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Articles 87271 - 87300 of 2913547
Full-Text Articles in Entire DC Network
Ole Miss Yearbooks From 1960-1980 Reveal How Traditional Southern Gender Roles, Sexual Double Standards, And The Policing Of Women's Behaviors And Bodies Persisted Through The Broader Cultural Shifts Of The Sexual Revolution, Haley Arnold
Venture: The University of Mississippi Undergraduate Research Journal
This study examines the portrayal of men’s and women’s sexuality in Ole Miss yearbooks from 1960 to 1980, analyzing how these depictions reflect the persistence of traditional Southern gender roles and sexual double standards despite the broader cultural shifts of the Sexual Revolution. Drawing from primary sources, including university yearbooks and sorority recruitment materials, as well as scholarly works on gender, sexuality, and Southern culture, this research highlights the ways in which women were consistently scrutinized and held to restrictive moral standards while men were granted greater sexual freedom. The study situates these portrayals within the historical context of shifting …
Identifying And Addressing Maternal Health Needs: Using Occupational Therapy To Empower, Educate, And Support Mothers, Anne K. Lyles
Identifying And Addressing Maternal Health Needs: Using Occupational Therapy To Empower, Educate, And Support Mothers, Anne K. Lyles
Department of Occupational Therapy Entry-Level Capstone Projects
There is a critical need for extended maternal support, particularly when viewed through the lens of occupational therapy. This capstone project aimed to address this gap by conducting a needs assessment using the Maternal Occupational Therapy Health & Environment Risk Screening (MOTHERS) to gain a deeper understanding of the challenges mothers face during the prenatal and postpartum periods. Findings from the needs assessment informed the development of practical, evidence-based resources—including digital products, social media content, educational flyers, and a virtual course—designed to support postpartum mothers in a format that is both accessible and empowering.
Microbiome–Immune Interaction And Harnessing For Next-Generation Vaccines Against Highly Pathogenic Avian Influenza In Poultry, Yongming Sang, Samuel N. Nahashon, Richard J. Webby
Microbiome–Immune Interaction And Harnessing For Next-Generation Vaccines Against Highly Pathogenic Avian Influenza In Poultry, Yongming Sang, Samuel N. Nahashon, Richard J. Webby
Food and Animal Sciences Faculty Research
Highly pathogenic avian influenza (HPAI) remains a persistent threat to global poultry production and public health. Current vaccine platforms show limited cross-clade efficacy and often fail to induce mucosal immunity. Recent advances in microbiome research reveal critical roles for gut commensals in modulating vaccine-induced immunity, including enhancement of mucosal IgA production, CD8+ T-cell activation, and modulation of systemic immune responses. Engineered commensal bacteria such as Lactococcus lactis, Bacteroides ovatus, Bacillus subtilis, and Staphylococcus epidermidis have emerged as promising live vectors for antigen delivery. Postbiotic and synbiotic strategies further enhance protective efficacy through targeted modulation of the gut microbiota. Additionally, artificial …
Enhancing Oral Absorption Of An Ester Prodrug By Coating Drug Crystals With Binary Lipid Systems And Evaluating The Influence Of Compositions, Xiaowei Dong, Tao Zhang, Hellen L. Moreno Sanchez, Jaylen C. Mans, Sung Hun Bae, Liangqiao Bian
Enhancing Oral Absorption Of An Ester Prodrug By Coating Drug Crystals With Binary Lipid Systems And Evaluating The Influence Of Compositions, Xiaowei Dong, Tao Zhang, Hellen L. Moreno Sanchez, Jaylen C. Mans, Sung Hun Bae, Liangqiao Bian
Pharmacy Faculty Scholarship
Background/Objectives: Prodrug strategies are a vital aspect of drug development, with ester prodrugs particularly notable for modifying parent drug properties through ester functional groups to enhance oral absorption. However, ester prodrugs are prone to hydrolysis by water and enzymes, making stability in the gastrointestinal (GI) tract prior to absorption a key challenge. Few formulation strategies effectively address this degradation issue. We recently introduced binary lipid systems (BLS), comprising a lipid and a water-soluble surfactant only that form stable microemulsions. This study aimed to explore the application of BLS for enhancing the oral absorption of ester prodrugs by coating drug crystals …
Native-Borns And Migrants Do Not Contribute Equally To Domestic Co2 Emissions, Carlo Andrea Bollino, Marzio Galeotti
Native-Borns And Migrants Do Not Contribute Equally To Domestic Co2 Emissions, Carlo Andrea Bollino, Marzio Galeotti
Fondazione Eni Enrico Mattei Working Papers
While population growth is a known driver of CO2 emissions, prevailing models often treat “population” as a homogeneous factor. This study addresses a critical gap, providing the first comprehensive empirical analysis to disaggregate the contributions of native-born and migrant populations to domestic CO2 emissions. Using an extended STIRPAT model for 172 countries (1990-2022), separated by OECD and non-OECD blocs, we uncover two novel insights.First, native-born populations consistently exhibit a substantially higher emissions elasticity than migrants in both country groups. Second, a dynamic shift occurred in OECD countries: migrants’ initially higher per capita emissions impact steadily declined over time, becoming lower …
Z-Degree Mississippi, University Of Mississippi
Z-Degree Mississippi, University Of Mississippi
University Website Migration from WordPress
The Mississippi Z-Degree project is three-year plan to expand adoption of Open Educational Resources (OER) in Mississippi public higher education. OER are course materials, including textbooks, which are free and shareable.
