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Seroprevalence Of Toxoplasmosis And Associated Risk Factors Among Migrant Workers In Malaysia, M.Z. Siti Nursheena

Research Publications (2016 to 2020)

No abstract provided.

University Of Texas Health Science Center At Tyler Catalog, 2016 - 2018, University Of Texas Health Science Center At Tyler

Catalogs

No abstract provided.

Genetic And Genomic Basis Of Antibody Response To Porcine Reproductive And Respiratory Syndrome (Prrs) In Gilts And Sows, Nick V. Serão, Robert A. Kemp, Benny Mote, Philip Willson, John C.S. Harding, Stephen C. Bishop, Graham S. Plastow, Jack C.M. Dekkers

Department of Animal Science: Faculty Publications

Background: Our recent research showed that antibody response to porcine reproductive and respiratory syndrome (PRRS), measured as sample-to-positive (S/P) ratio, is highly heritable and has a high genetic correlation with reproductive performance during a PRRS outbreak. Two major quantitative trait loci (QTL) on Sus scrofa chromosome 7 (SSC7; QTL_MHC and QTL₁₃₀) accounted for ~40 % of the genetic variance for S/P. Objectives of this study were to estimate genetic parameters for PRRS S/P in gilts during acclimation, identify regions associated with S/P, and evaluate the accuracy of genomic prediction of S/P across populations with different prevalences of …

Genome To Phenome: Improving Animal Health, Production, And Well-Being – A New Usda Blueprint For Animal Genome Research 2018–2027, Caird Rexroad, Jeffrey Vallet, Lakshmi Kumar Matukumalli, James Reecy, Derek Bickhart, Harvey Blackburn, Mark Boggess, Hans Cheng, Archie Clutter, Noelle Cockett, Catherine Ernst, Janet E. Fulton, John Liu, Joan Lunney, Holly Neibergs, Catherine Purcell, Timothy P. L. Smith, Tad Sonstegard, Jerry Taylor, Bhanu Telugu, Alison Van Eenennaam, Curtis P. Van Tassell, Kevin Wells

Department of Animal Science: Faculty Publications

In 2008, a consortium led by the Agricultural Research Service (ARS) and the National Institute for Food and Agriculture (NIFA) published the “Blueprint for USDA Efforts in Agricultural Animal Genomics 2008–2017,” which served as a guiding document for research and funding in animal genomics. In the decade that followed, many of the goals set forth in the blueprint were accomplished. However, several other goals require further research. In addition, new topics not covered in the original blueprint, which are the result of emerging technologies, require exploration. To develop a new, updated blueprint, ARS and NIFA, along with scientists in the …

Infections Caused By Live Vaccines In Cancer Research, Manuel Castro-Borobio, Shuchi Pandya, Sowmya Nanjappa, John Greene

Internal Medicine Faculty Publications

No abstract provided.

Self-Medication And "Personal Medicine" As Alternatives To Pharmaceuticals Among Young Adults With Mental Health Conditions, Jessica Hahne

Public Health Theses

Background:

Many studies have documented high rates of non-adherence to prescribed psychiatric medications among individuals receiving mental health services. Few studies have sought to understand how young adults with mental health conditions who are not consistently connected to mental health services view psychiatric medications, or what types of self-directed symptom management strategies they might prefer to psychiatric medications.

Methods and Results:

This secondary analysis on 11 pairs of semi-structured interviews with young adults (aged 24-28) used a grounded theory approach to elucidate common themes in self-management of mental health symptoms. Many participants described alcohol or marijuana use as preferred strategies …

My Dance With Cancer: An Autoethnographic Exploration Of The Journey, Vardine K. Simeus

Department of Family Therapy Dissertations and Applied Clinical Projects

Sometimes when a person who has been diagnosed with cancer finds out that his or her cancer returned and continuously has to go for surgeries, treatments, regular follow-ups, and continued overtime to deal with the same life-threatening illness, he or she can actually feel frozen due to feeling depressed and anxious in not knowing how to move forward with life. Dance is a metaphor used in this study to move forward. Psychotherapy can offer major benefits to help cancer patients cope with the depression, anxiety, stress, and other emotional reactions that often accompany a cancer diagnosis (Stuyck, 2008). Many studies …

