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2016

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The Pribram – Bohm Hypothesis Part Ii: The Physiology Of Consciousness, Shelli R. Joye Sep 2016

The Pribram – Bohm Hypothesis Part Ii: The Physiology Of Consciousness, Shelli R. Joye

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

A physiology of consciousness is elaborated, based upon implications of the Pribram-Bohm hypothesis (developed in Part I of this series). The model presented here is in sharp contrast to the prevailing conviction among neuroscientists that consciousness will eventually be discovered to be a physiological epiphenomenon of neuronal electrical impulses firing in the brain. In contrast, the Pribram-Bohm theory holds that consciousness, inherent in what Bohm views cosmologically as “the Whole,” manifests as a dynamic conscious energy resonance bridging the explicate space-time domain with the nonlocal, transcendent flux domain termed the “implicate order.” Presented in Part I, the Pribram-Bohm hypothesis posits …


Fecal Metabolome Of The Hadza Hunter-Gatherers: A Host-Microbiome Integrative View, S. Turroni, J Fiori, S Rampelli, S. L. Schnorr, C. Consolandi, M. Barone, E. Biagi, F. Fanelli, M. Mezzullo, Alyssa Crittenden, A. G. Henry, P. Brigidi, M. Candela Sep 2016

Fecal Metabolome Of The Hadza Hunter-Gatherers: A Host-Microbiome Integrative View, S. Turroni, J Fiori, S Rampelli, S. L. Schnorr, C. Consolandi, M. Barone, E. Biagi, F. Fanelli, M. Mezzullo, Alyssa Crittenden, A. G. Henry, P. Brigidi, M. Candela

Anthropology Faculty Research

The recent characterization of the gut microbiome of traditional rural and foraging societies allowed us to appreciate the essential co-adaptive role of the microbiome in complementing our physiology, opening up significant questions on how the microbiota changes that have occurred in industrialized urban populations may have altered the microbiota-host co-metabolic network, contributing to the growing list of Western diseases. Here, we applied a targeted metabolomics approach to profile the fecal metabolome of the Hadza of Tanzania, one of the world's few remaining foraging populations, and compared them to the profiles of urban living Italians, as representative of people in the …


Recent Insights Into Nitrite Signaling Processes In Blood, Christine C. Helms, Xiaohua Liu, Daniel B. Kim-Shapiro Sep 2016

Recent Insights Into Nitrite Signaling Processes In Blood, Christine C. Helms, Xiaohua Liu, Daniel B. Kim-Shapiro

Physics Faculty Publications

Nitrite was once thought to be inert in human physiology. However, research over the past few decades has established a link between nitrite and the production of nitric oxide (NO) that is potentiated under hypoxic and acidic conditions. Under this new role nitrite acts as a storage pool for bioavailable NO. The NO so produced is likely to play important roles in decreasing platelet activation, contributing to hypoxic vasodilation and minimizing blood-cell adhesion to endothelial cells. Researchers have proposed multiple mechanisms for nitrite reduction in the blood. However, NO production in blood must somehow overcome rapid scavenging by hemoglobin in …


A Note Regarding The Mathematical Treatment Of A Class Of Steady-State Compartmental Models Of The Circulation, Ronald White Sep 2016

A Note Regarding The Mathematical Treatment Of A Class Of Steady-State Compartmental Models Of The Circulation, Ronald White

Center for Advanced Mineral and Metallurgical Processing (CAMP)

A class of steady-state compartmental models of the circulation is examined and it is shown that the mathematical problem for this model class involves a single nonlinear equation. In an important subclass and with certain assumptions regarding the form of the Starling-type cardiac function curves, the single equation is of the form Z = μ + λ log[(1 − Z)/Z] where μ and λ are mathematical parameters related to the physiological parameters of the system and Z is proportional to the cardiac output. This result holds regardless of the number and arrangement of compartments within the model …


