Digital Commons Network^™

Improving Postexposure Hiv Follow-Up In Healthcare Workers, Linda Valles Gutierrez

Doctor of Nursing Practice Final Manuscripts

The purpose of this evidence-based practice (EBP) project is to improve the HIV postexposure follow-up (PEFU) rate in healthcare workers (HCWs) through implementation of a revised infection control policy and reminder system. Occupational exposure to HIV is a significant risk for all healthcare workers. In the United States every year, 1 out of 10 U.S. healthcare workers suffers a blood or body fluid exposure (BBFE). Transmission of one serious blood-borne infection can cost more than a million dollars for medications, follow-up laboratory testing, clinical evaluation, lost wages, and disability payments. Completion of HIV PEFU in HCWs is very low nationally. …

General Models For Ecological Drivers Of Poverty, Calistus Ngeh Ngonghala

Biology and Medicine Through Mathematics Conference

No abstract provided.

Hiv Vaccines: Progress, Limitations And A Crispr/Cas9 Vaccine, Omar A. Garcia Martinez

Biology: Student Scholarship & Creative Works

ABSTRACT: The HIV-1 pandemic continues to thrive due to ineffective HIV-1 vaccines. Historically, the world’s most infectious diseases, such as polio and smallpox, have been eradicated or have come close to eradication due to the advent of effective vaccines. Highly active antiretroviral therapy is able to delay the onset of AIDS but can neither rid the body of HIV-1 proviral DNA nor prevent further transmission. A prophylactic vaccine that prevents the various mechanisms HIV-1 has to evade and attack our immune system is needed to end the HIV-1 pandemic. Recent advances in engineered nuclease systems, like the CRISPR/Cas9 system, have …

Phylogenetic Analysis Of Human Cytomegalovirus Pus27 And Pus28: Ascertaining An Independent Or Linked Evolutionary History, Jessica A. Scarborough

Undergraduate Honors Theses

Human cytomegalovirus (HCMV) is a widespread pathogen that is particularly skilled at evading immune detection and defense mechanisms, largely due to extensive co-evolution with its host’s immune system. One aspect of this co-evolution involves the acquisition of four virally encoded GPCR chemokine receptor homologs, products of the US27, US28, UL33 and UL78 genes. G protein-coupled receptors (GPCR) are the largest family of cell surface proteins, found in organisms from yeast to humans. In this research, phylogenetic analysis was used to investigate the origins of the US27 and US28 genes, which are adjacent in the viral genome. The results indicate that …

Genetic Engineering And Sustainable Crop Disease Management: Opportunities For Case-By-Case Decision-Making, Paul Vincelli

Plant Pathology Faculty Publications

Genetic engineering (GE) offers an expanding array of strategies for enhancing disease resistance of crop plants in sustainable ways, including the potential for reduced pesticide usage. Certain GE applications involve transgenesis, in some cases creating a metabolic pathway novel to the GE crop. In other cases, only cisgenessis is employed. In yet other cases, engineered genetic changes can be so minimal as to be indistinguishable from natural mutations. Thus, GE crops vary substantially and should be evaluated for risks, benefits, and social considerations on a case-by-case basis. Deployment of GE traits should be with an eye towards long-term sustainability; several …

Rickettsia Parkeri Colonization In Ambylomma Maculatum: The Role Of Superoxide Dismutases, Gary Crispell, Khemraj Budachetri, Shahid Karim

Faculty Publications

Background

The Gulf Coast tick (Amblyomma maculatum) is an arthropod vector of Rickettsia parkeri, the causative agent of American boutonneuse fever and an infectious agent of public health significance. In this study, we evaluated the biological significance of the superoxide dismutases (SODs) of A. maculatum in hematophagy and R. parkeri colonization within the tick host.