Stains Induce Apoptosis And Autophagy In Primary And Transformed Mast Cells, Patrick A. Paez

Theses and Dissertations

Statin drugs are widely employed in the clinic to reduce serum low density lipoproteins (LDLs) in patients with hypocholesteremia. In addition to their cholesterol-lowering effects through HMG CoA reductase antagonism, isoprenyl lipids necessary for membrane anchorage and signaling of small G-proteins are abrogated. We previously found that statins suppress mast cell activation in murine and human cells, suggesting these drugs might be useful in treating allergic disease. While mast cell function is critical to allergic inflammation, mast cell hyperplasia and survival also impact these diseases, and were not studied in our previous work. In this study, we describe Fluvastatin-mediated apoptosis …

Genomic Comparisons And Genome Architecture Of Divergent Trypanosoma Species, Katie Bradwell

Theses and Dissertations

Virulent Trypanosoma cruzi, and the non-pathogenic Trypanosoma conorhini and Trypanosoma rangeli are protozoan parasites with divergent lifestyles. T. cruzi and T. rangeli are endemic to Latin America, whereas T. conorhini is tropicopolitan. Reduviid bug vectors spread these parasites to mammalian hosts, within which T. rangeli and T. conorhini replicate extracellularly, while T. cruzi has intracellular stages. Firstly, this work compares the genomes of these parasites to understand their differing phenotypes. Secondly, genome architecture of T. cruzi is examined to address the effect of a complex hybridization history, polycistronic transcription, and genome plasticity on this organism, and study its highly …

Assessment Of Novel Algal Biomass Sources As Potential Ingredients In Diets For Tilapia (Oreochromis Niloticus), Ben Eynon

School of Biological and Marine Sciences Theses

The aquaculture sector is currently seeking alternative feed ingredients to ensure future socioeconomic and environmental sustainability; microalgae sources are seen to be a promising option. Two nutrition trials were conducted in order to assess substituting plant based protein sources in diets for juvenile Nile tilapia (Oreochromis niloticus), with a range of inclusion levels of two proprietary defatted microalgae samples (Nannochloropsis sp. and Chlorella sp.). The experimental algal ingredients utilised were by-products sourced from a pilot-scale biofuel operation. In both trials all experimental algal diets, along with their respective algal free controls, were isonitrogenous and isoenergetic. Fish growth performance, feed utilisation, …

Role Of Microglial Α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator In Neuroinflammatory Pain Models In Mice, Muzaffar Abbas

Electronic Theses and Dissertations

Neuroinflammatory pain affects about 1.5% of the United States population. Around 20-40% patients having neurological disorders are affected with neuroinflammatory pain. As a part of the limbic system, hippocampus is known to play a critical role in pain perception and processing, and is densely populated with microglial cells and α7 nicotinic acetylcholine receptors (nAChRs). Given the role of microglial α7 nAChRs in neuroinflammation, the α7 nAChRs have emerged as potential target for neuroinflammatory pain treatment. We hypothesized that microglial α7 nAChRs positive allosteric modulation in the hippocampus will decrease neuroinflammatory pain at behavioral, cellular, biochemical, and molecular level. The primary …

The Effect Of Copper And Zinc Source On Pre-Weaning Performance Of Cows, Health And Performance Of Suckling Calves, And Post-Weaning Feedlot Performance, Carcass Composition, And Meat Quality Of Calves, Jesse Fulton

Electronic Theses and Dissertations

During gestation an elevated level of nutrient intake is required by the cow in order to meet the requirements of the maturing fetus and if these requirements are not met, changes in fetal development can occur. However, little is understood about the effects of gestational manipulation of specific nutrients, such as minerals, on progeny growth, performance and carcass traits. Previous research supports the hypothesis that minerals provided in an organic form should be more soluble and readily available to the body for absorption. Therefore the objectives of this study were to determine if source of gestational and post-natal Cu and …

Complying With The Hipaa Privacy Rule: Problems And Perspectives, Stacey A. Tovino

Faculty Articles

Twenty years ago, President Clinton signed the Health Insurance Portability and Accountability Act of 1996 (HIPAA) into law. Over the past two decades, the federal Department of Health and Human Services (HHS) has published several sets of rules implementing the Administrative Simplification provisions within HIPAA as well as the Health Information Technology for Economic and Clinical (HITECH) Act within the American Recovery and Reinvestment Act (ARRA). These rules include a final rule governing the use and disclosure of protected health information by covered entities and their business associates (Privacy Rule). This Article addresses the question of what it means for …

Fecal Microbiota Transplantation Outcomes In Immunocompetent And Immunocompromised Patients: A Single Center Experience, Kristen Zeitler, Ripal Joshi, Jose Montero, Sally Alrabaa

Internal Medicine Faculty Publications

No abstract provided.

Wrong Time, Wrong Place—A Hospital-Associated Outbreak Of Influenza A In The Summer, Richard Oehler, John Toney, Sandra Gompf, Miriam Ruisz, Vivian Vega, Jose Lezama, Yvonne Dunn

Internal Medicine Faculty Publications

No abstract provided.

Vaccinelink/La Salud Conexion: Successful Innovations With Vaccine Health Navigators (Vhns) To Identify And Overcome Vaccination Barriers In Underserved Communities, Jamie Morano, Meghan Borysova, Viviana Delgado, Mimi Roopini Ghosh, April Schenck, Manuel Castro-Borobio, Dawood Sultan

Internal Medicine Faculty Publications

No abstract provided.

A Simple Allergist-Led Intervention Improves Resident Training In Anaphylaxis, Artemio M. Jongco, Sheila Bina, Robert J. Sporter, Marie A. Cavuoto Petrizzo, Blanka Kaplan, Myriam Kline, Susan J. Schuval

Internal Medicine Faculty Publications

Physicians underrecognize and undertreat anaphylaxis. Effective interventions are needed to improve physician knowledge and competency regarding evidence-based anaphylaxis diagnosis and management (ADAM). We designed and evaluated an educational program to improve ADAM in pediatrics, internal medicine, and emergency medicine residents from two academic medical centers. Anonymous questionnaires queried participants’ demographics, prior ADAM clinical experience, competency, and comfort. A pretest assessing baseline knowledge preceded a 45-minute allergist-led evidence-based presentation, including practice with epinephrine autoinjectors, immediately followed by a posttest. A follow-up test assessed long-term knowledge retention twelve weeks later. 159 residents participated in the pretest, 152 participated in the posttest, and …

Pyoderma Gangrenosum Following Bilateral Deep Inferior Epigastric Perforator Flaps, Eric Clayman, Kristen Marcet, Lauren Kuykendall, Dunya M. Atisha

Surgery Faculty Publications

Pyoderma gangrenosum (PG) is an atypical ulcerative cutaneous condition, with an estimated six cases per million people per year in the United States.[1] One-half of patients have idiopathic disease, and it is most commonly associated with underlying systemic inflammatory conditions or hematologic malignancies.[1] [2] There have been several reported cases of PG following breast reduction procedures; however, postsurgical PG (PSPG) is rarely seen following autologous tissue breast reconstruction.[3]

In this article, the authors report the clinical course, treatment, and outcome of a patient diagnosed with PSPG following a delayed breast reconstruction with …

Environment And Host Species Shape The Skin Microbiome Of Captive Neotropical Bats, Virginie Lemieux-Labonté, Nicolas Tromas, B. Jesse Shapiro

KIP Articles

No abstract provided.

