Digital Commons Network^™

Curcumin/Melatonin Hybrids As Neuroprotective Agents For Alzheimer's Disease, John Saathoff

Theses and Dissertations

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia, affecting ~5.2 million Americans. Current FDA approved medications provide mainly symptomatic relief and there are no agents available to delay or cure this disease. Multiple factors such as amyloid-β aggregates, dyshomeostasis of biometals, oxidative stress, and neuroinflammation have been implicated in the development of AD. Even though significant advances have been made in understanding the mechanisms leading to AD, the exact etiology still remains elusive. Given AD’s multifactorial nature, a multifunctional strategy of small molecule design would help to identify novel chemical templates. Recently our lab …

Role Of Vav2 In Podocyte Inflammasome Activation And Glomerular Injury During Hyperhomocysteinemia, Sabena Conley

Theses and Dissertations

Hyperhomocysteinemia (hHcys) is a widely known pathogenic factor in the progression of end-stage renal disease (ESRD) and it is also associated with an increased risk for injurious cardiovascular pathologies during ESRD. HHcys is linked to the formation and activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, characterized as a critical early mechanism initiating the inflammatory response. NADPH oxidase (NOX)-derived reactive oxygen species (ROS) mediate the activation of the NLRP3 inflammasome in podocytes in response to elevated levels of homocysteine (Hcys) in vitro and in vivo. However, it remains unknown how NLRP3 inflammasome activation is triggered by NOX. The …

User-Centered Collection Development: A Citation Analysis Of Graduate Biology Theses, Paula Barnett-Ellis, Yingqi Tang

Research, Publications & Creative Work

The authors sought to identify biology collection usage among graduate students at Jacksonville State University. Forty Master’s student theses from 2008-2014 were examined. A total of 2,351 citations were analyzed, of which journals accounted for 75%, books for 10%, and the remaining 15% included government documents, web sites, dissertations, and theses. Findings are consistent with previous similar studies that students referenced journals more often than books and other sources. Journal and book citations present discrepancies between number of citations and number of authors citing. Wide ranges of journal subjects were cited due to the interdisciplinary nature of graduate programs. Recommendations …

Seroprevalence Of Caseous Lymphadenitis In Kangal Akkaraman Sheep, Öznur Aslan, Kadi̇r Semi̇h Gümüşsoy, İlknur Karaca Bekdi̇k, Aytaç Akçay, Ömer Orkun Demi̇ral

Turkish Journal of Veterinary & Animal Sciences

In this study, the seroprevalence of Corynebacterium pseudotuberculosis, the causative agent of caseous lymphadenitis (CLA) infection, in Kangal Akkaraman sheep flocks was examined. For this purpose, blood samples were collected from 25 different sheep flocks (n = 379). According to the ELISA results, the numbers of CLA-positive and CLA-negative samples were 138 (36.4%) and 241 (63.6%), respectively. CLA positivity was observed in 35.7% of the females (n = 241), 37.7% of the males (n = 138), 40.2% of the sheep with clinical symptoms (n = 184), and 32.8% of the sheep with no clinical symptoms (n = 195) (P > 0.05). …

The Effects Of Probiotics, Organic Acid, And A Medicinal Plant On The Immune Systemand Gastrointestinal Microflora In Broilers Challenged With Campylobacter Jejuni, Hossein Ebrahimi, Shaban Rahimi, Pejvak Khaki, Jesse L. Grimes, Sophia Kathariou

Turkish Journal of Veterinary & Animal Sciences

Campylobacter jejuni, a zoonotic bacterial pathogen with worldwide distribution, infects about 400 million humans in the world annually. In order to reduce C. Jejuni colonization in the gastrointestinal tracts of broilers and make chickens less susceptible to colonization, four commercial products based on organic acid, probiotics, and medicinal plants were used. In this experiment, 210 one-day-old male broiler chicks (Ross 308) were assigned to 7 treatment groups randomly with 3 replications and 10 birds in each pen. Birds were challenged on day 21 by 1 mL of 6 × 107 CFU/mL C. Jejuni live suspension and samples were collected on …

