Digital Commons Network^™

Evidence Of Glycolysis Up-Regulation And Pyruvate Mitochondrial Oxidation Mismatch During Mechanical Unloading Of The Failing Human Heart: Implications For Cardiac Reloading And Conditioning, Nikolaos A. Diakos, Sutip Navankasattusas, E. Dale Abel, Jared Rutter, Lauren Mccreath, Peter Ferrin, Stephen H. Mckellar, Dylan V. Miller, Song-Young Park, Russell S. Richardson, Ralph Deberardinis, James E. Cox, Abdallah G. Kfoury, Craig H. Selzman, Joseph C. Fang, Dean Y. Li, Stavros Drakos

Health and Kinesiology Faculty Publications

This study sought to investigate the effects of mechanical unloading on myocardial energetics and the metabolic perturbation of heart failure (HF) in an effort to identify potential new therapeutic targets that could enhance the unloading-induced cardiac recovery. The authors prospectively examined paired human myocardial tissue procured from 31 advanced HF patients at left ventricular assist device (LVAD) implant and at heart transplant plus tissue from 11 normal donors. They identified increased post-LVAD glycolytic metabolites without a coordinate increase in early, tricarboxylic acid (TCA) cycle intermediates. The increased pyruvate was not directed toward the mitochondria and the TCA cycle for complete …

Regional Cooperation And Legal Protection To Indonesian Women Migrant Worker, Sukawarsini Djelantik

Indonesian Journal of International Law

The increasing number of Indonesian women migrant workers (IWMWs) started since 1997, and remain high after the global financial crisis in 2008. The impact for Indonesian economy is quite significant in terms of social and economy. Unemployment rate increased significantly as well as number of people living below poverty line. Social and family relations changed as women forced to work in public sectors to support family economy. Domestic job scarcity turned thousands of Indonesian women as family bread winner by working overseas. The above push factors are combines by increasing demands of IWMWs in the newly industrialized countries in Southeast …

Pyk2 Activates The Nlrp3 Inflammasome By Directly Phosphorylating Asc And Contributes To Inflammasome-Dependent Peritonitis, I-Che Chung, Chun-Nan Ouyang, Sheng-Ning Yuan, Hsin-Pai P. Li, Jeng-Ting Chen, Hui-Ru Shieh, Yu-Jen Chen, David M. Ojcius, Ching-Liang Chu, Jau-Song Yu, Yu-Sun Chang, Lih-Chyang Chen

All Dugoni School of Dentistry Faculty Articles

The inflammasome adaptor protein, ASC, contributes to both innate immune responses and inflammatory diseases via self-oligomerization, which leads to the activation of the protease, caspase-1. Here, we report that the cytosolic tyrosine kinases, FAK and Pyk2, are differentially involved in NLRP3 and AIM2 inflammasome activation. The inhibition of FAK and Pyk2 with RNA interference or chemical inhibitors dramatically abolished ASC oligomerization, caspase-1 activation, and IL-1β secretion in response to NLRP3 or AIM2 stimulation. Pyk2 is phosphorylated by the kinase Syk and relocalizes to the ASC specks upon NLRP3 inflammasome activation. Pyk2, but not FAK, could directly phosphorylate ASC at Tyr146, …

Clinical Narrative Classification Using Discriminant Word Embeddings With Elm, Paula Lauren, Guangzhi Qu, Feng Zhang, Amaury Lendasse

Engineering Management and Systems Engineering Faculty Research & Creative Works

Clinical Texts Are Inherently Complex Due to the Medical Domain Expertise Required for Content Comprehension. in Addition, the Unstructured Nature of These Narratives Poses a Challenge for Automatically Extracting Information. in Natural Language Processing, the Use of Word Embeddings Are an Effective Approach to Generate Word Representations (Vectors) in a Low Dimensional Space. in This Paper We Use a Log-Linear Model (A Type of Neural Language Model) and Linear Discriminant Analysis with a Kernel-Based Extreme Learning Machine (Elm) to Map the Clinical Texts to the Medical Code. Experimental Results on Clinical Texts Indicate Improvement with Elm in Comparison to Svm …

College Health Care Providers’ Student-Centered Care, Cheryl Ann Lambert, Julie Donovan

