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The Role Of Hif1alpha And Hif2alpha In Muscle Development And Satellite Cell Function, Shiqi Yang

Open Access Theses

Hypoxia inducible factors (HIFs) are central mediators of cellular responses to fluctuations of oxygen, an environmental regulator of stem cell activity. Muscle satellite cells are myogenic stem cells whose quiescence, activation, self-renewal and differentiation are influenced by microenvironment oxygen levels. However, the in vivo roles of HIFs in quiescent satellite cells and activated satellite cells (myoblasts) are poorly understood. Expression analyses indicate that HIF1α and HIF2α are preferentially expressed in pre- and post-differentiation myoblasts, respectively. Interestingly, double knockout of HIF1α and HIF2α (HIF1α/2α dKO) in embryonic myoblasts results in apparently normal muscle development and growth. However, HIF1α/2α dKO in postnatal …

Forest Industry Byproducts Improve Soil Quality And Increase Pepper Growth In Three Soils Infested With Phythophthora Blight, Xiaojun Zhao

Open Access Theses

Phytophthora blight is a serious threat to the Midwest vegetable industry, because the oomycete pathogen responsible for this disease, Phytophthora capsici, has a wide host range, can spread quickly in fields, and produces resilient oospores that can survive in soil for years. Phytophthora capsici has become resistant to commonly used fungicides and resistant crop varieties are rare. Amending soil with complex organic substrates has potential to improve soil quality and suppress soil-borne pathogens including P. capsici. Indiana has a significant forest industry with many residual products that could be used as locally available amendments to meet this goal. …

Impact Of Dietary Modification On Aflatoxicosis In Poultry, Xi Chen

Open Access Dissertations

Aflatoxin contamination in feed and feed ingredients is of high worldwide prevalence, posing serious risks to the livestock industry. A series of studies were conducted to better understand the comprehensive impact of aflatoxicosis and its interrelationships with dietary modifications in broiler chicks and ducks. Results of these studies emphasize the many factors that the severity of aflatoxicosis depends on, including animal species, age, presence of mycotoxin adsorbent, and concentration of major dietary nutrients. Exposure to 2 mg/kg cultured AFB1 led to reduced feed intake, BW gain, depressed feed efficiency, increased relative liver weight, negatively affected serum measures and complement activity, …

Subsidies, Aquaculture Technology Adoption, And Welfare Impacts In Ghana And Kenya, Akuffo Amankwah

Open Access Dissertations

This dissertation empirically examines subsidies, aquaculture technology adoption, and welfare implications of fish farming households in Ghana and Kenya. It is divided into three separate chapters, each addressing a specific empirical issue related to aquaculture in the countries.

The second chapter of this dissertation applies the lognormal double hurdle model to a cross-section of fish farms to analyze commercial demand for improved feed, and whether the government feed subsidy program influences private demand for the feed. The results indicate that households’ decisions to participate in improved feed market are affected by the quantity of the subsidized feed received. Once the …

A Unique Perspective On The Demand For Livestock Product Attributes, Elizabeth S. Byrd

Open Access Dissertations

Consumers are increasingly concerned about the social and environmental impacts of the foods they purchase. Both choice experiments and best-worst scaling (BWS) methodology have been used to elicit consumer willingness to pay (WTP) for food attributes and the relative importance of food attributes to consumers. The dissertation consists of four essays. Chapter 2 presents a formal law review article exploring the laws associated with wild game harvest, consumption, and inspections. The remaining three essays (Chapters 3-5) each address an extension or application of choice experiment and/or BWS methodology focused on credence attributes of meat products. Two online surveys were used …

The Role Of African Leafy Vegetables In Food Security, Marcia M. Croft

Open Access Dissertations

African leafy vegetables (ALVs) are a diverse set of crops grown across sub-Saharan Africa. They have been a staple of traditional diets and contain many critical micronutrients but their importance has been largely ignored by researchers and policymakers at the expense of imported crops. Availability, accessibility, and utilization of ALVs are limited by factors across the supply chain. This research investigated seed systems, drought tolerance, hydroponic production, market barriers, consumer preference, and the impact of gender as related to ALVs. We found that ALVs play an important role in food security and that critical differences exist between formal and informal …

