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Joint Symposium Celebrates Diversity Of Ideas, University Relations

Campus News Archive

The UMM/UMTC Joint Symposium “Biology in the 21st Century: Complex Concepts, Amazing Opportunities” served as a model for intercampus collaboration.

Rio Grande Water Chemistry Data From Bernalillo County, New Mexico (2006-2007), David Van Horn, Clifford Dahm

Sevilleta LTER Program Data

Human populations in Colorado, New Mexico and Texas depend on the Rio Grande for municipal water, agricultural irrigation, and recreation. The Rio Grande and its riparian corridor also support thousands of species of plants, invertebrates and vertebrates, some of which include over 300 species of migratory birds and the endangered Rio Grande silvery minnow and southwestern willow flycatcher. Eutrophication and salinization are the two most important types of water quality degradation which negatively impact the human and nonhuman biological communities in this water poor region. In spite of their significance, few published studies have investigated anthropogenic and natural sources of …

Pinon-Juniper Overstory Density, Cover And Biomass Data From Cerro Montosa, Sevilleta National Wildlife Refuge, New Mexico (2006-2009), Esteban Muldavin

Sevilleta LTER Program Data

In 2006, to obtain a measure of pinon and juniper biomass in the Cerro Montosa area, belt transects were superimposed on transects along which understory net primary producitivy (NPP) is sampled. All trees rooted within 5 m to the north of each belt were tagged, although some shorter belts exist on which all trees within 5 m to either the north or south were tagged. The height of each tagged tree was measured, as was the diameter-at root-crown (DRC). Crown diameters both parallel and perpendicular to the belt transect were also measured. Trees were re-measured in 2007, 2008, and 2009.

Warming-El Nino-Nitrogen Deposition Experiment (Wenndex): Seasonal Biomass And Seasonal And Annual Npp At The Sevilleta National Wildlife Refuge, New Mexico (2006-Present), Scott Collins

Sevilleta LTER Program Data

Begun in winter 2006, this long-term study at the Sevilleta LTER examines how heightened winter precipitation, N addition, and warmer nighttime temperatures affect above-ground biomass production (ANPP) in a mixed desert-grassland. Net primary production is a fundamental ecological variable that quantifies rates of carbon consumption and fixation. Estimates of NPP are important in understanding energy flow at a community level as well as spatial and temporal responses to a range of ecological processes. While measures of both below- and above-ground biomass are important in estimating total NPP, this study focuses on above-ground net primary production (ANPP). Above-ground net primary production …

Bridging The Gap Between School And The Street, Jim C. Taylor Mr.

National Youth Advocacy & Resilience Conference

Existing within every society are various cultures and sub-cultures. This presentation examines the results when the classroom culture comes in to contact with the street culture. We will review existing practices designed to address these educational issues both in and out of the classroom and what are possible solutions that can maximize successful student education.

Jack's Brain, Jill's Brain: Why Gender Differences Matter, Shauna F. King

National Youth Advocacy & Resilience Conference

This workshop introduces participants to the rapidly emerging research on how the brains of females and males are developmentally, structurally and functionally different. Based on these differences, participants will learn academic approaches customized to the distinctly different learning styles of girls and boys.

Fundamentals Of Section 1983 Litigation, Martin A. Schwartz

Touro Law Review

No abstract provided.

Matter Of Kevin M., Donna A. Napolitano

Touro Law Review

No abstract provided.

The Lost Purpose Of The Doha Round, Raj Bhala

Journal of International and Comparative Law

No abstract provided.

National Security And U.S. Immigration Policy, Edward Alden

Journal of International and Comparative Law

No abstract provided.

Cyclin-Dependent Kinase Crk9, Required For Spliced Leader Trans Splicing Of Pre-Mrna In Trypanosomes, Functions In A Complex With A New L-Type Cyclin And A Kinetoplastid-Specific Protein., Nitika Badjatia, Sung Hee Park, Daniela L. Ambrósio, Justin K. Kirkham, Arthur Günzl

UCHC Articles - Research

In eukaryotes, cyclin-dependent kinases (CDKs) control the cell cycle and critical steps in gene expression. The lethal parasite Trypanosoma brucei, member of the phylogenetic order Kinetoplastida, possesses eleven CDKs which, due to high sequence divergence, were generically termed CDC2-related kinases (CRKs). While several CRKs have been implied in the cell cycle, CRK9 was the first trypanosome CDK shown to control the unusual mode of gene expression found in kinetoplastids. In these organisms, protein-coding genes are arranged in tandem arrays which are transcribed polycistronically. Individual mRNAs are processed from precursor RNA by spliced leader (SL) trans splicing and polyadenylation. CRK9 …