Methods

An RNA interference approach was used to measure the functional roles of tick SODs (Cu/Zn-SOD and Mn-SOD) in R. parkeri colonization of the tick vector. Total microbial load, R. parkeri infection rate, and compensatory mechanisms by tick genes were …

Growth, And Development Of Care For Leprosy Sufferers Provided By Religious Institutions From The First Century Ad To The Middle Ages, Philippa Juliet Meek

USF Tampa Graduate Theses and Dissertations

This thesis aims to outline the causes, symptoms, and treatments related to leprosy, and how it can be diagnosed in patients and identified in human remains. The thesis also aims to demonstrate the ways in which care for leprosy sufferers developed as the disease became more prevalent and more commonly, and correctly identified. It analyses the social stigmas inflicted upon sufferers, and the medical care and attention provided for them by religious institutions when other groups or organisations shunned those suffering from leprosy. The rationale for this study is to identify trends surrounding the social stigmas attached to leprosy and …

Population Denominators: Measuring Risk To Improve Health And Well-Being, Long Kightlinger

South Dakota Demography Conference

Population denominator numbers stratified age, race, gender, county and zip code are essential public health tools in determining disease burden and risk. Accurate disease incidence and prevalence data are needed by state and local health care providers and public policy makers to appropriately target health service delivery and public health interventions.

Working With American Indian Communities To Utilize And Improve Data For Heath Research, Jessica Hanson, Wyatt Pickner, Susan Puumala

South Dakota Demography Conference

This session will include three presentations on data collection with American Indian communities and discuss current gaps and possible solutions. The first presentation will be on community input and utilization of data for program development. The second presentation will discuss the availability and utility of local data. The final presentation will describe existing data sources for longitudinal regional and national data that may relate to American Indian health.

Beyond The Three Delays: A Case Study Of Haiti's Maternal Health Sector, Stephanie Rapp

Capstone Collection

This research seeks to understand how the maternal health sector in Haiti can be understood and perhaps improved through the framework of the Three Delays, developed by Thaddeus and Maine (1994). These delays are (1) the delay in the decision to seek care, (2) the delay in reaching a health facility, and (3) the delay in receiving adequate care at a health facility. The findings of this capstone strongly demonstrated that global health practitioners in Haiti often opt for technical solutions, but in fact there are numerous shadow delays preventing these solutions from taking hold and ameliorating maternal mortality. Tensions …

Evaluating Infection Prevention Strategies In Out-Patient Dialysis Units Using Agent-Based Modeling, Joanna R. Wares, Barry Lawson, Douglas Shemin, Erika D'Agata

Department of Math & Statistics Faculty Publications

Patients receiving chronic hemodialysis (CHD) are among the most vulnerable to infections caused by multidrug-resistant organisms (MDRO), which are associated with high rates of morbidity and mortality. Current guidelines to reduce transmission of MDRO in the out-patient dialysis unit are targeted at patients considered to be high-risk for transmitting these organisms: those with infected skin wounds not contained by a dressing, or those with fecal incontinence or uncontrolled diarrhea. Here, we hypothesize that targeting patients receiving antimicrobial treatment would more effectively reduce transmission and acquisition of MDRO. We also hypothesize that environmental contamination plays a role in the dissemination of …

Hiv-1 Genetic Variation Resulting In The Development Of New Quasispecies Continues To Be Encountered In The Peripheral Blood Of Well-Suppressed Patients., Will Dampier, Michael R Nonnemacher, Joshua Mell, Joshua Earl, Garth D Ehrlich, Vanessa Pirrone, Benjamas Aiamkitsumrit, Wen Zhong, Katherine Kercher, Shendra Passic, Jean W Williams, Jeffrey M Jacobson, Brian Wigdahl

Kimmel Cancer Center Faculty Papers

As a result of antiretroviral therapeutic strategies, human immunodeficiency virus type 1 (HIV-1) infection has become a long-term clinically manageable chronic disease for many infected individuals. However, despite this progress in therapeutic control, including undetectable viral loads and CD4+ T-cell counts in the normal range, viral mutations continue to accumulate in the peripheral blood compartment over time, indicating either low level reactivation and/or replication. Using patients from the Drexel Medicine CNS AIDS Research and Eradication Study (CARES) Cohort, whom have been sampled longitudinally for more than 7 years, genetic change was modeled against to the dominant integrated proviral quasispecies with …

Developing A Prototype System For Syndromic Surveillance And Visualization Using Social Media Data., Anup Aryal

Theses

Syndromic surveillance of emerging diseases is crucial for timely planning and execution of epidemic response from both local and global authorities. Traditional sources of information employed by surveillance systems are not only slow but also impractical for developing countries. Internet and social media provide a free source of a large amount of data which can be utilized for Syndromic surveillance.