Summit Report: The Russia-Ukraine War: Lessons For Future Conflicts, Heather Ashby, Tad Schnaufer, Heather Ward, Golfo Alexopoulos, Christopher Marsh
Summit Report: The Russia-Ukraine War: Lessons For Future Conflicts, Heather Ashby, Tad Schnaufer, Heather Ward, Golfo Alexopoulos, Christopher Marsh
GNSI Summit Reports
On March 4-5, 2025, the Global and National Security Institute (GNSI), hosted its fifth Tampa Summit, and the 11th installment in the Great Power Competition Conference Series: The Russia-Ukraine War: Lessons for Future Conflicts. GNSI brought together leading academics, defense experts, and international scholars for thought-provoking discussions on the strategic lessons learned from the Russia-Ukraine War, the evolving role of technology in conflict, and the impact of the war on Europe, NATO, and the rules-based international system. The war in Ukraine is not just a regional crisis; it is a harbinger of the future of warfare. In contrast to …
Maternal Mortality In Zambia: Associations With Health Services Utilization, Birth Spacing, And Province, Selina Mubwanga
Maternal Mortality In Zambia: Associations With Health Services Utilization, Birth Spacing, And Province, Selina Mubwanga
Walden Dissertations and Doctoral Studies
Maternal mortality remains one of the leading public health issues in Zambia characterized by elevated maternal mortality rates among women of reproductive age. This research study investigated the effect of birth spacing, province type and location, and maternal health services utilization on maternal deaths among women in the Lusaka, Eastern, Central, and North-Western provinces of Zambia. The theoretical underpinning of this investigation drew upon the social-ecological systems framework. Using secondary data from the 2018 Zambia Demographic and Health Survey (ZDHS) of 1,868 women aged 15–49 years, the study adopted a quantitative, descriptive, cross-sectional research design. Binary logistic regression analysis revealed …
Prisoner Re-Entry Into Society And Criminal Justice Social Work Practice, Aleeyah S. Norvell
Prisoner Re-Entry Into Society And Criminal Justice Social Work Practice, Aleeyah S. Norvell
Walden Dissertations and Doctoral Studies
This study explores the challenges faced by social workers in supporting the successful reintegration of formerly incarcerated individuals. Social workers play a critical role in the U.S. criminal justice system, yet they often encounter systemic barriers that limit their ability to meet clients’ basic needs, such as housing, employment, and healthcare. Using a generic qualitative research design, the study was conducted using semi-structured interviews with a sample of eight licensed social workers, using open-ended questions to gather rich, detailed accounts of their experiences. Guided by social learning theory and using thematic analysis, the findings reveal significant obstacles in adapting to …
Deliberate Lives: A Reassessment Of Post-Wwii American Women’S Agency, Caroline Elizabeth Stewart
Deliberate Lives: A Reassessment Of Post-Wwii American Women’S Agency, Caroline Elizabeth Stewart
Masters Theses
World War II had an important impact on American women’s social and economic roles, helping them gain opportunities and skills which impacted them long after the war. While scholars have debated the exact extent and longevity of the changes, an examination of these women’s lives and the many roles they filled shows their quiet agency in making these post-war decisions. Social pressures and expectations certainly impacted their experiences, but examining their lives shows that many women also showed agency in multiple ways. More recent post-war narratives have acknowledged agency in more rebellious women but have increasingly focused on social expectations …
Don't Say You Love Me, Breanna Dunwell
Don't Say You Love Me, Breanna Dunwell
Masters Theses
Teen dating violence is a silent epidemic that is not talked about enough or taken seriously. This shows that age does not matter when it comes to any type of abuse or harassment – physical, emotional, sexual, stalking, etc. The household that the victim lives in, race, parents marital status, and financial situation do not play a role into who is a victim versus someone who is not. The perpetrator does not care about those kinds of details. They only care about needing to be in control of the other person. Even though this is a snippet, the story shows …
Activation Or Deactivation? Rethinking Ferrate(Vi) Reactivity Within A Broader Modulation Framework, Zepei Tang, Yang Deng
Activation Or Deactivation? Rethinking Ferrate(Vi) Reactivity Within A Broader Modulation Framework, Zepei Tang, Yang Deng
Department of Earth and Environmental Studies Faculty Scholarship and Creative Works
No abstract provided.
