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2016

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Voxel Based Morphometry In Optical Coherence Tomography: Validation & Core Findings, Bhavna J. Antony, Min Chen, Aaron Carass, Bruno M. Jedynak, Omar Al-Louzi, Sharon D. Solomon, Shiv Saidha, Peter Calabresi, Jerry L. Prince Jan 2016

Voxel Based Morphometry In Optical Coherence Tomography: Validation & Core Findings, Bhavna J. Antony, Min Chen, Aaron Carass, Bruno M. Jedynak, Omar Al-Louzi, Sharon D. Solomon, Shiv Saidha, Peter Calabresi, Jerry L. Prince

Mathematics and Statistics Faculty Publications and Presentations

Optical coherence tomography (OCT) of the human retina is now becoming established as an important modality for the detection and tracking of various ocular diseases. Voxel based morphometry (VBM) is a long standing neuroimaging analysis technique that allows for the exploration of the regional differences in the brain. There has been limited work done in developing registration based methods for OCT, which has hampered the advancement of VBM analyses in OCT based population studies. Following on from our recent development of an OCT registration method, we explore the potential benefits of VBM analysis in cohorts of healthy controls (HCs) and …

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Family Aided Community Treatment For The Treatment Of Early Psychosis: A Proof Of Concept Study, Ryan P. Melton, Cass Dykeman Jan 2016

Family Aided Community Treatment For The Treatment Of Early Psychosis: A Proof Of Concept Study, Ryan P. Melton, Cass Dykeman

Regional Research Institute for Human Services

Major psychotic disorders are one of the leading causes of disability worldwide. If these conditions are identified early and treatment promptly implemented, the prognosis is improved. This study examined the impact of a yearlong family aided community treatment (FACT) intervention upon psychiatric symptoms. Psychiatric symptom scores improved with the FACT intervention. Improved training on early recognition for mental health clinicians, implementation of a specific treatment model in community settings and policy around treatment funding allocation are implications of this study.

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The Determinants Of Productivity In Medical Testing: Intensity And Allocation Of Care, Jason Abaluck, Leila Agha, Chris Kabrhel, Ali Raja, Arjun Venkatesh Jan 2016

The Determinants Of Productivity In Medical Testing: Intensity And Allocation Of Care, Jason Abaluck, Leila Agha, Chris Kabrhel, Ali Raja, Arjun Venkatesh

Dartmouth Scholarship

A large body of research has investigated whether physicians overuse care. There is less evidence on whether, for a fixed level of spending, doctors allocate resources to patients with the highest expected returns. We assess both sources of inefficiency exploiting variation in rates of negative imaging tests for pulmonary embolism. We document enormous across-doctor heterogeneity in testing conditional on patient population, which explains the negative relationship between physicians’ testing rates and test yields. Furthermore, doctors do not target testing to the highest risk patients, reducing test yields by one third. Our calibration suggests misallocation is more costly than overuse.

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Notices, Editorial Office Jan 2016

Notices, Editorial Office

Contemporary Aesthetics (Journal Archive)

No abstract provided.

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Macabre Fascination And Moral Propriety: The Attraction Of Horror, Marius A. Pascale Jan 2016

Macabre Fascination And Moral Propriety: The Attraction Of Horror, Marius A. Pascale

Contemporary Aesthetics (Journal Archive)

Why does the horror genre serve as a source of pleasure, given its aim to induce fear in the audience? I examine two general solutions to this phenomenon, referred to as the paradox of horror, which differ based upon their position regarding the possibility of deriving pleasure from fear. Each of the possible solutions contains significant flaws. I argue that, by adjusting a meta-theory originally proposed by Susan Feagin, it is possible to craft a solution that addresses the paradox while preserving the idea that, at times, fear can be enjoyed. The article concludes by considering the moral status of …

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Recent Publications, Editorial Office Jan 2016

Recent Publications, Editorial Office

Contemporary Aesthetics (Journal Archive)

No abstract provided.

