Digital Commons Network^™

Machine-Learning-Guided Design Of A Biomedical High-Entropy Alloy For Additive Manufacturing: Cast-State Benchmark And Preliminary Lpbf Feasibility Assessment, Deyu Jiang, Lai Chang Zhang, Kuaishe Wang, Wen Wang, Chenyuan Zhu, Yuanfei Fu, Kai Wang, Wei Zhai, Ching Chiuan Yen, Weijie Lu, Di Zhang, Liqiang Wang

Research outputs 2022 to 2026

Additive manufacturing of biomedical high-entropy alloys (BioHEAs) demands a combination of low elastic modulus, high strength, and damage tolerance, yet composition discovery remains largely empirical. Here, we establish a machine-learning framework that couples virtual screening with physical prototyping to link composition, deformation mechanism, and properties. Ensemble models for strength, elongation, and modulus were applied to screen Ti–Zr–Nb–Ta–Mo-centered quinary-to-septenary spaces (∼15 million compositions), revealing discrete performance islands anchored by a Ti–Zr backbone. A Zr-rich BCC alloy (Zr₃₉.₃Ti₁₉.₅Nb₁₇.₉Ta₁₆.₈Mo₆.₅) was identified and validated. In the as-cast state, it delivers ∼1.0 GPa yield strength, 22.3% elongation, and an 88 GPa elastic modulus; ductility originates …

Meta-Analysis Of Dna Methylation Aging Signatures In 17 Human Tissues, Macsue Jacques, Kirsten Seale, Sarah Voisin, Anna Lysenko, Robin Grolaux, Bernadette Jones-Freeman, Severine Lamon, Mandhri Abeysooriya, Itamar Levinger, Carlie Bauer, Adam P. Sharples, Aino Heikkinen, Elina Sillanpaa, Miina Ollikainen, Cassandra Smith, James R. Broatch, Navabeh Zarekookandeh, Linn Gillberg, Ida Blom, Jesse R. Poganik, Mahdi Moqri, Vadim N. Gladyshev, Matthew Taper, Cassandra Malecki, Sean Lal, Nathalie Saurat, Steve Horvath, Andrew Teschendorff, Nir Eynon

Research outputs 2022 to 2026

Epigenetic changes, in particular DNA methylation, accumulate with age across different tissues, but whether these changes follow consistent patterns across different organs remains poorly understood. Here we show, through a meta-analysis of more than 15,000 human methylation profiles spanning 17 tissues, that aging produces both conserved and tissue-specific epigenetic signatures. We identify systemic shifts in methylation levels, increases in methylation variability, and growing molecular disorder across tissues. Network analysis revealed tightly connected gene clusters that are not modified by beneficial interventions, alongside a more modifiable cluster linked to NAD⁺ metabolism, supporting NAD⁺ as a potential therapeutic target in …

Relating To Difficult Weather Through Creative Practice: Responses To Marrugeku’S Cut The Sky, Helena Grehan, Jo Pollitt, O. J.E. Slater, Sam Fox

Research outputs 2022 to 2026

In this paper we argue that performance and the arts invite a deliberate sensorial connection with the body and can support a bodily turn or return, in order to help artists, scholars and communities more broadly, better attune to increasing climate instability, through collaborative, supportive and reflexive storytelling. Drawing on the three “weather” symposia, the paper focusses on the second symposium which featured a keynote presentation by Rachael Swain, co-artistic director of Marrugeku, Australia’s leading Indigenous Intercultural Dance and Performance Company. Responses to Marrugeku’s work Cut the Sky are collectively presented to illuminate what Swain argues are, “Dramaturgies of consequence” …

Sulphur Metabolism As A Key Factor In The Evolution Of Environmental Adaptation Of Acidihalobacter, Eva Vergara, Himel Nahreen Khaleque, Gonzalo Neira, Elizabeth L.J. Watkin, Jorge H. Valdés, David S. Holmes

