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2016

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Why Didn’T I Know? Perspectives From Adult Children Of Elderly Parents With Dementia, Debbie Conner, Julie Postma, Catherine Van Son Dec 2016

Why Didn’T I Know? Perspectives From Adult Children Of Elderly Parents With Dementia, Debbie Conner, Julie Postma, Catherine Van Son

All Faculty and Staff Scholarship

Purpose: Approximately 27 million adults are living with undiagnosed dementia worldwide. The purpose of this study was to learn about the experiences of adult children of elderly parents who were ultimately diagnosed with dementia.

Data sources: A descriptive qualitative design was used for identifying if there were prodromal signs or symptoms that preceded the more commonly known warning signs of dementia. Twelve, 60-min interviews were conducted over the telephone.

Conclusions: The overarching theme was: “Why didn't I know?” Subthemes were “We ignored it because we didn't want it to be,” “We thought it was grief,” and “They wouldn't diagnose dementia.” …


University Fundraising Through Special Events: An Application Of The Theory Of Planned Behavior, Megan Elizabeth Hobbs Dec 2016

University Fundraising Through Special Events: An Application Of The Theory Of Planned Behavior, Megan Elizabeth Hobbs

Master's Theses

The purpose of this study was to apply the Revised Theory of Planned Behavior and EVENTQUAL models to explore (1) event qualities that significantly impact guests’ satisfaction with a university event that they attend, (2) significant factors influencing university loyalty as a result of an event, and (3) willingness to make a charitable donation to a university as a result of attending an event. An online survey was sent to attendees of an annual Cal Poly auction event between 2002 and 2016 that directly benefits Cal Poly students. The data were used to test a series of hypotheses to determine …


Metabolic Regulation And Cryotolerance Of In Vitro-Produced Holstein Embryos, Melissa Ann Roberts Dec 2016

Metabolic Regulation And Cryotolerance Of In Vitro-Produced Holstein Embryos, Melissa Ann Roberts

Master's Theses

In vitro production and transfer of embryos has become a common practice within the dairy industry to efficiently breed superior animals and meet the consumption demand of the growing population. Cyropreservation is necessary for the application of commercialized embryo transfer, however, in vitro-produced embryos show morphological and physiological defects which negatively impact their ability to withstand cryopreservation in comparison to their in vivo counterparts. These artifacts result from culture conditions that cause stress to the embryo during development, leading to an accumulation of intracellular lipids, mitochondrial dysfunction, and ultimately poor ability to withstand freezing and thawing. The objective of …


Social And Cultural Integration Process Among Syrian Refugees In The United States, Sheren Iskandar Shihadeh Dec 2016

Social And Cultural Integration Process Among Syrian Refugees In The United States, Sheren Iskandar Shihadeh

Electronic Theses, Projects, and Dissertations

The purpose of this study is to examine the cultural and social integration process among Syrian refugees in the United States, and to what extent the direct and indirect challenges have played a role in the process of their social and cultural integration. The challenges include, but are not limited to, cultural conflicts, religious values, stereotypes, and English language proficiency. In order to investigate my research questions, interviews as a research methodology were used as a theoretical framework for this project to collect and analyze data. I conducted semi-structured interviews with ten Syrian refugees who currently live in the United …


Expression Of Glycine-Rich Proteins Found In Salivary Glands Of The Lone Star Tick (Amblyomma Americanum) Using A Mammalian Cell Line, Annabelle Clark Dec 2016

Expression Of Glycine-Rich Proteins Found In Salivary Glands Of The Lone Star Tick (Amblyomma Americanum) Using A Mammalian Cell Line, Annabelle Clark

Honors Theses

Ticks play an important ecological role as well as a growing role in human health and veterinary care. Ticks are hosts to a plethora of microbial pathogens that can be transferred during feeding to cause tick-borne diseases in humans and many animals. Ticks may in large part owe the success of the transfer of these pathogens between hosts to their complex saliva. The saliva secreted upon a tick’s attachment to a host serves the following, among other, functions: anti-hemostasis of the blood pool, preventing an inflammatory response at the bite site, and serving as a natural anti-microbial substance. An important …


Gender Roles And Gender Stereotypes In Four Newbery Award-Winning Books, Alex P. Brower Dec 2016

Gender Roles And Gender Stereotypes In Four Newbery Award-Winning Books, Alex P. Brower