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Human Nature And Aesthetic Ecosystem Services: Nature In The Service Of Humankind And Humankind In The Service Of Nature, Yrjö Sepänmaa Jan 2016

Human Nature And Aesthetic Ecosystem Services: Nature In The Service Of Humankind And Humankind In The Service Of Nature, Yrjö Sepänmaa

Contemporary Aesthetics (Journal Archive)

The term “ecosystem services” refers to the material and spiritual benefits and goods that we receive from nature, or, in a broad sense, from all kinds of environment. The various forms of such benefits have begun to be called services. Nature serves people by producing the material and spiritual (intangible, non-material) prerequisites for life. This is also the foundation of our aesthetic well-being. Does humankind reciprocally serve nature, or only itself through nature, with the intention of exploiting it? We see when nature suffers or flourishes, and we also observe our own effect on its state. As much as our …

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Humor And Enlightenment, Part I: The Theory, Peter H. Karlen Jan 2016

Humor And Enlightenment, Part I: The Theory, Peter H. Karlen

Contemporary Aesthetics (Journal Archive)

Part I of this article advances a new theory of humor, the Enlightenment Theory, while contrasting it with other main theories, including the Incongruity, Repression/Relief/Release, and Superiority Theories. The Enlightenment Theory does not contradict these other theories but rather subsumes them. As argued, each of the other theories cannot account for all the aspects of humor explained by the Enlightenment Theory. The discussion is illustrated with examples of humor and explores the acts and circumstances of humor, its literary and artistic expressions, and its physical reactions. Part II shows how the Enlightenment Theory meets challenging issues in humor theory where …

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Humor And Enlightenment, Part Ii: The Theory Applied, Peter H. Karlen Jan 2016

Humor And Enlightenment, Part Ii: The Theory Applied, Peter H. Karlen

Contemporary Aesthetics (Journal Archive)

Part I of this article advanced a new theory of humor, the Enlightenment Theory, while contrasting it with other main theories, including the Incongruity, Repression/Relief/Release, and Superiority Theories. The Enlightenment Theory does not contradict these other theories but rather subsumes them. As argued, each of the other theories cannot account for all the aspects of humor explained by the Enlightenment Theory. Part II shows how the Enlightenment Theory meets challenging issues in humor theory where other theories falter, including failed humor, motivation for humor, tickling, laughing gas, and sadistic humor. Also mentioned are the Enlightenment Theory's application to literary and …

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Symposium On The Cultural Promise Of The Aesthetic By Monique Roelofs: Introduction, Editorial Office Jan 2016

Symposium On The Cultural Promise Of The Aesthetic By Monique Roelofs: Introduction, Editorial Office

Contemporary Aesthetics (Journal Archive)

No abstract provided.

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The Difference That Art Makes, Mariana Ortega Jan 2016

The Difference That Art Makes, Mariana Ortega

Contemporary Aesthetics (Journal Archive)

In the following essay I discuss Monique Roelofs’s The Cultural Promise of the Aesthetic. I show that Roelofs’s rich and complex notion of the aesthetic, informed by promises, modes of address, and aesthetic relationality, offers an important and novel way of understanding the aesthetic within a context attuned to questions of difference. I point out that Roelofs’s analysis may be enhanced by notions theorized by Audre Lorde, Gloria Anzaldúa, and María Lugones. Moreover, I raise a question regarding the intricate link between Roelofs’s notion of the aesthetic and morality

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The Aesthetic And Its Resonances: A Reply To Kathleen M. Higgins, Carolyn Korsmeyer, And Mariana Ortega, Monique Roelofs Jan 2016

The Aesthetic And Its Resonances: A Reply To Kathleen M. Higgins, Carolyn Korsmeyer, And Mariana Ortega, Monique Roelofs

Contemporary Aesthetics (Journal Archive)

This essay offers replies to the critical commentaries on The Cultural Promise of the Aesthetic presented by Kathleen M. Higgins, Carolyn Korsmeyer, and Mariana Ortega. The essay shows how the probing questions and criticisms that the three commentators raise bring out details in the framework of relationality, address, and promises through which the book theorizes the aesthetic.

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Naegleria Fowleri Meningoencephalitis Associated With Public Water Supply, Pakistan, 2014, Najia Ghanchi, Erum Khan, Azam Khan, Wali Muhammad, Faisal Riaz Malik, Afia Zafar Jan 2016

Naegleria Fowleri Meningoencephalitis Associated With Public Water Supply, Pakistan, 2014, Najia Ghanchi, Erum Khan, Azam Khan, Wali Muhammad, Faisal Riaz Malik, Afia Zafar

Department of Pathology and Laboratory Medicine

No abstract provided.