Anthropogenic Habitats Facilitate Dispersal Of An Early Successional Obligate: Implications For Restoration Of An Endangered Ecosystem, Katrina E. Amaral, Michael W. Palace, Kathleen M. O'Brien, Lindsey E. Fenderson, Adrienne I. Kovach

New Hampshire Agricultural Experiment Station Publications

Landscape modification and habitat fragmentation disrupt the connectivity of natural landscapes, with major consequences for biodiversity. Species that require patchily distributed habitats, such as those that specialize on early successional ecosystems, must disperse through a landscape matrix with unsuitable habitat types. We evaluated landscape effects on dispersal of an early successional obligate, the New England cottontail (Sylvilagus transitionalis). Using a landscape genetics approach, we identified barriers and facilitators of gene flow and connectivity corridors for a population of cottontails in the northeastern United States. We modeled dispersal in relation to landscape structure and composition and tested hypotheses about the influence …

Immuno And Affinity Cytochemical Analysis Of Cell Wall Composition In The Moss Physcomitrella Patens, Elizabeth A. Berry, Mai L. Tran, Christos S. Dimos, Michael J. Budziszek Jr., Tess R. Scavuzzo-Duggan, Alison Roberts

Biological Sciences Faculty Publications

In contrast to homeohydric vascular plants, mosses employ a poikilohydric strategy for surviving in the dry aerial environment. A detailed understanding of the structure, composition, and development of moss cell walls can contribute to our understanding of not only the evolution of overall cell wall complexity, but also the differences that have evolved in response to selection for different survival strategies. The model moss species Physcomitrella patens has a predominantly haploid lifecycle consisting of protonemal filaments that regenerate from protoplasts and enlarge by tip growth, and leafy gametophores composed of cells that enlarge by diffuse growth and differentiate into several …

Tile History: A Brief Presentation, Virginia Raguin

Documentation

Slide presentation used to introduce the art and history of ceramic tiling to participants who worked on Lungs of the Planet, a tile mural created as a collaborative art project by students in the Natural World Cluster of the Monserrat First Year Program at the College of the Holy Cross. The project was led by Virginia Raguin, Distinguished Professor of Humanities at the College. Particpants included students, faculty, staff and community members.

The presentation includes photographic examples of ceramic tiling in architecture located in Jerusalem and Istanbul.

Borrelia Burgdorferi Induces A Type I Interferon Response During Early Stages Of Disseminated Infection In Mice, Mary M. Petzke, Radha Iyer, Andrea Love, Zoe Spieler, Andrew Brooks, Ira Schwartz

NYMC Faculty Publications

BACKGROUND: Lyme borrelia genotypes differ in their capacity to cause disseminated disease. Gene array analysis was employed to profile the host transcriptome induced by Borrelia burgdorferi strains with different capacities for causing disseminated disease in the blood of C3H/HeJ mice during early infection.

RESULTS: B. burgdorferi B515, a clinical isolate that causes disseminated infection in mice, differentially regulated 236 transcripts (P < 0.05 by ANOVA, with fold change of at least 2). The 216 significantly induced transcripts included interferon (IFN)-responsive genes and genes involved in immunity and inflammation. In contrast, B. burgdorferi B331, a clinical isolate that causes transient skin infection but does not disseminate in C3H/HeJ mice, stimulated changes in only a few genes (1 induced, 4 repressed). Transcriptional regulation of type I IFN and IFN-related genes was measured by quantitative RT-PCR in mouse skin biopsies collected from the site of infection 24 h after inoculation with B. burgdorferi. The mean values for transcripts of Ifnb, Cxcl10, Gbp1, Ifit1, Ifit3, Irf7, Mx1, and Stat2 were found to be significantly increased in B. burgdorferi strain B515-infected mice relative to the control group. In contrast, transcription of these genes was not significantly changed in response to B. burgdorferi strain B331 or B31-4, a mutant that is unable to disseminate.

CONCLUSIONS: These results establish a positive association between the disseminating capacity of B. burgdorferi and early type I IFN induction in a murine model of Lyme disease.

Stem Stories, March 2016, #2, Ryan Lockard

STEM Stories

Faculty Profile - Joshua Sebree

P-Rex1 Promotes Resistance To Vegf/Vegfr-Targeted Therapy In Prostate Cancer, Hira Lal Goel, Bryan Pursell, Leonard D. Shultz, Dale L. Greiner, Rolf A Brekken, Craig W. Vander Kooi, Arthur M. Mercurio