Honors Theses

This research project examined the presentation of traditional gender roles and representation in four books that were awarded the Newbery Medal. The four books that were examined are the award recipients from 1922, 1923, 2014 and 2015. It was predicted that as gender equality has become a more prominent issue, and men and women have become more equal, one would expect this change to be reflected in children’s literature. A close reading was performed of these works, and special attention was paid to how the authors present the genders of the main characters in terms of personal interests, the roles …


Winning At The Graduate Level Of Warfare: Six Core Factors Of A Successful Counterinsurgency Campaign And The Example Of Sierra Leone, John D. Rimann Dec 2016

Winning At The Graduate Level Of Warfare: Six Core Factors Of A Successful Counterinsurgency Campaign And The Example Of Sierra Leone, John D. Rimann

Honors Theses

The most common form of warfare so far in the 21st Century has been insurgencies and counterinsurgencies, types of warfare which are particularly challenging for industrialized Western nations to wage effectively. This paper identifies six factors of primary importance which form the key to a successful counterinsurgency campaign. These factors are legitimacy, clarity, beneficial geopolitical factors, restraint, intellectual understanding, and an enduring commitment. This paper argues that these factors must all be present for a counterinsurgency campaign to succeed, and argues that without these factors being accounted for a counterinsurgency will fail. The British humanitarian intervention in Sierra Leone in …


Mythbusting Park Chung Hee: A Reexamination Of Park And His Coup, Justin Malzac Dec 2016

Mythbusting Park Chung Hee: A Reexamination Of Park And His Coup, Justin Malzac

Electronic Theses & Dissertations

Park Chung-Hee is a divisive figure. For some he is a saint that rescued his country from the brink of collapse and helped it rise into modernity. For others he is a devil, an iron-fisted dictator who cared more about his own power than his people. Both of these are politically slanted myths promoted as part of a corresponding political agenda. But even politically neutral writings on Park unwittingly conduct a mythmaking of their own. This paper is an attempt to show that Park Chung-Hee has become a mythological figure in Korean history because the scope of his power, agency …


Effect Of Time Duration Of Digestion/Decontamination Technique On Yield Of Mycobacteria And Contamination Rates From Sterile Body Fluids (Pleural And Ascitic Fluid) And Pus Specimens, Samreen Shafiq, Faryal Saleem, Kauser Jabeen, Joveria Farooqi, Warda Alam, Sadia Hanif, Shazia Ali, Sadia Shakoor, Rumina Hasan Dec 2016

Effect Of Time Duration Of Digestion/Decontamination Technique On Yield Of Mycobacteria And Contamination Rates From Sterile Body Fluids (Pleural And Ascitic Fluid) And Pus Specimens, Samreen Shafiq, Faryal Saleem, Kauser Jabeen, Joveria Farooqi, Warda Alam, Sadia Hanif, Shazia Ali, Sadia Shakoor, Rumina Hasan

Department of Pathology and Laboratory Medicine

Background:
Duration of digestion/decontamination has a considerable impact on yield of mycobacteria especially from sterile body fluids and pus specimens. Additionally, duration of digestion/decontamination affects the contamination rates. This study evaluates the effect of digestion/decontamination protocol for 15 and 20min versus inoculation of media directly from the sample on contamination rates as well as the yield of mycobacteria from pus and sterile fluids other than cerebrospinal fluids.
Methods:
Pleural fluid (n=60), pus (n=48) and ascitic fluid (n=12) specimens were cultured for mycobacteria and evaluated for contamination and mycobacterial yield using three different processing methodologies: without digestion/decontamination with 5% NaOH-NALC (D/D), …


Strategic Agility Dimensions And Adapted In Business Organizations: Field Research Analytical In Asiacell Mobile Telecommunications, Sana Abdul Saeed Abadi, Ola Fadhil Dec 2016

Strategic Agility Dimensions And Adapted In Business Organizations: Field Research Analytical In Asiacell Mobile Telecommunications, Sana Abdul Saeed Abadi, Ola Fadhil

Journal of Economics and Administrative Sciences

This reaserch seeks To answer Wondering :(Is there a possibility employ strategic agility In companies sample Serving in Iraq ?). This aims is to explore Strategic Agility rely upon Dimensions that interact with each other to form the intcllectual frame Strategic Agility, These dimensions are: (Clarity of vision, Selected Strategic Targets , Core capacities, Shared responsibility, Taking action, Empowerment, Organic Structure, Planning Strategy, Organizational learning, Information technology, Human resourse management , Organized). The study was based on the case study method for mobile communications sector in my company) Zain and Asiacell (and has been used questionnaire to collect data, hypotheses …