The Qualitative Report

Patient care in the university setting is indelibly connected to college health care providers. College health care providers adapt to a specific set of circumstances unique to the university context in their patient care roles. The authors therefore sought to investigate the patient care phenomenon from college health care providers’ lived experiences. The patient care phenomenon was explored via in-depth interviews with 11 college health care providers at universities in the Midwest and Northeast regions of the United States. The phenomenological theoretical framework of the study revealed five themes of patient care during data analysis: health education, behavioral health, student …

Innovations In Rural Health System Development: Maine's Behavioral Health Services, Amanda Burgess Mppm, Andrew F. Coburn Phd

Health System Reform

This series of briefs were produced by the Maine Health Access Foundation (MeHAF) in conjunction with the Maine Rural Health Research Center to describe robust and innovative models and strategies from Maine and other parts of the country related to the areas of health finance and payment, governance, workforce, and service delivery that have the potential to be replicated or adapted here in Maine.

Other briefs in this series:

• Moving Rural Health Systems to Value-Based Payment
• Recruiting and Retaining Maine's Health Care Workforce
• Governance
• Service Delivery Advances in Care Coordination, Emergency Care, and Telehealth
• Federally Qualified Health Center Initiatives

Learn …

Design And Optimization Of Solid Fermentation Of Porcine Blood Powder Medium For Clostridium Butyricum, Qin Dongfang, Liu Aimin, Li Hao

Food and Machinery

For the purpose of joint production of hydrolysis of porcine blood and microbial ecology preparation of Clostridium butyricum, it was studied that the solid medium formulation suitable for the growth and reproduction of C. butyricum was made of porcine blood powder, and the fermentation products would be used in feed. The formulation of the solid medium formulation was designed and optimized by the mean of mixture design. Moreover, the mathematical regression model of three components of solid medium was established, and the various components and the interaction between them were also discussed. Furthermore, the results showed that the optimum formula …

Computing And Applying Atomic Regulons To Understand Gene Expression And Regulation, Jose P. Faria, James J. Davis, Janaka N. Edirisinghe, Ronald C. Taylor, Pamela B. Weisenhorn, Robert D. Olson, Rick Stevens, Miguel Rocha, Isabel Rocha, Aaron A. Best, Matthew Dejongh, Nathan L. Tintle, Bruce Parrelo, Ross Overbeek, Christopher S. Henry

Faculty Work Comprehensive List

Understanding gene function and regulation is essential for the interpretation prediction and ultimate design of cell responses to changes in the environment. An important step toward meeting the challenge of understanding gene function and regulation is the identification of sets of genes that are always co-expressed. These gene sets Atomic Regulons ARs represent fundamental units of function within a cell and could be used to associate genes of unknown function with cellular processes and to enable rational genetic engineering of cellular systems. Here we describe an approach for inferring ARs that leverages large-scale expression data sets gene context and functional …

The Impact Of Sharps Injuries On Student Nurses: A Systematic Review, Kevin Hambridge, Andrew Nichols, Ruth Endacott

School of Nursing and Midwifery

No abstract provided.

Vitamin D Levels In Malnourished Children Under 5 Years In A Tertiary Care Center At Muhimbili National Hospital, Dar Es Salaam, Tanzania—A Cross-Sectional Study, Nahida Z. Walli, Emmanuel K. Munubhi, Said Aboud, Karim P. Manji

Paediatrics and Child Health, East Africa

Objective: To evaluate vitamin D levels/deficiency among malnourished children < 5 years admitted at a tertiary care center, the Muhimbili National Hospital, Dar es Salaam, Tanzania. Children with malnutrition may have co-existing vitamin D deficiency (VDD), which may be severe.

Methods: Serum vitamin D and alkaline phosphatase were evaluated, and X-ray of the wrist was carried out on 134 children.

Results: VDD was found in 41 of 134 children (30.6%). The mean vitamin D level was 74.8 nmol/l. The mean alkaline phosphatase level was 176.6 U/l. Sixty-four (48%) children were found to have severe stunting, of whom 20 (31.2%) were vitamin D deficient. Marasmic children had higher odds of VDD compared with other forms of malnutrition.