Variation In The Glucose Transporter Gene Slc2a2 Is Associated With Glycemic Response To Metformin, Kaixin Zhou, Sook-Wah Yee, Eric L. Seiser, Nienke Van Leeuwen, Roger Tavendale, Amanda J. Bennett, Christopher J. Groves, Ruth L. Coleman, Amber A. Van Der Heijden, Joline W. Beulens, Catherine E. De Keyser, Linda Zaharenko, Daniel M. Rotroff, Mattijs Out, Kathleen A. Jablonski, Ling Chen, Martin Javorský, Jozef Židzik, Albert M. Levin, Keoki L. Williams, Tanja Dujic, Sabina Semiz, Michiaki Kubo, Huan-Chieh Chien, Shiro Maeda, John S. Witte, Longyang Wu, Ivan Tkáč, Adriaan Kooy, Ron Hn Van Schaik, Coen Da Stehouwer, Lisa Logie, Calum Sutherland, Janis Klovins, Valdis Pirags, Albert Hofman, Bruno H Stricker, Alison A Motsinger-Reif, Michael J Wagner, Federico Innocenti, Leen M 'T Hart, Rury R Holman, Mark I Mccarthy, Monique M Hedderson, Colin N A Palmer, Jose C Florez, Kathleen M Giacomini, Ewan R Pearson Sep 2016

Variation In The Glucose Transporter Gene Slc2a2 Is Associated With Glycemic Response To Metformin, Kaixin Zhou, Sook-Wah Yee, Eric L. Seiser, Nienke Van Leeuwen, Roger Tavendale, Amanda J. Bennett, Christopher J. Groves, Ruth L. Coleman, Amber A. Van Der Heijden, Joline W. Beulens, Catherine E. De Keyser, Linda Zaharenko, Daniel M. Rotroff, Mattijs Out, Kathleen A. Jablonski, Ling Chen, Martin Javorský, Jozef Židzik, Albert M. Levin, Keoki L. Williams, Tanja Dujic, Sabina Semiz, Michiaki Kubo, Huan-Chieh Chien, Shiro Maeda, John S. Witte, Longyang Wu, Ivan Tkáč, Adriaan Kooy, Ron Hn Van Schaik, Coen Da Stehouwer, Lisa Logie, Calum Sutherland, Janis Klovins, Valdis Pirags, Albert Hofman, Bruno H Stricker, Alison A Motsinger-Reif, Michael J Wagner, Federico Innocenti, Leen M 'T Hart, Rury R Holman, Mark I Mccarthy, Monique M Hedderson, Colin N A Palmer, Jose C Florez, Kathleen M Giacomini, Ewan R Pearson

Internal Medicine Articles

Metformin is the first-line antidiabetic drug with over 100 million users worldwide, yet its mechanism of action remains unclear. Here the Metformin Genetics (MetGen) Consortium reports a three-stage genome-wide association study (GWAS), consisting of 13,123 participants of different ancestries. The C allele of rs8192675 in the intron of SLC2A2, which encodes the facilitated glucose transporter GLUT2, was associated with a 0.17% (P = 6.6 × 10(-14)) greater metformin-induced reduction in hemoglobin A1c (HbA1c) in 10,577 participants of European ancestry. rs8192675 was the top cis expression quantitative trait locus (cis-eQTL) for SLC2A2 in 1,226 human liver samples, suggesting a key role …


The Concentration Of Stress At The Rotator Cuff Tendon-To-Bone Attachment Site Is Conserved Across Species, F. Saadat, A. C. Deymier, Victor Birman, S. Thomopoulos, G. M. Genin Sep 2016

The Concentration Of Stress At The Rotator Cuff Tendon-To-Bone Attachment Site Is Conserved Across Species, F. Saadat, A. C. Deymier, Victor Birman, S. Thomopoulos, G. M. Genin

Mechanical and Aerospace Engineering Faculty Research & Creative Works

No abstract provided.


Physiology And Political Beliefs: A Response To Knoll, O’Daniel, And Cusato, Johnathan C. Peterson, Kevin Smith, John Hibbing Sep 2016

Physiology And Political Beliefs: A Response To Knoll, O’Daniel, And Cusato, Johnathan C. Peterson, Kevin Smith, John Hibbing

Department of Political Science: Faculty Publications

n a recent paper in this journal, Knoll et al. question three studies from our laboratory. In this response to that paper, we address deficiencies in their “reproduction.” Notably, we demonstrate that their data provide little evidence of a negativity bias among research subjects, suggesting a failure not only to reproduce findings from our earlier studies, but also a failure to find a widely acknowledged universal human physiological response trait. This situation raises a number of questions regarding the data on which their analyses are based. We explore these questions below and speculate that Knoll et al.’s data collection procedures …