Molecular and Cellular Biochemistry Faculty Publications

Autocrine VEGF signaling is critical for sustaining prostate and other cancer stem cells (CSCs), and it is a potential therapeutic target, but we observed that CSCs isolated from prostate tumors are resistant to anti-VEGF (bevacizumab) and anti-VEGFR (sunitinib) therapy. Intriguingly, resistance is mediated by VEGF/neuropilin signaling, which is not inhibited by bevacizumab and sunitinib, and it involves the induction of P-Rex1, a Rac GEF, and consequent Rac1-mediated ERK activation. This induction of P-Rex1 is dependent on Myc. CSCs isolated from the PTEN^pc−/− transgenic model of prostate cancer exhibit Rac1-dependent resistance to bevacizumab. Rac1 inhibition or P-Rex1 downregulation increases the …

Amidine-Mediated Zwitterionic Ring-Opening Polymerization Of N-Alkyl N-Carboxyanhydride: Mechanism, Kinetics, And Architecture Elucidation, Ang Li, Lu Lu, Xin Li, Li Lin He, Changwoo Do, Jayne C. Garno, Donghui Zhang

Faculty Publications

© 2016 American Chemical Society. Zwitterionic ring-opening polymerization (ZROP) of N-butyl N-carboxyanhydrides (Bu-NCAs) has been investigated using 1,8-diazabicycloundec-7-ene (DBU), a bicyclic amidine initiator. It was found that poly(N-butylglycine)s (PNBGs) with molecular weight (Mn) in the 3.5-32.4 kg mol-1 range and polydispersity index (PDI) in the 1.02-1.12 range can be readily obtained by systematically varying the initial monomer to initiator feed ratio. The polymerization exhibits characteristics of a controlled polymerization, as evidenced by the linear increase of polymer molecular weight with conversion and the successful enchainment experiments. Kinetic studies revealed that the reaction is first-order dependent on the monomer and the …

Daily Eastern News: March 08, 2016, Eastern Illinois University

March

No abstract provided.

A Colletotrichum Graminicola Mutant Deficient In The Establishment Of Biotrophy Reveals Early Transcriptional Events In The Maize Anthracnose Disease Interaction, Maria F. Torres, Noushin Ghaffari, Ester A. S. Buiate, Neil Moore, Scott Schwartz, Charles D. Johnson, Lisa J. Vaillancourt

Plant Pathology Faculty Publications

Background: Colletotrichum graminicola is a hemibiotrophic fungal pathogen that causes maize anthracnose disease. It progresses through three recognizable phases of pathogenic development in planta: melanized appressoria on the host surface prior to penetration; biotrophy, characterized by intracellular colonization of living host cells; and necrotrophy, characterized by host cell death and symptom development. A “Mixed Effects” Generalized Linear Model (GLM) was developed and applied to an existing Illumina transcriptome dataset, substantially increasing the statistical power of the analysis of C. graminicola gene expression during infection and colonization. Additionally, the in planta transcriptome of the wild-type was compared with that of …

The Sun Star Vol 35 No 21 ( March 8th, 2016), N/A N/A

Sun Star

No abstract provided.

The Sun Star, Vol. 35 No. 21 (March 08, 2016) , N/A N/A

Sun Star

No abstract provided.

Improving Cell Mixture Deconvolution By Identifying Optimal Dna Methylation Libraries (Idol), Devin C. Koestler, Meaghan J. Jones, Joseph Usset, Brock C. Christensen, Rondi A. Butler, Michael S. Kobor, John K. Weincke, Karl T. Kelsey

Dartmouth Scholarship

Background:

Confounding due to cellular heterogeneity represents one of the foremost challenges currently facing Epigenome-Wide Association Studies (EWAS). Statistical methods leveraging the tissue-specificity of DNA methylation for deconvoluting the cellular mixture of heterogenous biospecimens offer a promising solution, however the performance of such methods depends entirely on the library of methylation markers being used for deconvolution. Here, we introduce a novel algorithm for Identifying Optimal Libraries (IDOL) that dynamically scans a candidate set of cell-specific methylation markers to find libraries that optimize the accuracy of cell fraction estimates obtained from cell mixture deconvolution.

Results:

Application of IDOL to training set …

The Adp-Ribose Polymerase Tankyrase Regulates Adult Intestinal Stem Cell Proliferation During Homeostasis In Drosophila, Zhenghan Wang, Ai Tian, Hassina Benchabane, Ofelia Tacchelly-Benites, Eungi Yang, Hisashi Nojima, Yashi Ahmed

Dartmouth Scholarship

Wnt/β-catenin signaling controls intestinal stem cell (ISC) proliferation, and is aberrantly activated in colorectal cancer. Inhibitors of the ADP-ribose polymerase Tankyrase (Tnks) have become lead therapeutic candidates for Wnt-driven cancers, following the recent discovery that Tnks targets Axin, a negative regulator of Wnt signaling, for proteolysis. Initial reports indicated that Tnks is important for Wnt pathway activation in cultured human cell lines. However, the requirement for Tnks in physiological settings has been less clear, as subsequent studies in mice, fish and flies suggested that Tnks was either entirely dispensable for Wnt-dependent processes in vivo, or alternatively, had tissue-specific roles. Here, …

