Digital Commons Network^™

Crystal Structure Of Deinococcus Phytochrome In The Photoactivated State Reveals A Cascade Of Structural Rearrangements During Photoconversion, E Sethe Burgie, Junrui Zhang, Richard D. Vierstra

Biology Faculty Research

Phytochromes are photochromic photoreceptors responsible for a myriad of red/far-red light-dependent processes in plants and microorganisms. Interconversion is initially driven by photoreversible isomerization of bilin, but how this alteration directs the photostate-dependent changes within the protein to actuate signaling is poorly understood. Here, we describe the structure of the Deinococcus phytochrome photosensory module in its near complete far-red light-absorbing Pfr state. In addition to confirming the 180° rotation of the D-pyrrole ring, the dimeric structure clearly identifies downstream rearrangements that trigger large-scale conformational differences between the dark-adapted and photoactivated states. Mutational analyses verified the importance of residues surrounding the bilin …

Kenyon Collegian - February 4, 2016

The Kenyon Collegian

No abstract provided.

Management And Preservation Of Non-Book Materials In Academic Libraries: A Case Study Of Three University Libraries In Nigeria, Daniel Olusegun Ikegune

Library Philosophy and Practice (e-journal)

Abstract

This study investigates the management and preservation of non-book materials at the University of Ibadan, Obafemi Awolowo University and Ladoke Akintola University. Relevant literature on the need for management, preservation, importance, challenges and factors responsible for deterioration of this non-book materials as well as remedies, suggestion and/or recommendations for improvement was reviewed. The descriptive survey research design was adopted for this study. The study population consisted of one hundred and forty one (141) staff in the three selected university libraries. The population of the study consists of para-professionals and professionals librarian. Data were collected using questionnaire and interview. Data …

Research-Based Student Learning At The Post-Secondary Level, Joanne P. Labeouf

Bollinger-Rosado Teaching & Learning Effectiveness Symposium Proceedings

Research-based student learning is an educationally sound approach to learning adding value to undergraduate courses and enhancing students' long term academic experience. Research-based learning should recognize the student as researcher, begin at the undergraduate level, and be embedded in all discipline courses and across the curriculum. It requires active student engagement, and can be complemented by the use of qualitative methodology in research and critical thinking very early in the education experience. Post-secondary institutions need transformational leaders to meet the challenge of placing research at the center of student learning. To reach student goals, institutions must develop a strategic plan, …

Expeditionary Blended Learning: New Opportunities And Lessons From The United Kingdom, Ian R. Mcandrew, Indra R. Sinka, Michael S. Wills

Bollinger-Rosado Teaching & Learning Effectiveness Symposium Proceedings

Recent experiences in live course delivery at ERAU's UK campus, combined with dramatic changes in the operational deployment tempo of US military forces assigned at these bases, creates both challenges and opportunities. Exploiting experiences with blended learning at The Open University, traditional learning at the University of Hertfordshire and other UK universities, and teaching concepts in use within the UK's military staff colleges leads to the proposed "Expeditionary" model for blended learning within the ERAU European Region. This model can deliver enhanced student involvement and increased enrollments, provided suitable changes in ERAU's underlying business model can be made. A Strengths …

Tracking Esl Students, Douglas Magrath

Bollinger-Rosado Teaching & Learning Effectiveness Symposium Proceedings

A major multicultural issue facing college instructors is how to deal with the increasing numbers of students whose home language is not English. These students typically finish an intensive ESL program, pass the TOEFL and enter regular or on-line classrooms where they face difficulties with academic English. This presentation will discuss and propose some solutions, which include higher TOEFL requirements, transition courses and orientation programs.

