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2016

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Articles 16171 - 16200 of 29301

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Expression Profiles Of Mirna Subsets Distinguish Human Colorectal Carcinoma And Normal Colonic Mucosa, Daniel F. Pellatt, John R. Stevens, Roger K. Wolff, Lila E. Mullany, Jennifer S. Herrick, Wade Samowitz, Martha L. Slattery Mar 2016

Expression Profiles Of Mirna Subsets Distinguish Human Colorectal Carcinoma And Normal Colonic Mucosa, Daniel F. Pellatt, John R. Stevens, Roger K. Wolff, Lila E. Mullany, Jennifer S. Herrick, Wade Samowitz, Martha L. Slattery

Mathematics and Statistics Faculty Publications

OBJECTIVES: MicroRNAs (miRNAs) are small, non-protein-coding RNA molecules that are commonly dysregulated in colorectal tumors. The objective of this study was to identify smaller subsets of highly predictive miRNAs.

METHODS: Data come from population-based studies of colorectal cancer conducted in Utah and the Kaiser Permanente Medical Care Program. Tissue samples were available for 1,953 individuals, of which 1,894 had carcinoma tissue and 1,599 had normal mucosa available for statistical analysis. Agilent Human miRNA Microarray V.19.0 was used to generate miRNA expression profiles; validation of expression levels was carried out using quantitative PCR. We used random forest analysis and verified findings …

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Chemotherapeutic Efficiency Of Drugs In Vitro: Comparison Of Doxorubicin Exposure In 3d And 2d Culture Matrices, Alan Casey, Mahmoud Gargotti, Franck Bonnier, Hugh Byrne Mar 2016

Chemotherapeutic Efficiency Of Drugs In Vitro: Comparison Of Doxorubicin Exposure In 3d And 2d Culture Matrices, Alan Casey, Mahmoud Gargotti, Franck Bonnier, Hugh Byrne

Articles

The interest in the use of 3D matrices for in vitro analysis, with a view to increasing the relevance of in vitro studies and reducing the dependence on in vivo studies, has been growing in recent years. Cells grown in a 3D in vitro matrix environment have been reported to exhibit significantly different properties to those in a conventional 2D culture environment. However, comparison of 2D and 3D cell culture models have recently been noted to result in differing responses of cytotoxic assays, without any associated change in viability. The effect was attributed to differing conversion rates and effective concentrations …

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Information Thermodynamics Of Cytosine Dna Methylation, Robersy Sanchez Rodriguez, Sally Ann Mackenzie Mar 2016

Information Thermodynamics Of Cytosine Dna Methylation, Robersy Sanchez Rodriguez, Sally Ann Mackenzie

Department of Agronomy and Horticulture: Faculty Publications

Cytosine DNA methylation (CDM) is a stable epigenetic modification to the genome and a widespread regulatory process in living organisms that involves multicomponent molecular machines. Genome-wide cytosine methylation patterning participates in the epigenetic reprogramming of a cell, suggesting that the biological information contained within methylation positions may be amenable to decoding. Adaptation to a new cellular or organismal environment also implies the potential for genome-wide redistribution of CDM changes that will ensure the stability of DNA molecules. This raises the question of whether or not we would be able to sort out the regulatory methylation signals from the CDM background …

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The East Texan, 2016-03-10, Texas A&M University-Commerce Mar 2016

The East Texan, 2016-03-10, Texas A&M University-Commerce

All Issues

A color copy of The East Texan, a student newspaper published at Texas A&M University-Commerce.

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Beyond Detection: Investing In Practical And Theoretical Applications Of Emotion + Visualization, R. Jordan Crouser, Lane Harrison, Daniel Afergan, Evan M. Peck Mar 2016

Beyond Detection: Investing In Practical And Theoretical Applications Of Emotion + Visualization, R. Jordan Crouser, Lane Harrison, Daniel Afergan, Evan M. Peck

Computer Science: Faculty Publications

Emotion is a dynamic variable that modulates how we perceive, reason about, and interact with our environment. Recent studies have established that emotion’s influence carries to data analysis and visualization, impacting performance in ways both positive and negative. While we are still in the infancy of understanding the role emotion plays in analytical contexts, advances in physiological sensing and emotion research have raised the possibility of creating emotion-aware systems. In this position paper, we argue that it is critical to consider the potential advances that can be made even in the face of imperfect sensing, while we continue to address …

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Spring Daylight Saving Time May Cause An Increased Risk Of Heart Attacks, Adam Pope Mar 2016

Spring Daylight Saving Time May Cause An Increased Risk Of Heart Attacks, Adam Pope

Browse All News

No abstract provided.