Physiological Aspects Of Relative Changes In Nitrogen And Plant Density Stress Tolerances Over A 38-Year Period Of Us Maize Hybrid Introductions, Keru Chen

Open Access Dissertations

Incremental gains in grain yield of maize hybrids over the decades are the consequence of genotype, environment and management interactions. Historically, genetic improvements in newer hybrids have included longer active grain filling periods (achieved by advancing silking and extending functional stay green in maize leaves); stronger source and sink during grain filling; enhanced tolerance to higher density; and canopy architecture changes. Newer hybrids were known to accumulate more dry matter and nitrogen in the post-silking period, but achieving a more comprehensive knowledge of pre-silking and post-silking dynamics required further understanding of dry matter and nitrogen partitioning in individual organs, as …

Managing Bacterial Wilt, Caused By Erwinia Tracheiphila, On Muskmelon With Early Control Of Striped Cucumber Beetle ( Acalymma Vittatum (F)), And Through Varietal Selection, Ahmad Shah Mohammadi

Open Access Dissertations

Muskmelon (Cucumis melo L), is an important vegetable crop in the United States. It is grown throughout the US, and Indiana ranked 4th in production after California, Arizona and Georgia with 12.4 thousand metric tons and market value of $7.6 million in 2015. Bacterial wilt of cucurbits, which is caused by Erwinia tracheiphila (E. F. Smith), and vectored by striped cucumber beetle (Acalymma vittatum (F)), is one of the most serious diseases of muskmelon that influences muskmelon quality and yield. Many cultivars of muskmelon are grown around the United States, especially in the Midwest. Muskmelon cultivars differ in …

Laser-Processed Parchment Paper For Fabrication Of Chronic Wound Dressings With Selective Oxygenation, Manuel Ochoa

Open Access Dissertations

Chronic non-healing wounds (e.g., diabetic foot ulcers and bed sores) impact over 6.5 million Americans per year, costs in excess of $25 billion to treat on an annual basis, and are on the rise due to increasing levels of obesity and diabetes compounded by an aging population. A major inhibitor of healing is suboptimal oxygenation of the wound bed. Unlike acute injuries that receive sufficient oxygen via a functional blood vessel network, chronic wounds often suffer from the lack of a proper vascular network; thus being incapable of providing sufficient oxygen for tissue growth. Typical medical treatment of hypoxic chronic …

Investigation Of Methods For Reducing Aflatoxin Contamination In Distillers Grains, Hu Shi

Open Access Dissertations

The overall goal of this project was to reduce the aflatoxin level in the final coproduct of ethanol bioprocessing--DDGS. This was pursued by examining the effects of reduction of aflatoxin in the incoming corn prior to bioprocessing, the degradation of aflatoxin in the intermediate products, namely DWG and CDS, during processing, and aflatoxin degradation in the DDGS. Segregation techniques (size screening and density sorting) and detoxification methods (conventional and microwave heating, food additives, and high voltage atmospheric cold plasma) were evaluated for their effectiveness in aflatoxin reduction.

Effectiveness of physical segregation of aflatoxin contaminated corn was investigated by size screening …

The Relationship Between Protein And Phosphorus Digestion And Retention In Growing Pigs And Broiler Chickens, Pengcheng Xue

Open Access Dissertations

Xue, Pengcheng. Ph.D., Purdue University, December 2016. The Relationship between Protein and Phosphorus Digestion and Retention in Growing Pigs and Broiler Chickens. Major Professor: Dr. Layi Adeola. The objective of this study was to investigate the relationship between protein and P digestion and retention in growing pigs and broiler chickens. The methodology of determining the digestibility of AA and P and the effect of dietary N and P on the digestion and retention of these two nutrients were investigated.

