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The Patriot Talon (March 1, 2016), University Of Texas At Tyler

The Patriot Talon/The Patriot

The official newspaper for the University of Texas at Tyler before it was changed back to the UT Tyler Patriot. Articles in this issue include: University President Dr. Mabry to retire; Campus carry working group holds Town Hall meeting; Taking Flight; Announcement of tobacco policy coming in March; Heels, wheels and lipstick; Living in reverse; Who should choose the next Supreme Court justice?; Environmental fee: should we have a "green" campus?; Employers' ideas about tattoos are changing; Center for Ethics holds panel discussion on Syrian refugee crisis; University reviews learning management systems; What's Happening: University Spring 2016 Patriot Preview day …

Semantic, Cognitive, And Perceptual Computing: Paradigms That Shape Human Experience, Amit P. Sheth, Pramod Anantharam, Cory Henson

Kno.e.sis Publications

Unlike machine-centric computing, in which efficient data processing takes precedence over contextual tailoring, human-centric computation provides a personalized data interpretation that most users find highly relevant to their needs. The authors show how semantic, cognitive, and perceptual computing paradigms work together to produce actionable information.

God's Dice: The Law In A Probabilistic World, Alessandro Romano

University of Dayton Law Review

No abstract provided.

Identifying The Presence Of Amd-Derived Soil Co₂ In Field Investigations Using Isotope Ratios, Kwame Awuah-Offei, Moagabo Mathiba, Fred J. Baldassare

Mining Engineering Faculty Research & Creative Works

Recent incidents of hazardous accumulations of CO₂ in homes on or adjacent to reclaimed mine land have been shown to be linked to neutralization reactions between acidic mine drainage and carbonate material. An efficient and economic method is necessary to identify the presence of acid mine drainage- (AMD-) derived CO₂ on reclaimed mine land, prior to construction. One approach to identify the presence of AMD-derived CO₂ is to characterize stable carbon isotope ratios of soil CO₂. To do so, a viable method is necessary to acquire soil gas samples for isotope ratio analysis. This paper …

Manufacturing Barriers To Biologics Competition And Innovation, W. Nicholson Price Ii., Arti K. Rai

Articles

As finding breakthrough small-molecule drugs becomes more difficult, drug companies are increasingly turning to "large molecule" biologics. Although biologics represent many of the most promising new therapies for previously intractable diseases, they are extremely expensive. Moreover, the pathway for generic-type competition set up by Congress in 2010 is unlikely to yield significant cost savings. This Article provides a fresh diagnosis of and prescription for this major public policy problem. It argues that the key cause is pervasive trade secrecy in the complex area of biologics manufacturing. Under the current regime, this trade secrecy, combined with certain features of Food and …

Shame And Resilience Among Mental Health Trainees: A Scale Construction Study, Claire T. Hauser

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Contemporary research has revitalized interest in the construct of shame, and the pervasive nature with which it impacts psychological functioning. It has been argued that mental health professionals encounter shame regularly in the therapeutic milieu and must be equipped to assist clients in developing shame resilience. The process of learning to provide shame attendant therapy begins during graduate training, as mental health trainees (MHTs) gain first hand experience with feeling shame through the evaluative nature of the training process. Although shame in the MHT role has been discussed in prior literature, it is difficult to study due to lacking instrumentation. …

Development Of A Direct Activity Probe For Rho-Associated Protein Kinase, Maia Kelly

Department of Chemistry: Dissertations, Theses, and Student Research

Hepatocellular carcinoma (HCC) is an extremely aggressive form of liver cancer with a low survival rate due to high recurrence. Increases in Rho-associated Protein Kinase (ROCK) activity are correlated with a more aggressive, metastatic phenotype associated with advanced HCC. Inhibitors for ROCK have shown potential for the reduction of this metastatic phenotype of HCC. We outline the design and optimization of a direct activity sensor for ROCK that utilizes a phosphorylation-sensitive sulfonamido-oxine fluorophore, termed Sox, and is capable of reporting on the inhibition of ROCK. This CSox-based activity probe utilizes chelation-enhanced fluorescence (ex. = 360 nm and em. = 485 …