Conclusion: The high prevalence of VDD in malnourished children underlines the need for active surveillance …

Building Viral Replication Organelles: Close Encounters Of The Membrane Types, Peter D. Nagy, Jeroen R. P. M. Strating, Frank J. M. Van Kuppeveld

Plant Pathology Faculty Publications

Positive-strand (+)RNA viruses are important and emerging pathogens of humans, animals, and plants. Upon infection, they induce the formation of specialized membranous replication organelles with unique lipid composition to facilitate robust virus replication. In this article, the authors discuss the proviral role of virus-induced membrane contact sites (vMCSs). The emerging picture is that vMCSs channel lipids to viral membranes and tune the lipid composition for optimal generation and functioning of replication organelles.

2016-October-27-Rdc Study, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Signaling Through Lrg1, Rho1 And Pkc1 Governs Candida Albicans Morphogenesis In Response To Diverse Cues, Jinglin L. Xie, Nora Grahl, Trevor Sless, Michelle Leach, Sang Hu Kim, Deborah Hogan

Dartmouth Scholarship

The capacity to transition between distinct morphological forms is a key virulence trait for diverse fungal pathogens. A poignant example of a leading opportunistic fungal pathogen of humans for which an environmentally responsive developmental program underpins virulence is Candida albicans. C. albicans mutants that are defective in the transition between yeast and filamentous forms typically have reduced virulence. Although many positive regulators of C. albicans filamentation have been defined, there are fewer negative regulators that have been implicated in repression of filamentation in the absence of inducing cues. To discover novel negative regulators of filamentation, we screened …

An Examination Of Career Satisfaction For Medical Laboratory Professionals Using Wlodkowski's Motivational Framework, Kathleen Mcloughlin Kenwright

Electronic Theses and Dissertations Archive

Medical laboratory science professionals are healthcare practitioners who provide laboratory data that aids in the diagnosis, treatment, and prevention of disease. However, there is a large shortage of these professionals who perform the laboratory tests behind the scenes with very minimal patient contact. The purpose of this research was to determine which job features create motivation and career satisfaction to retain personnel in the medical laboratory profession. The four research questions which guided this study were based on Wlodkowski's theory of motivation: Is there a difference in perceived career satisfaction among medical laboratory scientists who: (a) feel more included by …

Volume 54, Number 11: October 26, 2016, University Of North Dakota

University Letter Archive

No abstract provided.

Addressing The Intersection Between Alcohol Consumption And Antiretroviral Treatment: Needs Assessment And Design Of Interventions For Primary Healthcare Workers, The Western Cape, South Africa, M. Schneider, M. Chersich, Marleen Temmerman, C. D. Parry

Obstetrics and Gynaecology, East Africa

Background: At the points where an infectious disease and risk factors for poor health intersect, while health problems may be compounded, there is also an opportunity to provide health services. Where human immunodeficiency virus (HIV) infection and alcohol consumption intersect include infection with HIV, onward transmission of HIV, impact on HIV and acquired immunodeficiency syndrome (AIDS) disease progression, and premature death. The levels of knowledge and attitudes relating to the health and treatment outcomes of HIV and AIDS and the concurrent consumption of alcohol need to be determined. This study aimed to ascertain the knowledge, attitudes and practices of primary …

Hiv And Aging: Global Implications For Social Care Of A Vulnerable Population, Mark Brennan-Ing

Aging Studies Institute

In the early 1980s when Human Immunodeficiency Virus (HIV), the cause Acquired Immune Deficiency Syndrome (AIDS), was first identified, life expectancy following diagnosis was approximately two years (Halkitis, 2013). With the advent of highly-active antiretroviral therapy (HAART) in the mid-1990s, life expectancy for people with HIV (PWH) increased sharply. PWH receiving HAART treatment shortly after diagnosis can now expect to live as long as uninfected individuals (van Sighem, Gras, Reiss, Brinkman, & de Wolf, 2010). As a result the population with HIV is aging. It is estimated that in 2015, 50% of PWH in the U.S. were age 50 and …

Prevalence Of Nasal Colonization By Methicillin-Resistant Staphylococcus Aureus In Persons Using A Homeless Shelter In Kansas City, Megan Ottomeyer, Charles D. Graham, Avery D. Legg, Elizabeth S. Cooper, Chad D. Law, Mariam Molani, Karine Matevossian, Jerry Marlin, Charlott Williams, Ramon E. Newman, Jason A. Wasserman, Larry Segars, Tracey A.H. Taylor

