Digital Commons Network^™

Critical Quality Attributes Of Topical Semi-Solid Dosage Forms: Solvent Activity, Muralikrishnan Angamuthu

Electronic Theses and Dissertations

Critical quality attribute has been defined as “a physical, chemical, biological or microbiological property or characteristic that should be within an appropriate limit, range, or distribution to ensure the desired product quality”. Deviations from preset quality metrics may potentially result in drug products with inferior therapeutic efficacy and unacceptable clinical safety profile. Topical cream formulations may possess numerous quality attributes that can affect the permeation of the drug through skin and consequently therapeutic efficacy. CQAs of topical formulations are often aimed at characterizing either the physicochemical properties of APIs or bulk characteristics of the formulation itself. Solvent systems constitute a …

Hot-Melt Extrusion: A Versatile Pharmaceutical Technology, Hemlata Patil

Electronic Theses and Dissertations

Hot-melt extrusion (HME) is a promising technology for the production of new chemical entities in the developmental pipeline and for improving products already on the market. The first objective of this research work was to describe a continuous process for the production of solid lipid nanoparticles (SLN) as drug-carrier systems via hot-melt extrusion (HME) using Quality by Design (QbD) principles. Fenofibrate SLN were prepared by combining two processes: HME technology for melt-emulsification and high-pressure homogenization (HPH) for size reduction. Varying the process parameters enabled the production of SLN below 200 nm. At the end of a 5-h in-vitro dissolution study, …

Nlpc/P60 Domain-Containing Proteins Of Mycobacterium Avium Subspecies Paratuberculosis That Differentially Bind And Hydrolyze Peptidoglycan, J. P. Bannantine, Cari K. Lingle, Philip R. Adam, Kasra X. Ramyar, William J. Mcwhorter, William D. Picking, Brian V. Geisbrecht

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

A subset of proteins containing NlpC/P60 domains are bacterial peptidoglycan hydrolases that cleave noncanonical peptide linkages and contribute to cell wall remodeling as well as cell separation during late stages of division. Some of these proteins have been shown to cleave peptidoglycan in Mycobacterium tuberculosis and play a role in Mycobacterium marinum virulence of zebra fish; however, there are still significant knowledge gaps concerning the molecular function of these proteins in Mycobacterium avium subspecies paratuberculosis (MAP). The MAP genome sequence encodes five NlpC/P60 domain-containing proteins. We describe atomic resolution crystal structures of two such MAP proteins, MAP_1272c and MAP_1204. These …

Vapor Deposited Cr-Doped Zns Thin Films: Towards Optically Pumped Mid-Infrared Waveguide Lasers, Eric A. Karhu, Charles R. Ildstad, Stefano Poggio, Vedran Furtula, Nikolai Tolstik, Irina T. Sorokina, Joseph J. Belbruno, Ursula J. Gibson

Dartmouth Scholarship

Compact, affordable mid-IR lasers require the development of gain materials in waveguide form. We report on the high vacuum deposition of Cr:ZnS films with concentration ranging from 10¹⁸-10²⁰ dopants/cm³ . At low concentrations, films display well-isolated absorption associated with substitutional Cr²⁺ ions in the lattice. Spatial modulation of the dopant concentration suppresses the absorption associated with this substitution. Lateral crystallite sizes less than 30 nm are associated with the lowest substrate temperatures (<50 °C) used during deposition, and waveguide losses as low as 8dB/cm are observed. These materials are promising candidates as gain media for fabrication of waveguide mid-IR lasers.