Biomimetic And Vascularized 3-D Liver Cancer Model, Derek Yip Aug 2016

Biomimetic And Vascularized 3-D Liver Cancer Model, Derek Yip

Dissertations

Anti-angiogenic drugs have failed to show significant extended mortality, except when co-administered with chemotherapy drugs in clinical trials. This should be predicted by in vitro models, and yet 2D in vitro models of liver cancer co-administered with these two types of drugs show increased cell viability, contradicting clinical trials. In vitro models should mimic clinical trials in order to accurately predict drug outcomes. 2D in vitro models fail because they lack features of the cancer environment such as presence of stromal cells and a vasculature.

In order to achieve a biomimetic and vascularized in vitro model that would better recapitulate …


“Get Married Or Teach School”: Women’S Writing And Women’S Education In Antebellum America, Lindsey Sheppard Aug 2016

“Get Married Or Teach School”: Women’S Writing And Women’S Education In Antebellum America, Lindsey Sheppard

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

Abstract: This article will examine the views expressed by American female writers about the roles of women and purposes of women’s education in the early 19th century. During the antebellum period (1820-1860), the American education system prepared white female students for two roles: to be teachers before marriage and to be ideal wives and mothers. This society believed that women, as wives and mothers, should manage the home and instill traditional American and Christian values in their children. During this period, women wrote a large body of nonfiction articles about social issues, such as education reform, and the roles of …


Forced Exercise Increases Muscle Mass In Eae Despite Early Onset Of Disability, D. I. Patel, L. J. White, V. A. Lira, D. S. Criswell Aug 2016

Forced Exercise Increases Muscle Mass In Eae Despite Early Onset Of Disability, D. I. Patel, L. J. White, V. A. Lira, D. S. Criswell

Health & Kinesiology Faculty Publications and Presentations

We aimed to determine whether 10 days of treadmill exercise can increase skeletal muscle mass and intramuscular concentrations of brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in experimental autoimmune encephalomyelitis (EAE). Forty female Lewis rats were randomly assigned to either EAE sedentary (EAE-Sed), EAE exercise (EAE-Ex), Control sedentary (Con-Sed) and Control exercise (Con-Ex). Exercising animals completed a 10 day forced exercising training program. Hind limb skeletal muscles were excised and weighed with soleus muscle used for BDNF and NGF quantification. Statistical analysis was done using a one-way analysis of variance. Disability was more pronounced in the EAE-Ex …


Evaluating The Effectiveness Of Integrating Food Science Lessons In High School Biology Curriculum In Comparison To High School Chemistry Curriculum, Lauren Elizabeth Ivey Aug 2016

Evaluating The Effectiveness Of Integrating Food Science Lessons In High School Biology Curriculum In Comparison To High School Chemistry Curriculum, Lauren Elizabeth Ivey

Theses and Dissertations

Historically, high school chemistry has been the predominate venue for introducing food science curriculum to students. The purpose of this research was to determine if high school students in a biology class without a chemistry background could comprehend eight basic food science principles equally as well as students in a chemistry class that were taught the same principles. This study assessed baseline knowledge of high school students, determined the effect of food science-based lessons on baseline knowledge and level of understanding, and determined the effect of food science-based lessons on students’ awareness of and interest in food science. Baseline knowledge …


General Catalog 2016-2017, Utah State University Aug 2016

General Catalog 2016-2017, Utah State University

University Catalogs

This catalog contains information on the Academic Departments and Programs as well as Course Descriptions for the above school year at Utah State University. To avoid large file downloads, the Academic Departments and Programs information is located in this file. The Course Description information is located in the secondary file.


Fundamental Principles Of Tremor Propagation In The Upper Limb, Andrew Doran Davidson Aug 2016

Fundamental Principles Of Tremor Propagation In The Upper Limb, Andrew Doran Davidson

Theses and Dissertations

Although tremor is the most common movement disorder, there exist few effective tremor-suppressing devices, in part because the characteristics of tremor throughout the upper limb are unknown. To clarify, optimally suppressing tremor requires a knowledge of the mechanical origin, propagation, and distribution of tremor throughout the upper limb. Here we present the first systematic investigation of how tremor propagates between the shoulder, elbow, forearm, and wrist. We simulated tremor propagation using a linear, time-invariant, lumped-parameter musculoskeletal model relating joint torques and the resulting joint displacements. The model focused on the seven main degrees of freedom (DOF) from the shoulder to …


Characterization Of Transit Ride Quality, Cutr Aug 2016

Characterization Of Transit Ride Quality, Cutr

Research Reports

No abstract provided.


