Digital Commons Network^™

Non-Medical Use Of Prescription Stimulants For Weight Loss: Predictors, Consequences, And Implications For Intervention In A National Young Adult Sample, Amy J. Jeffers

Theses and Dissertations

The non-medical use of prescription drugs is an important public health concern. Non-medical use of prescription stimulants (NMUPS), specifically medications used to treat Attention Deficit Hyperactivity Disorder (ADHD), is particularly concerning. One timely concern regarding NMUPS, especially among young adults, is their role in appetite suppression/weight loss. Indeed, some individuals are motivated to misuse such drugs for the purpose of losing weight. Engaging in NMUPS for weight loss has been examined only minimally in the research literature. However, extant data demonstrate that this behavior is associated with other unhealthy behaviors and poor psychosocial health. Limitations of prior research include the …

Curcumin/Melatonin Hybrids As Neuroprotective Agents For Alzheimer's Disease, John Saathoff

Theses and Dissertations

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia, affecting ~5.2 million Americans. Current FDA approved medications provide mainly symptomatic relief and there are no agents available to delay or cure this disease. Multiple factors such as amyloid-β aggregates, dyshomeostasis of biometals, oxidative stress, and neuroinflammation have been implicated in the development of AD. Even though significant advances have been made in understanding the mechanisms leading to AD, the exact etiology still remains elusive. Given AD’s multifactorial nature, a multifunctional strategy of small molecule design would help to identify novel chemical templates. Recently our lab …

The Instructional Technology Resource Teacher: A Descriptive Case Study Of Deployment, Use, And Perceptions, Mary Sepelyak

Theses and Dissertations

This case study describes one professional development approach to support technology integration at all public schools in one large county in central Virginia. Using data obtained from daily time logs, the frequency of Instructional Technology Resource Teacher (ITRT) use by classroom teachers was analyzed. Descriptive statistics were used to describe overall percentage of ITRT use, the various types of professional development requested by teachers, the consistency of those activities over time, and if the frequencies of activities varied as a function of school level, Title I status at the elementary level, or subject area taught by teachers at the secondary …

The New Gatekeepers: How Blogs Subverted Mainstream Book Reviews, Rebecca E. Johnson

Theses and Dissertations

Book reviewing has a fraught history in the United States. Reviewers have long been accused of not being analytical enough. It should be no wonder then with the emergence of social media that online book reviewing has become increasingly popular. Online reviewers, especially book bloggers, are no literary gatekeepers in their own right, shaping the tastes of readers across the world. Book blogs in particular pay special attention to titles which have long been derided by institutions such as libraries, academia, publishers, and bookstores. These literary gatekeepers typically ignore romance, fantasy, mystery, science fiction, young adult fiction, comic books, and …

Electrochemical Studies Of Cerium And Uranium In Licl-Kcl Eutectic For Fundamentals Of Pyroprocessing Technology, Dalsung Yoon

Theses and Dissertations

Understanding the characteristics of special nuclear materials in LiCl-KCl eutectic salt is extremely important in terms of effective system operation and material accountability for safeguarding pyroprocessing technology. By considering that uranium (U) is the most abundant and important element in the used nuclear fuel, measurements and analyses of U properties were performed in LiCl-KCl eutectic salt. Therefore, the electrochemical techniques such as cyclic voltammetry (CV), open circuit potential (OCP), Tafel, linear polarization (LP), and electrochemical impedance spectroscopy (EIS) were conducted under different experimental conditions to explore the electrochemical, thermodynamic, and kinetic properties of U in LiCl-KCl eutectic. The ultimate goal …

Nostalgia And Iphone Camera Apps: An Ethnographic Visual Approach To Iphoneography, Maria L. De Panbehchi

Theses and Dissertations

The iPhone is the most popular smartphone and camera on social media. iPhoneography, the photography taken or edited with the iPhone, has set the trend of nostalgic photography on social media during the 2010s; thus, the iPhone, a high-tech camera, produces low-tech-looking images. This dissertation attempts to find out why iPhone photographers (iPhoneographers) take, edit, and share images that mimic photographs taken with analog photographic equipment. I argue that nostalgia allows iPhoneographers to use the iPhone as a creative tool and to belong to a community. Based on the arguments of Vilém Flusser—who suggested that photographers are more interested in …

Beyond The Single Story: How Analog Hypertext Facilitates Representation Of Multiple Critical Perspectives In An Art Museum Object Study Gallery, Aimee D. Hunt

Theses and Dissertations

This project utilized a form of arts based educational research described as analog hypertext to develop interpretative material representing multiple critical, theoretical, and disciplinary perspectives on objects in a university art museum’s object study gallery. Drawing on scholars’ recommendations for postcolonial interpretation of non-Western art, the project created a web of information, which simultaneously revealed and critiqued the underlying ideologies and power structures shaping the museum’s display in an effort to change existing interpretive practice. The project developed five color-coded thematic self-guided tours—art as commodity, spiritual practice, technology and cultural evolutionism, mortuary rituals, and postcolonial perspectives—presented to the public as …

