Digital Commons Network^™

Selective Binding Of Airapl Tandem Uims To Lys48-Linked Tri-Ubiquitin Chains, Simin Rahighi, Ilauna Braunstein, Nicola Ternette, Benedikt Kessler, Masato Kawasaki, Ryuichi Kato, Tsutomu Matsui, Ariel Stanhill, Soichi Wakatsuki

Pharmacy Faculty Articles and Research

Lys48-linked ubiquitin chains act as the main targeting signals for protein degradation by the proteasome. Here we report selective binding of AIRAPL, a protein that associates with the proteasome upon exposure to arsenite, to Lys48-linked tri-ubiquitin chains. AIRAPL comprises two ubiquitin-interacting motifs in tandem (tUIMs) that are linked through a flexible inter-UIM region. In the complex crystal structure UIM1 binds the proximal ubiquitin, whereas UIM2 (the double-sided UIM) binds non-symmetrically to the middle and distal ubiquitin moieties on either side of the helix. Specificity of AIRAPL for Lys48-linked ubiquitin chains is determined by UIM2, and the flexible inter-UIM linker increases …

Panther - February 2016 - Vol. Xcvi, No.10, Prairie View A&M University

PV Panther Newspapers

No abstract provided.

Chanticleer | February 11, 2016, Jacksonville State University

Chanticleer

No abstract provided.

Abortion In Paraguay Case Study, Eileen A. Ruppel

Augustana Center for the Study of Ethics Essay Contest

No abstract provided.

Systems Perturbation Analysis Of A Large-Scale Signal Transduction Model Reveals Potentially Influential Candidates For Cancer Therapeutics, Bhanwar L. Puniya, Laura Allen, Colleen Hochfelder, Mahbubul Majumder, Tomáš Helikar

Mathematics Faculty Publications

Dysregulation in signal transduction pathways can lead to a variety of complex disorders, including cancer. Computational approaches such as network analysis are important tools to understand system dynamics as well as to identify critical components that could be further explored as therapeutic targets. Here, we performed perturbation analysis of a large-scale signal transduction model in extracellular environments that stimulate cell death, growth, motility, and quiescence. Each of the model’s components was perturbed under both loss-of-function and gain-of-function mutations. Using 1,300 simulations under both types of perturbations across various extracellular conditions, we identified the most and least influential components based on …

Wsu Board Of Trustees Meeting Minutes, February 11-12, 2016

Board of Trustees Minutes

Minutes from the Wright State University Board of Trustees Meeting held on February 11-12, 2016.

Science Ama Series: Antarctic Peninsula Paleontology Project, Matt Lamanna, Julia Clarke, Pat O'Connor, Ross Macphee, Erik Gorscak, Abby West, Chris Torres, Kerin M. Claeson, Meng Jin, Steve Salisbury, Eric Roberts, Zubair Jinnah

PCOM Scholarly Works

Transcript of an online colloquium between members of the APPP expedition and readers of the online bulletin board Reddit.

Kenyon Collegian - February 11, 2016

The Kenyon Collegian

No abstract provided.

The Eastern Echo, February 11, 2016, Eastern Michigan University

EMU Student Newspaper: The Normal News & The Eastern Echo

No abstract provided.

Spartan Daily, February 11, 2016, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2016

Volume 146, Issue 6

The Parthenon, February 11, 2016, Megan Osborne

The Parthenon

The Parthenon, Marshall University’s student newspaper, was published by students Monday through Friday during the regular semester and weekly on Thursdays during the summer. Due to budgetary constraints, beginning with the 2015 Fall semester, the newspaper is only published four days a week. There is no issue on Mondays, physical issues are printed on Tuesdays and Fridays, and online issues only are published on Wednesdays and Thursdays. The editorial staff is responsible for the news and the editorial content.

Lanthorn, Vol. 50, No. 41, February 11, 2016, Grand Valley State University

Volume 50, July 13, 2015 - June 6, 2016

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

The George-Anne, Georgia Southern University

The George-Anne

• Puzzles
• News
• Opinions
• Features
• Sports

The Inkwell, Armstrong State University

The Inkwell

No abstract provided.

The Missouri Miner, February 11, 2016

The Missouri Miner Newspaper

No abstract provided.

An Evaluation Of Extraction Techniques For Arsenic In Staple Diets (Fish And Rice) Utilising Both Classical And Enzymatic Extraction Methods, Bashdar A. Sadee, Mike E. Foulkes, Steve J. Hill

School of Geography, Earth and Environmental Sciences

Enzymatic extraction methods were evaluated with classical extraction approaches for the determination of arsenic in food. The extraction efficiency for total arsenic was determined by analysing CRM materials DORM-3 fish protein, NIES 106 rice flour and GBW10015 spinach. These were compared with total arsenic concentration determined using microwave-assisted acid digestion and ICP-MS. The total arsenic concentrations in the CRM materials were in good agreement with the certified values. Enzymatic hydrolysis using trypsin has been successfully employed to extract arsenic species in DORM-3 and fish samples. Whilst this method of hydrolysing the proteins worked well for the fish samples, an alternative …

Introduction, Alison Cook-Sather, Laura Perry

Teaching and Learning Together in Higher Education

No abstract provided.