Daily Rhythms Of Physiological Parameters In The Dromedary Camel Under Natural And Laboratory Conditions, Ahmed A. Al-Haidary, Khalid A. Abdoun, Emad M. Samara, Aly B. Okab, Mamane Sani, Roberto Refinetti Aug 2016

Daily Rhythms Of Physiological Parameters In The Dromedary Camel Under Natural And Laboratory Conditions, Ahmed A. Al-Haidary, Khalid A. Abdoun, Emad M. Samara, Aly B. Okab, Mamane Sani, Roberto Refinetti

Psychological Sciences Faculty Publications and Presentations

Camels are well adapted to hot arid environments and can contribute significantly to the economy of developing countries in arid regions of the world. Full understanding of the physiology of camels requires understanding of the internal temporal order of the body, as reflected in daily or circadian rhythms. In the current study, we investigated the daily rhythmicity of 20 physiological variables in camels exposed to natural oscillations of ambient temperature in a desert environment and compared the daily temporal courses of the variables. We also studied the rhythm of core body temperature under experimental conditions with constant ambient temperature in …


Diabetes, Insulin Secretion, And Beta Cell Function, Jeffery Tessem Aug 2016

Diabetes, Insulin Secretion, And Beta Cell Function, Jeffery Tessem

BYU Research Development Office Research Networking Conference

The intricate processes of nutrient metabolism and their biochemical pathways are fundamental to understanding human physiology and health. This research focuses on exploring the biochemical mechanisms underlying nutrient metabolism and how deviations in these processes can lead to metabolic disorders and associated human diseases.


Cfd Simulation Of The Airflow Through The Human Respiratory Tract, Jamasp Azarnoosh Aug 2016

Cfd Simulation Of The Airflow Through The Human Respiratory Tract, Jamasp Azarnoosh

Masters Theses and Doctoral Dissertations

This study compares the effect of extra-thoracic airways (ETA) on the flow field through the lower airways by carrying out simulations of the airflow through the human respiratory tract. Three geometries, consisting of the ETA, CT-derived lower airway, and a combination of the two were utilized in simulations that were performed for transient breathing in addition to constant inspiration/expiration. Physiologically-appropriate regional ventilation for two different flow rates was induced at the distal boundaries by imposing appropriate lobar specific flow rates. Two breathing rates were considered, i.e., 7.5 and 15 breaths per minute with a tidal volume of 0.5 liter. For …


A Transcutaneous Data And Power Transfer System For Osteogenesis Monitoring Sensors, Deepak Dileepkumar Aug 2016

A Transcutaneous Data And Power Transfer System For Osteogenesis Monitoring Sensors, Deepak Dileepkumar

Masters Theses

Implant devices are widely used in health care applications such as life support systems, patient rehabilitation devices and patient monitoring devices. Medical implants have enabled physicians to obtain relevant real time information regarding an organ, or a site of interest with in the body and suggest treatment accordingly. In some cases, the position of the implant within the body or threats of infections prevents wired communication techniques to extract information from the implant. Wireless communication is the alternative in such cases. Distraction osteogenesis is one such application where wireless communication can be established with callus growth monitoring sensors to obtain …


Between Flesh And Being: Theorizing The Racial Body And The Position Of Personhood In Claudia Rankine's Citizen, Lanja Najmalddin Karim Aug 2016

Between Flesh And Being: Theorizing The Racial Body And The Position Of Personhood In Claudia Rankine's Citizen, Lanja Najmalddin Karim

All Theses

In this paper I argue that Claudia Rankine, in Citizen (2014), by concentrating on the place and position of the radicalized body, creates a technique of resistance that emerges as assemblages against contemporary racism. Citizen narrates the stories of a range of racist incidents that happen to individuals, including the author herself and celebrities in Western societies. Those incidents have been narrated and re-contextualized through a unique technique of representation, where multiple genres, such as lyric, prose, and visual images, all collaborate in telling those stories in the text. In Citizen, resistance is the predominant mode of narration. The text …