Critical Thinking Skills: Building Blocks For Success, Frances Johnson

Bollinger-Rosado Teaching & Learning Effectiveness Symposium Proceedings

Although research has been done to identity critical thinking skills, little has been done to extrapolate a comprehensive hierarchy of critical thinking skills sets necessary to the enhancement of academic performance. The link between critical thinking skills and course specific content has not been broken nor is there evidence to indicate that a link has been forged between course specific critical thinking skills and utility in life beyond the classroom. The extrapolation of a comprehensive hierarchy of sets of critical thinking skills provides the foundation to do the following:

1. Move beyond the course-specific link;

2. Develop methods to select …

Involving Adults In The Learning Of Mathematics, Walter R. Deckert

Bollinger-Rosado Teaching & Learning Effectiveness Symposium Proceedings

Preparing adults for the mathematics skills necessary for the twenty first century is a challenge. It is especially challenging if those adults have had past traumatic experiences learning mathematics. Involving students in the learning process involves more than the presentation of mathematical concepts by the teacher and the simple regurgitation of rote memorization by the students. It requires a concerted effort by both the teacher and the student. The teacher must present mathematical concepts that are inclusionary, challenging, in an environment created for learning, in class settings that are technologically advanced, and geared to the student's level. The student must …

Leadership And The Transformation Of Values, George A. Farrah, Ruth K. Meyer, Alfred A. Pabst

Bollinger-Rosado Teaching & Learning Effectiveness Symposium Proceedings

This article on leadership serves as an important point of entry to the understanding and teaching of values with the goal of improving teacher effectiveness. As a dynamic process, leadership can take many forms. Considerable attention has been given to this process in both formal and informal sources. In fact, the literature abounds with information relating to the numerous theoretical points of entry that are possible for exercising leadership. However, as described in what follows, there is a paucity of information pertaining to the linkage between values and leadership as the transformation of values. The central purpose of this article …

The Bates Student - Volume 146 Number 12 - February 3, 2016, Bates College

The Bates Student

No abstract provided.

Using Cosmic-Ray Neutron Probes To Monitor Landscape Scale Soil Water Content In Mixed Land Use Agricultural Systems, Trenton E. Franz, Ammar Wahbi, Mariette Vreugdenhil, Georg Weltin, Lee Hang, Markus Oismueller, Peter Strauss, Gerd Dercon, Darin Desilets

School of Natural Resources: Faculty Publications

With an ever-increasing demand for natural resources and the societal need to understand and predict natural disasters, soil water content (SWC) observations remain a critical variable to monitor in order to optimally allocate resources, establish early warning systems, and improve weather forecasts.However, routine agricultural production practices of soil cultivation, planting, and harvest make the operation andmaintenance of direct contact point sensors for long-termmonitoring challenging. In this work, we explore the use of the newly established Cosmic-Ray Neutron Probe (CRNP) and method to monitor landscape average SWC in a mixed agricultural land use systemin northeastAustria.Thecalibrated CRNP landscape SWC values compare well …

A Bacterial Quorum-Sensing Precursor Induces Mortality In The Marine Coccolithophore, Emiliania Huxleyi, Elizabeth L. Harvey, Robert W. Deering, David C. Rowley, Abrahim El Gamal, Michelle Schorn, Bradley Moore, Matthew Johnson, Tracy J. Mincer, Kristen E. Whalen

Biomedical and Pharmaceutical Sciences Faculty Publications

Interactions between phytoplankton and bacteria play a central role in mediating biogeochemical cycling and food web structure in the ocean. However, deciphering the chemical drivers of these interspecies interactions remains challenging. Here, we report the isolation of 2-heptyl-4-quinolone (HHQ), released by Pseudoalteromonas piscicida, a marine gamma-proteobacteria previously reported to induce phytoplankton mortality through a hitherto unknown algicidal mechanism. HHQ functions as both an antibiotic and a bacterial signaling molecule in cell–cell communication in clinical infection models. Co-culture of the bloom-forming coccolithophore, Emiliania huxleyi with both live P. piscicida and cell-free filtrates caused a significant decrease in algal growth. Investigations …

The Collegian: February 03, 2016, The Collegian Staff

The Collegian, 2015-2016

Volume 131
Issue 15

The Lumberjack, February 3, 2016, The Lumberjack Staff

2016

The student newspaper of Humboldt State University

Law, Justice & Culture Panel Examines Immigration And Civil Rights, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

We Are...Marshall, February 3, 2016, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Gene Expression Microarray Data From Human Microvascular Endothelial Cells Supplemented With A Low Concentration Of Niacin, Nica M. Borradaile, Jennifer M. Hughes-Large