Organizational Ethnography And Its Reflection In The Resonant Leadership Case Study At The University Of Kufa, Laith Ali Al-Hakim, Laith Zuhair Alsakafi, Essam Aliwi Al-Obeidi Dec 2016

Organizational Ethnography And Its Reflection In The Resonant Leadership Case Study At The University Of Kufa, Laith Ali Al-Hakim, Laith Zuhair Alsakafi, Essam Aliwi Al-Obeidi

Journal of Economics and Administrative Sciences

The purpose of this research is to investigate the relationship between organizational ethnography and resonant leadership in the University of Kufa, importance of research includes rare of studies that investigated the relationship between organizational ethnography and resonant leadership. Moreover, it comes as an attempt to reduce or bridge the knowledge gap between the variables of the research. As well as try to put the right foundations and appropriate for industry leaders of various Iraqi organizations aimed at profit or service. Based on the random sampling, 450 questionnaires were distributed to employees at the University of Kufa. Only 392 questionnaires were …


Black-White Disparities In Criminal Justice Referrals To Drug Treatment: Addressing Treatment Need Or Expanding The Diagnostic Net?, Karen Mcelrath, Angela Taylor, Kimberly K. Tran Dec 2016

Black-White Disparities In Criminal Justice Referrals To Drug Treatment: Addressing Treatment Need Or Expanding The Diagnostic Net?, Karen Mcelrath, Angela Taylor, Kimberly K. Tran

College of Humanities and Social Sciences

Slightly more than half of admissions to U.S. publicly-funded treatment for marijuana use are referred by the criminal justice system; this pattern has remained for at least 20 years. Nationally, Blacks comprise nearly a third of treatment admissions for marijuana use. This article explores the interplay between race and criminal justice referrals to treatment for marijuana use. Using data from the (U.S.) 2011 Treatment Episode Data Set, we examine the relationship between race and diagnosis of cannabis use disorder (dependence versus abuse) among referrals to community-based treatment in North Carolina. We compare Black/White differences in cannabis diagnoses across four referral …


Investigating The Highest Melting Temperature Materials: A Laser Melting Study Of The Tac-Hfc System, Omar Cedillos-Barraza, Dario Manara, K. Boboridis, Tyson Watkins, Salvatore Grasso, Daniel D. Jayaseelan, Rudy J. M. Konings, Michael J. Reece, William E. Lee Dec 2016

Investigating The Highest Melting Temperature Materials: A Laser Melting Study Of The Tac-Hfc System, Omar Cedillos-Barraza, Dario Manara, K. Boboridis, Tyson Watkins, Salvatore Grasso, Daniel D. Jayaseelan, Rudy J. M. Konings, Michael J. Reece, William E. Lee

Mechanical and Aerospace Engineering Student Publications and Presentations

TaC, HfC and their solid solutions are promising candidate materials for thermal protection structures in hypersonic vehicles because of their very high melting temperatures (>4000 K) among other properties.  The melting temperatures of slightly hypostoichiometric TaC, HfC and three solid solution compositions (Ta1−xHfxC, with x = 0.8, 0.5 and 0.2) have long been identified as the highest known. In the current  research, they were reassessed, for the first time in the last fifty years, using a laser heating technique.  They were found to melt in the range of 4041–4232 K, with HfC having the highest and TaC the lowest. …


Assessing The Impact Of The Sunwise Program On Youth Sun Safety Knowledge, Attitudes, And Behaviors In Clark County, Nevada, Sabina Malik Dec 2016

Assessing The Impact Of The Sunwise Program On Youth Sun Safety Knowledge, Attitudes, And Behaviors In Clark County, Nevada, Sabina Malik

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: Skin Cancer rates in Nevada continue to increase and remain above the

national average. One important method to combat rising rates is education related to the

prevention of sunburns, the main risk factor for developing skin cancer. This study aimed

to assess the impact of the SunWise Program, a sun safety education program developed

by the Environmental Protection Agency, to increase knowledge, improve attitudes, and

change behaviors of participants based on constructs of the Health Belief Model.