An experiment was conducted in growing pigs to investigate the additivity of AID or SID of CP and AA in mixed …

The Effects Of Dietary Probiotic Inclusion On Skeletal Health Of Poultry And Its Possible Mechanisms, Feifei Yan

Open Access Dissertations

Probiotics are live microorganisms which may confer health benefits on the host when administered in appropriate amounts. Numerous studies have shown that probiotics improve bone health in humans and rodents with less information available on the skeletal health of avians given probiotics. The objective of this study was to determine the effects of probiotic supplementation on bone health of egg-laying and meat-type chickens. Dietary supplementation of a multi-species based probiotic reduced the percentage of shell-less eggs beginning at 4 wk following treatment and increased tibial and femoral bone mineral density in egg-laying hens at 7 wk post-treatment. Similarly, bone mineralization …

Mechanistic Insight Into The Role Of Dietary Fibers And Short Chain Fatty Acids In The Regulation Of Metabolism And Inflammation In The Pig, Hui Yan

Open Access Dissertations

Dietary fiber is a diverse mixture of polysaccharides exerting multiple functions as it passes through the gastrointestinal tract (GIT). Besides the influence on nutrient digestibility, dietary fiber affects growth performance and host metabolism via modulation of gut microbial community structure and production of short chain fatty acids (SCFA). A series of in vivo experiments were conducted to determine the effects of dietary fiber on pig growth performance and gut microbial community as well as host metabolism. In the first study, a comparison between soluble and insoluble fibers was conducted in terms of pig growth, gut microbial structure and SCFA production …

Metabolic Syndrome Screening In Seriously Mentally Ill Patients: A Quality Improvement Project, Annabel Moreno

Student Projects for Graduate Degrees

Seriously mentally ill patients who are taking second-generation antipsychotics have a high risk of metabolic complications, including obesity, diabetes mellitus type II, hypertension, and hyperlipidemia. Guidelines to screen for metabolic syndrome were established by the American Diabetes Association, American Psychiatric Association, American Association of Clinical Endocrinologists, and North American Association for the Study of Obesity (Clark, 2004). Compliance with implementing the guidelines to screen and monitor for metabolic syndrome vary from regular monitoring to little or none. This quality improvement project provided an educational intervention on screening and monitoring for metabolic syndrome in patients who were seriously mentally ill. The …

Implementation And Evaluation Of A Prescribed Exercise Program Led By A Nurse Practitioner, Leigh Aurora Keefer

Student Projects for Graduate Degrees

Insufficient physical exercise contributes to many disease processes and increases mortality and morbidity rates worldwide. If the world population were to adhere to recommended levels of physical activity, health outcomes would improve. To that end, clinical practices need to consider exercise interventions to improve patient self-efficacy to adhere to recommended physical activity guidelines. A family nurse practitioner led such an intervention in a primary care clinic in Anchorage, Alaska. It evaluated a prescriptive-exercise program using the Exercise is Medicine® (EIM) guidelines of the American College of Sports Medicine. This pilot targeted healthy adults between 18 and 64 years old who …

The Role Of Nutrition Education And Active Choice To Increase Fruit And Vegetable Consumption Among Second Grade Students During Lunchtime, Robyn M. Cafiero

Theses, Dissertations and Culminating Projects

Fruit and vegetable intake within the United States is considerably lower than the standards set by the United States Department of Agriculture. With this information, there is no surprise that these rates are especially low for school aged children. Although many studies have tried to incorporate programs that would effectively increase the consumption of fruits and vegetables among youngsters, many have fallen short with being able to sustain consumption over time. This study provided a way to increase fruit and vegetable consumption during lunchtime for second grade students by using a dual module of the Social Cognitive Theory and active …

Second Look Commission 2016 Annual Report, Tennessee. Commission On Children And Youth.

Second Look Commission Annual Report

No abstract provided.