Research outputs 2022 to 2026

This study compares predicted sulphur metabolism genes across four Acidihalobacter type strains and two metagenome-assembled genomes (MAGs), revealing genomic differences that appear to correspond to ecological specialization. Phylog-enomic analysis separates the species into two clades: clade I includes Acidihalobacter ferrooxydans from a geothermal region in Italy and the two MAGs derived from deep-sea hydrothermal vents in the Pacific Ocean, while clade II comprises Acidihalo-bacter aeolianus and Acidihalobacter prosperus from a geothermal region in Italy and Acidihalobacter yilgarnensis from a saline and acidic drainage in Australia. Variations in sulphide/quinone oxidoreductases (SQRs) across the species, in particular in Ah. ferrooxydans and Ah. …

Thinking With Trees: Responding To Sympoietic Plant Relations Through Visual Art, Xiaoyu Yang

Research outputs 2022 to 2026

Societal Impact Statement: Amid escalating climate crises, this paper explores how we might rethink our relationship with the natural world, particularly with plants and trees, through the perspectives of visual art. This paper reveals how art invites us to see trees and other plant life not as passive background scenery, but as living beings with their own forms of experience and individuality. Rather than offering technical solutions to the climate crisis, visual art creates something equally important: a shift in how we think and feel about ‘othering’ non-human life. By making visible the inner lives and behaviours of plants, art …

A Collaborative Communities-Of-Practice Methodology For Environmental Design Research: A Case Study Application In Palliative Care, Emil E. Jonescu, Benjamin Farrell, Chamil Erik Ramanayaka, Lori Delaney, Edward Litton, Talia J. Uylaki, Gareth Watts, Bella Brigham, Frances Bellemore, Davinia Seah

Research outputs 2022 to 2026

Environmental design in palliative care settings receives increasing attention, yet methodologies for studying such environments often lack interdisciplinary integration. Traditional research designs may overlook the lived expertise of clinicians and designers. Objectives: This article describes a collaborative, cross-disciplinary communities-of-practice model developed as a methodological framework to enable effective environmental evaluation and design processes in healthcare settings. Its application is illustrated through a case study in a palliative care unit. Methods: A co-designed, multi-methods approach was developed by a team of clinicians, facility managers, and academic researchers. The methodology included a scoping review, site-specific environmental data logging (sound, temperature, lighting), and …

Hard-Wired For Success? Unravelling Genomic Signatures In Pollinators, Saam Hasan

School of Biological and Marine Sciences Theses

Global decline among bumblebees shows strong evidence of phylogenetic structure, with the subgenus Pyrobombus over-represented among stable/range-expanding species. Based on this striking pattern, a hypothesis was drawn up suggesting that Pyrobombus species have acquired advantageous traits that enhance their survivability and dispersal compared to other subgenera. This hypothesis explores the possibility that these advantageous traits were acquired via the evolutionary process and are detectable as genomic signatures unique to the subgenus when compared with other subgenera.Twenty-four bumblebee species, representing all 15 subgenera and including 6 Pyrobombus species, were compared. The first study investigated genomic inversions and duplications. Pyrobombus was characterized …

Uncorrected, Janet Freilich, W. Nicholson Price Ii

Faculty Scholarship

In addition to making rules and deciding outcomes, the legal system generates, curates and shares information. When the system gets rules and outcomes wrong, it is obviously a problem, and much effort (and scholarly attention) goes into identifying those mistakes and fixing them. But the system also gets information wrong; a problem mostly overlooked by policymakers and scholars. Those information mistakes matter too: they are prevalent and harmful. We show here that even when the mistakes are widely known and the errors broadly acknowledged, the information very often goes uncorrected. As a result, people make decisions based on bad information …

Professional Quality Of Life Among Medical Surgical And Telemetry Registered Nurses, William Lim, Emy-Lee Marie Anglo Ricafrente, Jenny Carrillo

Publications 2026-present

No abstract provided.