Methods: Participants included youth from ages 7-18 years old who attended 6 Boys and

Girls Clubs of Southern Nevada. Boys and Girls …


From Novice To Independent Researcher: A Content Analysis Of Phd Student Blogs, Sarah J. Cox Dec 2016

From Novice To Independent Researcher: A Content Analysis Of Phd Student Blogs, Sarah J. Cox

Dissertations

The work of completing a PhD is complex, requiring a student to make sense of many uncertain processes in multiple contexts as they move toward independent scholarship. A setting that provides support in learning the tasks of PhD-related work is the informal learning environment of the Internet. Social media sites, such as blogs and wikis, supply a vast number of resources related to PhD work. Of particular interest to this study, are blog sites maintained by students who are sharing practices related to PhD work. It is possible to use a qualitative method to explore what blogs show us about …


An Investigation Of Perceived Principal Stress And Its Impact On Principals In Southwest Georgia, Dorothy Young Ingram Dec 2016

An Investigation Of Perceived Principal Stress And Its Impact On Principals In Southwest Georgia, Dorothy Young Ingram

Theses and Dissertations

The purpose of the study was to determine to what extent southwest Georgia principals perceive they are stressed, identify principal stressors and how the stressors impact the principals’ work. Principals are leaders of school building who are experiencing increased stress. Therefore; it is important to understand what causes principal stress as well as how the stressors impact principal work. Principals are expected to maintain building safety, student safety, student achievement, retention of quality teachers, as well as act as instructional leaders. The mixed method study of public elementary school principals was conducted in four southwest Georgia school districts. The researcher …


The Court Of Appeals As The Middle Child, Raymond Lohier Dec 2016

The Court Of Appeals As The Middle Child, Raymond Lohier

Fordham Law Review

It’s said that middle children are most likely to be forgotten in the chaos of family life. The same could be said of the U.S. Courts of Appeals, which in 2016, mark their 125th anniversary, and which are the middle child of the federal judicial family. As too few people, even academics, know, the courts of appeals were created in 1891 by the Evarts Act, more than a century after the Constitution and the First Judiciary Act. The history of the courts of appeals has accordingly hovered somewhat uneasily next to that of the U.S. Supreme Court and the district …


Rethinking Presidential Eligibility, Eugene D. Mazo Dec 2016

Rethinking Presidential Eligibility, Eugene D. Mazo

Fordham Law Review

Many aspiring American Presidents have had their candidacies challenged for failing to meet the Constitution’s eligibility requirements. Although none of these challenges have ever been successful, they have sapped campaigns of valuable resources and posed a threat to several ambitious men. This Article examines several notable presidential eligibility challenges and explains why they have often been unsuccessful. The literature on presidential eligibility traditionally has focused on the Eligibility Clause, which enumerates the age, residency, and citizenship requirements that a President must satisfy before taking office. By contrast, very little of it examines how a challenge to one’s candidacy impacts a …


Time To End Presidential Caucuses, Sean J. Wright Dec 2016

Time To End Presidential Caucuses, Sean J. Wright

Fordham Law Review

Following the 2016 election cycle, there will be a great opportunity to implement reform. A major change should be to move away from presidential caucuses. They persist with, in the words of John Oliver, “complex, opaque rules.” These complex rules, which include participating in person for over an hour, negatively impacts participation in the electoral process. For example, in 2012, “participation rates in the Republican Party’s caucuses averaged 3 percent.” 3 percent. Compellingly, PolitiFact has observed that “[c]aucuses and delegate math can be incredibly confusing, and the arcane party structures don’t reflect how most people assume presidential selection works.” Yet, …


Ground-Penetrating Radar Water Content Mapping Of Golf Course Green Sand Layers, Barry J. Allred, Robert S. Freeland, Katherine R. Grote, Edward L. Mccoy, Luis R. Martinez, Debra L. Gamble Dec 2016

Ground-Penetrating Radar Water Content Mapping Of Golf Course Green Sand Layers, Barry J. Allred, Robert S. Freeland, Katherine R. Grote, Edward L. Mccoy, Luis R. Martinez, Debra L. Gamble

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Information on the spatial distribution of water content across the sand layer component of a golf course green can be important to golf course superintendents for evaluating drainage effectiveness and scheduling irrigation. To estimate the bulk volumetric water content of the sand layer at point locations across the green, a technique was developed that combined (1) depth (or thickness) of the sand layer measured with a steel shaft tile probe, (2) radar signal two-way travel time from the base of the sand layer obtained using a ground-penetrating radar (GPR) system with 900 MHz antennas, and (3) an empirical equation relating …


The Question Concerning Technology In Compliance, Sean J. Griffith Dec 2016

The Question Concerning Technology In Compliance, Sean J. Griffith

Brooklyn Journal of Corporate, Financial & Commercial Law

In this symposium Essay, I apply insights from philosophy and psychology to argue that modes of achieving compliance that focus on technology undermine, and are undermined by, modes of achieving compliance that focus on culture. Insisting on both may mean succeeding at neither. How an organization resolves this apparent contradiction in program design, like the broader question of optimal corporate governance arrangements, is highly idiosyncratic. Firms should therefore be accorded maximum freedom in designing their compliance programs, rather than being forced by enforcement authorities into a set of de facto mandatory compliance structures.