Examination Of Infographics-Based Reusable Learning Objects (Rlo) And Traditional Didactic Lectures (Tdl) To Improve Consumer Knowledge And Perceptions About The Safe Use Of Plastic Food Containers In A Microwave Oven, Najla Ahmed Khateeb Aug 2016

Examination Of Infographics-Based Reusable Learning Objects (Rlo) And Traditional Didactic Lectures (Tdl) To Improve Consumer Knowledge And Perceptions About The Safe Use Of Plastic Food Containers In A Microwave Oven, Najla Ahmed Khateeb

All Dissertations

This study was a quasi-experimental trials that compared relative effectiveness of Infographics Based Reusable Learning Objects Educational Intervention (RLO and Traditional Didactic Lectures (TDL). A total of 282 Clemson university students were randomized into four groups – Control, RLD, TDL and RLO+TDL and changes in their pre-test and post-test scores were compared before and after each interventions. Specific outcomes tracked included the number of correctly recognized symbols identifying a type plastic, the number of correctly answered question about the safety of using plastic food containers in a microwave and the satisfaction with the instruction. The analysis suggests that RLO intervention …


Effects Of Experimental Noise Exposure On Songbird Nesting Behaviors And Nest Success, Tracy I. Mulholland Aug 2016

Effects Of Experimental Noise Exposure On Songbird Nesting Behaviors And Nest Success, Tracy I. Mulholland

Master's Theses

Anthropogenic noise is an increasingly prevalent global disturbance. Animals that rely on the acoustical environment, such as songbirds, are especially vulnerable to these sounds. Traffic noise, in particular, overlaps with the frequency range of songbirds, creating masking effects. We investigated the effects of chronic traffic noise on provisioning behaviors and breeding success of nesting western bluebirds (Sialia mexicana) and ash-throated flycatchers (Myiarchus cinerascens). Because anthropogenic noise exposure has the potential to interrupt parent-offspring communication and alter vigilance behaviors, we predicted that traffic noise would lead to changes in provisioning behaviors, such as fewer visits to the …


Functional Vasodilation And Vascular Reactivity In Arteriolar Collaterals In The Spinotrapezius Of Males And Females, Britta C. Nelson Aug 2016

Functional Vasodilation And Vascular Reactivity In Arteriolar Collaterals In The Spinotrapezius Of Males And Females, Britta C. Nelson

Biomedical Engineering

Peripheral arterial occlusive disease (PAOD) occurs when there is narrowing or blockage of the peripheral arteries that carry blood to the extremities, most commonly the legs. The most common symptom of PAOD is intermittent claudication, or ischemic pain during exercise. Women with PAOD experience a greater extremity functional impairment than men. Since impaired vasodilation might cause the ischemic pain from PAOD, we should evaluate vasodilation post ligation in males and females in collateral vessels, which connect two arterial segments to maintain blood flow to an otherwise hypoxic area. First, we need to examine collateral vasodilation in unoperated male and female …


Vitamin K2 (Menaquinone) Supplementation And Its Benefits In Cardiovascular Disease, Osteoporosis, And Cancer, Grant S. Buchanan, Md, Thomas Melvin, Brandon Merritt, Charles Bishop, Md, Franklin D. Shuler, Md, Phd Jul 2016

Vitamin K2 (Menaquinone) Supplementation And Its Benefits In Cardiovascular Disease, Osteoporosis, And Cancer, Grant S. Buchanan, Md, Thomas Melvin, Brandon Merritt, Charles Bishop, Md, Franklin D. Shuler, Md, Phd

Marshall Journal of Medicine

Vitamin K is known to play an essential role in the coagulation cascade; however, a growing body of research has found that a subtype of this vitamin, vitamin K2 (menaquinone) may have a beneficial effect in osteoporosis, cardiovascular disease, and cancer. This purpose of this article is to provide a comprehensive review of recent literature regarding menaquinone and its role in human health. This review discusses the physiology of menaquinone, its clinical benefits in cardiovascular disease, osteoporosis, and cancer, and how it may interact with certain medications. The authors conclude that menaquinone supplementation has been shown to improve carboxylation …


