And Energycane Biomass, Kun Jun Han, Younghwan Moon, Donal F. Day, William D. Pitman

Faculty Publications

Efficient ethanol production from lignocellulosic biomass requires highly degradable feedstock; therefore, there is a similarity between forage crop production for ruminant animals and ethanol production from lignocellulosic biomass. Feed value analysis techniques may be used to estimate lignocellulosic biomass quality. Because lignin and its derivatives in cell walls are major compounds interrupting biomass degradation, fiber analysis and in vitro incubation tests were conducted with switchgrass (Panicum virgatum) and energycane (Saccharum spp.) biomass collected at 100 and 120g lignin (acid detergent lignin) kg-1 DM (dry matter). Mean NDF (neutral detergent fiber) in switchgrass was consistently greater than that of energy cane …

Today - February 2016, Loma Linda University Health

TODAY

Inside this issue:

-- 23rd annual Foundation Gala raises more than $1.3 million for LLU Children's Hospital
-- Doctors perform unprecedented facial re-implantation surgery on 2-year-old dog bite victim
-- 'LIVE IT' commercial goes viral on Facebook
Adventist Health Study-2 anticipates significant findings in 2016
-- Nearly $36,000 raised during Ontario Reign's LLU Children's Hospital Night
-- Faculty are invited to the first annual Service Learning Spring Colloquium
-- Representatives from Mexican Consulate in San Bernardino meet with Loma Linda University School of Public Health
-- Big Hearts for Little Hearts Loma Linda Guild treats patients to Valentine's Day craft …