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Agreement Of Direct Antifungal Susceptibility Testing From Positive Blood Culture Bottles With The Conventional Method For Candida Species, Kauser Jabeen, Haresh Kumar, Joveria Farooqi, Raunaq Mehboob, Mary E. Brandt, Afia Zafar Jan 2016

Agreement Of Direct Antifungal Susceptibility Testing From Positive Blood Culture Bottles With The Conventional Method For Candida Species, Kauser Jabeen, Haresh Kumar, Joveria Farooqi, Raunaq Mehboob, Mary E. Brandt, Afia Zafar

Department of Pathology and Laboratory Medicine

Early availability of antifungal susceptibilities can ensure timely institution of targeted therapy in candidemia, which can improve patient outcomes. This study prospectively determines the agreement between the results of direct testing of antifungal susceptibilities from blood culture bottles by disk diffusion and Etest and the results of standardized susceptibility testing methods; direct testing would allow susceptibility results to be available 1 to 2 days earlier. A total of 104 blood cultures with different Candida species (28% C. albicans, 27% C. parapsilosis, 26% C. tropicalis, etc.) were evaluated between January 2012 and May 2013 for agreement of fluconazole, voriconazole, and amphotericin …

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Identification Of A Novel Gene On 10q221 Causing Autosomal Dominant Retinitis Pigmentosa (Adrp), Stephen P Daiger, Lori S Sullivan, Sara J Bowne, Daniel C Koboldt, Susan H Blanton, Dianna K Wheaton, Cheryl E Avery, Elizabeth D Cadena, Robert K Koenekoop, Robert S Fulton, Richard K Wilson, George M Weinstock, Richard A Lewis, David G Birch Jan 2016

Identification Of A Novel Gene On 10q221 Causing Autosomal Dominant Retinitis Pigmentosa (Adrp), Stephen P Daiger, Lori S Sullivan, Sara J Bowne, Daniel C Koboldt, Susan H Blanton, Dianna K Wheaton, Cheryl E Avery, Elizabeth D Cadena, Robert K Koenekoop, Robert S Fulton, Richard K Wilson, George M Weinstock, Richard A Lewis, David G Birch

Faculty, Staff and Students Publications

Whole-genome linkage mapping identified a region on chromosome 10q21.3-q22.1 with a maximum LOD score of 3.0 at 0 % recombination in a six-generation family with autosomal dominant retinitis pigmentosa (adRP). All known adRP genes and X-linked RP genes were excluded in the family by a combination of methods. Whole-exome next-generation sequencing revealed a missense mutation in hexokinase 1, HK1 c.2539G > A, p.Glu847Lys, tracking with disease in all affected family members. One severely-affected male is homozygous for this region by linkage analysis and has two copies of the mutation. No other potential mutations were detected in the linkage region nor were …

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Activation Of Signal Transduction Pathways During Hepatic Oncogenesis, W Chung, M Kim, S De La Monte, L Longato, R Carlson, B L. Slagle, X Dong, J R. Wands Jan 2016

Activation Of Signal Transduction Pathways During Hepatic Oncogenesis, W Chung, M Kim, S De La Monte, L Longato, R Carlson, B L. Slagle, X Dong, J R. Wands

Faculty, Staff and Students Publications

BACKGROUND AND AIMS: Understanding the molecular pathogenesis of hepatocellular carcinoma (HCC) is essential to identify therapeutic targets. A hepatitis B virus (HBV) related double transgenic murine model was developed. METHODS: Liver specific expression of HBV X protein (HBx) and insulin receptor substrate 1 (IRS1) was achieved and transgenic mice were followed from birth to age 21 months. Liver and tumor tissue were assessed for histologic changes as well as activation of signal transduction pathways by qRT-PCR and multiplex ELISA protein assays. RESULTS: Overexpression of HBx and IRS1 stimulates liver cell proliferation in the double transgenic mice. Only the male mice …