Wreading, Performing, And Reflecting: The Application Of Narrative Hypertext And Virtual World Experiences To Social Work Education, Linda Ayscue Gupta Phd

Theses and Dissertations

In this dissertation I propose the use of a new media composition of narrative hypertext, performances in a virtual world, and a dialogic process of writing to provide a continuum of learning opportunities in social work education. I suggest that the structure of the hypertext narrative, embedded with hypermedia, mirrors the dissociative aspects of traumatic memory. I argue that work with the multivocality and multisequentiality of narrative hypertext emulates the process of discovery in the clinical interview. The immersive component of work in a virtual world deepens the realism and affective impact of simulations and creates opportunities to practice and …

A Study About How To Create A Mythical Beast Successfully, Focusing On The Example Of The Nine-Tailed Fox In Eastern Art, Yidan Xie

Theses and Dissertations

Mythical beasts appear in many forms across multiple cultures throughout human history. Their narratives and visual designs express important beliefs and desires of a given culture. By focusing on the aesthetics and history of the nine-tailed fox, a Chinese mythological, this thesis will explore the constructions and artistic techniques that have given shape to the myth. This thesis will also discuss my thesis project named Classic of Mountains and Seas. The ultimate aim of my creative project has been to develop an animation of new mythical beasts, and this paper situates my creations within the much broader history that has …

Urban Stressors And Child Asthma: An Examination Of Child And Caregiver Models, Gillian G. Leibach

Theses and Dissertations

The purpose of the present study was to examine how low-income, racial and ethnic minority, urban families experience and manage their child’s asthma. The rationale for this study stems from existing literature on asthma disparities and documented predictors of increased asthma morbidity and mortality. In particular, this study considered how specific types of stress may disproportionately impact low-income, racial and ethnic minority, urban families that have a child with asthma. This study aimed to determine associations between urban stressors (stressful life events, perceived discrimination, subjective socioeconomic status) and child asthma outcomes (emergency department visits, school days missed, asthma control), and …

Investigation Of Anaplasma Phagocytophilum And Anaplasma Marginale Adhesin-Host Cell Interactions, Kathryn S. Hebert

Theses and Dissertations

Anaplasma phagocytophilum and A. marginale are the etiologic agents of bovine anaplasmosis and human granulocytic anaplasmosis, respectively. As obligate intracellular pathogens, binding and entry of host cells is a prerequisite for survival. The molecular events associated with these processes are poorly understood. Identifying the adhesins mediating binding, delineating their key functional domains, and determining the molecular determinants to which they bind not only benefits better understanding of Anaplasma spp. pathobiology, but could also benefit the development of novel approaches for protecting against infection. We previously demonstrated that A. phagocytophilum outer membrane protein A (ApOmpA) is critical for bacterial binding and …

In Vitro Visualization Of Pediatric Sized Mechanical Heart Valve Performance Using Aortic Root Model In Mock Circulatory Loop, Sarah Lederer

Theses and Dissertations

Congenital heart valve disease is one of the most common abnormalities in children, with common valve defects being aortic stenosis, mitral stenosis, and valvular regurgitation. Although adult sized mechanical heart valve (MHV) replacements are widely studied and utilized, there are currently no FDA approved prosthetic heart valves available for the pediatric population. This is due to a variety of reasons such as a limited patient pool for clinical trials, limited valve sizes, and complex health histories in children. Much like adult sized mechanical heart valves, potential complications with pediatric heart valve replacements include thrombosis, blood damage due to high shear …

Egyptianization: Culture Hacking As A Method, Hadeer Omar

Theses and Dissertations

In a broad sense, cultures undergo a metamorphoses due to the external influences and systems impacting the evolution of internal identities. Conversely, Individuals within cultures react to those external influences and systems.The act of hacking a culture is an opportunity to challenge an existing or imported system in order to bring about change and improvement. An aspect of culture hacking is to create messages of satire or irony in order to criticize, or completely reject established systems within cultures.