The Effects Of Varying Levels Of Dietary Starch On Reproductivetraits In Lactating Dairy Cows, Abdulkadi̇r Keski̇n, Hidir Gençoğlu, Gülnaz Meci̇toğlu, İsmai̇l Çeti̇n, Çağdaş Kara, Duygu Udum Küçükşen, Ebru Bi̇len, Bariş Güner, Abdülkadi̇r Orman, Ahmet Gümen

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to determine the effects of three different dietary starch levels on postpartum milk yield, blood metabolites, and reproductive traits in cows. A total of 23 primiparous Holstein-Friesian cows were fed three different diets including different starch levels on a dry matter basis from parturition until day 80. Cows were randomly assigned into the three groups according to the starch levels: low (LS, 16%, n = 7), medium (MS, 20%, n = 8), and high (HS, 24%, n = 8). Milk yields were recorded daily, and body condition score (BCS) was determined every week. Transrectal …

Analysis Of Risk Factors In The Management Of Foot-And-Mouth Disease In Turkey, Berri̇n Şentürk, Cengi̇z Yalçin, Aytaç Akçay

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to perform a risk analysis of the management of foot-and-mouth disease (FMD) epidemics in Turkey. The relationship between disease outbreaks and risk was analyzed by evaluating 11 disease risk factors related to the input, processing, production, movement, and marketing infrastructure aspects of the animal production chain. A progressive (hierarchical) clustering analysis method was employed to group the quantitative data obtained for each of the risk variables. The total risk scores were grouped in a dendrogram. There was a strong positive relationship (72%) between risk variables and total outbreak numbers (P < 0.01). Results showed the districts in which the FMD risk is high and indicate where the appropriate measures should be taken to eradicate or at least minimize outbreaks.

Detection Of Helicobacter Heilmannii Type Ii And Helicobacter Pylori Indogs And Their Role In The Development Of Gastritis, Si̇nem Ülgen, Sevgi̇ Ergi̇n, Gülbi̇n Şennazli, Utku Bakirel

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to detect the presence of Helicobacter pylori and Helicobacter heilmannii type II in dogs and evaluate the role of Helicobacter spp. İn chronic gastritis. Gastroscopy was performed in a total of 40 dogs (22 symptomatic and 18 asymptomatic) admitted to the small animal clinic of İstanbul University. In this study, the density of spiral bacteria and the degree and type of gastritis by histopathology were determined. Rapid urease tests were performed on gastric biopsy samples, and the species identity was determined using nested polymerase chain reaction to assess for the presence of H. Heilmannii …

Surgical Intensivist And Global Critical Care: Is There A Role?, Jana B.A. Macleod, Orlando C. Kirton, Linda L. Maerz

Abington Jefferson Health Papers

No abstract provided.

Concealing Stigmatized Sexual Orientation, Accepting Versus Non-Accepting Attitudes, And Ego Depletion, Nicole Gigi Giordano

Theses and Dissertations

The current study was designed with the aim of increasing the understanding of

how concealing or disclosing a stigmatized sexual identity to a perceived accepting/non- accepting person affects ego depletion. Ego Depletion, (Baumeister, 1998) refers to the idea that certain tasks exhaust a limited pool of cognitive resources. Previous literature has explored how concealing a stigmatized identity is ego depleting; however, an examination of the relationship between ego depletion and the concealment of the specific identity as a sexual minority has not yet been explored. LGBQ individuals are often faced with the challenge of navigating social situations to determine if …

Characterization Of Two Surface Proteins From The Lyme Spirochete And Their Roles During Mammalian Infection, Robert Anthony Gaultney

Theses and Dissertations

Borrelia burgdorferi is an enigmatic bacterial pathogen that afflicts a large proportion of the world population as the causative agent of Lyme disease. The bacterium has a number of factors that promote virulence including a complex and dynamic array of extracellular proteins that can interact with various molecules of an infected host. One such molecule, fibronectin, is a key glycoprotein in the ECM of mammalian hosts with multiple characterized functions. B. burgdorferi encodes multiple known Fn-binding proteins, and has an additional putative protein BB0347 that may also bind Fn. Another protein, MlpJ, is homologous to a known hemin-binding protein, which …