Excluded At The Root: Health Insurance Discrimination Against Hair Loss Conditions, Stacey A. Tovino, Tracy Hresko Pearl

Faculty Articles

No abstract provided.

Assessing Interactions Between Wild Host Plants And Stemborer Species In East Africa, Elie Ntirenganya, Venuste Nsengimana, Bonoukpoè Mawuko Sokame, Simon Boniface Boni, Yoseph Assefa, Janvier Uwayezu, Muluken Goftishu

All Rsif Scholars' Publications

Lepidopteran stemborers are among the most destructive pests of maize, sorghum, and sugarcane in Africa. Yet, data on their species composition and host range in Rwanda remain limited. This study provides the first comprehensive assessment of stemborer diversity, seasonal dynamics, and altitudinal distribution across eastern (low altitude), central (mid-altitude), and northern (high altitude) Rwanda. Surveys were conducted during both the rainy (maize growing) and dry seasons of 2023–2024, targeting infested maize fields and surrounding wild vegetation. A total of 2691 stemborer individuals were recovered from nine host plants, with 1474 (54.8%) from wild and fodder vegetation and 1217 (45.2%) from …

Dietary Responses Of Taste Receptor Genes To Plant-Based Diets In Farmed Fish: A Literature Review, Leonildo Dos Anjo Viagem, Jean Nepomuscene Hakizimana, Cyrus Rumisha, Brunno Da Silva Cerozi, Gerald Misinzo

All Rsif Scholars' Publications

Taste receptor genes, particularly those in the bitter (tas2r) and umami/sweet (tas1r) families, are critical in regulating chemosensory perception and feeding behavior, influencing fish’s acceptance of plant-based diets. This review synthesizes the current research on how these genes respond to plant-based diets in farmed fish. A comprehensive search of scientific databases, including Web of Science, Scopus, PubMed, and Google Scholar, was conducted to identify relevant studies. Plant-based diets modulate gene expression, receptor activity, and signaling pathways, enabling fish to adapt to alternative feeds. The findings of the studies analyzed in this review show that plant ingredients affect fish taste receptor …

Gut And Blood Microbiota Of Nile Tilapia (Oreochromis Niloticus) Reared With Lettuce (Lactuca Sativa) And Challenged With Escherichia Coli And Vibrio Cholerae In Aquaponic Systems, Ang´Elica Adiaç˜ Ao Jossefa, Leonildo Dos Anjo Viagem, Brunno Da Silva Cerozi, Sebastian Wilson Chenyambuga

All Rsif Scholars' Publications

Aquaponics, a bio-integrated system that combines fish farming and vegetable cultivation, has gained significant attention due to its rapid expansion and potential for sustainable food production. In aquaponics, along with plants and fish, both beneficial and harmful microorganisms are also present. This study was conducted to assess the microbiota diversity of Nile tilapia reared with lettuce in aquaponic systems, with a focus on food safety implications. A total of 144 Nile tilapia juveniles with an average initial weight of 30.7 ± 0.03 g were randomly stocked and allocated to three treatments, each with three replicates. In treatment one, the fish …

Agroclimatic Sensing, Communication, And Computational Systems-Based Methods And Technologies For Precision Irrigation Management: Current State And Prospects, Aminata Sarr, Abhilash K. Chandel, Lamine Diop Lamine Diop, Yrébégnan Moussa Soro, Alain K. Tossa, Smrutilipi Hota, Arunachalam Manimozhian

All Rsif Scholars' Publications

Agriculture uses most of the world’s fresh water. Given that the worldwide population is expanding at an alarming rate, more land cultivation is apparently in demand. As a result, much more water would be required to irrigate cultivable lands. However, fresh water is becoming scarce at a faster rate due to climate uncertainties and over-exploitation. Several controlled irrigation techniques, such as drip and sprinkler irrigation, have been introduced to safeguard water resources. However, these techniques do not readily meet crop water demands and often end up causing overapplication of water. Under these circumstances, smart precision irrigation is the best solution. …