Post Arab spring, Egyptians practiced culture hacking by applying their cultural tools to external systems and influences, producing a process of …

The Study Of The Regulon Of Oxyr In Escherichia Coli And Porphyromonas Gingivalis, Christopher K. Pham

Theses and Dissertations

The facultative anaerobe, Escherichia coli and the obligate anaerobe, Porphyromonas gingivalis are two bacteria that reside in our body. Although they reside in separate environments, they are both subject to hydrogen peroxide stress and have mechanisms to regulate the stress. OxyR is the primary transcriptional regulator/sensor of oxidative stress response caused by hydrogen peroxide. OxyR in P. gingivalis is not well-characterized compared to OxyR in E. coli. We sought to characterize and compare the two forms of OxyR in order to gain a better understanding of the protein. We determined the oligomeric state of both proteins: primarily a tetramer for …

Jpg Artifacts, Abbey Lee Sarver

Theses and Dissertations

This thesis examines my artistic practice over the past two years at Virginia Commonwealth University, which has led to the installation of my thesis exhibition, JPG Artifacts. My work inspects the current process of image making within a responsive studio practice of deconstructing the digital image into a physical space. While my thesis exhibition is just one culminating formal installation of my experimental studio practice, this paper will examine some main points of reference towards what has led me to the most present public iteration of my work. I hope to position my research in context of contemporary art and …

Courageous Solstice: Reconstructing Fairy Tales For A Black Youth Aesthetic, Tanya Boucicaut

Theses and Dissertations

This thesis interrogates the historical, philosophical, and existential implications of the Black Arts Movement and its major artists on the recurring themes of social injustice, Western hegemony, and the fight for aesthetic authenticity to reimagine fairy tales for the youth Black Aesthetic. As a personal reflection and foundational document for a larger project, this work weaves these implications through the practical application of the varied stages of program development for youth artists. This project also is a handbook that encompasses scholarly research, reflective analysis and anecdotal journal evidence. The subsequent chapters explore the theological and theatre pedagogical educational influences that …

The Effects Of Amixicile, A Pyruvate Ferredoxin Oxidoreductase Inhibitor, On Oral Treponemes, Lucas A. Reed

Theses and Dissertations

Periodontal disease (PD) is a polymicrobial infection characterized by inflammation of the gingiva, alveolar bone resorption, and tooth loss (edentulism). Treponema denticola along with Porphyromonas gingivalis and Tannerella forsythia are among the “Red Complex” and are main etiological agents in PD. Treponemes are a member of the Spirochaeta phylum and are obligate anaerobes, that express pyruvate ferredoxin oxidoreductase (PFOR). The enzyme catalyzes the oxidation of pyruvate to acetyl-CoA and reduced ferredoxin. Amixicile is a novel bacteriostatic derivative of nitazoxanide and an inhibitor of PFOR. In light of the fact that Treponemes express PFOR, this study was conducted to investigate the …

Functional Consequences Of Mtdna Methylation On Mitochondrial Transcription Factor Binding And Transcription Initiation, Elliot N. Burton

Theses and Dissertations

The role of cytosine modifications on nuclear transcription has been well characterized, but the function of DNA methylation in the mitochondrial genome has not been determined. Previous studies conducted by the Taylor laboratory have shown overexpression of the mitochondrial isoform of DNMT1 leads to strand-specific changes in gene expression. Here, we show that increased mtDNMT1 expression leads to an increase in the polycistronic transcript encoding the ND1 and Cox1 sequences. In order to understand the mechanistic basis of these changes, we investigated the effects of CpG methylation in the heavy strand promoter on transcription initiation and TFAM binding. Methylation was …

Supporting Teen Leaders: Validation Of The I Drive Smart Survey, Cynthia M. George

Theses and Dissertations

Recent policy change allows states to spend federal dollars directly on teen-led driver safety efforts and requires regular evaluations of effectiveness. There are currently no standardized instruments to measure change in teen driving behavior relevant to teen leaders. This study serves the Tennessee Department of Safety and Homeland Security, Tennessee Highway Safety Office and their network of teen leaders to empirically test and refine the I Drive Smart survey developed by partners and grounded in the Theory of Planned Behavior (TPB). The survey is designed to be administered by teen leaders to their peers and produce data relevant for use …

Methcathinone Analogue Activity At The Human Serotonin Transporter, William Drake Varn

Theses and Dissertations

In the last few years, there has been continued concern about synthetic drug abuse in both the United States and worldwide. Small adjustments in drug compound structure often allow synthetic drug makers to manufacture a legal product that can produce the same highs as illegal counterparts. Unfortunately, this is happening faster than the government can outlaw the drug compounds, and a wide variety of synthetics are now appearing on the street. This study evaluated the effects on the human serotonin transporter of six different 4-para substituted methcathinone compounds. Using a Xenopus oocyte model, the efficacy of each MCAT analogue …

Collective Cadence, Alicia Dietz

Theses and Dissertations

Collective Cadence

Stories that start at birth,

end with death,

and include everything in-between.

A Medal of Honor recipient,

A mistake.

Morning coffee;

a late night call.

Whispered first names;

an off-key chorus;

deafening explosions;

silence.

One child playing;

another lifeless.

On the battlefield,

concealment is a survival skill.