The Law And Economics Of Proportionality In Discovery, Jonah B. Gelbach, Bruce H. Kobayashi

Georgia Law Review

This Article analyzes the proportionality standard in discovery. Many believe the renewed emphasis on this standard contained in the 2015 Amendments to the Federal Rules of Civil Procedure has the potential to infuse litigation practice with considerably more attention to questions related to the costs and benefits of discovery. We discuss the history and rationale of proportionality's inclusion in Rule 26, adopting an analytical framework that focuses on how costs and benefits can diverge in litigation generally, and discovery in particular. Finally, we use this framework to understand the mechanics and challenges involved in deploying the six factors included in …

Effects Of Hermetic Bag Storage On Insect Pest Damage, Mould Infection And A Flatoxin Contamination On Maize Grain In Makueni County, Kenya, Jeremiah Kinuthia Ng'ang'a

All Master’s Theses

For centuries, maize producers in sub-Saharan Africa have been plagued by post-harvest losses from insect infestation and mould infections, with small-scale producers representing the most vulnerable populations. Participatory on-farm trials were conducted to assess the effectiveness of triple layer hermetic (PICSâ„¢) bags for storage of maize in small-scale farmers' stores in rural villages in Makueni County,Kenya. PICS bags are three-layer hermetic bag-system that forms a barrier against the influx of oxygen and the escape of carbon dioxide.Shelled maize grain was purchased from the participating farmers, filled into jute,woven polypropyleneor PICS bags, and kept in the farmers' own stores for 35 …

Choosing An Allograft Or Autograft In Orthopedic Surgeries For Athletes, Cassandra M. Izzo

Honors Theses and Capstones

Athletes and their doctors have the choice of using an allograft or autograft in reconstruction surgeries. The purpose of this study is to see if there is a difference in the healing mechanism and surgical outcome in using an allograft or autograft during orthopedic surgical procedures, as well as to analyze graft rejection and disease transmission through donor tissue.

Doctors and athletic trainers were interviewed in order to learn about the healing mechanisms and advantages and disadvantages of allografts and autografts in order to conclude if one was better than the other. College level athletes on different sports teams were …

Faculty Publications 2015, Lsu Health Sciences Center New Orleans

Historical Faculty Publications

This Faculty bibliography contains 890 publications.

Folate And Inflammatory Markers Moderate The Association Between Helicobacter Pylori Exposure And Cognitive Function In Us Adults, Bruce L. Brown, Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Dawson W. Hedges

Faculty Publications

Background: Helicobacter pylori(H. pylori) infection is associated with cogni-tive deficits in humans, an association potentially mediated or moderated byfolate concentration or inflammation.Materials and

Methods: We used the National Health and Nutrition Exami-nation Survey (NHANES) datasets to examine whether folate concentrationor inflammation mediates or moderates the relationship betweenH. pyloriand cognitive function. Models were performed using linear, Poisson, andzero-inflated Poisson regression, and we performed separate analyses forgroups aged 20–59 and 60–90 years with sample sizes ranging from 700 to1700.Results:We did not find evidence of mediation in either age group. In the20- to 59-year group, interactions betweenH. pyloriand ferritin (pvaluesranging from .004 to …

No Association Between Latent Toxoplasmosis And Multiple Body Measures In U.S. Adults, Bruce L. Brown, Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Dawson W. Hedges

Faculty Publications

Toxoplasma gondii (Nicolle et Manceaux, 1908) is an intracellular parasite that can cause ongoing latent infection persisting for the duration of a non-definitive host's life. Affecting approximately one-third of the world's population, latent toxoplasmosis has been associated with neuropsychological outcomes and a previous report suggested an association between latent toxoplasmosis and adult height. Given the large number of people with latent toxoplasmosis and its potential associations with human height, we sought to better understand the association between latent toxoplasmosis and human morphology by evaluating seropositivity for T. gondii and multiple body measures reported in the National Health and Nutrition Examination …