We propose developing a prototype system for gathering, storing, filtering and presenting data collected from Twitter (a popular social media platform). Since social media data is inherently noisy we describe ways to preprocess the gathered data and utilize SVM (Support …

Preventing And Reducing Clabsi With Daily 2% Chg Wipes, Karen Ha

Master's Projects and Capstones

This project aims to decrease central line associated bloodstream infections in pediatric patients my microsystem hospital. The process begins re-enforcing daily CHG (2% Chlorhexidine Gluconate) wipes to 100% compliance rates on our patients with central lines tailored to their age and body weights. The process ends with reducing the CLABSI rates of our unit and the entire hospital to 0. By working on the process we expect personal and organizational commitment to transform the culture of safety through integration of standardized communication, issue escalation, non punitive response to errors, rounding by all leaders, and culture of continuous improvement. It is …

Toward A Common Secure Future: Four Global Commissions In The Wake Of Ebola, Lawrence O. Gostin, Oyewale Tomori, Suwit Wibulpolprasert, Ashish K. Jha, Julio Frenk, Suerie Moon, Joy Phumaphi, Peter Piot, Barbara Stocking, Victor J. Dzau, Gabriel M. Leung

Georgetown Law Faculty Publications and Other Works

The world is becoming increasingly vulnerable to pandemics resulting from globalization, urbanization, intense human/animal interchange, and climate change. A series of global health crises have emerged since 2000, ranging from Severe Acute Respiratory Syndrome (SARS) and its phylogenetic cousin Middle East Respiratory Syndrome (MERS), to pandemic Influenza A (H1N1), Ebola, and the ongoing Zika virus epidemic. The Ebola epidemic gave rise to four global commissions proposing a bold new agenda for global health preparedness and response for future infectious disease threats.

Four global commissions reviewing the recent Ebola virus disease epidemic response consistently recommended strengthening national health systems, consolidating and …

Improving Policies Impacting School Absenteeism Due To Influenza Using Agent-Based Simulation Modeling., Galina V. Miller

Purdue P-12 Networking Summit & Poster Session

No abstract provided.

Volume 53, Number 40: May 18, 2016, University Of North Dakota

University Letter Archive

No abstract provided.

The Impact Of Hla-Dm On Peptide Binding To Mhc Class Ii, Megan Templeton

Chemistry and Biochemistry

Recognition of peptides bound to class II major histocompatibility complex (MHCII) molecules by T cell receptors of CD4+ T cells initiates an adaptive immune response. Analysis of the antigen presentation pathway indicates that elements of the epitope selection process are critical to generation of the peptide repertoire presented to T cells. Antigen presentation by dedicated cells (APCs) involves the intracellular fragmentation of protein antigens by cathepsins, binding of the derived peptide epitopes to MHCII with the participation of the peptide-editing molecule HLA-DM (DM), and subsequent transport to the surface for recognition. This thesis focuses on the energetics and structural flexibility …

World Allergy Organization-Mcmaster University Guidelines For Allergic Disease Prevention (Glad-P): Vitamin D, Juan José Yepes-Nuñez, Alessandro Fiocchi, Ruby Pawankar, Carlos A. Cuello-Garcia, Yuan Zhang, Gian Paolo Morgano, Kangmo Ahn, Suleiman Al-Hammadi, Arnav Agarwal, Shreyas Gandhi, Kirsten Beyer, Wesley Burks, Giorgio W. Canonica, Motohiro Ebisawa, Rose Kamenwa, Bee Wah Lee, Haiqi Li, Susan Prescott, John J. Riva, Lanny Rosenwasser, Hugh Sampson, Michael Spigler, Luigi Terracciano, Andrea Vereda, Susan Waserman, Holger J. Schünemann, Jan L. Brożek

Paediatrics and Child Health, East Africa

Background: The prevalence of allergic diseases is approximately 10 % in infants whose parents and siblings do not have allergic diseases and 20–30 % in those with an allergic first-degree relative. Vitamin D is involved in the regulation of the immune system and it may play a role in the development, severity and course of asthma and other allergic diseases.