Ne Stem 4u: An Out-Of-School Time Academic Program To Improve Achievement Of Socioeconomically Disadvantaged Youth In Stem Areas, Christine E. Cutucache, Jamie L. Luhr, Kari L. Nelson, Neal Grandgenett, William E. Tapprich

Biology Faculty Publications

Background

The Nebraska Science, Technology, Engineering, and Mathematics 4U (NE STEM 4U) program was initiated at the University of Nebraska at Omaha (UNO) in 2013. NE STEM 4U is a student-run, faculty-led program facilitating problem-based learning (PBL) sessions in science, technology, engineering, and mathematics (STEM) for socioeconomically disadvantaged kindergarten through grade 8 (K-8) students. PBL sessions are provided throughout the academic year in a twice-weekly, after-school, informal education program. The instructional material provided after school builds upon the curricula of the school day. Importantly, this program is a partnership between faculty members and administrators in higher education at UNO with …

Shaping The Growth Behaviour Of Biofilms Initiated From Bacterial Aggregates, Gavin Melaugh, Jaime B. Hutchison, Kasper N. Kragh, Yasuhiko Irie, Aled E. L. Roberts, Thomas Bjarnsholt, Stephen P. Diggle, Vernita Gordon, Rosalind J. Allen

Biology Faculty Publications

Bacterial biofilms are usually assumed to originate from individual cells deposited on a surface. However, many biofilm-forming bacteria tend to aggregate in the planktonic phase so that it is possible that many natural and infectious biofilms originate wholly or partially from pre-formed cell aggregates. Here, we use agent-based computer simulations to investigate the role of pre-formed aggregates in biofilm development. Focusing on the initial shape the aggregate forms on the surface, we find that the degree of spreading of an aggregate on a surface can play an important role in determining its eventual fate during biofilm development. Specifically, initially spread …

Essay: Faculty, The Courts, And The First Amendment, Neal Hutchens, Frank Fernandez, Azalea Hulbert

Penn State Law Review (2003 - Present)

No abstract provided.

Commentary: Five Decades Of Skepticism About Pbl In Medical Education: A Reflection And Outlook In The Asia Pacific Context, Chiu-Yin Kwan

Journal of Medical Education

文章暫無收錄摘要

Constructing A Conceptual Model For Team-Based Learning Program In Medical School Through A Qualitative Lens, Meng-Fang Tsai, Chau-Chyun Sheu, Jer-Chia Tsai, Yin-Chun Tien, Keh-Min Liu

Journal of Medical Education

Purpose: Since 2012, medical teachers at a university in Taiwan, where the study was conducted, have increasingly implemented team-based learning (TBL) to the integrated basic and clinical science course, block-based curriculum. The TBL conceptual model has not been studied well in different contexts nor discussed through students’ perspectives in existing research. Constructing a conceptual model suitable for the TBL implementation is imperative. Method: Medical students’ narrative comments regarding TBL teaching were recorded in 2015. Seventy-five student volunteers (15 post-baccalaureate medical and 60 medical students) gave their thoughts on the TBL program. Based on themes coded through directed content analysis and …

Sialomes And Mialomes: A Systems-Biology View Of Tick Tissues And Tick-Host Interactions, Jindrich Chmelar, Jan Kotal, Shahid Karim, Petr Kopacek, Ivo M.B. Francischetti, Joao H.F. Pedra, Michail Kotsyfakis

Faculty Publications

Tick saliva facilitates tick feeding and infection of the host. Gene expression analysis of tick salivary glands and other tissues involved in host-pathogen interactions has revealed a wide range of bioactive tick proteins. Transcriptomic analysis has been a milestone in the field and has recently been enhanced by next-generation sequencing (NGS). Furthermore, the application of quantitative proteomics to ticks with unknown genomes has provided deeper insights into the molecular mechanisms underlying tick hematophagy, pathogen transmission, and tick-host-pathogen interactions. We review current knowledge on the transcriptomics and proteomics of tick tissues from a systems-biology perspective and discuss future challenges in the …

Program And Abstracts Of The 62nd Annual Conference Of The Mississippi Entomological Association, October 19-20, 2015, Mississippi Entomological Association

Midsouth Entomologist

No abstract provided.