Physiology and Pharmacology Publications

The systemic lipid modifying drug, niacin, can directly improve human microvascular endothelial cell angiogenic function under lipotoxic conditions, possibly through activation of niacin receptors [1]. Here we provide accompanying data collected using Affymetrix GeneChip microarrays to identify changes in gene expression in human microvascular endothelial cells treated with 10 μM niacin. Statistical analyses of robust multi-array average (RMA) values revealed that only 16 genes exhibited greater than 1.3-fold differential expression. Of these 16, only 5 were identified protein coding genes, while 3 of the remaining 11 genes appeared to be small nuclear/nucleolar RNAs. Altered expression of EFCAB4B, …

Conservation Groups Fight To Halt Development In Environmentally Sensitive Area Near Cancãºn, Carlos Navarro

SourceMex

No abstract provided.

Structural And Evolutionary Analyses Show Unique Stabilization Strategies In The Type Iv Pili Of Clostridium Difficile, Kurt H. Piepenbrink, Grace A. Maldarelli, Claudia F. Martinez De La Pena, Tanis C. Dingle, George L. Mulvey, Amanda Lee, Erik Von Rosenvinge, Glen D. Armstrong, Michael S. Donnenberg, Eric J. Sundberg

Food for Health: Publications

Type IV pili are produced by many pathogenic Gram-negative bacteria and are important for processes as diverse as twitching motility, biofilm formation, cellular adhesion and horizontal gene transfer. However, many Gram-positive species, including C. difficile, also produce Type IV pili. Here, we identify the major subunit of the Type IV pili of C. difficile, PilA1, and describe multiple three-dimensional structures of PilA1, demonstrating the diversity found in three strains of C. difficile. We also model the incorporation of both PilA1 and a minor pilin, PilJ, into the pilus fiber. Although PilA1 contains no cysteine residues, and therefore cannot form the …

Distinct Lymphocyte Antigens 6 (Ly6) Family Members Ly6d, Ly6e, Ly6k And Ly6h Drive Tumorigenesis And Clinical Outcome., Linlin Luo, Peter Mcgarvey, Subha Madhavan, Rakesh Kumar, Yuriy Gusev, Geeta Upadhyay

Biochemistry and Molecular Medicine Faculty Publications

Stem cell antigen-1 (Sca-1) is used to isolate and characterize tumor initiating cell populations from tumors of various murine models [1]. Sca-1 induced disruption of TGF-β signaling is required in vivo tumorigenesis in breast cancer models [2, 3-5]. The role of human Ly6 gene family is only beginning to be appreciated in recent literature [6-9]. To study the significance of Ly6 gene family members, we have visualized one hundred thirty gene expression omnibus (GEO) dataset using Oncomine (Invitrogen) and Georgetown Database of Cancer (G-DOC). This analysis showed that four different members Ly6D, Ly6E, Ly6H or Ly6K have increased gene expressed …

Curcumin Nanoformulation For Cervical Cancer Treatment, Mohd S. Zaman, Neeraj Chauhan, Murali M. Yallapu, Rishi K. Gara, Diane M. Maher, Sonam Kumari, Mohammed Sikander, Sheema Khan, Nadeem Zafar, Meena Jaggi, Subhash C. Chauhan

School of Medicine Publications

Cervical cancer is one of the most common cancers among women worldwide. Current standards of care for cervical cancer includes surgery, radiation, and chemotherapy. Conventional chemotherapy fails to elicit therapeutic responses and causes severe systemic toxicity. Thus, developing a natural product based, safe treatment modality would be a highly viable option. Curcumin (CUR) is a well-known natural compound, which exhibits excellent anti-cancer potential by regulating many proliferative, oncogenic, and chemo-resistance associated genes/proteins. However, due to rapid degradation and poor bioavailability, its translational and clinical use has been limited. To improve these clinically relevant parameters, we report a poly(lactic-co-glycolic acid) based …

Filtering Genetic Variants And Placing Informative Priors Based On Putative Biological Function, Stefanie Friedrichs, Dörthe Malzahn, Elizabeth W. Pugh, Marcio Almeida, Xiao Qing Liu, Julia N. Bailey