Like A Bad Neighbor, Hackers Are There: The Need For Data Security Legislation And Cyber Insurance In Light Of Increasing Ftc Enforcement Actions, Jennifer Gordon Dec 2016

Like A Bad Neighbor, Hackers Are There: The Need For Data Security Legislation And Cyber Insurance In Light Of Increasing Ftc Enforcement Actions, Jennifer Gordon

Brooklyn Journal of Corporate, Financial & Commercial Law

Privacy has come to the forefront of the technology world as third party hackers are constantly attacking companies for their customers’ data. With increasing instances of compromised customer information, the Federal Trade Commission (FTC) has been bringing suit against companies for inadequate data security procedures. The FTC’s newfound authority to bring suit regarding cybersecurity breaches, based on the Third Circuit’s decision in FTC v. Wyndham Worldwide Corp., is a result of inaction—Congress has been unable to pass sufficient cybersecurity legislation, causing the FTC to step in and fill the void in regulation. In the absence of congressional action, this self-proclaimed …


The Cybersecurity Threat: Compliance And The Role Of Whistleblowers, Jennifer M. Pacella Dec 2016

The Cybersecurity Threat: Compliance And The Role Of Whistleblowers, Jennifer M. Pacella

Brooklyn Journal of Corporate, Financial & Commercial Law

In today’s technologically dependent world, concerns about cybersecurity, data breaches, and compromised personal information infiltrate the news almost daily. The Securities and Exchange Commission (SEC) has recently emerged as a regulator that is keenly focused on cybersecurity, specifically with respect to encouraging disclosures in this arena by regulated entities. Although the SEC has issued non-binding “guidance” to help companies navigate their reporting obligations in this sector, the agency lacks binding cybersecurity disclosure regulations as they pertain generally to public companies. Given that the SEC has already relied on such guidance in threatening enforcement actions, reporting companies are increasingly pressured for …


Preserving Human Agency In Automated Compliance, Onnig H. Dombalagian Dec 2016

Preserving Human Agency In Automated Compliance, Onnig H. Dombalagian

Brooklyn Journal of Corporate, Financial & Commercial Law

As technology transforms financial services, so too must it transform the regulation of financial markets and intermediaries. The imperative of real-time, prophylactic regulation increasingly compels reallocation of regulatory and compliance budgets to surveillance and enforcement technology. At the same time, in light of the well-known weaknesses of automated systems, securities firms (and their regulators) must temper investment in automation with efforts to augment the agency of compliance professionals. This symposium contribution considers how investment in the professional development of compliance personnel can better integrate automated tools within established compliance and supervisory structures and thereby advance regulatory and operational objectives.


Understanding Wellness International Network, Ltd. V. Sharif: The Problems With Allowing Parties To Impliedly Consent To Bankruptcy Court Adjudication Of Stern Claims, Elizabeth Jackson Dec 2016

Understanding Wellness International Network, Ltd. V. Sharif: The Problems With Allowing Parties To Impliedly Consent To Bankruptcy Court Adjudication Of Stern Claims, Elizabeth Jackson

Brooklyn Journal of Corporate, Financial & Commercial Law

The 2011 Supreme Court case Stern v. Marshall defined which claims bankruptcy courts had the authority to adjudicate, but it’s complicated holding left lower courts perplexed. Specifically, the Stern decision created “Stern claims”—claims that bankruptcy courts have the statutory, but not the constitutional, authority to adjudicate. Subsequent cases, such as Executive Benefits Insurance Agency v. Arkison and Wellness International Network, Ltd. v. Sharif, have grappled with whether Stern claims should be treated as “core” claims, which bankruptcy courts can enter final judgments on, or “non-core” claims, which bankruptcy courts can only enter final judgments on if the litigating parties consent. …


The Role Of Streptococcus Gallolyticus Subspecies Gallolyticus In Colon Cancer Development, Jennifer L. Herold Dec 2016

The Role Of Streptococcus Gallolyticus Subspecies Gallolyticus In Colon Cancer Development, Jennifer L. Herold

Dissertations and Theses (Open Access)