Subreption, Radical Institutionalism, And Evolutionary Economics, John B. Hall, Alexander Dunlap, Joe Mitchell-Nelson

Economics Faculty Publications and Presentations

This inquiry seeks to establish the importance of subreption as an approach to economic and social evolution that also proves integral to the tradition of radical institutionalism. We relate subreption’s etymology and appearances in Roman, Canon and Scots Law, as well as in Philosophy, to its applications found in writings advanced by Thorstein Veblen and carried on later as William Dugger details the rise of corporate hegemony. Understood as an approach derivable from selected philosophical writings of Immanuel Kant, in social science subreption is suggested to occur through the introduction of an outside value that sets off a form of …

A Comparison Of Shovel Testing And Surface Collection As Archaeological Site Discovery Methods: A Case Study Using Mississippian Farmsteads, Cameron Smith Howell

Electronic Theses and Dissertations

Shovel testing and controlled surface collection are commethods of archaeological site investigation that are generally approved by state and federal agencies as well as the academic community for cultural resource management projects and research. While both techniques are equally utilized, little research has been conducted on how equivalent these techniques are in terms of their efficacy for finding site. This thesis seeks to find a way to compare these techniques by creating mathematical models to describe how well the methods behave when tested on known datasets generated from Mississippian period farmsteads. The predicted performance can then be compared to real …

Localization And Mapping Of Unknown Locations And Tunnels With Unmanned Ground Vehicles, Doris Turnage

Electronic Theses and Dissertations

The main goals of this research were to enhance a commercial off the shelf (COTS) software platform to support unmanned ground vehicles (UGVs) exploring the complex environment of tunnels, to test the platform within a simulation environment, and to validate the architecture through field testing. Developing this platform will enhance the U. S. Army Engineering Research and Development Center’s (ERDC’s) current capabilities and create a safe and efficient autonomous vehicle to perform the following functions within tunnels: (1) localization (e.g., position tracking) and mapping of its environment, (2) traversing varied terrains, (3) sensing the environment for objects of interest, and …

Rain Induced Runoff Simulation Using A 2d Numerical Model, Tahmina Shirmeen

Electronic Theses and Dissertations

Runoff plays an important role in the agricultural and urbanized environments. Surface runoff is determined primarily by the amount of precipitation and by infiltration characteristics related to soil type, soil moisture, antecedent rainfall, land cover type, impervious surfaces, and surface retention. In this study, CCHE2D, a numerical model for free surface flow hydrodynamics, is applied to study the rain induced runoff and channel flow mixed problems. The main goal of this study is to incorporate rainfall as an input into the existing free surface flow model, CCHE2D; to verify and validate the CCHE2D model’s runoff simulation capability using analytical solutions …

Remobilization Of Cobalt, Copper, Nickel, Lead, And Zinc In A Riparian Wetland Model, Richard Glenn Dolly

Electronic Theses and Dissertations

The mobility of chemically persistent metals in riparian wetland systems that could have a detrimental impact on the environment is an area of active research. This study utilized a physical model consisting of open water and wetland cells designed to simulate a natural riparian wetland to examine the mobility of five metals. The objective of the study was to determine if riparian wetlands have the potential to serve as permanent sinks for metals, or if they only serve as temporary sinks and with time metals could be remobilized and released. Specifically, this study examined the long-term behavior of Co, Cu, …

On Topological Indices And Domination Numbers Of Graphs, Shaohui Wang

Electronic Theses and Dissertations

Topological indices and dominating problems are popular topics in Graph Theory. There are various topological indices such as degree-based topological indices, distance-based topological indices and counting related topological indices et al. These topological indices correlate certain physicochemical properties such as boiling point, stability of chemical compounds. The concepts of domination number and independent domination number, introduced from the mid-1860s, are very fundamental in Graph Theory. In this dissertation, we provide new theoretical results on these two topics. We study k-trees and cactus graphs with the sharp upper and lower bounds of the degree-based topological indices(Multiplicative Zagreb indices). The extremal cacti …

Development Of A Dynamic Coupled Hydro-Geomechanical Code And Its Application To Induced Seismicity, Md Mamun Miah

Electronic Theses and Dissertations

No abstract provided.