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(Re)Claiming The Body Of The Somali Woman In Nuruddin Farah’S From A Crooked Rib, Helmi Ben Meriem Mar 2016

(Re)Claiming The Body Of The Somali Woman In Nuruddin Farah’S From A Crooked Rib, Helmi Ben Meriem

Bildhaan: An International Journal of Somali Studies

No abstract provided.

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Stuck In The Pipeline: An Analysis Of The Hague Convention And Its Effects On Those In The Process Of International Adoptions, Sarah M. Baird Mar 2016

Stuck In The Pipeline: An Analysis Of The Hague Convention And Its Effects On Those In The Process Of International Adoptions, Sarah M. Baird

Journal of International and Comparative Law

No abstract provided.

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Design And Testing Of An Ecological Invert Culvert, Joseph W. Fisher, Scott D. Aston Mar 2016

Design And Testing Of An Ecological Invert Culvert, Joseph W. Fisher, Scott D. Aston

Purdue Road School

Consideration of stream ecology and stream biology is an emerging trend in the effective design of culverts. Current methods of burying the inverts of culvert have been shown to provide limited or no benefits. To address limitations in existing technologies and current design practices, Colorado State University has developed a culvert invert technology that retains streambed material and provides stream ecology benefits. In this session we will review the development and testing process from Colorado State University.

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Transfer Student-Athlete Scores Medical School In Utah, Sarah Gardner, Dave Albee Mar 2016

Transfer Student-Athlete Scores Medical School In Utah, Sarah Gardner, Dave Albee

Press Releases

The road to medical school for Mckenna Kimball ’15 started at the United States Air Force Academy, but really took off at Dominican.

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Volume 111 Issue 19, Southwestern Oklahoma State University Mar 2016

Volume 111 Issue 19, Southwestern Oklahoma State University

The Southwestern - Archive

No abstract provided.

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Comparison Of Protein Phosphatase Inhibition Assay With Lc-Ms/Ms For Diagnosis Of Microcystin Toxicosis In Veterinary Cases, Caroline E. Moore, Jeanette Juan, Yanping Lin, Cynthia L. Gaskill, Birgit Puschner Mar 2016

Comparison Of Protein Phosphatase Inhibition Assay With Lc-Ms/Ms For Diagnosis Of Microcystin Toxicosis In Veterinary Cases, Caroline E. Moore, Jeanette Juan, Yanping Lin, Cynthia L. Gaskill, Birgit Puschner

Veterinary Diagnostic Laboratory Faculty Publications

Microcystins are acute hepatotoxins of increasing global concern in drinking and recreational waters and are a major health risk to humans and animals. Produced by cyanobacteria, microcystins inhibit serine/threonine protein phosphatase 1 (PP1). A cost-effective PP1 assay using p-nitrophenyl phosphate was developed to quickly assess water and rumen content samples. Significant inhibition was determined via a linear model, which compared increasing volumes of sample to the log-transformed ratio of the exposed rate over the control rate of PP1 activity. To test the usefulness of this model in diagnostic case investigations, samples from two veterinary cases were tested. In August …

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Minutes Of The Faculty Senate Meeting, March 9, 2016, University Of Arkansas, Fayetteville. Faculty Senate Mar 2016

Minutes Of The Faculty Senate Meeting, March 9, 2016, University Of Arkansas, Fayetteville. Faculty Senate

Faculty Senate Minutes

No abstract provided.

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We Are...Marshall, March 9, 2016, Office Of Marshall University Communications Mar 2016

We Are...Marshall, March 9, 2016, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

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The Lumberjack, March 9, 2016, The Lumberjack Staff Mar 2016

The Lumberjack, March 9, 2016, The Lumberjack Staff

2016

The student newspaper of Humboldt State University

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Spartan Daily, March 9, 2016, San Jose State University, School Of Journalism And Mass Communications Mar 2016

Spartan Daily, March 9, 2016, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2016

Volume 146, Issue 17

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Easterner, Vol. 67, No. 20, March 9, 2016, Associated Students Of Eastern Washington University Mar 2016

Easterner, Vol. 67, No. 20, March 9, 2016, Associated Students Of Eastern Washington University

Student Newspapers

This issue of the Easterner contains articles about a proposed sustainability major, changes to the relationship between the Eastern and Cheney police departments, the Student Rights and Responsibilities program, a student production of Love's Labour's Lost: The Musical, an art exhibit called Appropriate Ambitions, the Queens in Wonderland event, the conclusion of the men's basketball season, and the decision to halt the development of a school softball team.