Table Of Contents, Human Biology Editors

Human Biology

No abstract provided.

Media Response: Genome Of The Ancient One (A.K.A. Kennewick Man), Jennifer Raff

Human Biology

The author discusses the media treatment of the publication of the genome of the Kennewick Man, an 8,500-year-old burial from Washington, closely related to Northern Native Americans.

Weekly News Digest 02/10/2016, Jenna Ray

Weekly Bulletin Archive

In This Issue:

• Campus Assembly Dates for Spring 2016 Announced
• Student Organic Gardening Club Celebrates Outstanding Season
• Forbord Talks Food Skills with Minnesota Food Charter

Use Of Galvanic Skin Responses, Salivary Biomarkers, And Self-Reports To Assess Undergraduate Student Performance During A Laboratory Exam Activity, Idalis Villanueva, Maria Valladares, Wade H. Goodridge

Engineering Education Faculty Publications

Typically, self-reports are used in educational research to assess student response and performance to a classroom activity. Yet, addition of biological and physiological measures such as salivary biomarkers and galvanic skin responses are rarely included, limiting the wealth of information that can be obtained to better understand student performance. A laboratory protocol to study undergraduate students' responses to classroom events (e.g., exams) is presented. Participants were asked to complete a representative exam for their degree. Before and after the laboratory exam session, students completed an academic achievement emotions self-report and an interview that paralleled these questions when participants wore a …

The Lumberjack, February 10, 2016, The Lumberjack Staff

2016

The student newspaper of Humboldt State University

Spartan Daily, February 10, 2016, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2016

Volume 146, Issue 5

The Collegian: February 10, 2016, The Collegian Staff

The Collegian, 2015-2016

Volume 131
Issue 16

Our Flight From Death Is Killing Us: Applying A Psychological Framework To A Christian Understanding Of The Human Condition, G. Mark Griffith

Doctor of Ministry

Our awareness of mortality motivates us to subconsciously act in ways that are damaging. This dissertation engages the problems to individual and communities generated by our unexamined awareness of death. This awareness motivates us to attempt to flee death's grasp—even though we know there is no escape. The flight from death robs us not only of our ability to live full lives but also robs us of our ability to faithfully follow Jesus into the world. At times, we even distort religion and use it to shield us from death. Faith practices can be manipulated to draw us away from …

We Are...Marshall, February 10, 2016, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Signed, Sealed, Delivered: Baptism As Beginning In Christ, And Becoming Like Christ, Eric E. Peterson

Doctor of Ministry

This dissertation involves applied research, relying on the foundation of sacramental
theology, to answer the question, "What is the sign that has the power to help people
embrace not only a sacred self-identity, but to live holy, meaningful, and abundant
lives in a largely broken and sacrilegious world?" Beginning with a review of the major
and various assumptions people have historically adhered to in the pursuit of a good
life, the dissertation proceeds to argue for the superiority of a sacramental
perspective. Employing a semiotics of baptism, chapter two provides a critical analysis
of the opposing forces of "cultural baptism" …

Flyer News, Vol. 63, No. 11 (Feb. 10, 2016), University Of Dayton

Flyer News

Student-run newspaper of the University of Dayton.

Biblical Hospitality: An Environment For Leader Development, Joanne L. Holz

Doctor of Ministry

The Salvation Army in the southeastern United States is currently facing challenges with retention of its ordained leaders called Officers. Causes for post- commissioning defection center around the need for changes in the context in which training and learning occurs. This study examines the need for Biblical Hospitality as an environment that hosts transformational opportunities and creates the context needed for leadership development across the system and within individuals in the U. S. A. Southern Territory.

There is a return to Biblical Hospitality, which is finding its place in multiple areas of life with life-transforming opportunities and results. For the …

Jim Matthews, Jim Matthews, Meg Miner

All oral histories

Matthews views Myers as a "well-educated liberal arts specialist...who can talk with anybody intelligently about anything that person is interested in." Myers recommended book purchases to Matthews and he summarizes the effect that and conversations about French history had on him. He recounts why and how Myers recruited him to be Dean of Students and describes changes to Student Affairs that followed, what he saw in Cabinet and Board of Trustee meetings about budget decisions, an incidence of racism involving Sodexho (ca 2000), and remarks Myers made on the first anniversary of September 11, 2001 [n.b., there are no recordings …