Forecasting Future Adoption Rates Of Agroecological Innovations Using Machine Learning: Perspectives From Burkina Faso’S 45 Provinces From 2010 To 2020, Theodore Nikiema, Pamela Giselle Katic, Issaka Abdou Razakou Kiribou, Sylvain Kpenavoun Chogou, Eugene C. Ezin

All Rsif Scholars' Publications

Implementation of agroecological innovations tends to be long-term processes, withthe practices of one year often linked to those of previous years. However, previousstudies have focused on understanding drivers of adoption at farm level, with adoptionmeasured at a point in time. In this study, we use a decade of panel data from thePermanent Agricultural Survey in Burkina Faso from 2010 to 2020 and machine learningapproaches, to model adoption rates of agroecological innovations at the provinciallevel as an autoregressive process. This modeling approach allows us to exploit the timeseries nature of our dataset to forecast future adoption rates. Our results showcase thepotential …

Osteogenic Differentiation Properties Of Blgfs/Odex Hydrogel Doped With Collagen Derived From Chambo Tilapia Fish Skin, Bhahat Lawlley Zimba, Xiaohan Yang, Mwemezi Rwiza, Elingarami Sauli, Shenqi Wang

All Rsif Scholars' Publications

Background

Bone defects caused by trauma, congenital disorders and degenerative diseases such as osteoporosis remain a major clinical challenge, especially in developing regions. Although bone grafting is the current gold standard for treating bone defects, it faces limitations, including donor site morbidity, limited availability and immune rejection. This study developed and evaluated a novel hybrid biomaterial composed of bovine β-lactoglobulin fibrils (BLGFs), oxidized dextran (ODEX) and collagen (COL) extracted from Chambo tilapia fish skin for bone tissue engineering applications.

Methods

BLGFs were synthesized from whey protein, while ODEX was produced by oxidizing dextran. Three biomaterials–COL, BLGFs/ODEX and BLGFs/ODEX/COL–were synthesized and …

Functionalized Blgfs/Odex Hydrogel Scaffold Incorporating Oreochromis Lidole Skin Collagen For Bone Tissue Regeneration, Bhahat Lawlley Zimba, Xiaohan Yang, Mwemezi Rwiza, Elingarami Sauli, Shenqi Wang

All Rsif Scholars' Publications

Background: Bones provide support to the body and protect vital internal organs. Bones have the capacity to repair minor defects, but this ability is substantially impaired in large defects. Mineralization, which is an essential stage of osteogenesis during bone defect repair, occurs through the deposition of calcium phosphate crystals to form the structural framework of bone tissue. In the present study, BLGFs/ODEX/COL hydrogel scaffolds were synthesized and characterized to determine their osteogenic differentiation capabilities. The hydrogel scaffolds were also applied to bone defect in SD rats and the regeneration of bone tissue was assessed. Methods: Whey protein was used to …

Negotiating Relationships With Food, The Body, And Physical Activity: Who Is The Healthiest Of Them All?, Valeria Varea, Victoria Evans, Dawn Penney, Eibhlish O'Hara

Research outputs 2022 to 2026

Healthy eating and regular exercise are things that many people aspire to, mainly for health reasons. However, these practices can be complex given broader societal discourses. This paper aims to critically interrogate the social conditions and discursive formations that underpin everyday exercisers’ relationships with food, the body, and physical activity by using biopower and biopedagogies as a theoretical approach, and healthism as a set of discourses. Photo elicitation interviews with vignettes were conducted with nine participants who were regular exercisers. We constructed three different scenarios from the interview data and the theoretical approach: 1. Anna: A performance-driven, health compliant, private …

Precision Exercise For Breast Cancer-Related Outcomes: Towards Personalised Training Based On Tumour, Treatment And Patient Characteristics, Cristina Crespo-Garcia, Anita Borsati, Dennis R. Taaffe, Carolyn J. Peddle-Mcintyre, John P. Campbell, Alice Avancini, Emily Jeffery, Daniel A. Galvao, Robert U. Newton