Suitability Testing For Possum Scientist-Astronaut Candidates Using The Suborbital Space Flight Simulator With An Iva Spacesuit, Pedro J. Llanos, Erik Seedhouse, Ryan L. Kobrick Jul 2016

Suitability Testing For Possum Scientist-Astronaut Candidates Using The Suborbital Space Flight Simulator With An Iva Spacesuit, Pedro J. Llanos, Erik Seedhouse, Ryan L. Kobrick

Publications

This paper evaluates key functional data parameters that must be considered for suborbital spaceflight participants wearing pressurized suits for intravehicular activity (IVA). Data parameters of an analog spacesuit worn in an analog flight environment were obtained from 40 civilian participants using the Suborbital Space Flight Simulator (SSFS) at Embry-Riddle Aeronautical University (ERAU) while donning Final Frontier Design’s (FFD) fully pressurized third-generation spacesuit as part of their training for Project PoSSUM (the Polar Suborbital Science in the Upper Mesosphere Project). The physiological data collected included: blood pressure, electrocardiograms, heart rate, grip strength, and skin temperature. These parameters were measured using a …


Data Based Conceptual Model Of Gbv And Women's Risk For Hiv Contraction And Progression, Jacquelyn C. Campbell Jul 2016

Data Based Conceptual Model Of Gbv And Women's Risk For Hiv Contraction And Progression, Jacquelyn C. Campbell

International Nursing Research Congress (INRC)

Session presented on Monday, July 25, 2016:

Purpose: Construct a biobehavioral model of the linkages of Gender Based Violence and HIV acquisition and progression through biological and behavioral risk factors including the physiological stress and immune system dysfunction linkages, STI and vaginal wall physiology, forced anal sex, mental health (depression, PTSD, suicidality), and behavioral risks resulting from violence such as substance abuse, inconsistent condom use, and multiple partners.

Methods: Deductive processes from systematic reviews along with data from a large Case (N = 543 abused) Control (N = 358) study of women in the US Virgin Islands and the US …


Trace Elements And Human Obesity: An Overview, Shamshad Karatela, Neil I. Ward Jul 2016

Trace Elements And Human Obesity: An Overview, Shamshad Karatela, Neil I. Ward

Manipal Journal of Nursing and Health Sciences

The human body requires certain amount of trace elements to function properly (especially those that are classified as essential to health). Most elements are co-factors in the molecular mechanisms within the body but when in excess can also cause toxicity. Concentrations of some elements in excess (above optimum) or deficient amount can progress to some types of metabolic abnormalities which could lead to obesity. Obesity is a multifactorial condition with multiple pathways including environmental, dietary, and genetic. All these factors, including elemental abnormalities can disrupt the molecular mechanisms. Whilst there is evidence that obesity causes several elemental deficiencies, there is …


Biology, Saint Mary's College Of California Jul 2016

Biology, Saint Mary's College Of California

Undergraduate Academic Catalog

No abstract provided.


Pre-Professional Curricula, Saint Mary's College Of California Jul 2016

Pre-Professional Curricula, Saint Mary's College Of California

Undergraduate Academic Catalog

No abstract provided.


2016-2017 Lsu Health Sciences Center In New Orleans Catalog/Bulletin, Office Of The Registrar Jul 2016

2016-2017 Lsu Health Sciences Center In New Orleans Catalog/Bulletin, Office Of The Registrar

Catalogs and Bulletins

No abstract provided.


Differential Association Of Vitronectin And Fibronectin With Glass And Electrospun Fibers Of A Poly (D-Lysine) /Poly (Acrylic Acid), Syed Muhammad Sohaib Zafar Zafar Jul 2016

Differential Association Of Vitronectin And Fibronectin With Glass And Electrospun Fibers Of A Poly (D-Lysine) /Poly (Acrylic Acid), Syed Muhammad Sohaib Zafar Zafar

USF Tampa Graduate Theses and Dissertations

Proteins represent major constituent of the extracellular matrix which plays an important role in the formation, maintenance and remodeling of tissues, this project focuses on adsorption of two specific serum proteins fibronectin (FN) and vitronectin (VTN) responsible for mediating cell matrix interaction through integrin binding, tripeptide Arg-Gly-Asp (RGD) sequence found in these protein features are recognized by αβV3 integrin which ultimately helps in clot formation.