Student Publications

Nasal colonization of methicillin-resistant Staphylococcus aureus (MRSA) plays an important role in the epidemiology and pathogenesis of disease. Situations of close-quarter contact in groups are generally regarded as a risk factor for community-acquired MRSA strains due to transmission via fomites and person-to-person contact. With these criteria for risk, homeless individuals using shelter facilities, including showers and toilets, should be considered high risk for colonization and infection. The aim of this study was to determine the prevalence of nasal colonization of MRSA in a homeless population compared to established rates of colonization within the public and a control group of subjects …

An Unusual Case Of Escherichia Coli Meningitis And Bacteremia In An Elderly Woman Presenting With Intractable Low Back Pain, Andrea M. Lauffer, Mahmoud Shorman, Carl Mccomas

Marshall Journal of Medicine

Abstract

Introduction:

We report an unusual case of E. coli meningitis in an elderly woman who presented to the emergency room with a chief complaint of intractable low back pain.

Case Description:

A 67 year old woman presented to the emergency room for a chief complaint of intractable low back pain. After admission, the patient developed delirium. Blood cultures were drawn. Patient underwent a lumbar puncture which revealed purulent cerebrospinal fluid. Results of the cerebrospinal fluid and blood cultures revealed pan-sensitive E. coli.

Conclusion:

In the geriatric population, delayed presentation of meningitis can occur for various reasons. With the older …

When It Isn’T Always Lyme: Expanding The Differential Diagnosis For Acute-Onset Polyarthralgia In The West Virginia Eastern Panhandle, Natalie A. Moffett, Rosemarie Lorenzetti

Marshall Journal of Medicine

This case presentation discusses a 36 year-old female animal care worker presenting with an acute-onset polyarthropathy during the summer months in a Lyme endemic region. Though she appeared to be a good candidate for the diagnosis of Lyme borreliosis, her screening serology reported negative results and alternative diagnoses were considered. Her subsequent diagnosis with parvovirus B19 acts to remind the general practitioner to have confidence in the accuracy of a negative Lyme screen and, upon negative result, to expand the differential to include less common infections including parvovirus B19. It also highlights the need to remember parvovirus B19 in a …

Privacy's Place At The Table: A Reflection On Richard Turkington's Approach To Valuing And Balancing Privacy Interests, Doris Deltosto Brogan

Villanova Law Review (1956 - )

No abstract provided.

Airborne Infectious Agents And Other Pollutants In Automobiles For Domestic Use: Potential Health Impacts And Approaches To Risk Mitigation, Syed A. Sattar, Kathryn E. Wright, Bahram Zargar, Joseph R. Rubino, M. Khalid Ijaz

Publications and Research

Theworld total of passenger cars is expected to go fromthe current one billion to >2.5 billion by 2050. Cars for domestic use account for ∼74% of the world’s yearly production ofmotorized vehicles. In North America, ∼80% of the commuters use their own car with another 5.6% travelling as passengers.With the current life-expectancy of 78.6 years, the average North American spends 4.3 years driving a car! This equates to driving 101 minutes/day with a lifetime driving distance of nearly 1.3 million km inside the confined and often shared space of the car with exposure to a mix of potentially harmful pathogens, …

Sociodemographic Factors Associated With Igg And Igm Seroprevalence For Human Cytomegalovirus Infection In Adult Populations Of Pakistan: A Seroprevalence Survey, Saira Ibrahim, Anwar Ali Siddiqui, Amna Siddiqui, Waquaruddin Ahmed, Paul A. H. Moss, El Nasir Lalani

Department of Biological & Biomedical Sciences

Background: The seroprevalence of human cytomegalovirus (HCMV) infection ranges from 30 to 90 % in developed countries. Reliable estimates of HCMV seroprevalence are not available for Pakistan. This study determined the seroprevalence and sociodemographic factors associated with HCMV infection in adult populations of Karachi, Pakistan.
Methods: A seroprevalence survey was conducted on 1000 adults, including residents of two semi-urban communities, and visitors to a government and a private hospital. Questionnaire-based interviews were conducted. Sera were analysed for HCMV-specific IgG and IgM. Chi-square or Fisher’s exact test was used for comparing sociodemographic variables against seropositivity of HCMV-IgG or IgM. Multiple logistic …

Ms 018 Guide To Saul Kit, Phd Papers (1958-1974), Saul Kit (1920-2008)

Manuscript Finding Aids

The Saul Kit, PhD papers contain research journals, reprints, copies, and an undated manuscript documenting his career in biochemistry. This collection focuses on his research published from 1958-1974. The collection consists of one box, equaling .25 cubic feet. The materials are in good condition. See more at MS 018.