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Local Corticotropin Releasing Hormone (Crh) Signals To Its Receptor Crhr1 During Postnatal Development Of The Mouse Olfactory Bulb, Isabella Garcia, Paramjit K Bhullar, Burak Tepe, Joshua Ortiz-Guzman, Longwen Huang, Alexander M Herman, Lesley Chaboub, Benjamin Deneen, Nicholas J Justice, Benjamin R Arenkiel Jan 2016

Local Corticotropin Releasing Hormone (Crh) Signals To Its Receptor Crhr1 During Postnatal Development Of The Mouse Olfactory Bulb, Isabella Garcia, Paramjit K Bhullar, Burak Tepe, Joshua Ortiz-Guzman, Longwen Huang, Alexander M Herman, Lesley Chaboub, Benjamin Deneen, Nicholas J Justice, Benjamin R Arenkiel

Faculty, Staff and Students Publications

Neuropeptides play important physiological functions during distinct behaviors such as arousal, learning, memory, and reproduction. However, the role of local, extrahypothalamic neuropeptide signaling in shaping synapse formation and neuronal plasticity in the brain is not well understood. Here, we characterize the spatiotemporal expression profile of the neuropeptide corticotropin-releasing hormone (CRH) and its receptor CRHR1 in the mouse OB throughout development. We found that CRH-expressing interneurons are present in the external plexiform layer, that its cognate receptor is expressed by granule cells, and show that both CRH and CRHR1 expression enriches in the postnatal period when olfaction becomes important towards olfactory-related …

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Marijuana Compounds: A Nonconventional Approach To Parkinson’S Disease Therapy, Mariana Babayeva, Haregewein Assefa, Paramita Basu, Sanjeda Chumki, Zvi G. Loewy Jan 2016

Marijuana Compounds: A Nonconventional Approach To Parkinson’S Disease Therapy, Mariana Babayeva, Haregewein Assefa, Paramita Basu, Sanjeda Chumki, Zvi G. Loewy

Touro College of Pharmacy (New York) Publications and Research

Parkinson’s disease (PD), a neurodegenerative disorder, is the second most common neurological illness in United States. Neurologically, it is characterized by the selective degeneration of a unique population of cells, the nigrostriatal dopamine neurons. The current treatment is symptomatic and mainly involves replacement of dopamine deficiency.This therapy improves only motor symptoms of Parkinson’s disease and is associated with a number of adverse effects including dyskinesia. Therefore, there is unmet need for more comprehensive approach in the management of PD. Cannabis and related compounds have created significant research interest as a promising therapy in neurodegenerative and movement disorders. In this review …

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Editorial: Biology Of Cognitive Aging: Model Systems, Technologies, And Beyond, Shin Murakami Jan 2016

Editorial: Biology Of Cognitive Aging: Model Systems, Technologies, And Beyond, Shin Murakami

Faculty Publications & Research of the TUC College of Osteopathic Medicine

The author provides an introduction to a research issue of Frontiers in Genetics on models and techniques related to age-related memory impairment.

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The Anti-Inflammatory Caspase-12 Gene Does Not Influence Sle Phenotype In African-Americans, Trista Fuchs, Jennifer A. Kelly, Emily Simon, Kathy L. Sivils, Evan Hermel Jan 2016

The Anti-Inflammatory Caspase-12 Gene Does Not Influence Sle Phenotype In African-Americans, Trista Fuchs, Jennifer A. Kelly, Emily Simon, Kathy L. Sivils, Evan Hermel

Faculty Publications & Research of the TUC College of Osteopathic Medicine

No abstract provided.

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A Brief Review Of Speaker Recognition Technology, Clark D. Shaver, John M. Acken Jan 2016

A Brief Review Of Speaker Recognition Technology, Clark D. Shaver, John M. Acken

Electrical and Computer Engineering Faculty Publications and Presentations

This paper reviews the development of speaker recognition systems from pre-computing days to current trends. Advances in various sciences which have allowed autonomous speaker recognition systems to become a practical means of identity authentication are also reviewed.