Connection Between Involvement In Dance And Building Character: An Analysis Of Student Behavior, Megan L. Hoggarth

Doctoral Scholarly Projects & Capstones

The purpose of this study was to investigate the effects of dance involvement on

high school students’ behaviors. This quantitative and qualitative study was designed to answer the three essential questions and to determine the connection if any between involvement in dance class, and changes in students’ character traits and behaviors. The research instruments were a student character trait survey, student interviews, and observation forms. The study is based from the seven character traits listed in Paul Tough’s book, How Children Succeed: Grit, Curiosity, and the Hidden Power of Character and from the Knowledge is Power Program (KIPP). The seven …

Volumetry Of Low-Contrast Liver Lesions With Ct: Investigation Of Estimation Uncertainties In A Phantom Study, Qin Li, Yongguang Liang, Qiao Huang, Min Zong, Benjamin Berman, Marios A. Gavrielides, Lawrence H. Schwartz, Binsheng Zhao, Nicholas Petrick

United States Food and Drug Administration: Publications

Purpose: To evaluate the performance of lesion volumetry in hepatic CT as a function of various imaging acquisition parameters.

Methods: An anthropomorphic abdominal phantom with removable liver inserts was designed for this study. Two liver inserts, each containing 19 synthetic lesions with varying diameter (6–40 mm), shape, contrast (10–65 HU), and both homogenous and mixed-density were designed to have background and lesion CT values corresponding to arterial and portal-venous phase imaging, respectively. The two phantoms were scanned using two commercial CT scanners (GE 750 HD and Siemens Biograph mCT) across a set of imaging protocols (four slice thicknesses, …

Implementation Of Shared Medical Appointments To Address Cardiovascular Disease Risk In Patients With Metabolic Syndrome, Jill Rife

Student Projects for Graduate Degrees

Metabolic syndrome is a condition in which the components – central adiposity, insulin resistance, atherogenic dyslipidemia, and elevated blood pressure - confer increased cardiovascular morbidity and mortality. A pilot clinical practice improvement project was developed and implemented using shared medical appointments to address cardiovascular disease risk in adult patients at a rural health care clinic on the southern Kenai Peninsula, Alaska who met the diagnostic criteria for metabolic syndrome. Statistically significant improvement in self-reported minutes of exercise was demonstrated for the nominal group of participants. Participants were at least as satisfied or more satisfied with shared medical appointments compared to …

Obese Mice Fed A Diet Supplemented With Enzyme-Treated Wheat Bran Display Marked Shifts In The Liver Metabolome Concurrent With Altered Gut Bacteria, Dorothy A. Kieffer, Brian D. Piccolo, Maria L. Marco, Eun Bae Kim, Michael L. Goodson, Michael J. Keenan, Tamara N. Dunn, Knud Erik Bach Knudsen, Sean H. Adams, Roy J. Martin

Faculty Publications

Background: Enzyme-treated wheat bran (ETWB) contains a fermentable dietary fiber previously shown to decrease liver triglycerides (TGs) and modify the gut microbiome in mice. It is not clear which mechanisms explain how ETWB feeding affects hepatic metabolism, but factors (i.e., xenometabolites) associated with specific microbes may be involved. Objective: The objective of this study was to characterize ETWB-driven shifts in the cecal microbiome and to identify correlates between microbial changes and diet-related differences in liver metabolism in diet-induced obese mice that typically display steatosis. Methods: Five-week-old male C57BL/6J mice fed a 45%-lard-based fat diet supplemented with ETWB (20% wt:wt) or …

Mice Fed A High-Fat Diet Supplemented With Resistant Starch Display Marked Shifts In The Liver Metabolome Concurrent With Altered Gut Bacteria, Dorothy A. Kieffer, Brian D. Piccolo, Maria L. Marco, Eun Bae Kim, Michael L. Goodson, Michael J. Keenan, Tamara N. Dunn, Knud Erik Bach Knudsen, Roy J. Martin, Sean H. Adams

Faculty Publications

Background: High-amylose-maize resistant starch type 2 (HAMRS2) is a fermentable dietary fiber known to alter the gut milieu, including the gut microbiota, which may explain the reported effects of resistant starch to ameliorate obesityassociated metabolic dysfunction. Objective: Our working hypothesis was that HAMRS2-induced microbiome changes alter gut-derived signals (i.e., xenometabolites) reaching the liver via the portal circulation, in turn altering liver metabolism by regulating gene expression and other pathways. Methods: We used a multi-omics systems biology approach to characterize HAMRS2-driven shifts to the cecal microbiome, liver metabolome, and transcriptome, identifying correlates between microbial changes and liver metabolites under obesogenic conditions …

Manipulating, Fast And Slow: The Law Of Non-Verbal Market Manipulations, Shmuel I. Becher, Yuval Feldman

Cardozo Law Review

Consumers make purchasing decisions in various markets every day. Contrary to common belief, such decision-making is often not the result of deliberate analysis of information or of rational thinking. Rather, it is frequently based on feelings, sensations and intuition. Purchasing decisions are not made in a vacuum and are regularly influenced by sellers' manipulation and selling tactics.