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Novel Biodegradable Protonic Ionic Liquid For The Fischer Indole Synthesis Reaction, William C. Neuhaus, Ian J. Bakanas, Joseph R. Lizza, Charles T. Boon Jr., Gustavo Moura-Letts Mar 2016

Novel Biodegradable Protonic Ionic Liquid For The Fischer Indole Synthesis Reaction, William C. Neuhaus, Ian J. Bakanas, Joseph R. Lizza, Charles T. Boon Jr., Gustavo Moura-Letts

College of Science & Mathematics Departmental Research

Novel eco-friendly tetramethylguanidinium propanesulfonic acid trifluoromethylacetate ([TMGHPS][TFA]) ionic liquid was developed as catalyst and medium for the Fischer indole synthesis of a wide variety of hydrazines and ketones. The indole products were isolated in high yields and with minimal amounts of organic solvent. This reaction showed that [TMGHPS][TFA] can be regenerated and reused with reproducible yields without eroding the integrity of the ionic liquid.

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Rio Grande River Sonde Data From Bernalillo County, New Mexico (2006-2007), David Van Horn, Clifford Dahm Mar 2016

Rio Grande River Sonde Data From Bernalillo County, New Mexico (2006-2007), David Van Horn, Clifford Dahm

Sevilleta LTER Program Data

Human populations in Colorado, New Mexico and Texas depend on the Rio Grande for municipal water, agricultural irrigation, and recreation. The Rio Grande and its riparian corridor also support thousands of specie of plants, invertebrates and vertebrates, some of which include over 300 species of migratory birds and the endangered Rio Grande silvery minnow and southwestern willow flycatcher. Eutrophication and salinization are the two most important types of water quality degradation which negatively impact the human and nonhuman biological communities in this water poor region. In spite of their significance, few published studies have investigated anthropogenic and natural sources of …

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Molecular Evolution And Functional Divergence Of Trace Amine–Associated Receptors, Seong-Il Eyun, Hideaki Moriyama, Federico G. Hoffmann, Etsuko N. Moriyama Mar 2016

Molecular Evolution And Functional Divergence Of Trace Amine–Associated Receptors, Seong-Il Eyun, Hideaki Moriyama, Federico G. Hoffmann, Etsuko N. Moriyama

School of Biological Sciences: Faculty Publications

Trace amine-associated receptors (TAARs) are a member of the G-protein-coupled receptor superfamily and are known to be expressed in olfactory sensory neurons. A limited number of molecular evolutionary studies have been done for TAARs so far. To elucidate how lineage-specific evolution contributed to their functional divergence, we examined 30 metazoan genomes. In total, 493 TAAR gene candidates (including 84 pseudogenes) were identified from 26 vertebrate genomes. TAARs were not identified from non-vertebrate genomes. An ancestral-type TAAR-like gene appeared to have emerged in lamprey.We found four therian-specific TAAR subfamilies (one eutherian-specific and three metatherian- specific) in addition to previously known nine …

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Vaccine Expert Offit To Give 2016 Kennamer Distinguished Lecture In Montgomery, Uab Heersink School Of Medicine News Mar 2016

Vaccine Expert Offit To Give 2016 Kennamer Distinguished Lecture In Montgomery, Uab Heersink School Of Medicine News

Browse All News

No abstract provided.

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Antarctica Researcher Named Recipient Of Uab's Ireland Prize For Scholarly Distinction, Staff Mar 2016

Antarctica Researcher Named Recipient Of Uab's Ireland Prize For Scholarly Distinction, Staff

Browse All News

No abstract provided.

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The Path To Violent Behavior: The Harmful Aftermath Of Childhood Trauma, Nicholas Michael Perez Mar 2016

The Path To Violent Behavior: The Harmful Aftermath Of Childhood Trauma, Nicholas Michael Perez

USF Tampa Graduate Theses and Dissertations

Adverse childhood experiences can lead to a number of harmful outcomes throughout an individual’s life, ranging from medical problems to criminal behavior. These traumatic experiences, comprised of different forms of maltreatment and dysfunctional household environments, can affect the development of a child in a variety of different ways. The multitude of developmental changes can produce compounding harmful effects on the child’s life and lead to acutely maladaptive outcomes. Under the perspective of developmental psychopathology, the ever-changing biological, psychological, and social dynamics of children who experience trauma can contribute to deficiencies in all aspects of their subsequent development. Each of these …

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A Journey To Peace, Jennifer Saunders Mar 2016

A Journey To Peace, Jennifer Saunders

UNH Today Archive

No abstract provided.