Colorectal cancer (CRC) is the third most common cancer in men and women and is also the third most common cause of cancer death. A large body of evidence points towards the possibility that bacteria can have a significant impact on the development of cancer. It has been suggested that Streptococcus gallolyticus subsp. gallolyticus, a group D streptococci, may play a role in the development of CRC. Sg, formerly S. bovis biotype I, has been shown to be highly associated with CRC. In observing patients with either Sg bacteremia or endocarditis it was found that 25-80% of …


Concomitant Targeting Of The Mtor/Mapk Pathways: Novel Therapeutic Strategy In Subsets Of Non-Small Cell Lung Cancer, Dennis Ruder Dec 2016

Concomitant Targeting Of The Mtor/Mapk Pathways: Novel Therapeutic Strategy In Subsets Of Non-Small Cell Lung Cancer, Dennis Ruder

Dissertations and Theses (Open Access)

Over the last decade, a paradigm-shift in lung cancer therapy has evolved into targeted-driven medicinal approaches. However, patients frequently relapse and develop resistance to available therapies. Herein, we utilized genomic mutation data from advanced chemorefractory non-small cell lung cancer (NSCLC) patients enrolled in the Biomarker-Integrated Approaches of Targeted Therapy for Lung Cancer Elimination (BATTLE-2) clinical trial to characterize novel actionable genomic alterations potentially of clinical relevance. We identified RICTOR alterations (mutations, amplifications) in 17% of lung adenocarcinomas and found RICTOR expression correlates to worse overall survival. There was enrichment of MAPK pathway genetic aberrations in key oncogenes (e.g. KRAS, BRAF, …


Characterization Of Vesicular Monoamine Transporter 2 And Its Role In Parkinson's Disease Pathogenesis Using Drosophila, Antonio Joel Tito Jr., Sheng Zhang Dec 2016

Characterization Of Vesicular Monoamine Transporter 2 And Its Role In Parkinson's Disease Pathogenesis Using Drosophila, Antonio Joel Tito Jr., Sheng Zhang

Dissertations and Theses (Open Access)

Parkinson’s disease (PD) is a progressive neurodegenerative disorder caused by the selective loss of the dopaminergic neurons in the Substantia nigra pars compacta region of the brain. PD is also the most common neurodegenerative disorder and the second most common movement disorder. PD patients exhibit the cardinal symptoms, including tremor of the extremities, rigidity, slowness of movement, and postural instability, after 70-80% of DA neurons degenerate. It is, therefore, imperative to elucidate the underlying mechanisms involved in the selective degeneration of DA neurons. Although increasing numbers of PD genes have been identified, why these largely widely expressed genes induce …


Her4 Promotes A Stem-Like Phenotype In Osteosarcoma, Rocio K. Rivera-Valentin Dec 2016

Her4 Promotes A Stem-Like Phenotype In Osteosarcoma, Rocio K. Rivera-Valentin

Dissertations and Theses (Open Access)

Metastatic disease to the lungs is the primary cause of death for patients with pediatric osteosarcoma (OS). OS has a high degree of heterogeneity and genomic instability, making understanding the pathogenesis and drivers of metastasis of this disease challenging. In an effort to explain tumoral heterogeneity, the tumor initiating cell model (TIC) states that tumors are composed of cells that form the majority of the tumor and are terminally differentiated. This model however, attributes tumorigenesis, metastasis and chemoresistance to a distinct cell population with a stem-like phenotype that can be identified using selective markers. OS appears to follow this model …


Organ Specific Vascular Response To Fibrosis Affects Breast Cancer Metastatic Organotropism, Eliot S. Fletcher, Eliot S. Fletcher Dec 2016

Organ Specific Vascular Response To Fibrosis Affects Breast Cancer Metastatic Organotropism, Eliot S. Fletcher, Eliot S. Fletcher

Dissertations and Theses (Open Access)

The solid tumor microenvironment, pre-metastatic niche, and fibrotic environment are known to have significant biochemical and biomechanical similarities to the fibrotic environment. All have significantly increased levels of factors such as TGFβ, HIF1α, TNFα, PDGF, VEGF, FGF, interleukins and other growth factors that are known to be pro-tumorigenic. Clinical and basic science research has shown that fibrosis presents an environment that favors tumor growth, such as hepatocellular carcinoma being commonly preceded by liver cirrhosis, or bleomycin induced lung fibrosis enhancing pulmonary metastasis in mouse models of breast cancer. In addition to the evidence indicating that fibrosis enhances primary tumor growth …