Research outputs 2022 to 2026

Exercise is a promising strategy associated with improved cancer-related outcomes through multiple biological mechanisms. However, current exercise guidelines largely adopt a one-size-fits-all approach and overlook inter-individual variability in response. Given the heterogeneity of breast cancer, precision exercise prescriptions may better target biological pathways linked to therapeutic efficacy and long-term prognosis. Observational studies consistently show that higher physical activity levels are associated with improved survival outcomes, including reduced all-cause and breast cancer-specific mortality. In contrast, evidence from interventional trials remains limited and inconsistent, with effects on tumour response and survival largely derived from secondary or exploratory analyses. These discrepancies likely reflect …

The Complex And Multifaceted Nature Of Social Media: Perspectives From Young Adolescents, Parents And Experts, Cindy Branch-Smith, Diarmuid Hurley, Nasim Salehi

Research outputs 2022 to 2026

Purpose: This study explores the complex and multifaceted nature of social media use among young adolescents, drawing on the perspectives of young adolescents, parents and experts. It examines both the benefits and risks of social media and associated implications for adolescent mental health, self-development and social relationships. Methodology: A qualitative, interpretive design was utilised, using interviews across three stakeholder groups, with data analysed using reflexive thematic analysis. Findings: The analysis identified a range of perceived opportunities, benefits and challenges associated with adolescent social media engagement. Participants highlighted its role in fostering connection, education and self-expression, alongside significant risks, including cyberbullying, …

Heidegger And Eco-Anxiety: Constructing Ways To Deal With Eco-Anxiety Through Interpretations Of Heidegger, Leif Gajkowski

Student Scholarship

No abstract provided.

Micro-Moments In Acl Injury: Analysis Of The Posture Of The Lower Leg During Change Of Direction, Joseph Reed Nobili

Student Scholarship

No abstract provided.

Introduction – Academic Freedom And Vulnerability, Elizabeth L. Rosenblatt

Case Western Reserve Law Review

No abstract provided.

Banned, Burned, And Bound: Increasing Protections Surrounding Students’ Right To Receive Information In K-12 Schools, Catherine A. Mcclure

Case Western Reserve Law Review

No abstract provided.

When To Bite Back: Queerness, Resistance, And Reclamation Of The Monstrous Identity In Andrew Joseph White’S Hell Followed With Us, Aster J. Mehigan Mx.

English

Who gets the right to define morality? Who gets to define what is monstrous? Frankenstein’s Creature, the vampires of Lost Boys, The Craft’s head witch Nancy Downs; these characters follow a pattern through the decades of those alienated from society, in this case being written with queer subtext, being deemed as monstrous. These queer monsters become the villains of the story, causing chaos, death and destruction in their wake, seeking revenge against a world that ostracizes them. The 2022 dystopian YA horror of Hell Followed With Us by Andrew Joseph White challenges the villanized monstrous identity through its transgender protagonist …

Dog Waste Creates A Preference-Performance Mismatch For Urban Dung Beetles, Erin L. Mccullough, Beatrice M. Altopp, Daniel F. Kellogg, Madelyn S. Mcinnis, Luna J. Pagan

Biology

Urban environments expose animals to novel conditions that may favor behavioral flexibility but can create preference-performance mismatches when attractive resources are associated with reduced reproductive success. Dung beetles are often considered dietary generalists, yet little is known about how they respond to altered food availability in human-dominated habitats. We combined field surveys and laboratory experiments using two domestic dung types to examine diet preference, maternal provisioning, and offspring performance in the urban dung beetle Onthophagus orpheus. Beetles strongly preferred dog dung over cow dung, and offspring reared on dog dung developed faster and emerged as larger adults. Despite these apparent …

Clinical Challenges Associated With Enhancing Hypertension Among The Underserved African American Population, Ashley Richardson

Doctor of Nursing Practice (DNP) Scholarly Projects

Background 

African Americans face a significantly higher prevalence of hypertension, tend to develop complications at younger ages, and have disproportionately higher mortality rates. Key social determinants of health (SDoH)—including food deserts, unequal access to healthcare, and geographic disparities in healthcare resources—contribute to these ongoing inequities. Addressing both systemic and individual barriers is crucial for effective hypertension management.