Off that battlefield,

transparency enables survival.

Stories that shape the fabric of our experience

The threads that bind us

Through the telling of each,

we are united as one.

In the telling of the collective,

We find our own.

These are our stories.

This is our story.

Boomerang Studio: Community Design For Action, Jessica Walton

Theses and Dissertations

An arts education space, focusing on concepts of design thinking aimed at providing low income middle and high school teens of color the opportunity to learn about interior design, architecture and crafts. Ultimately, Boomerang Studio hopes to engage students in the world of design as a means of creating greater diversity within these disciplines.

No Woman Is An Island, Adele Ball

Theses and Dissertations

We have gathered the following pages to archive our time here in Richmond, Virginia. We have been here for two years, growing slowly, moving when needed to new anchorholds to avoid detection or arrest. We scrutinize the urban environment like modern archeologists. We collect stories and speculate about new uses of old things. It is imperative to be resourceful here, and we do so out of necessity but also in the spirit of practice. These pages were made en route, each an exploration of the tools at hand when on the move. The method of creation is just as important …

A (Dis)Assemblage Of The Gallery-Growlery, Levester R. Williams

Theses and Dissertations

A (dis)Assemblage of the Gallery-Growlery exhibition and writing presents itself as a site of a morphological exploration of language, sound, and objects in tandem with the irreducibly venting black expression. Venting, the black expression never seeks wholeness within objects or language itself for it is a thing-in-itself. Its presence affords critical reception to a residue of delimiting forms. All growls eschew verbal objects for the manifestation of pure phonetics. A growl in a gallery is the growl. The growl resounds through the physicality of the objects and gallery. Also, it unwinds the object-among-objects as the phono-present stretches the discursive …

Monitor, Shana Hoehn

Theses and Dissertations

Descriptions of a scene interwoven with thoughts on how aesthetics sets behavioral expectations, observation as proof, views from a single perspective, casting of characters, spaces that evoke complicated histories, and my own history.

Truth And Doubt In Representation, Mathew Gasparek

Theses and Dissertations

My work deals with the connection between the act of representation and conceptions of truth in the contemporary image-mediated social environment. This thesis details elements of my paintings in exchange with methods and ideas from artists and writers in order to position my aesthetic and conceptual sensibilities within a historical and contemporary framework.

A Theoretical Simulation Of The Settling Of Proppants In A Hydraulic Fracturing Process, Nisreen Alseamr

Theses and Dissertations

Hydraulic fracturing is a process for the extraction of hydrocarbons from underground formations. It involves pumping a specialized fluid into the wellbore under high pressures to form and support fractures in the rock. Fracturing stimulates the well to increase the production of oil and the natural gas which are the pillars of the energy economy. Key to this process is the use of proppants, which are solid materials used to keep the fractures open. Understanding the transport of proppant particles through a fluid is important to improve the efficiency and reduce environmental impact of fracturing. An increase of the settling …

Antithetical Commentaries On X, Y And The Disruption Of Being, Eva Rocha

Theses and Dissertations

Through discursive essays and poetic narrative, Antithetical Commentaries on X, Y and the Disruption of Being explores the tenuous relationship between modes of measurement and the struggle for human relevance in the post-contemporary digital age. In the introductory essay, “Not the Feather, but the Bird”, I give an overview of the inherent problems of object-oriented ontology, and how it relates to aesthetics and social issues of our times. In the Developmental Overview, I detail how I developed my installation approach and techniques, particularly with regard to the three-way dynamic of the artist:work:viewer relationship and how it can encourage …

Identifying Misconceptions Associated With Inaccurate Survey Reporting In The Combined Use Of Caffeine And Alcohol, Kathryn Polak

Theses and Dissertations

Research on college student use of caffeine combined with alcohol (CAC) and public health concern over such use has been hampered by the absence of psychometrically sound measures of caffeine and CAC use. The present study examined agreement between survey (CAS) and interview (TLFB) methods for collecting data on caffeine, alcohol and CAC use. Participants were N=50 college students randomized to complete CAS followed by TLFB or the reverse. Qualitative follow-up interviews with N=15 participants were used to identify factors contributing to CAS-TLFB discrepancies. Responses varied by method of administration, with largest discrepancy magnitudes found for CAC, followed …

Holistic Products: Designing With Time, Gifts, And Ritual, Jeremy P. Zietz

Theses and Dissertations

The notion of “you are what you buy” is an updated adage from “you are what you eat”. It makes a connection between our everyday objects and their effect on our lived experience. Looking at our relationships with our things as a type of contract, we must be intentional to shape these object contracts for our own good and health. Instead of our society’s design talents being put toward a consumerist agenda, designers must direct research and development which addresses the effects of our products holistically.

Various concepts have emerged in my creative practice which demand a deeper research and …