Objective: The World Allergy Organization (WAO) convened a guideline panel to develop evidence-based recommendations addressing the use of vitamin D in primary prevention of allergic diseases.

Methods: Our WAO guideline panel identified the most relevant clinical questions and performed a …

New And Innovative Beef Supply Chains In Thailand, Carey Ramm

Animal production and livestock published reports

The Department of Agriculture and Food Western Australia (DAFWA) has contracted AEC Group Pty Ltd (AEC) to undertake this pre-feasibility study into the creation of new and innovative beef supply chain models in Thailand.

The purpose of this study is to consider the potential industry benefits of diverting existing live export cattle into a dedicated supply chain featuring leading technology and best management practice. A range of potential supply chain models were considered, with detailed analysis focussing on importing, holding, intensively feeding, processing and distributing Western Australian live exported cattle to Thai in-country and regional export markets.

This pre-feasibility study …

Unh Scientist Helps Uncover How Disease Is Transmitted Between Livestock, Lori Wright

Media Relations

No abstract provided.

Hiv Vaccine Design Should Adapt As Hiv Virus Mutates, Alicia Rohan

Browse All News

No abstract provided.

Unh Scientist Helps Uncover How Disease Is Transmitted Between Livestock, Lori Tyler Gula

UNH Today Archive

No abstract provided.

Sonographic Estimation Of The Prevalence Of Hepatic Steatosis In Hiv Monoinfected Patients At Aga Khan University Nairobi., Bernadette Wambui Muthee

Master of Medicine in Imaging and Diagnostic Radiology

Introduction: Human immunodeficiency virus disease (HIV) is a worldwide health problem. It is estimated that 38.6 million people are infected with HIV globally. It has remained endemic in the African continent for close to 20 years and is a long term developmental challenge in Africa which bears 69 % of the HIV/AIDS global burden. The introduction of highly active antiretroviral therapy (HAART) has caused dramatic improvement in prognosis of HIV disease. Consequently, this has resulted in substantial reduction in Acquired Immune Deficiency Syndrome (AIDS) related morbidity and mortality. In contrast, this has been accompanied by an upsurge in liver- related …

Norovirus Infection And Acquired Immunity In 8 Countries: Results From The Mal-Ed Study, Furqan Kabir, Adil Kalam, Pascal Bessong Pascal Bessong, Zulfiqar Ahmed Bhutta, Anita K. M. Zaidi, (Mal-Ed) Network Investigators, Imran Ahmed, Didar Alam, Syed Asad Ali, Shahida Qureshi, Muneera Rasheed, Sajid Bashir Soofi, Ali Turab, Aisha Khizar Yousafzai

Department of Paediatrics and Child Health

Background: Norovirus is an important cause of childhood diarrhea. We present data from a longitudinal, multicountry study describing norovirus epidemiology during the first 2 years of life.
Methods: A birth cohort of 1457 children across 8 countries contributed 7077 diarrheal stools for norovirus testing. A subset of 199 children contributed additional asymptomatic samples (2307) and diarrheal stools (770), which were used to derive incidence rates and evaluate evidence for acquired immunity.
Results: Across sites, 89% of children experienced at least 1 norovirus infection before 24 months, and 22.7% of all diarrheal stools were norovirus positive. Severity of norovirus-positive diarrhea was …

Inhibitory Effects Of Unique Sulfonamides On Leishmania Tarentolae And Potential Pathway Of Inhibition, Jade M. Katinas