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Fastpop: A Rapid Principal Component Derived Method To Infer Intercontinental Ancestry Using Genetic Data, Yafang Li, Jinyoung Byun, Guoshuai Cai, Xiangjun Xiao, Younghun Han, Olivier Cornelis, James E. Dinulos, Joe Dennis, Douglas Easton, Ivan Gorlov, Michael F. Seldin, Christopher I. Amos Mar 2016

Fastpop: A Rapid Principal Component Derived Method To Infer Intercontinental Ancestry Using Genetic Data, Yafang Li, Jinyoung Byun, Guoshuai Cai, Xiangjun Xiao, Younghun Han, Olivier Cornelis, James E. Dinulos, Joe Dennis, Douglas Easton, Ivan Gorlov, Michael F. Seldin, Christopher I. Amos

Dartmouth Scholarship

Identifying subpopulations within a study and inferring intercontinental ancestry of the samples are important steps in genome wide association studies. Two software packages are widely used in analysis of substructure: Structure and Eigenstrat. Structure assigns each individual to a population by using a Bayesian method with multiple tuning parameters. It requires considerable computational time when dealing with thousands of samples and lacks the ability to create scores that could be used as covariates. Eigenstrat uses a principal component analysis method to model all sources of sampling variation. However, it does not readily provide information directly relevant to ancestral origin; the …

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Generalized Scaling And The Master Variable For Brownian Magnetic Nanoparticle Dynamics, Daniel B. Reeves, Yipeng Shi, John B. Weaver Mar 2016

Generalized Scaling And The Master Variable For Brownian Magnetic Nanoparticle Dynamics, Daniel B. Reeves, Yipeng Shi, John B. Weaver

Dartmouth Scholarship

Understanding the dynamics of magnetic particles can help to advance several biomedical nanotechnologies. Previously, scaling relationships have been used in magnetic spectroscopy of nanoparticle Brownian motion (MSB) to measure biologically relevant properties (e.g., temperature, viscosity, bound state) surrounding nanoparticles in vivo. Those scaling relationships can be generalized with the introduction of a master variable found from non-dimensionalizing the dynamical Langevin equation. The variable encapsulates the dynamical variables of the surroundings and additionally includes the particles’ size distribution and moment and the applied field’s amplitude and frequency. From an applied perspective, the master variable allows tuning to an optimal MSB …

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Three-Dimensional Interstitial Space Mediates Predator Foraging Success In Different Spatial Arrangements, Stephen Gregory Hesterberg Mar 2016

Three-Dimensional Interstitial Space Mediates Predator Foraging Success In Different Spatial Arrangements, Stephen Gregory Hesterberg

USF Tampa Graduate Theses and Dissertations

Habitat structure modifies the strength of predator-prey interactions, but it remains unclear how to describe the three-dimensional spatial arrangement of structural components in a way that consistently predicts outcomes. Interstitial space may provide a useful target for measurement, but most studies use only two-dimensional methods to describe 3D space, limiting their predictive power. Using a novel technology to produce identical components, this study tests whether the 3D interstitial space of oyster shell mimics modifies the ability of blue crabs (Callinectes sapidus) to capture their mud crab prey (Eurypanopeous depressus) in mesocosms and a variety of reef-associated …

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Spectator 2016-03-09, Editors Of The Spectator Mar 2016

Spectator 2016-03-09, Editors Of The Spectator

The Spectator

No abstract provided.

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Micu1 Regulation Of Mitochondrial Ca(2+) Uptake Dictates Survival And Tissue Regeneration., Anil Noronha Antony, Melanie Paillard, Cynthia Moffat, Egle Juskeviciute, Jason Correnti, Brad Bolon, Emanual Rubin, Md, György Csordás, Erin L Seifert, Jan B. Hoek, György Hajnóczky Mar 2016

Micu1 Regulation Of Mitochondrial Ca(2+) Uptake Dictates Survival And Tissue Regeneration., Anil Noronha Antony, Melanie Paillard, Cynthia Moffat, Egle Juskeviciute, Jason Correnti, Brad Bolon, Emanual Rubin, Md, György Csordás, Erin L Seifert, Jan B. Hoek, György Hajnóczky

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Mitochondrial Ca(2+) uptake through the recently discovered Mitochondrial Calcium Uniporter (MCU) is controlled by its gatekeeper Mitochondrial Calcium Uptake 1 (MICU1). However, the physiological and pathological role of MICU1 remains unclear. Here we show that MICU1 is vital for adaptation to postnatal life and for tissue repair after injury. MICU1 knockout is perinatally lethal in mice without causing gross anatomical defects. We used liver regeneration after partial hepatectomy as a physiological stress response model. Upon MICU1 loss, early priming is unaffected, but the pro-inflammatory phase does not resolve and liver regeneration fails, with impaired cell cycle entry and extensive necrosis. …

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Kennesaw State University Men's Ensemble Acda Conference, Sherri N. Barrett Mar 2016

Kennesaw State University Men's Ensemble Acda Conference, Sherri N. Barrett

Bailey School of Music Concert Programs

The KSU Men’s Ensemble is honored to perform at the 2016 American Choral Directors Southern Division Conference in Chattanooga, Tennessee.

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