The Fast-Evolving Phy-2 Gene Modulates Sexual Development In Response To Light In The Model Fungus Neurospora Crassa, Zheng Wang, Ning Li, Jigang Li, Jay C. Dunlap, Frances Trail, Jeffrey P. Townsend

Dartmouth Scholarship

Rapid responses to changes in incident light are critical to the guidance of behavior and development in most species. Phytochrome light receptors in particular play key roles in bacterial physiology and plant development, but their functions and regulation are less well understood in fungi. Nevertheless, genome-wide expression measurements provide key information that can guide experiments that reveal how genes respond to environmental signals and clarify their role in development. We performed functional genomic and phenotypic analyses of the two phytochromes in Neurospora crassa, a fungal model adapted to a postfire environment that experiences dramatically variable light conditions. Expression of phy-1 …

Stoichiometry And Change Of The Mrna Closed-Loop Factors As Translating Ribosomes Transit From Initiation To Elongation, Xin Wang, Wen Xi, Shaun Toomey, Yueh-Chin Chiang, Jiri Hasek, Thomas M. Laue, Clyde L. Denis

New Hampshire Agricultural Experiment Station Publications

Protein synthesis is a highly efficient process and is under exacting control. Yet, the actual abundance of translation factors present in translating complexes and how these abundances change during the transit of a ribosome across an mRNA remains unknown. Using analytical ultracentrifugation with fluorescent detection we have determined the stoichiometry of the closed-loop translation factors for translating ribosomes. A variety of pools of translating polysomes and monosomes were identified, each containing different abundances of the closed-loop factors eIF4E, eIF4G, and PAB1 and that of the translational repressor, SBP1. We establish that closed-loop factors eIF4E/eIF4G dissociated both as ribosomes transited polyadenylated …

Prediction Of The Export And Fate Of Global Ocean Net Primary Production: The Exports Science Plan, David A. Siegel, Ken O. Buesseler, Michael J. Behrenfeld, Claudia R. Benitez-Nelson, Emmanuel Boss, Mark A. Brzezinski, Adrian Burd, Craig A. Carlson, Eric A. D'Asaro, Scott C. Doney, Mary J. Perry, Rachel H. R. Stanley, Deborah K. Steinberg

Faculty Publications

Ocean ecosystems play a critical role in the Earth's carbon cycle and the quantification of their impacts for both present conditions and for predictions into the future remains one of the greatest challenges in oceanography. The goal of the EXport Processes in the Ocean from Remote Sensing (EXPORTS) Science Plan is to develop a predictive understanding of the export and fate of global ocean net primary production (NPP) and its implications for present and future climates. The achievement of this goal requires a quantification of the mechanisms that control the export of carbon from the euphotic zone as well as …

The George-Anne, Georgia Southern University

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Alterations In Cortical Sensorimotor Connectivity Following Complete Cervical Spinal Cord Injury: A Prospective Resting-State Fmri Study, Akinwunmi Oni-Orisan, Mayank Kaushal, Wenjun Li, Jack Leschke, B. Douglas Ward, Aditya Vedantam, Benjamin Kalinosky, Matthew D. Budde, Brian D. Schmit, Shi-Jiang Li, Viashnavi Muqeet, Shekar N. Kurpad

Biomedical Engineering Faculty Research and Publications

Functional magnetic resonance imaging (fMRI) studies have demonstrated alterations during task-induced brain activation in spinal cord injury (SCI) patients. The interruption to structural integrity of the spinal cord and the resultant disrupted flow of bidirectional communication between the brain and the spinal cord might contribute to the observed dynamic reorganization (neural plasticity). However, the effect of SCI on brain resting-state connectivity patterns remains unclear. We undertook a prospective resting-state fMRI (rs-fMRI) study to explore changes to cortical activation patterns following SCI. With institutional review board approval, rs-fMRI data was obtained in eleven patients with complete cervical SCI (>2 years …

Small Mammal Exclosure Study (Smes) Leaf Litter Study In The Chihuahuan Desert Grassland And Shrubland At The Sevilleta National Wildlife Refuge, New Mexico, David Lightfoot

Sevilleta LTER Program Data

The purpose of this study is to determine whether or not the activities of small mammals regulate plant community structure, plant species diversity, and spatial vegetation patterns in Chihuahuan Desert shrublands and grasslands. What role if any do indigenous small mammal consumers have in maintaining desertified landscapes in the Chihuahuan Desert? Additionally, how do the effects of small mammals interact with changing climate to affect vegetation patterns over time? This is data for cover of dead plant leaf litter accumulations on soil surfaces measured on each of the SMES study plots. Leaf litter cover was measured from each of the …