Objective

This study aims to assess the effectiveness of a culturally relevant, community-based intervention designed to reduce both systolic and diastolic blood pressure among Black adults with uncontrolled hypertension.

Methods 

Quality improvement (QI) initiatives typically employ multicomponent, equity-focused models. The primary components of …

The Postsynaptic Scaffolding Protein Sapap3 Shapes Mitochondrial Activity: The Case Of Huntington's Disease, Patrícia Coelho, Ildete Luísa Ferreira, Ana Sofia Lourenço, Daniela Marinho, Sandra Isabel Anjo, Zongwei Fang, Lígia Fão, Sandra I. Mota, Philippe J. Mas, Mário Carvalho, Rui Jorge Nobre, Carina Henriques, Joana Fraga, Dongqing Wang, Sandra Macedo Ribeiro, Luís Pereira De Almeida, Patrícia Monteiro, Isaura Simões, Darren J. Hart, Bruno Manadas, João Peça, Pedro Castanheira, A. Cristina Rego

Biological Sciences Faculty Publications

Postsynaptic scaffolding protein SAP90/PSD95-associated protein 3 (SAPAP3) modulates cortico-striatal signalling and regulates the maintenance of synaptic structure. Notably, SAPAP3 defects have been reported in several human psychiatric disorders that share pathophysiological features with Huntington’s disease (HD), a neurodegenerative disorder characterized by the expression of mutant huntingtin (mHTT) and marked dysfunction of cortico-striatal synapses and mitochondria. However, the role of SAPAP3 in mitochondrial function and HD pathophysiology remains unexplored. SAPAP3 was extracted from striatal synaptoneurosomes and analyzed by SWATH-MS proteomics to identify potential interactors, revealing SAPAP3 association with several mitochondrial proteins, particularly Mic60. These data were further complemented with proximity ligation …

Herbivore Identity And Species Richness Shape Fruit Chemical And Quality Responses To Foliar Herbivory, Xavier Ozowara, Taylor M. Sloey, Susan R. Whitehead

Biological Sciences Faculty Publications

The cascading consequences of foliar herbivory on fruit chemistry and quality remain relatively underexplored, with most existing studies focusing on the effects of only one or two attackers. In this study, we examine how increasing herbivore species richness during foliar herbivory alters strawberry (Fragaria × ananassa Duch) fruit quality and phenolic chemistry. We conducted a greenhouse experiment with single species feeding and different combinations of feeding by three generalist lepidopteran species: Spodoptera frugiperda, Heliothis virescens, Helicoverpa zea. Species fed on leaves for 72 h as fruits ripened, and fully ripe fruits were harvested 72 h after …

Carbaryl Exposure Alters Gut Microbiome Composition Without Affecting Morphometrics In Eastern Purple Martin (Progne Subis Subis) Nestlings, Stephanie A. Gaspar

Graduate Studies Theses and Dissertations 2026

Eastern purple martins (Progne subis subis) rely entirely on human-provided nesting structures throughout their breeding range in eastern North America. To control haematophagous mites that commonly infest these nests, many landlords apply the carbamate insecticide, carbaryl. Although effective at reducing ectoparasite populations, carbaryl exposure may have unintended effects on the gut microbiome, growth, and condition of developing birds. This study examined the effects of carbaryl exposure on gut microbial communities and morphometric condition in wild nestlings. Nests were experimentally treated with carbaryl, and nestling morphometrics and fecal microbiomes were compared between treated and untreated groups at 18 days …