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Service-Learning And The Hungry And Homeless: Tangible Sensibilities Of Care Among Young Urban Adolescents, Dilafruz R. Williams Jan 2016

Service-Learning And The Hungry And Homeless: Tangible Sensibilities Of Care Among Young Urban Adolescents, Dilafruz R. Williams

Educational Leadership and Policy Faculty Publications and Presentations

For over 20 years, Sunnyside Environmental School in Portland, Oregon has adopted service-learning as an instructional approach to engage young people with local communities. This report explores the voices of sixth through eighth graders illustrated by their Reflection Journals as they interacted with hungry and homeless individuals in the community. The human-scale connections resulted in tangible sensibilities of care evident in students’ reflections: dispelling stereotypes as students became open-minded, making a noticeable difference however small, developing compassion through new understandings, and taking action to correct social injustices in the communities where they live.

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Brine Impacted Soils In Semi-Arid Rangelands: Greenhouse Electrical Conductivity Thresholds And Ex Situ/In Situ Remediation Comparisons, Hannah Angie Kelsey Tomlinson Jan 2016

Brine Impacted Soils In Semi-Arid Rangelands: Greenhouse Electrical Conductivity Thresholds And Ex Situ/In Situ Remediation Comparisons, Hannah Angie Kelsey Tomlinson

Range Science

Brine is a by-product of oil and gas extraction that can have profound impacts on soil chemistry and vegetation assemblages when discharged onto the soil surface. Brine spill remediation aims to remove or minimize the saturated paste electrical conductivity (ECe) to levels suitable for plant growth. My research focused on evaluating ECe and plant parameters on topsoil excavation and chemical amendment sites, and examining brine thresholds of several native grasses. Halophytic grasses had a higher brine threshold between 18.6 and 34.6 dS m-1 whereas glycophytic grasses exhibited a lower threshold (9.70 and 18.6 dS m-1). Halophytes examined in this study …

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The Influence Of Soil Properties On Marsh Edge Erosion, Cody Lee Johnson Jan 2016

The Influence Of Soil Properties On Marsh Edge Erosion, Cody Lee Johnson

LSU Master's Theses

Coastal Louisiana exhibits some of the highest rates of land conversion to open water in the world. This is most apparent in Terrebonne Bay, Barataria Bay, and Breton Sound (Couvillion et. al, 2011). The hypothesis is made that locally generated wind waves are responsible for the observed land loss. Recent research has attempted to relate the marsh edge erosion rate to wave energy flux density. Under the appropriate assumptions, this relationship is modeled reasonably well by a linear relationship between erosion rate and wave energy flux. Such a model is a valuable tool for coastal resource management. A deficiency of …

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Contemporary Perspectives On Wrongful Conviction: An Introduction To The 2016 Innocence Network Conference, San Antonio, Texas, Gwen Jordan, Aliza B. Kaplan, Valena Beety, Keith A. Findley Jan 2016

Contemporary Perspectives On Wrongful Conviction: An Introduction To The 2016 Innocence Network Conference, San Antonio, Texas, Gwen Jordan, Aliza B. Kaplan, Valena Beety, Keith A. Findley

Articles by Maurer Faculty

Innocent people have been convicted of crimes they did not commit throughout history. The exact number of wrongful convictions is unknowable. In 2014, however, the National Academy of Sciences (“NAS”) released a study of the cases of criminal defendants who were convicted and sentenced to death and concluded that 4.1% were wrongfully convicted. The researchers explained that “this is a conservative estimate of the proportion of false conviction among death sentences in the United States.” According to the U.S. Department of Justice, Bureau of Justice Statistics, 1,561,500 adults were incarcerated in federal prisons, state prisons, and county jails in 2014, …

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Effect Of Two-Year Caloric Restriction On Bone Metabolism And Bone Mineral Density In Non-Obese Younger Adults: A Randomized Clinical Trial, Dt Villareal, L Fontana, Sk Das, Et Al. Jan 2016

Effect Of Two-Year Caloric Restriction On Bone Metabolism And Bone Mineral Density In Non-Obese Younger Adults: A Randomized Clinical Trial, Dt Villareal, L Fontana, Sk Das, Et Al.