Using A Novel Partitivirus In Pseudogymnoascus Destructans To Understand The Epidemiology Of White-Nose Syndrome, Vaskar Thapa, Gregory G. Turner, Susan Hafenstein

KIP Articles

White-nose syndrome is one of the most lethal wildlife diseases, killing over 5 million North American bats since it was first reported in 2006. The causal agent of the disease is a psychrophilic filamentous fungus, Pseudogymnoascus destructans. The fungus is widely distributed in North America and Europe and has recently been found in some parts of Asia, but interestingly, no mass mortality is observed in European or Asian bats. Here we report a novel double-stranded RNA virus found in North American isolates of the fungus and show that the virus can be used as a tool to study the epidemiology …

Infection With The Sand Flea Tunga Penetrans (Tungiasis) In A Traveller Returning From Cameroon, Africa, D. J. Richardson, A. M. Mangili

Journal of the Arkansas Academy of Science

Tungiasis refers to human infection with adult fleas, Tunga penetrans. Although common throughout the tropics, tungiasis is rarely encountered by physicians in the United States such that it may be improperly diagnosed and inappropriately treated. We provide a case report of tungiasis in a traveler from Cameroon and a brief review of reported cases in the United States and Canada.

The Medicalization Of End-Of-Life Care: The Role Of Health Professions Education, Philip Fung, Miguel Paniagua

Saint Louis University Journal of Health Law & Policy

In the past 100 years, the advances in medical science and technology have shaped the health care delivery system in remarkable ways. The side effect of these advances has been a tendency to dehumanize the dying process, and consequently it has led to the rise of a specialty focused merely on bridging this gap in care. The public’s expectations of our legal, licensing, and medical education systems have also reflected this evolution in health care.

Discovery Of Novel Compound From Cytotoxic Active Plants, Suraj Kumar Pokharel

Theses

The phytochemical study of extracts of cytotoxic active plant species Drypetes lasiogyna and Tabebuia bahamensis species from Paluma rainforest, Northern Queensland, Australia and Abaco Island, Bahamas, respectively, has been carried out where separation, identification and characterization of chemical components were done by applying chromatographic and spectroscopic techniques. The pharmacologically active components isolated from Drypetes lasiogyna include novel compound 5α-dammar-20-ene-24,25-diol-3-yl caffeate along with 5α-dammar-20-ene-3β,24,25-triol and friedelin whereas taraxeryl acetate was extracted from Tabebuia bahamensis. 5α-Dammar-20-ene-3β,24,25-triol was shown to have good cytotoxic activity against cancer cell lines 5637, MCF-7 and MDA-MB-231 with % kill of 100%, 89.65% and 69.98%, respectively. On the …

Reference Intervals For Thyroid Stimulating Hormone And Free Thyroxine Derived From Neonates Undergoing Routine Screening For Congenital Hypothyroidism At A University Teaching Hospital In Nairobi, Kenya: A Cross Sectional Study, Geoffrey Omuse, Ali Kassim, Francis Kiigu, Syeda Hussain, Mary Limbe

Pathology, East Africa

Background: In order to accurately interpret neonatal thyroid function tests (TFTs), it is necessary to have population specific reference intervals (RIs) as there is significant variation across different populations possibly due to genetic, environmental or analytical issues. Despite the importance of RIs, globally there are very few publications on RIs for neonatal TFTs primarily due to ethical and technical issues surrounding recruitment of neonates for a prospective study. To the best of our knowledge, this is the first report from Africa on neonatal RIs for TFTs.

Methods: We used hospital based data largely derived from neonates attending the wellness clinic …

Cytosolic Dna Sensor Upregulation Accompanies Dna Electrotransfer In B16.F10 Melanoma Cells, Katarina Znidar, Masa Bosnjak, Maja Cemazar, Loree C. Heller

Bioelectrics Publications

In several preclinical tumor models, antitumor effects occur after intratumoral electroporation, also known as electrotransfer, of plasmid DNA devoid of a therapeutic gene. In mouse melanomas, these effects are preceded by significant elevation of several proinflammatory cytokines. These observations implicate the binding and activation of intracellular DNA-specific pattern recognition receptors or DNA sensors in response to DNA electrotransfer. In tumors, IFN β mRNA and protein levels significantly increased. The mRNAs of several DNA sensors were detected, and DAI, DDX60, and p204 tended to be upregulated. These effects were accompanied with reduced tumor growth and increased tumor necrosis. In B16. F10 …