Bacteria Prediction For Recreational Waters Through The Use Of Artificial Neural Networks, Christopher Douglas

Electronic Theses and Dissertations

Many scientists and government agencies rely on Fecal Indicator Bacteria (FIB) to determine the risk of exposure to pathogens in water. If there is a presence of these indicator bacteria, pathogenic microorganisms may also be present. These bacteria in recreational water bodies pose a health threat to people if ingested during activities such as swimming or from the consumption of marine life. The most commonly tested FIBs are total coliforms, Fecal coliforms, Escherichia coli, Fecal streptococci, and enterococci. The measurement of bacteria can be time consuming (up to 48 hours) and expensive, creating a difficulty in warning the public of …

What Tutor Researchers And Their Mentors Tell Us About Undergraduate Research In The Writing Center: An Exploratory Study, Christopher Ervin

The Writing Center Journal

No abstract provided.

Development Of Nanoelectrodes For Electrochemical Applications, Séan Barry

Theses

The demand for direct, selective and rapid determination of chemical and biological analytes has led to a growing interest in electrochemical sensor devices. Particularly the use of nanomaterials and nanoelectrodes has received increased interest due to their enhanced electrochemical properties. In this thesis these enhanced properties are exploited in order to develop multiple sensing applications.

Firstly a sensitive microband based sensor is described for the detection of trinitrotoluene and for its discrimination from other nitroaromatic compounds. Square wave voltammetry was used to identify characteristic reduction peaks for these compounds and a calibration plot for the quantification of TNT was also …

Ultrashort Pulse Generation In Inas Quantum Dot Semiconductors, Patrick Finch

Theses

In this thesis, the effect of operating two-section InAs quantum dot passively mode- locked semiconductor lasers in the random population regime is examined in detail in an attempt to achieve wide optical bandwidths and ultrashort optical pulses. It is demonstrated in this work that large increases in optical bandwidths can be observed in the random population regime. Random population was achieved with an undoped device by lowering the operating temperature to 20 K. An emission bandwidth of 27 nm was measured using an undoped device at 20 K, with corresponding pulses of 290 fs, shorter than any previously reported with …

Emission Properties And Carrier Dynamics Of Iii-V Nanostructures For Next Generation Photonic Devices, Katarzyna Komolibus

Theses

A majority of modern day applications, ranging from telecommunications, charge storage memories and solar cells to more recently silicon photonics, have at their core compound semiconductor based optoelectronic devices. Particular attention has focused on the use of Group-III and Group-V elements in these devices and thus drives a desire for improved understanding. This thesis therefore studies a variety of novel III-V nanostructures, which have shown immense promise for inclusion in next-generation photonic devices, examining in detail these structures in terms of their optical properties and inherent carrier dynamics.

Backward Dijkstra Algorithms For Finding The Departure Time Based On The Specified Arrival Time For Real-Life Time-Dependent Networks, Gelareh Bakhtyar, Vi Nguyen, Mecit Cetin, Duc Nguyen

Civil & Environmental Engineering Faculty Publications

A practical transportation problem for finding the “departure” time at “all source nodes” in order to arrive at “some destination nodes” at specified time for both FIFO (i.e., First In First Out) and Non-FIFO “Dynamic ” Networks is considered in this study. Although shortest path (SP) for dynamic networks have been studied/documented by various researchers, contributions from this present work consists of a sparse matrix storage scheme for efficiently storing large scale sparse network’s connectivity, a concept of Time Delay Factor (TDF) combining with a “general piece- wise linear function” to describe the link cost as a function of time …

Temporal Variations Of Streamflow In A Mid-Latitude Eurasian Steppe Watershed In The Past Half Century, Xixi Wang

Civil & Environmental Engineering Faculty Publications

Previous studies either did not identify abrupt change or identified such change but did not exclude it from the detection of trend in streamflow. As a result, an overall downward trend might be erroneously detected as an upward trend because of abrupt increase, while an overall upward trend could be faked as a downward trend due to abrupt decrease. The objectives of this study were to: (1) present a methodology to analyze trend in streamflow in the presence of abrupt change; and (2) use this methodology to detect trend and extreme occurrence of streamflow in the Upper Balagaer River watershed, …