Dataset For Ectoparasite And Trichomonosis Management Improve Nestling Golden Eagle (Aquila Chrysaetos) Health And Survival: An Effective Mitigation Strategy, Julie A. Heath, Caitlin M. Davis, Benjamin M. Dudek, Christopher J.W. Mcclure, Kevin T. Myers, Emma K. Regnier, Brian W. Rolek, Ashley L. Santiago
Dataset For Ectoparasite And Trichomonosis Management Improve Nestling Golden Eagle (Aquila Chrysaetos) Health And Survival: An Effective Mitigation Strategy, Julie A. Heath, Caitlin M. Davis, Benjamin M. Dudek, Christopher J.W. Mcclure, Kevin T. Myers, Emma K. Regnier, Brian W. Rolek, Ashley L. Santiago
Biological Sciences Data
1. Management of emerging pathogen and parasite threats could provide cost-effective compensatory mitigation options for protected species, such as golden eagles (Aquila chrysaetos). Golden eagle nestlings are vulnerable to infestations of poultry bugs (Haematosiphon inodorus), a blood-sucking ectoparasite that lives in nest material, and trichomonosis, a highly lethal disease caused by the protozoan Trichomonas spp. We aimed to develop effective treatment protocols for poultry bugs and trichomonosis and project whether nestling parasite and disease management would have population-level effects in this long-lived apex predator.
2. We collected pre-treatment data on poultry bug loads in eagle nests, then we applied 1 …
Gnsi Decision Brief: Building Trust In Digital Response: The Role Of Chatbots In Cybercrime Prevention Open-Source Tools For Safer Digital Reporting And Public Trust, George Burruss, Loni Hagen, Ly Dinh, Lingyao Li
Gnsi Decision Brief: Building Trust In Digital Response: The Role Of Chatbots In Cybercrime Prevention Open-Source Tools For Safer Digital Reporting And Public Trust, George Burruss, Loni Hagen, Ly Dinh, Lingyao Li
GNSI Decision Briefs
Cybercrime poses a growing global threat, inflicting financial harm on individuals, businesses, and governments. In 2024 alone, the FBI's Internet Crime Complain Center (IC3) received over 800,000 complains, with reported losses exceeding $16.6 billion, a 33 percent increase from the prior year. The damage extends beyond financial loss: cybercrime undermines trust in digital systems and can cause psychological harm. Its anonymous and complex nature makes detection and prosecurtion difficult, creating low-risk, high-reward conditions for offenders.
Analysis Of Lifespan Across Diversity Outbred Mouse Studies Identifies Multiple Longevity-Associated Loci., Martin N Mullis, Kevin M Wright, Anil Raj, Daniel M Gatti, Peter C. Reifsnyder, Kevin Flurkey, Jonathan R Archer, Laura Robinson, Andrea Di Francesco, Karen L. Svenson, Ron Korstanje, David E Harrison, J Graham Ruby, Gary Churchill
Analysis Of Lifespan Across Diversity Outbred Mouse Studies Identifies Multiple Longevity-Associated Loci., Martin N Mullis, Kevin M Wright, Anil Raj, Daniel M Gatti, Peter C. Reifsnyder, Kevin Flurkey, Jonathan R Archer, Laura Robinson, Andrea Di Francesco, Karen L. Svenson, Ron Korstanje, David E Harrison, J Graham Ruby, Gary Churchill
Faculty Research 2025
Lifespan is an integrative phenotype whose genetic architecture is likely to highlight multiple processes with high impact on health and aging. Here, we conducted a genetic mega-analysis of longevity in Diversity Outbred (DO) mice that included 2,444 animals from 3 independently conducted lifespan studies. We identified 8 loci that contributed significantly to lifespan independently of diet and drug treatment in at least one study. One of these loci also influenced lifespan in a sex-dependent manner, and we detected an additional locus with a diet-specific effect on lifespan. Collectively, these loci explained over half of the estimated heritable variation in lifespan …
October 7 And International Police Cooperation: The Silence Of Interpol, Mathieu Deflem
October 7 And International Police Cooperation: The Silence Of Interpol, Mathieu Deflem
Faculty Publications
Aim: The aim of this study is to explore the background and interpretation of Interpol’s silence following the terrorist attacks committed by Hamas against Israel on October 7, 2023. The author examines the international policing im-plications of the events, with special attention to why the world’s largest police organization failed to issue any substantive response.
Methodology: The research is based on asociological analysis combining ahistorical and institutional overview of Interpol’s counterterrorism activities with the examination of the organization’s communications and institutional decisions. It relies on qualitative sources and an interpretive, case study-based approach using public documents, records, and statements.
Findings: …
Understanding, Deterring, And Preparing For A Great-Power War In The Twenty-First Century, Antulio J. Echevarria Ii, Larry P. Goodson, Brennan Deveraux
Understanding, Deterring, And Preparing For A Great-Power War In The Twenty-First Century, Antulio J. Echevarria Ii, Larry P. Goodson, Brennan Deveraux
Integrated Research Projects
The US government and the US Army are unprepared for a great-power war. This integrated research project (IRP), sponsored by Vice Chief of Staff of the Army General James J. Mingus, is a critical first step in helping senior US Army leaders increase their knowledge of, and preparations for, deterring or fighting a great-power war in the twenty-first century. No one knows how long the US government and the US Army have to prepare for a future conflict. Consequently, the US Department of Defense faces difficult decisions as it balances preparing for a future war with maintaining readiness to address …
Motivational Factors Affecting Female Students' Choice Of Stem And Non-Stem Majors At Us Universities, Buthaina Ruyyashi
Motivational Factors Affecting Female Students' Choice Of Stem And Non-Stem Majors At Us Universities, Buthaina Ruyyashi
Walden Dissertations and Doctoral Studies
The problem addressed in this study is the persistently low enrollment of female undergraduate students in science, technology, engineering, and mathematics (STEM) majors within U.S. universities. The purpose of this quantitative study was to examine the relationship between female undergraduate students' choice of STEM versus non-STEM majors and their motivational factors, as measured by the Motivations Influencing Course Choice (MICC) survey. The study was grounded in social cognitive career theory, which emphasizes the role of self-efficacy, outcome expectations, and personal goals in academic decision-making. The analysis assessed the predictive power of career aspiration, interest, helping, and loafing in determining major …
A Toolkit For Treating Obesity In Children With Metabolic Syndrome, Karen Mayers-Scott
A Toolkit For Treating Obesity In Children With Metabolic Syndrome, Karen Mayers-Scott
Walden Dissertations and Doctoral Studies
This doctoral project seeks to bridge the existing knowledge gap in using Metformin to manage childhood obesity in patients with metabolic syndrome. The primary goal was to develop a complete toolkit to educate healthcare providers on utilizing Metformin in obese children with metabolic syndrome. Metabolic syndrome, characterized by higher triglycerides, decreased high-density lipoprotein cholesterol, increased blood pressure, elevated fasting plasma glucose, and increased waist circumference, offers considerable health hazards for children. The practice-focused question is, Is the toolkit deemed useful to providers for treating obesity in children with metabolic syndrome using metformin?” The project employed the theory of planned behavior, …
From Assessment To Action: The Role Of Data In Shaping Tiered Literacy Instruction, Trisha J. Uebele
From Assessment To Action: The Role Of Data In Shaping Tiered Literacy Instruction, Trisha J. Uebele
Masters Projects
Abstract
This project supports educators in identifying students’ literacy needs and implementing targeted, evidence-based interventions through a user-friendly, data-driven approach grounded in the Response to Intervention (RTI) framework and the Science of Reading. By enabling educators to input and analyze commonly available assessment data, the project aims to make data-informed instruction accessible even to those with limited training in data literacy. A digital tracking tool will monitor individual student progress across key reading domains (phonemic awareness, phonics, fluency, and comprehension), allowing for the creation of flexible, skill-based instructional groups. The project includes an intervention guide with links to research-based activities …
Pressure Free Care: Empowering Staff With The Hapi Prevention Reference Sheet, A Quality Improvement Project, Harmony Le, Melissa Suthar, Olivia Tubao, David Valdez, Mckenna Wallace
Pressure Free Care: Empowering Staff With The Hapi Prevention Reference Sheet, A Quality Improvement Project, Harmony Le, Melissa Suthar, Olivia Tubao, David Valdez, Mckenna Wallace
Master's Projects and Capstones
Hospital-acquired pressure injuries (HAPIs) can significantly impact a patient’s quality of care, increase organizational costs, and pose significant risks for patient safety. According to the United Hospital Fund, “Hospital-acquired pressure injuries (HAPIs)—also known as pressure ulcers or bed sores—can pose significant problems for both the patient and hospital. Being an injury to the skin or underlying tissue, HAPIs can be painful, cause infections, hinder recovery, and prolong a patient’s time in the hospital” (United Hospital Fund, 2025). This quality improvement (QI) project took place in a small, urban southern California hospital with a high incidence and prevalence rate of HAPIs …
Powering Up Clinical Scholarship, Evelyn Wang
Powering Up Clinical Scholarship, Evelyn Wang
HSLIC Faculty and Staff Instructional Resources
This presentation offers a practical overview of clinical scholarship pathways for Emergency Medicine residents. It covers research question formulation (using PICOT and rubric tools), efficient literature search strategies tailored for emergency care, database and resource navigation, hands-on keyword and subject heading demonstrations, and leveraging HSLIC library services. The session aims to empower residents to engage in scholarly activities by providing actionable tips, relevant resources, and institutional support.
Sport And Black/African-Palestinian Transnational Solidarity: A Conversation, Joezer Antoine, Sean Jacobs, Munene Mwaniki, Yasmin Elgoharry, Jess Nachman, Chen Chen, Roc Rochon, Anthony J. Weems
Sport And Black/African-Palestinian Transnational Solidarity: A Conversation, Joezer Antoine, Sean Jacobs, Munene Mwaniki, Yasmin Elgoharry, Jess Nachman, Chen Chen, Roc Rochon, Anthony J. Weems
Sport Management Collection
This paper is an edited transcript of an online panel that took place February 11, 2025, exploring the historical and contemporary forms of Black/African solidarity with the Palestinian liberation movement in the context of sport. Foregrounding the long tradition of leveraging sport within various anti-racist, anti-colonial, and anti-imperialist movements worldwide, this conversation emphasizes the urgency of developing sustained and renewed strategies of resistance. First, we outline Black-Palestinian Transnational Solidarity (BPTS) as a historical movement sustained by shared anti-imperialist principles. For decades, radical and revolutionary Black and African peoples have recognized Zionism as an extension of the racialized Western imperial project …
Dynamic Mutational Profiling Of Binding Interactions And Allosteric Networks In Conformational Ensembles Of The Sars-Cov-2 Spike Protein Complexes With Classes Of Antibodies Targeting Cryptic Binding Sites: Confluence Of Binding And Allostery Determines Molecular Mechanisms And Hotspots Of Immune Escape, Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Gennady M. Verkhivker
Dynamic Mutational Profiling Of Binding Interactions And Allosteric Networks In Conformational Ensembles Of The Sars-Cov-2 Spike Protein Complexes With Classes Of Antibodies Targeting Cryptic Binding Sites: Confluence Of Binding And Allostery Determines Molecular Mechanisms And Hotspots Of Immune Escape, Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Gennady M. Verkhivker
Mathematics, Physics, and Computer Science Faculty Articles and Research
The ongoing evolution of SARS-CoV-2 variants has underscored the need to understand not only the structural basis of antibody recognition but also the dynamic and allosteric mechanisms that could underlie complexity of broad and escape-resistant neutralization. In this study, we employed a multi-scale approach integrating structural analysis, hierarchical molecular simulations, mutational scanning and network-based allosteric modeling to dissect how Class 4 antibodies (represented by S2X35, 25F9, and SA55) and Class 5 antibodies (represented by S2H97, WRAIR-2063 and WRAIR-2134) can modulate conformational behavior, binding energetics, allosteric interactions and immune escape patterns of the SARS-CoV-2 spike protein. Using hierarchical simulations of the …
August 6, 2025 Blazer Weekly, University Of Alabama At Birmingham
August 6, 2025 Blazer Weekly, University Of Alabama At Birmingham
Blazer Weekly (student newsletter)
No abstract provided.
Dosimetric Evaluation Of Clearsight Bolus Versus Superflab Bolus For Vmat Head And Neck Treatment, Courtney M. Williams
Dosimetric Evaluation Of Clearsight Bolus Versus Superflab Bolus For Vmat Head And Neck Treatment, Courtney M. Williams
Masters Projects
This study compares the dosimetric performance and fit accuracy of ClearSight and Superflab boluses in head and neck (HN) volumetric modulated arc therapy (VMAT) treatment plans, focusing on dose distribution and air gap volumes. A RANDO anthropomorphic phantom was used to simulate HN VMAT treatment for oral cavity cancer with positive lymph nodes, prescribed 70 Gy in 35 fractions. Four configurations were tested: ClearSight bolus over a thermoplastic mask (CSO), ClearSight under a mask (CSU), Superflab over a mask (SFO), and Superflab under a mask (SFU). Five computed tomography (CT) scans, one without bolus and four with bolus, were performed …
Autopathography And Identity In Head Above Water: Reflections On Illness By Shahd Alshammari, Reham M. Samir
Autopathography And Identity In Head Above Water: Reflections On Illness By Shahd Alshammari, Reham M. Samir
Pharmacy
Disability/illness is an enigma that we experience but whose implications we have not fully fathomed. One's sense of self is impacted by disability/ illness. Autopathographies gave people with disability/ chronic illness a chance to share their life with a disability or a chronic illness, which also reflects on identity. Moreover, identity is influenced by social stigma as well as gender. This paper examines the impact of Multiple Sclerosis (MS) on the life and sense of self of the Kuwaiti writer and scholar, Shahd Alshammari's The paper also analyzes the relation between disability, gender and race drawing attention to the impact …
Can The Government Control Hurricanes? New Survey Results On Conspiracies And Science, Lawrence C. Hamilton
Can The Government Control Hurricanes? New Survey Results On Conspiracies And Science, Lawrence C. Hamilton
Carsey Publications
In this brief, author Lawrence Hamilton explores the results of a nationwide 2025 survey that asked over 1,000 people whether they agreed with conspiratorial claims such as government control of hurricanes, flat Earth, or faked Moon landings. Mixed in with the conspiracy questions were others asking about agreement with basic scientific facts such as Earth orbiting the Sun. Nine to 38 percent agreed with the conspiracies whereas 40 to 75 percent agreed with the science; many others were unsure.
Generation and political identity both correlate with conspiracism. Gen X, Millennial, and Gen Z respondents more often agreed with conspiratorial statements; …
How Parents Experience Language During Iep Meetings: A Study Of Elementary School Parents' Perceptions Of Their Children, Michael Anthony Mooren
How Parents Experience Language During Iep Meetings: A Study Of Elementary School Parents' Perceptions Of Their Children, Michael Anthony Mooren
Dissertations (1934 -)
This qualitative hermeneutic phenomenological study explored how parents of elementary-age students receiving special education services experience the language used by educators during Individualized Education Program (IEP) meetings, and how this language affects their perceptions of their children. The literature review focused on the explanation of four language assumptions that served as foundational components of the study. Seven parents participated through purposive sampling, completing surveys leading up to and semi-structured interviews immediately following their child's annual IEP meeting. The analysis involved coding and led to an interpretation of four key findings that focused on collaborative, emotional experiences; accessibility of clarified language …
Pcsk9–Dyslipidemia Interplay In Children And Adolescents With Type 1 Diabetes: A Potential Modulator Of Vasculopathy, Eman Ramadan
Pcsk9–Dyslipidemia Interplay In Children And Adolescents With Type 1 Diabetes: A Potential Modulator Of Vasculopathy, Eman Ramadan
Pharmacy
BACKGROUND: Proprotein convertase subtilisin/kexin type-9 (PCSK9) has recently emerged as an important vasculopathy modulator. However, limited data exist on its level and expression in children and adolescents with type 1 diabetes (T1D). AIM: To assess serum PCSK9 and gene expression among children and adolescents with T1D and correlate them with glycemia, dyslipidemia, and microvascular complications. METHODS: Fifty children and adolescents with T1D were compared to 50 matched healthy controls. Serum PCSK9 enzyme-linked immunosorbent assay (ELISA) and reverse transcription polymerase chain reaction (RT-PCR) gene expression, glycated-hemoglobin, fundus, urinary albumin-to-creatinine ratio (uACR) and fasting lipids were assessed with calculation of the estimated-glucose …