Analysis Of Envelope Glycoprotein Complex Of Arenaviruses, Sundaresh Shankar

Graduate Student Theses, Dissertations, & Professional Papers

Arenaviruses, the causative agents of severe hemorrhagic fevers, are endemic in rodent populations and can be transmitted to humans by contact. Without effective treatment or licensed vaccines, these viruses pose serious public health and biodefense concern. The sole treatment option is the off-label use of the nucleoside analog ribavirin, which is effective only when given at an early stage of infection and shows significant toxicity in humans. Hence, there exists a clear need for developing better therapies. Arenavirus entry into the cell is initiated by the virus envelope glycoprotein complex (GPC), primed to undergo conformational changes triggered by the acidic …

Development Of Replication-Competent Vsv-Based Vaccines For Protection Against Hantaviruses, Joshua Ovila Marceau

Graduate Student Theses, Dissertations, & Professional Papers

This study looks at the effects of the position and numbers of foreign immunogens in the vesicular stomatitis virus (VSV) genome on vector attenuation and vaccine efficacy. To generate the recombinant vaccine vectors, a VSV Indiana strain was modified by removing the native VSV glycoprotein and replacing it with one or two foreign glycoproteins; one derived from the filovirus Zaire ebolavirus (ZEBOVgp) and the other from the hantavirus Andes virus (ANDVgpc). Two monovalent (rVSVΔG-ANDVgpc and rVSVΔG-ZEBOVgp) and two bivalent (rVSVΔG-ANDVgpc-ZEBOVgp and rVSVΔG-ZEBOVgp-ANDVgpc recombinant vectors were compared. All vectors were attenuated in cell culture and in immunocompetent hamsters when compared to …

Honors @ Georgia Southern, University Honors Program Students And Staff, Georgia Southern University

Honors College: News & Publications (2008-2020)

• Honors Alumnae Published
• Honors LLC
• Honors in Action
• Alumni News

Thermal Assisted In Vivo Gene Electrotransfer, Amy Donate, Anna Bulysheva, Chelsea Edelblute, Derrick Jung, A. Malik, Siqi Quo, Niculina Burcus, Karl Schoenbach, Richard Heller

Bioelectrics Publications

Gene electrotransfer is an effective approach for delivering plasmid DNA to a variety of tissues. Delivery of molecules with electric pulses requires control of the electrical parameters to achieve effective delivery. Since discomfort or tissue damage may occur with high applied voltage, the reduction of the applied voltage while achieving the desired expression may be an important improvement. One possible approach is to combine electrotransfer with exogenously applied heat. Previous work performed in vitro demonstrated that increasing temperature before pulsing can enhance gene expression and made it possible to reduce electric fields while maintaining expression levels. In the study reported …

Large Genomic Differences Between Moraxella Bovoculi Isolates Acquired From The Eyes Of Cattle With Infectious Bovine Keratoconjunctivitis Versus The Deep Nasopharynx Of Asymptomatic Cattle, Aaron M. Dickey, John D. Loy, James L. Bono, Timonthy P. L. Smith, Mike D. Apley, Brian V. Lubbers, Keith D. Dedonder, Sarah F. Capik, Robert L. Larson, Brad J. White, Jochen Blom, Carol G. Chitko-Mckown, Michael L. Clawson

School of Veterinary and Biomedical Sciences: Faculty Publications

Moraxella bovoculi is a recently described bacterium that is associated with infectious bovine keratoconjunctivitis (IBK) or “pinkeye” in cattle. In this study, closed circularized genomes were generated for seven M. bovoculi isolates: three that originated from the eyes of clinical IBK bovine cases and four from the deep nasopharynx of asymptomatic cattle. Isolates that originated from the eyes of IBK cases profoundly differed from those that originated from the nasopharynx of asymptomatic cattle in genome structure, gene content and polymorphism diversity and consequently placed into two distinct phylogenetic groups. These results suggest that there are genetically distinct strains of M. …