Theses and Dissertations

Leishmaniasis is an endemic disease caused by the protozoan parasite Leishmania. Current treatments for the parasite are limited by cost, availability, and drug resistance as the worldwide occurrence of leishmaniasis continues to be more prevalent. Sulfonamides are a class of compounds with medicinal properties that have been used to treat bacterial and parasitic diseases via various pathways. In this study, newly synthesized, unique structural analogs of sulfonamide compounds were assessed for their impact on Leishmania cell viability and potential pathways for inhibition were evaluated. Leishmania tarentolae (ATCC Strain 30143) axenic promastigote cells were grown in BHI medium and treated with …

Antibiotic Resistance: Use Of Delayed Prescriptions For Viral Syndromes In Urgent Care, Patricia Hansen

Seton Hall University DNP Final Projects

Purpose: Widespread use of antibiotics leads to a development of antimicrobial resistance, an increasing global problem. The rise of antibiotic-resistant bacterial strains represents a serious threat to the public. The Centers for Disease Control and Prevention (CDC) estimates at least two million illnesses and 23,000 deaths are caused by antibiotic resistant bacteriain the United States (CDC, 2014). The strategy of delayed antibiotic prescribing, sometimes called “wait and see” prescriptions, may reduce antibiotic use for viral syndromes in primary care settings. The overall purpose of this scholarly project is to explore delayed prescriptions used by providers in two urgent care settings, …

Shining A Light On Task-Shifting Policy : Exploring Opportunities For Adaptability In Non-Communicable Disease Management Programmes In Uganda, Godfrey Katende, Mary Donnelly

Sultan Qaboos University Medical Journal

In terms of disease burden, many low- and middle-income countries are currently experiencing a transition from infectious to chronic diseases. In Uganda, non-communicable diseases (NCDs) have increased significantly in recent years; this challenge is compounded by the healthcare worker shortage and the underfunded health system administration. Addressing the growing prevalence of NCDs requires evidence-based policies and strategies to reduce morbidity and mortality rates; however, the integration and evaluation of new policies and processes pose many challenges. Task-shifting is the process whereby specific tasks are transferred to health workers with less training and fewer qualifications. Successful implementation of a task-shifting policy …

Healthcare-Associated Methicillin-Resistant Staphylococcus Aureus : Clinical Characteristics And Antibiotic Resistance Profile With Emphasis On Macrolide-Lincosamide..., Jyoti Kumari, Shalini M. Shenoy, Shrikala M, Chakrapani, Gopalkrishna K. Bhat

Sultan Qaboos University Medical Journal

Objectives: Healthcare-associated methicillin-resistant Staphylococcus aureus (MRSA) is a common pathogen worldwide and its multidrug resistance is a major concern. This study aimed to determine the clinical characteristics and antibiotic susceptibility profile of healthcare-associated MRSA with emphasis on resistance to macrolide-lincosamide-streptogramin B (MLSB) phenotypes and vancomycin. Methods: This cross-sectional study was carried out between February 2014 and February 2015 across four tertiary care hospitals in Mangalore, South India. Healthcare-associated infections among 291 inpatients at these hospitals were identified according to the Centers for Disease Control and Prevention guidelines. Clinical specimens were collected based on infection type. S. aureus and MRSA isolates …

Aspergillus Flavus-Induced Brain Abscess In An Immunocompetent Child : Case Report, Nawal Al-Maskari, Ibrahim Hussain, Suleiman Al-Shail, Essam A.

Sultan Qaboos University Medical Journal

Intracranial aspergillosis is an extremely rare manifestation of invasive aspergillosis in immunocompetent children and is associated with high morbidity and mortality. We report a 12-year-old immunocompetent male child who was referred to the King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, in May 2010 after a sudden-onset headache and loss of consciousness. Brain imaging revealed a large right space-occupying occipital lesion and the patient underwent a craniotomy and resection. Histopathology of the lesion revealed necrotising granulomatous fungal encephalitis with many hyphae engulfed by multinucleated giant histiocytes. Two days later, a computed tomography scan showed debulking of the fungal …