Nutritional Status And Tuberculosis Risk In Adult And Pediatric Household Contacts, Omowunmi Aibana, Xeno Acharya, Chuan-Chin Huang, Mercedes C Becerra, Jerome T Galea, Silvia S Chiang, Carmen Contreras, Roger Calderon, Rosa Yataco, Gustavo E Velásquez, Karen Tintaya, Judith Jimenez, Leonid Lecca, Megan B Murray

Faculty, Staff and Student Publications

BACKGROUND: Studies show obesity decreases risk of tuberculosis (TB) disease. There is limited evidence on whether high body mass index also protects against TB infection; how very high body mass indices influence TB risk; or whether nutritional status predicts this risk in children. We assessed the impact of body mass index on incident TB infection and disease among adults and children.

METHODS AND FINDINGS: We conducted a prospective cohort study among household contacts of pulmonary TB cases in Lima, Peru. We determined body mass index at baseline and followed participants for one year for TB infection and disease. We used …

Menjadi "Positive Deviant" Di Antara Yang Positif (Kajian Deskriptif Tentang Anak Dengan Hiv/Aids), Johanna Debora Imelda, Annisah -

Antropologi Indonesia

In Indonesia, since 1987, cases of children with HIV/AIDS (CLWHA) have increased. Several studies reveal that CLHWA cannot live up to the age of 5 years without ARV treatment. However, data from Ministry of Health and NGO’s documentation show a different fact. Some CLWHA can live longer than the others although they have not started the antiretroviral treatment yet. In social science, there is an approach called “Positive Deviance”. This study examines how CLWHA live as Positive Deviant and how families and social systems support them through their lives.This study used a qualitative approach using FGD and in-depth interviews for …

Highly Efficient F, Cu Doped Tio2 Anti-Bacterial Visible Light Active Photocatalytic Coatings To Combat Hospital-Acquired Infections, Nigel S. Leyland, Joanna Podporska-Carroll, John Browne, Steven J. Hinder, Brid Quilty, Suresh Pillai

Articles

Bacterial infections are a major threat to the health of patients in healthcare facilities including hospitals. One of the major causes of patient morbidity is infection with Staphylococcus aureus. One of the the most dominant nosocomial bacteria, Methicillin Resistant Staphylococcus aureus (MRSA) have been reported to survive on hospital surfaces (e.g. privacy window glasses) for up to 5 months. None of the current anti-bacterial technology is efficient in eliminating Staphylococcus aureus. A novel transparent, immobilised and superhydrophilic coating of titanium dioxide, co-doped with fluorine and copper has been prepared on float glass substrates. Antibacterial activity has demonstrated (by using Staphylococcus …

International Intellectual Property Shelters, Sam Halabi

Articles, Chapters in Books and Other Contributions to Scholarly Works

No abstract provided.

Positive Organizational Leadership And Pro-Environmental Behavior: The Phenomenon Of Institutional Fossil Fuel Divestment, Abigail Abrash Walton

Antioch University Dissertations & Theses

Climate change is one of the most significant dynamics of our time.The predominant contributor to climate change is combustion of fossil fuels by humans.This study deepened understanding of organizational leaders’ role in enacting one approach to addressing climate change:institutional fossil fuel divestment.The study used a qualitative research design to explore U.S.-based foundation leaders’ readiness to pursue fossil fuel divestment by their institutions.The study examined leaders’ motivations and actions in pursuing divestment, while simultaneously exercising their fiduciary duty to steward institutional assets.Research questions focused on the divestment behavior change process and the outcomes of divestment on leaders and their organizations.Data collection …

Twenty-First Century Regression: The Disparate Impact Of Hiv Transmission Laws On Gay Men, Siobhán Elizabeth Stade Murillo

Law Student Scholarship

No abstract provided.

Symptom Experience And Influenza-Like Illness In A Military Population, Monique Bouvier

Dissertations

AIMS: The primary objective of this study was to identify if symptom presentation expressed over the course of an influenza-like illness (ILI) can predict virus type by use of unsupervised machine learning. The secondary objective was to describe clinical characteristics of strain specific coronavirus. Finally, examine the psychometric properties of the Canadian Acute Respiratory Illness and Flu Scale (CARIFS).