Faculty, Staff and Students Publications

Although caloric restriction (CR) could delay biologic aging in humans, it is unclear if this would occur at the cost of significant bone loss. We evaluated the effect of prolonged CR on bone metabolism and bone mineral density (BMD) in healthy younger adults. Two-hundred eighteen non-obese (body mass index [BMI] 25.1?±?1.7?kg/m(2) ), younger (age 37.9?±?7.2 years) adults were randomly assigned to 25% CR (CR group, n?=?143) or ad libitum (AL group, n?=?75) for 2 years. Main outcomes were BMD and markers of bone turnover. Other outcomes included body composition, bone-active hormones, nutrient intake, and physical activity. Body weight (-7.5?±?0.4 versus …

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Geospatial Analysis Of Food Environment Demonstrates Associations With Gestational Diabetes, Mk Kahr, Ma Suter, J Ballas, Sm Monga, W Lee, M Hu, Cd Shope, A Chesnokova, L Krannich, En Griffin, J Mastrobattista, Ga Dildy, Sl Strehlow, R Ramphul, Et Al. Jan 2016

Geospatial Analysis Of Food Environment Demonstrates Associations With Gestational Diabetes, Mk Kahr, Ma Suter, J Ballas, Sm Monga, W Lee, M Hu, Cd Shope, A Chesnokova, L Krannich, En Griffin, J Mastrobattista, Ga Dildy, Sl Strehlow, R Ramphul, Et Al.

Faculty, Staff and Students Publications

BACKGROUND: Gestational diabetes mellitus (GDM) is one of most common complications of pregnancy, with incidence rates varying by maternal age, race/ethnicity, obesity, parity, and family history. Given its increasing prevalence in recent decades, covariant environmental and sociodemographic factors may be additional determinants of GDM occurrence. OBJECTIVE: We hypothesized that environmental risk factors, in particular measures of the food environment, may be a diabetes contributor. We employed geospatial modeling in a populous US county to characterize the association of the relative availability of fast food restaurants and supermarkets to GDM. STUDY DESIGN: Utilizing a perinatal database with >4900 encoded antenatal and …

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Lawyers, Power, And Strategic Expertise, Colleen F. Shanahan, Anna Carpenter, Alyx Mark Jan 2016

Lawyers, Power, And Strategic Expertise, Colleen F. Shanahan, Anna Carpenter, Alyx Mark

Articles, Chapters in Books and Other Contributions to Scholarly Works

This empirical study analyzes what the parties and lawyers described above experience – a party’s power, representation, and the strategic expertise they bring to a dispute. These factors clarify how representation may solve the access to justice crisis for low-income Americans. We find that a representative helps most parties most of the time, but the representation on the other side of the dispute and the representative’s strategic expertise are also significant factors for understanding representation for civil litigants. This study analyzes a database of 1,700 unemployment insurance appeals in the District of Columbia over a two-year period, the broadest and …

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Obesity Management: Clinical Review And Update Of The Pharmacologic Treatment Options, Raymond A. Plodkowski, Megan E. Mcgarvey, Keith Reisinger-Kindle, Bradley Kramer, Erik Nelson, Jennifer Lee, Quang T. Nguyen Jan 2016

Obesity Management: Clinical Review And Update Of The Pharmacologic Treatment Options, Raymond A. Plodkowski, Megan E. Mcgarvey, Keith Reisinger-Kindle, Bradley Kramer, Erik Nelson, Jennifer Lee, Quang T. Nguyen

College of Osteopathic Medicine (TUN) Publications and Research

The toolbox of medications available for medical weight management is more robust than ever and includes a wide variety of mechanisms of actions and options for patients.

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Can A Little Representation Be A Dangerous Thing?, Colleen F. Shanahan, Anna E. Carpenter, Alyx Mark Jan 2016

Can A Little Representation Be A Dangerous Thing?, Colleen F. Shanahan, Anna E. Carpenter, Alyx Mark

Articles, Chapters in Books and Other Contributions to Scholarly Works

Access to justice interventions that provide a little representation, including nonlawyer representation and various forms of limited legal services, may be valuable solutions for low- and middle-income Americans. However, a thoughtful approach to improving access to justice efforts should recognize that a little representation may have risks. In particular, one potential risk of a little representation is that while it provides assistance with a discrete legal need in a specific moment, the nature of the assistance is incompatible with challenging the law. As a result, individual litigants do not have the benefit of legal challenges in their own cases, and …

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