Can A Diary Encourage Others To Be Citizen Scientists?, Jerry H. Kavouras

Biology Department Faculty Articles

No abstract provided.

Long Non-Coding Rnas As Prognostic Markers In Human Breast Cancer, Hairong Liu, Juan Li, Pratirodh Koirala, Xianfeng Ding, Binghai Chen, Yiheng Wang, Zheng Wang, Chuanxin Wang, Xu Zhang, Yin-Yuan Mo

Faculty Publications

Long non-coding RNAs (lncRNAs) have been recently shown to play an important role in gene regulation and normal cellular functions, and disease processes. However, despite the overwhelming number of lncRNAs identified to date, little is known about their role in cancer for vast majority of them. The present study aims to determine whether lncRNAs can serve as prognostic markers in human breast cancer. We interrogated the breast invasive carcinoma dataset of the Cancer Genome Atlas (TCGA) at the cBioPortal consisting of ~ 1,000 cases. Among 2,730 lncRNAs analyzed, 577 lncRNAs had alterations ranging from 1% to 32% frequency, which include …

Unintended Pregnancies In Brazil - A Challenge For The Recommendation To Delay Pregnancy Due To Zika, Cynthia Schuck-Paim, Daniel Lopez, Lone Simonsen, Wladimir Alonso

Global Health Faculty Publications

Because of the potential link between the ongoing Zika virus outbreak and a surge in the number of cases of congenital microcephaly, officials in Latin America have recommended that women postpone pregnancy until this association is firmly established or the outbreak subsides. However, in all these countries a large proportion of babies are still born out of unplanned pregnancies. Teenage girls are particularly at high risk, as they often lack access to preventive contraception methods, or the knowledge to use them appropriately. To gauge the magnitude of the barriers preventing the implementation of such a recommendation in Brazil, the country …

Adolescent Non-Suidical Self-Injury: Analysis Of The Youth Risk Behavior Survey, Kelly Emelianchik-Key, Rebekah J. Byrd, Amanda C. La Guardia

ETSU Faculty Works

Self-injury is a significant issue with a variety of psychological, social, legal and ethical consequences and implications (Froeschle & Moyer, 2004; McAllister, 2003; Nock & Mendes, 2008; White Kress, Drouhard, & Costin, 2006). Self-injurious behavior is commonly associated with the cutting, bruising or burning of the skin. It also can include trichotillomania, interfering with wound healing and extreme nail biting (Klonsky & Olino, 2008; Zila & Kiselica, 2001). In assessing severity, it is important to note that self-inflicted wounds typically do not require any medical attention, as those who engage in self-injury will usually care for any open wounds in …

Chlamydial Antibiotic Resistance And Treatment Failure In Veterinary And Human Medicine, Nicole Borel, Cory Leonard, Jessica Slade, Robert V. Schoborg

ETSU Faculty Works

The Chlamydiaceae are widespread pathogens of both humans and animals. Chlamydia trachomatis infection causes blinding trachoma and reproductive complications in humans. Chlamydia pneumoniae causes human respiratory tract infections and atypical pneumonia. Chlamydia suis infection is associated with conjunctivitis, diarrhea, and failure to gain weight in domestic swine. Chlamydial infections in humans and domesticated animals are generally controlled by antibiotic treatment—particularly macrolides (usually azithromycin) and tetracyclines (tetracycline and doxycycline). Tetracycline-containing feed has also been used to limit infections and promote growth in livestock populations, although its use has decreased because of growing concerns about antimicrobial resistance development. Because Sandoz and Rockey …

Improving Cotton Agronomics With Diverse Genomic Technologies, Aaron Robert Sharp

Theses and Dissertations

Agronomic outcomes are the product of a plant's genotype and its environment. Genomic technologies allow farmers and researchers new avenues to explore the genetic component of agriculture. These technologies can also enhance understanding of environmental effects. With a growing world population, a wide variety of tools will be necessary to increase the agronomic productivity. Here I use massively parallel, deep sequencing of RNA (RNA-Seq) to measure changes in cotton gene expression levels in response to a change in the plant's surroundings caused by conservation tillage. Conservation tillage is an environmentally friendly, agricultural practice characterized by little or no inversion of …

Discovery Of Low-Molecular Weight Novel Serum Biomarkers For Diagnosing Preeclampsia And Alzheimer's Disease, Swati Anand

Theses and Dissertations

Preeclampsia (PE), a life threatening pregnancy-related disorder, is characterized mainly by new onset of hypertension and proteinuria after 20 weeks of gestation. Currently, PE cannot be predicted prior to onset of symptoms and there is no cure for the disease. There is a clear value in having biomarkers able, early in a pregnancy, to identify women at risk for PE so that proper treatment therapies could be developed. Although a number of serum candidate markers have been proposed to be altered in PE patients, their use is limited due to poor sensitivity and specificity. Therefore, there is ongoing need for …

Trio-Eligible Students And Study Abroad: Influential Factors, Barriers, And Benefits, Michael R. Minton

Theses and Dissertations

Despite the fact that only 1.8% of U.S. undergraduate students choose to participate in a study abroad program, the popularity of study abroad has grown significantly in recent years (Open Doors, 2013). Participation in study abroad programs has grown by over 97% since 2000, and has increased every year since 2008-09 (Open Doors, 2013). Many institutions recognize the importance of this educational activity in preparing their students to be productive citizens in an ever-growing global economy and society.

While the number of U.S. undergraduate students participating in study abroad has continued to increase overall, it is important to note that …

Teachers’ Perspectives On Academic Achievement And Educational Growth Of U.S.-Born Hispanic Students In A Midwestern Spanish Language Immersion Program, Herlinda Arlene Galve Salgado

Dissertations

Elementary Spanish language immersion programs have become more popular in the educational field in the United States to support the academic achievement of minority students. The final goal of immersion programs is to develop proficiency in the home language and dominant language, identified as first language (L1) and second language (L2), to impact the understanding of academic concepts. This study explores teachers’ perspectives of U.S.-born ELL Hispanic students’ academic achievement and educational growth in a Spanish language immersion program. Ultimately, the study aimed to identify processes that educational leaders could incorporate into instructional models to improve as many Hispanic students’ …

The Role Of Hypoxia On Pyruvate Kinase M2, Mammalian Target Of Rapamycin, Mitochondrial Function, And Cell Invasion In The Trophoblast, Rebecca Lutz Kimball

Theses and Dissertations

This thesis will be organized into two chapters discussing the role of hypoxia in the human placenta. The goal of this thesis is to characterize pyruvate kinase M2, mammalian target of rapamycin, mitochondrial function, and cell invasion in hypoxic conditions in the trophoblast. Understanding the mechanisms of placental metabolism can lead to further treatments for placental diseases. Chapter one covers the background of intrauterine growth restriction, hypoxia, placental metabolism, and pyruvate kinase M2 (PKM2). Little is currently understood about the role of the mitochondria in placental diseases. Expression of PKM2, trophoblast cell invasion, and mitochondrial function is shown to be …

The Gratification Niches Of Traditional And Digital Radio, Don G. Shelline

Theses and Dissertations

We live in an age where science fiction is quickly becoming science fact. Dick Tracy's 2-way wrist TVs are Apple Watches. Automated smart homes are plentiful. Cars are now able to drive themselves. And in those cars, riders no longer need to depend on a deejay to choose their music for them; these listeners build their own radio stations, on the spot, out of any music and conversation they want to hear, all at the touch of a button that is fully connected to Wi-Fi, the internet, and unlimited cell data plans.This research will examine digital radio's impact upon traditional …