Social Acceptance Of Renewable Energy : Exploring A Citizen Centric Paradigm, Paul O'Brien

Theses

The energy landscape in Ireland is being transformed. Energy policy is geared towards substantially decarbonising the electricity system by 2050. The implementation of large scale renewable energy generation remains a key policy objective. The scale of the transformation presents challenges in terms of policy and technology, as well as social acceptance.

This study was conducted to explore social acceptance of renewable energy within the context of a broader energy transition. A concurrent mixed method design integrates three distinct strands of primary research. A series of semi-structured interviews with multidisciplinary energy professionals explored contemporary social issues, from a developer, utility and …

Cloud Practical Exam Invigilation Control Systems With The Objective Of Enhancing Quality Control For Online Exams, Gordon O'Reilly

Theses

Online cloud computing courses are becoming more common place facilitating a student to study from home from anywhere in the world. Coupled with this trend is a need for educational institutions to facilitate students to take tests or exams online from home. It reduces the remote student’s time and cost of travel to an exam invigilation centre as well as reducing the educational institution’s test administration overhead. It does however introduce potential quality control concerns. A new industry called online proctoring has emerged that attempts to provide quality control in these online test scenarios.

This research provides an insight into …

Beneficial Reuse Of Marine Sediment, Sinead Tangney

Theses

Dredging is essential for ports and harbours to maintain navigational access. In Ireland approximately 1.2 million m^ is dredged annually and the management of this dredged sediment is an ongoing issue. This thesis investigates the management options available for marine dredged sediment and examines the technical, environmental and economic feasibility and social acceptability of a range of specific beneficial uses of marine sediment.

A literature review is presented on the international dredging industry and outlines why dredging is an essential infrastructural activity. Current dredged marine sediment management techniques are presented and discussed.

An overview of the Irish dredging industry is …

Exploration And Implementation Of Innovative Efficiencies/Devices In Beet Processing For Energy Production, Patrick Mcinerney

Theses

The imminent depletion of fossil fuels, as well as concerns for energy security and the obligation to respond to climate change has led to expanding worldwide popularity of Anaerobic Digestion (AD) of energy crops. Sugar beet is a popular AD feedstock due to its favourable characteristics; however it can be quite labour intensive requiring a range of specialist equipment to process the crop prior to undergoing AD. A crucial stage of this process involves the size reduction of beet by a mechanical chopper unit; this pretreatment breaks open the cellulose structure of the crop and increases the surface area available …

Doing Qualitative Research Online Book Review, Donna M. Busarow

Journal of Social, Behavioral, and Health Sciences

A recent addition to qualitative instruction is Salmon's (2016) book, Doing Qualitative Research Online. This book review examines the book as an educational tool for student researchers.

Nebraska Summary: S1061 Massey Ferguson 7716, Nebraska Tractor Test Lab

Nebraska Tractor Tests

ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …

Nebraska Summary: S1056 New Holland T7.315, Nebraska Tractor Test Lab

Nebraska Tractor Tests

ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …

Nebraska Summary: S1057 Massey Ferguson 7714, Nebraska Tractor Test Lab

Nebraska Tractor Tests

ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …

Nebraska Summary: S1031 Challenger Mt565e, Nebraska Tractor Test Lab

Nebraska Tractor Tests

ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …

Nebraska Summary: S1033 Challenger Mt585e, Nebraska Tractor Test Lab

Nebraska Tractor Tests

ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …

Nebraska Summary: S1029a Massey Ferguson 7726s, Nebraska Tractor Test Lab

Nebraska Tractor Tests

ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …

Nebraska Summary: S1026 Massey Ferguson 7720, Nebraska Tractor Test Lab

Nebraska Tractor Tests

ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …