Digital Commons Network^™

Challenges Of Adoptive (T-)Cell Transfer Immunotherapy For Cancer, Aaron Volk

Biology: Student Scholarship & Creative Works

Background and significance: The rebirth of the theory of immunosurveillance in 2001 rejuvenated interest in anticancer immunotherapies. In particular, T-cell-based therapies have garnered substantial interest due to the robustness and tumor antigen-specific cytotoxicity of T-cell anticancer immune responses.

Hypothesis: The efficacy of adoptive cell transfer (ACT) T-cell immunotherapy could significantly improve and gain widespread approval if future innovations in ACT-based approaches account for the pro- and antitumoral properties of non-CD8⁺ lineages of effector T-cells, evasion of T-cell antitumor immunity, and tumor-induced suppression of antitumor immunity.

Problem Analysis: Despite numerous reports of highly successful ACT-based clinical trials, no such therapy …

The Echo: February 12, 2016, Taylor University

2015-2016 (Volume 103)

Not your average teacher – Taylor hosts Special Olympics – “What do you guys actually do?” – Critical learning – Outsiders on the rise – Zika virus runs rampant – Marry me, Marylou – Love-Struck Professors – The flirting power of emojis – The bi-weekly bachelor and bachelorette – Echograms #TaylorU -- #TaylorU’s op Tweets – Films for failures – Recording hope in Rwanda – And the Oscar goes to… -- Darling, you will always be number…two – Cam’s collapse – Allah = Yahweh? – Trojans impress at Indiana Wesleyan – Weekly Preview – Wildcats throttle Trojans – Athlete of …

Sexual Selection In A Changing World: How Human- Induced Environmental Change Affects Sexual Selection And Consequently The Health Of Populations, Rickey Cothran

Faculty Articles & Research

No abstract provided.

Observational Evidence For The Convective Transport Of Dust Over The Central United States, C. A. Corr, L. D. Ziemba, Eric M. Scheuer, B. E. Anderson, A. J. Beyersdorf, G. Chen, E. Crosbie, R. H. Moore, M. Shook, K. L. Thornhill, E. Winstead, R. P. Lawson, M. C. Barth, J. R. Schroeder, D. R. Blake, Jack E. Dibb

All Materials

Bulk aerosol composition and aerosol size distributions measured aboard the DC-8 aircraft during the Deep Convective Clouds and Chemistry Experiment mission in May/June 2012 were used to investigate the transport of mineral dust through nine storms encountered over Colorado and Oklahoma. Measurements made at low altitudes (<5 km mean sea level (MSL)) in the storm inflow region were compared to those made in cirrus anvils (altitude > 9 km MSL). Storm mean outflow Ca2+ mass concentrations and total coarse (1 µm < diameter < 5 µm) aerosol volume (Vc) were comparable to mean inflow values as demonstrated by average outflow/inflow ratios greater than 0.5. A positive relationship between Ca2+, Vc, ice water content, and large (diameter > 50 µm) ice particle number concentrations was not evident; thus, the influence of ice shatter on these measurements was assumed small. Mean inflow aerosol number concentrations calculated over a diameter range (0.5 µm < diameter < 5.0 µm) relevant for proxy ice nuclei (NPIN) were ~15–300 times higher than ice particle concentrations for all storms. Ratios of predicted interstitial NPIN (calculated as the difference between inflow NPIN and ice particle concentrations) and inflow NPIN were consistent with those calculated for Ca2+ and Vc and indicated that on average less than 10% of the ingested NPIN were activated as ice nuclei during anvil formation. Deep convection may therefore represent an efficient transport mechanism for dust to the upper troposphere where these particles can function as ice nuclei cirrus forming in situ.

Changes In Shape And 'Squishiness' Can Help Drug-Containing Microcapsules Reach Tumors, Jeff Hansen

Browse All News

No abstract provided.

Regards Data Show Diabetics Who Use Verapamil Have Lower Glucose Levels, Tyler Greer

Browse All News

No abstract provided.

Darwinian Sex Roles Confirmed Across The Animal Kingdom, Tim Janicke, Ines K. Häderer, Marc J. Lajeunesse, Nils Anthes

Integrative Biology Faculty and Staff Publications

Since Darwin's conception of sexual selection theory, scientists have struggled to identify the evolutionary forces underlying the pervasive differences between male and female behavior, morphology, and physiology. The Darwin-Bateman paradigm predicts that anisogamy imposes stronger sexual selection on males, which, in turn, drives the evolution of conventional sex roles in terms of female-biased parental care and male-biased sexual dimorphism. Although this paradigm forms the cornerstone of modern sexual selection theory, it still remains untested across the animal tree of life. This lack of evidence has promoted the rise of alternative hypotheses arguing that sex differences are entirely driven by environmental …

One-Dimensional Nanostructure And Sensing Applications: Tin Dioxide Nanowires And Carbon Nanotubes, Hoang Anh Tran

Dissertations and Theses

The key challenge for a nanomaterial based sensor is how to synthesize in bulk quantity and fabricate an actual device with insightful understanding of operational mechanisms during performance. I report here effective, controllable methods that exploit the concepts of the "green approach" to synthesize two different one-dimensional nanostructures, including tin oxide nanowires and carbon nanotubes. The syntheses are followed by product characterization and sensing device fabrications as well as sensor performance understanding at the molecular level. Sensor-analyte response and recovery kinetics are also presented.

The first part of the thesis describes bulk-scale synthesis and characterization of tin oxide nanowires by …

The Wooster Voice (Wooster, Oh), 2016-02-12, Wooster Voice Editors

The Voice: 2012-Present

The Story of the Week in this Wooster Voice issue is "President Bolton hears from students at first fireside chat," reporting on Bolton's "listening session" with students regarding a range of topics on campus. Other news articles include "Williams Hall plan coming together," in reference to the construction plans for the replacement of Mateer Hall, "Lewis House residents move out after floor sags," and "Tentative future facilities plan presented." The Features section includes articles on the Living Wage Campaign, Valentine's Day, and the creation of a College of Wooster Youth Development Program. In Arts and Entertainment, there are articles on …

Eggshell Pigment Composition Covaries With Phylogeny, Kaat Brulez, Ivan Miksik, Christopher R. Cooney, Mark E. Hauber, Paul George Lovell, Golo Maurer, Steven J. Portugal, Douglas Russell, Silas James Reynolds, Phillip Cassey

Publications and Research

No single hypothesis is likely to explain the diversity in eggshell coloration and patterning across birds, suggesting that eggshell appearance is most likely to have evolved to fulfill many nonexclusive functions. By controlling for nonindependent phylogenetic associations between related species, we describe this diversity using museum eggshells of 71 British breeding passerine species to examine how eggshell pigment composition and concentrations vary with phylogeny and with life-history and nesting ecology traits. Across species, concentrations of biliverdin and protoporphyrin, the two main pigments found in eggshells, were strongly and positively correlated, and both pigments strongly covaried with phylogenetic relatedness. Controlling for …

Volume Cxxxiii, Number 14, February 12, 2016, Lawrence University

The Lawrentian

No abstract provided.

A Feature Selection Algorithm To Compute Gene Centric Methylation From Probe Level Methylation Data, Brittany Baur, Serdar Bozdag

Mathematics, Statistics and Computer Science Faculty Research and Publications

DNA methylation is an important epigenetic event that effects gene expression during development and various diseases such as cancer. Understanding the mechanism of action of DNA methylation is important for downstream analysis. In the Illumina Infinium HumanMethylation 450K array, there are tens of probes associated with each gene. Given methylation intensities of all these probes, it is necessary to compute which of these probes are most representative of the gene centric methylation level. In this study, we developed a feature selection algorithm based on sequential forward selection that utilized different classification methods to compute gene centric DNA methylation using probe …

Effect Of The North Equatorial Counter Current On The Generation And Propagation Of Internal Solitary Waves Off The Amazon Shelf (Sar Observations), Jorge Manuel Magalhães, J.C.B. Da Silva, Maarten C. Buijsman, Carlos A.E. Gaercia

Faculty Publications

. Synthetic aperture radar (SAR) imagery from the Amazon shelf break region in the tropical west Atlantic reveals for the first time the two-dimensional horizontal structure of an intense Internal Solitary Wave (ISW) field, whose first surface manifestations are detected several hundred kilometres away from the nearest forcing bathymetry. Composite maps and an energy budget analysis (provided from the Hybrid Coordinate Ocean Model – HYCOM) help to identify two major ISW pathways emanating from the steep slopes of a small promontory (or headland) near 44◦ W and 0 ◦ N, which are seen to extend for over 500 km into …

Brain Injury Research, Brittany Gaston

UNH Today Archive

No abstract provided.

Event Program, Emory Law Journal

Randolph W. Thrower Symposium

No abstract provided.

Book Review: International Law--The Conduct Of Armed Conflict And Air Operations, Donald P. Gilmore

Georgia Journal of International & Comparative Law

No abstract provided.

Frankia As A Biodegrading Agent, Medhat Rehan, Erik Swanson, Louis S. Tisa

New Hampshire Agricultural Experiment Station Publications

The Frankia actinorhizal plant symbiosis plays an important role in colonization ofsoils contaminated with toxic aromatic hydrocarbons. Our understanding of thebacterial partner, Frankia, in the actinorhizal symbiosis has been greatly facilitated bythe availability of sequenced genomes. The analysis of these Frankia genomes hassuggested that these bacteria are metabolically diverse and have potential for toxicaromatic hydrocarbon degradation. In this chapter, we explore what is known aboutthat metabolic potential.

Observations And Modeling Of Exchange And Residence Time In Tidal Inlets, Patrick Forde Rynne

Open Access Dissertations

The exchange of water in a coastal embayment with seawater is forced by tidally driven and gravitational flows. Tidal flows oscillate temporally based on planetary motion, while gravitational flows like those found in rivers act in one direction from high to low altitude. These flows determine the residence time, or the time water will remain within an embayment. At the ocean boundary, many coasts contain barrier islands with inlets through which these flows propagate. The effect that inlets have on the exchange of inland water with the sea has been the subject of research for nearly a century. Residence time …

The Firece Green Fire: Vol. 6 Issue 14, Wofford College Environmental Studies Program

The Fierce Green Fire

No abstract provided.

Western News, Feb. 11, 2016, Western Michigan University

Western News (1972-2018)

Story highlights: WMU adds to group’s scholarship program; Spring Convocation starts new annual program honoring researchers, employees; Teaching With Technology Symposium scheduled; On Campus with JoAnne O’Rourke.

Veiled Glory: How Conservative Anabaptist Women Reflect The Feminine Image And Glory Of God, Elaine V. Yoder

Doctor of Ministry

Through the lens of the metaphor “Veiled Glory,” this dissertation explores how a traditional conservative Anabaptist view of the feminine reflects specific aspects of God’s image and glory. Drawing from Scriptures that detail feminine aspects of God’s image, such as mother, mystery, wisdom, and a Jewish rabbinic and mystical understanding of the Shekinah glory of God, one discovers significant feminine images of God threaded throughout the biblical account. Embracing these aspects of God’s image can bring personal identity and shalom, a Hebrew word describing a deep inner peace and sense of wellbeing, to women belonging to traditional Anabaptist communities.

Section …

The Tiger Vol. 110 Issue 10 2016-02-11, Clemson University

Tiger Newspapers 2016

No abstract provided.

The Setonian, February 11, 2016, Seton Hall University

2016

No abstract provided.

Ua12/2/1 College Heights Herald, Vol. 91, No. 6, Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news.

• Camp, Jodi. Student Government Association Passes Four Bills in Tuesday Meeting
• Collins, Emma. Kentucky Senate to Hear Tuition Freeze Bill
• Clark, Samantha. WKU Forensics Team Sweeps Tournament in Illinois
• Kast, Monica. New Minors Approved by Board of Regents – Curriculum
• Abri, Madihah. Students Learn Culture from Calligraphy – China
• Kast, Monica. Finalists Chosen in Study Abroad & Global Learning Director Search
• Camp, Jodi. Hot Water to Return to Minton Hall By End of Week – Housing & Residence Life
• King, Jennifer. Editorial Cartoon Weather in Kentucky Explained
• Critchelow, Andrew. …

V. 83, Iss. 11, February 11, 2016

Archway (1946-2020)

No abstract provided.

Wmu Board Of Trustees Formal Session February 11, 2016, Wmu Board Of Trustees

WMU Board of Trustees Meetings

Minutes of the WMU Board of Trustees meeting include appendices:

• Proposed minutes of the December 8 and 18, 2015 meetings
• Conferring of an Honorary Degree for Michel Legrand
• Gift Report
• Grant Report
• Personnel Report
• Curriculum Proposals

Unh Research: Lactation, Weather Found To Predict Colostrum Quality In Dairy Cows, Lori Tyler Gula

UNH Today Archive

No abstract provided.

Distribution And Abundance Of Glucocorticoid And Mineralocorticoid Receptors Throughout The Brain Of The Great Tit (Parus Major), Rebecca A. Senft , '15, S. L. Meddle, Alexander T. Baugh

Biology Faculty Works

The glucocorticoid stress response, regulated by the hypothalamic-pituitary-adrenal (HPA) axis, enables individuals to cope with stressors through transcriptional effects in cells expressing the appropriate receptors. The two receptors that bind glucocorticoids—the mineralocorticoid receptor (MR) and glucocorticoid receptor (GR)—are present in a variety of vertebrate tissues, but their expression in the brain is especially important. Neural receptor patterns have the potential to integrate multiple behavioral and physiological traits simultaneously, including self-regulation of glucocorticoid secretion through negative feedback processes. In the present work, we quantified the expression of GR and MR mRNA throughout the brain of a female great tit (Parus major), …

The Utah Statesman, February 11, 2016, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Bedwell Named Interim Chair Of Biochemistry, Kendra Carter

Browse All News

No abstract provided.