What Makes A Prion: Infectious Proteins From Animals To Yeast, Kyle S. Maclea

Life Sciences Faculty Scholarship

While philosophers in ancient times had many ideas for the cause of contagion, the modern study of infective agents began with Fracastoro's 1546 proposal that invisible “spores” spread infectious disease. However, firm categorization of the pathogens of the natural world would need to await a mature germ theory that would not arise for 300 years. In the 19th century, the earliest pathogens described were bacteria and other cellular microbes. By the close of that century, the work of Ivanovsky and Beijerinck introduced the concept of a virus, an infective particle smaller than any known cell. Extending into the early–mid-20th century …

Synthesis, Structure And Antimicrobial Property Of Green Composites From Cellulose, Wool, Hair And Chicken Feather, Chieu D. Tran, Franja Prosenc, Mladen Franko, Gerald Benzi

Chemistry Faculty Research and Publications

Novel composites between cellulose (CEL) and keratin (KER) from three different sources (wool, hair and chicken feather) were successfully synthesized in a simple one-step process in which butylmethylimidazolium chloride (BMIm⁺Cl⁻), an ionic liquid, was used as the sole solvent. The method is green and recyclable because [BMIm⁺Cl⁻] used was recovered for reuse. Spectroscopy (FTIR, XRD) and imaging (SEM) results confirm that CEL and KER remain chemically intact and homogeneously distributed in the composites. KER retains some of its secondary structure in the composites. Interestingly, the minor differences in the structure of KER …

Volume 70 Issue 1 (Fall/Winter 2016)

Utah Science

2: What's on Your Plate?

When studying cancer in mice, USU researchers are starting with a “Western diet” and finding more connections between diet and health… good and bad.

5: Uncommon Hamsters Helping Fight Common Viruses

New genetically modified hamsters play an important role in studying human diseases caused by adenovirus, and may also be valuable in studies of Ebola, dengue and hanta viruses.

8: Science vs. Viruses

When viruses cause enough damage to make the news, it’s rarely “news” to scientists at the Institute for Antiviral Research. Learning how viruses work, and testing drugs to stop them, is what …

Detection Of Nucleic Acid Sequence Differences Using The Ligase Detection Reaction With Addressable Arrays, Francis Barany, George Barany, Robert P. Hammer, Maria Kempe, Herman Blok, Monib Zirvi

College of Science Patents

No abstract provided.

Interleukin-17a Promotes Cd8 T Cell Cytotoxicity To Facilitate West Nile Virus Clearance, Amber M. Paul, Dhiraj Acharya, Penghua Wang, Jianfeng Dai, David Gate

Publications

CD8 T cells are crucial components of immunity and play a vital role in recovery from West Nile virus (WNV) infection. Here, we identify a previously unrecognized function of interleukin-17A (IL-17A) in inducing cytotoxic-mediator gene expression and promoting CD8 T cell cytotoxicity against WNV infection in mice. We find that IL-17A-deficient (Il17a/) mice are more susceptible to WNV infection and develop a higher viral burden than wild-type (WT) mice. Interestingly, the CD8 T cells isolated from Il17a/ mice are less cytotoxic and express lower levels of cytotoxic-mediator genes, which can be restored by supplying recombinant IL-17A in vitro and in …

Online Cross-Validation-Based Ensemble Learning, David Benkeser, Samuel D. Lendle, Cheng Ju, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

Online estimators update a current estimate with a new incoming batch of data without having to revisit past data thereby providing streaming estimates that are scalable to big data. We develop flexible, ensemble-based online estimators of an infinite-dimensional target parameter, such as a regression function, in the setting where data are generated sequentially by a common conditional data distribution given summary measures of the past. This setting encompasses a wide range of time-series models and as special case, models for independent and identically distributed data. Our estimator considers a large library of candidate online estimators and uses online cross-validation to …