It is well documented that people receive a substantial part of the information they possess via non-verbal communication. One of the most alarming aspects of this reality is that consumers are mostly unaware of non-verbal cues and the ways they can influence them. …

The Chief Justice And Statutory Construction: Holding The Government's Feet To The Fire, Pratik A. Shah

Cardozo Law Review

The article examines Chief Justice John Roberts' approach to statutory construction, highlighting his tendency to limit government overreach by narrowly interpreting statutes, particularly in federal criminal law and agency deference cases. His decisions reflect a commitment to curbing prosecutorial and agency discretion, ensuring the government operates within legal boundaries.

Mapping The Geography Of Child Mortality: A Key Step In Addressing Disparities, Zulfiqar Ahmed Bhutta

Department of Paediatrics and Child Health

No abstract provided.

Research & Strategic Partnerships: Quarterly Review, Volume 3, Issue 3, Portland State University. Research & Strategic Partnerships

Portland State Research Magazine

This issue of the Quarterly Review focuses on population health and strategies to improve it. Although these strategies may be revised and added to in the years ahead, the “Triple Aim” of addressing health costs, improving the experience of care, and maintaining healthy populations will undoubtedly remain unchanged, as will our drive to better understand the role of public health in developing resilient people and communities.

The research highlighted in this issue also bears witness to the importance of community and the ways in which Portland State University and the OHSU-PSU School of Public Health are empowering communities to live …

It’S Complicated: Does Food Web Structure Affect Detrital Processing In Streams?, Stephen H. Tentinger

Biology Theses

Trophic cascades involve powerful feeding interactions that can alter the flow of energy and the abundance of species in an ecosystem. In western NY streams, the negative impacts of a new benthic invertivore, the round goby (Neogobius melanostomus) is altering benthic community structure and leaf litter decomposition. Streams with round gobies have a reduced abundance of shredders and slower leaf decay than streams without gobies. However, crayfish, as shredders of leaf litter, may be large or aggressive enough to avoid predation by round gobies. I used a 30-day full factorial field experiment with blocks to determine if round gobies affected …

Arkansas Animal Science Department Report 2016, Paul Beck, Jason Apple, Shane Gadberry, Beth Kegley, Charles Rosenkrans Jr.

Arkansas Agricultural Experiment Station Research Series

No abstract provided.

Minding Ps And Qs: The Political And Policy Questions Framing Health Care Spending, William M. Sage

Faculty Scholarship

Tracing the evolution of political conversations about health care spending and their relationship to the formation of policy is a valuable exercise. Health care spending is about science and ethics, markets and government, freedom and community. By the late 1980s the unique upward trajectory of post-Medicare U.S. health care spending had been established, recessions and tax cuts were eroding federal and state budgets, and efforts to harness market forces to serve policy goals were accelerating. From the initial writings on “managed competition,” through the failed Clinton health reform effort in the early 1990s, to the passage of the Affordable Care …

Uptake Of Actinides And Nuclear Fission Products In Graminaceous And Nongraminaceous Plants, Stephanie Lynn Ely

All Theses

Radionuclides exist within the environment naturally and also from release during nuclear power and weapons production. The ability of plants to uptake radionuclides may prove beneficial for exploitation in the field of phytoremediation and as a biomonitor within the field of nuclear forensics. The fact that plants have the ability to take up radionuclides as an unintended metabolic process is well known, however, the mechanisms through which uptake occur present large gaps within the current research. Therefore, gaining further knowledge regarding overall plant radionuclide uptake and specific mechanisms may prove as an invaluable tool to enhance phytoremediation and nuclear forensic …