In Vitro Molecular Modification Of Human Cultured And Primary Cells Using Lance Array Nanoinjection, John W. Sessions

Theses and Dissertations

Fundamentally altering cellular function at a genetic level is a major area of interest in the biologic sciences and the medical community. By engineering transfectable constructs that can be inserted to dysfunctional cellular systems, scientists can mitigate aberrant genetic behavior to produce proper molecular function. While viral vectors have been a mainstay in the past, there are many limitations, particularly related to safety, that have changed the focus of genome editing to incorporate alternative methods for gene delivery. Lance Array Nanoinjection (LAN), a second-generation microfabricated transfection biotechnology, is one of these alternative technologies. LAN works by utilizing both simultaneous electrostatic …

A Neuroimaging Investigation Of The Effects Of Age And Sleep On Pattern Separation, Christopher Robert Doxey

Theses and Dissertations

Effective memory representations must be specific to prevent interference between episodes that may overlap in terms of place, time, or items present. Pattern separation, a computational process performed by the hippocampus overcomes this interference by establishing non-overlapping memory representations. This project explores pattern separation and how it is impacted by age and sleep. Experiment 1. Structures of the medial temporal lobe (MTL) are known to be involved in declarative memory processes. However, little is known about how age-related changes in MTL structures, white matter integrity, and functional connectivity affect pattern separation processes in the MTL. In the present study, we …

The Effect Of Whole Body Vibration On Exercise-Induced Muscle Damage And Delayed-Onset Muscle Soreness, Ryan Darin Magoffin

Theses and Dissertations

Current scientific evidence suggests that when whole body vibration (WBV) is used as a warm-up prior to performing eccentric exercise, delayed-onset muscle soreness (DOMS) is mitigated and strength loss recovers faster. These benefits were observed primarily in nonresistance-trained individuals. The aim of this study was to determine if WBV could mitigate soreness and expedite strength recovery for resistance-trained individuals when used as a warm-up prior to eccentric exercise. Thirty resistance-trained males completed 300 maximal eccentric contractions of the quadriceps after warming up with (WBV) or without (CON) WBV. Both CON and WBV experienced significant isometric (27.8% and 30.5%, respectively) and …

Extracellular Matrix From Whole Porcine Heart Decellularization For Cardiac Tissue Engineering, Nima Momtahan

Theses and Dissertations

Heart failure is one of the leading causes of death in the United States. Every year in the United States, more than 800,000 people are diagnosed with heart failure and more than 375,000 people die from heart disease. Current therapies such as heart transplants and bioartificial hearts are helpful, but not optimal. Decellularization of porcine whole hearts followed by recellularization with patient-specific human cells may provide the ultimate solution for patients with heart failure. Great progress has been made in the development of efficient processes for decellularization, and the design of automated bioreactors. In this study, the decellularization of porcine …

Rab8 Mediates Trpv4 Vesicle Trafficking To The Plasma Membrane In Hgf-Stimulated Mdck Cells, Hillary Jean Haws

Theses and Dissertations

Epithelial to mesenchymal transition (EMT) is a process whereby epithelial cells, which act collectively through robust cell–cell interactions, take on mesenchymal characteristics, breaking cell–cell junctions to become solitary, invasive and motile. Our previous results show that a transient increase in calcium influxes through TRP channels at the plasma membrane is required for hepatocyte growth factor (HGF)– stimulated EMT. Since this transient increase requires an intact microtubule cytoskeleton, we propose that HGF stimulation results in the mobilization of calcium channels to the plasma membrane from an intracellular compartment via microtubule–dependent vesicle trafficking. Through immunofluorescence, we show that prior to HGF treatment, …