School of Medicine Publications

High-density genetic marker data, especially sequence data, imply an immense multiple testing burden. This can be ameliorated by filtering genetic variants, exploiting or accounting for correlations between variants, jointly testing variants, and by incorporating informative priors. Priors can be based on biological knowledge or predicted variant function, or even be used to integrate gene expression or other omics data. Based on Genetic Analysis Workshop (GAW) 19 data, this article discusses diversity and usefulness of functional variant scores provided, for example, by PolyPhen2, SIFT, or RegulomeDB annotations. Incorporating functional scores into variant filters or weights and adjusting the significance level for …

Dynamics And Thermal Sensitivity Of Ballistic And Non-Ballistic Feeding In Salamanders, Stephen M, Deban, Jeffrey A. Scales

Integrative Biology Faculty and Staff Publications

Low temperature reduces the performance of muscle-powered movements, but in movements powered by elastic recoil mechanisms, this effect can be mitigated and performance can be increased. To better understand the morphological basis of high performance and thermal robustness of elastically powered movements, we compared feeding dynamics at a range of temperatures (5-25°C) in two species of terrestrial plethodontid salamanders, Plethodon metcalfi and Ensatina eschscholtzii, which differ in tongue muscle architecture and the mechanism of tongue projection. We found that Ensatina is capable of ballistic projection with a mean muscle mass-specific power of 2100 W kg(-1), revealing an elastic mechanism. Plethodon, …

Emu Today, February 3, 2016, Eastern Michigan University

EMU Today

No abstract provided.

Daily Eastern News: Feburary 03, 2016, Eastern Illinois University

February

No abstract provided.

Oncomodulin, An Ef-Hand Ca2+ Buffer, Is Critical For Maintaining Cochlear Function In Mice, Benton Tong, Aubrey J. Hornak, Stéphane F. Maison, Kevin K. Ohlemiller, M Charles Liberman, Dwayne D. Simmons

Open Access Publications

UNLABELLED: Oncomodulin (Ocm), a member of the parvalbumin family of calcium binding proteins, is expressed predominantly by cochlear outer hair cells in subcellular regions associated with either mechanoelectric transduction or electromotility. Targeted deletion of Ocm caused progressive cochlear dysfunction. Although sound-evoked responses are normal at 1 month, by 4 months, mutants show only minimal distortion product otoacoustic emissions and 70-80 dB threshold shifts in auditory brainstem responses. Thus, Ocm is not critical for cochlear development but does play an essential role for cochlear function in the adult mouse.

SIGNIFICANCE STATEMENT: Numerous proteins act as buffers, sensors, or pumps to control …

Large-Scale Degradation Of A Kelp Ecosystem In An Ocean Warming Hotspot, Karen Filbee-Dexter, Colette Feehan, Robert E. Scheibling

Department of Biology Faculty Scholarship and Creative Works

Understanding the impacts of climate change on biological systems requires observational data over multi-decadal time spans and broad spatial scales. Extensive research at an ocean warming hotspot off Nova Scotia, Canada, enabled us to evaluate the impact of 3 decades of observed temperature rise on a coastal marine ecosystem. Here, we document changes in the kelp community from sites monitored since 1949, 1968 and 1984, and from coastal surveys in 1982, 2000, 2007 and 2014. We show that mean kelp biomass has declined by 85-99% over the past 4-6 decades, and a catastrophic phase shift has occurred from luxuriant kelp …

Aauw Athens Hosts Dynamic Math And Science Program For Girls On, May 14, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

February 3, 2016 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Marital Satisfaction, Error-Observation, And The Brain: Harmful Or Beneficial Effects Of Spouse Observation?, Chelsea Romney, Michael Larson

Journal of Undergraduate Research

Romney, Chelsea Marital Satisfaction, Error-observation, and the Brain: Harmful or Beneficial Effects of Spouse Observation? Faculty Mentor: Larson, Michael, Department of Psychology and Neuroscience Introduction Rewarding marital relationships are associated with many positive outcomes in one’s physical and mental health (Robles, & Kiecolt-Glaser, 2003). These benefits include improved cardiovascular functioning (Kiecolt-Glaser, & Newton, 2001), decreased depression risk (Robins & Reiger, 1991), higher self-reported levels of happiness (Proulx & Snyder-Rivas, 2013), and overall lower rates of mortality (Manzoli, Villari, Pirone & Boccia, 2007). Furthermore, positive health outcomes are not only due to marital status, but also to the quality of one’s …