BACKGROUND: ILI outbreaks have been a significant source of non-battle injury among military personnel. Many different viruses cause ILI, and it is difficult to determine which virus is causing the illness. Recent studies have examined the etiology and epidemiology of ILIs. …

The Impact Of Urbanization On Mosquito-Borne Viruses, Nikhita Puthuveetil

UROP Posters

Mosquito-borne diseases such as yellow fever, dengue, and West Nile are rapidly emerging across the globe. Their emergence is often aided by the growth of their vector population, or the organisms that transmit the virus to the host. Urbanization and land use often destroys the habitat of the virus and its vector. However, the virus and its vector often survive despite the changes to its environment. The goal of this paper is to find out exactly how urbanization and changes in land use affect mosquito-borne viruses and how these viruses survive despite the destruction of their habitats. To understand how …

Viable Influenza A Virus In Airborne Particles Expelled During Coughs Versus Exhalations, William G. Lindsley, Francoise M. Blachere, Donald H. Beezhold, Robert E. Thewlis, Bahar Noorbakhsh, Sreekumar Othumpangat, William T. Goldsmith, Cynthia M. Mcmillen, Michael E. Andrew, Carmen N. Burrell, John D. Noti

Faculty & Staff Scholarship

Background To prepare for a possible influenza pandemic, a better understanding of the potential for the airborne transmission of influenza from person to person is needed.

Objectives The objective of this study was to directly compare the generation of aerosol particles containing viable influenza virus during coughs and exhalations.

Methods Sixty-one adult volunteer outpatients with influenza-like symptoms were asked to cough and exhale three times into a spirometer. Aerosol particles produced during coughing and exhalation were collected into liquid media using aerosol samplers.The samples were tested for the presence of viable influenza virus using a viral replication assay (VRA).

Results …

Retrospective Cohort Study Of Tobacco Dependence Treatment Patterns In A Us Commercially Insured Population, Elizabeth Anne Maclean

Open Access Dissertations

Recognizing the substantial public health impact of tobacco dependence (TD) and consequent importance of reducing tobacco use, the United States Public Health Service (USPHS) issues evidence based clinical practice guidelines (CPG) that urge “clinicians and health care delivery systems to consistently identify and document tobacco use status and treat every tobacco user seen in a health care setting”. The latest guidelines, published in 2008, were written “in response to new, effective clinical treatments for tobacco dependence” identified since 1999 and contain strategies and recommendations designed to assist clinicians, administrators, insurers, and purchasers in “delivering and supporting effective treatments for tobacco …

January 2016 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Development Of Inducible Anti-Influenza Therapies, Cynthia Marie Mcmillen

Graduate Theses, Dissertations, and Problem Reports (ETD)

Influenza viruses continue to cause significant morbidity and mortality each year despite the development of vaccines and antiviral therapies targeting these viruses. The inherent ability of influenza viruses to accumulate mutations over time has led to the emergence of strains resistant to antiviral therapies. Furthermore, genetic reassortment creates antigenically diverse viruses, making it difficult to develop vaccines that yield broad protection. The objective of the following research studies is to develop two alternative approaches to current methods of antiviral therapeutics.;Six new siRNAs targeting influenza protein expression by RNA interference (RNAi) were characterized. Three siRNAs (M747, M776, M832) knocked down the …

Hydroclimatic Assessment Of Changing Climate On Diarrheal Diseases With Reference To Cholera, Fariborz Nasr Azadani

Graduate Theses, Dissertations, and Problem Reports (ETD)

The association of cholera with the climatic processes is well documented. However the effects of changing climate on occurrence of cholera is not yet evaluated, perhaps due to unavailability of geophysical data and their quantitative linkages with cholera. Global climate models (GCMs) outputs are available at coarse resolution of 200-300km, but the diseases usually occur at 10-15 km, therefore, it is rather challenging to link any GCM outputs with a disease. The goal of this research is to develop algorithms that can link diarrheal diseases with changing climatic conditions. Within this context, cholera is used as a model disease due …