Digital Commons Network^™

Mock Flow Loop (Mfl) For Self-Powered Fontan Circulation, Shanice Jones, Kristin Sverrisdottir, Arka Das, Gabriela Espinoza

ASEE EDGD Midyear Conference

The Fontan procedure is the current treatment for babies born with Hypoplastic Left Heart Syndrome (HLHS). The surgery entails multiple severe complications and a survival rate of less than 50% by adulthood. Modification to the Fontan surgery is proposed to lower mortality rate in patients. A bifurcating graft (IJS) has been designed and validated via computational fluid dynamics (CFD) to increase velocity and reduce pressure within the pulmonary arteries. A dynamically scaled mock flow loop (MFL) will be configured to validate the optimized IJS results obtained from the CFD design. The MFL will be based on a reduced Fontan lumped-parameter …

The Re-Designed Lego, Connor Powers, Renee Spear, Derek Wood, Abhimanyu Harish

ASEE EDGD Midyear Conference

Our team's goal is to redesign and improve upon the Lego brick. We believe that Legos are an incredible outlet for creativity for all ages, but as builders grow older and more experienced with Lego construction the complexity that stimulates the creative mind begins to dwindle. To remedy this issue, we re-designed traditional Lego bricks to have stronger links between pieces as well as greater constructive maneuverability. Our improved Lego aims to benefit the community of Lego enthusiasts that create grand complex structures. The new Lego allows for more defined features in large builds and greater structural integrity in all …

Visualization Of Hiv-Associated Neurocognitive Disorders, Tim Fitzgerald

Theses

It is widely known that human immunodeficiency virus type-1 (HIV-1) can cause acquired immune deficiency syndrome (AIDS), but treatments to prevent the virus from escalating to that severity have come a long way since the virus was first described in the 1980s. The medications, combined antiretroviral therapy (cART), keep the virus from replicating, thus stopping its progression to AIDS. However, this treatment does not seem to ultimately benefit the brain, in part because cART does not uniformly penetrate the blood-brain barrier (BBB), and in part because HIV-1 seems to permanently turn on the part of the immune system that causes …

Ancient Animal Ethics: The Earliest Arguments For The Ethical Consideration Of Nonhuman Animals, Joshua J. Sias

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

Primarily focused on the ancient Greek philosophers, this work offers a survey of the earliest arguments for and against the inclusion of nonhuman animals in human realms of ethical consideration. By following the trends of ancient western thought concerning animal ethics, the influencing factors behind the downfall of the subject in Medieval times, both in terms of discourse and practice, is discovered in the philosophical exchange that preceded medieval thought.

Interpersonal Mistreatment, Organizational Attitudes And Well-Being: The Impact Of Instigator’S Hierarchical Position And Demographic Characteristics, Nurul Ain Hidayah Binti Abas, Kathleen Otto

Organization Management Journal

Identifying the consequences of interpersonal mistreatment on the targets' organizational attitudes and well-being is key to promoting a healthy organizational culture. Across two experiments, we explored the impact of an instigator’s hierarchical position and demographic characteristic on the targets’ organizational attitudes and situational well-being. In the first experiment, respondents were presented with a vignette describing an interpersonal mistreatment scenario in which an instigator’s hierarchical position and gender had been manipulated. As hypothesized, interpersonal mistreatment conducted by a supervisor significantly decreased the targets’ organizational commitment and increased turnover intentions. Also, higher turnover intentions and more positive emotions were experienced by those …

Central Washington University 2016-2017 Graduate Catalog, Central Washington University

Course Catalogs

No abstract provided.

Triterpenoid Saponin-Rich Fraction Of Centella Asiatica Decreases Il-1ss Andnf-?B, And Augments Tissue Regeneration And Excision Wound Repair, Amena Mahmood, Ambrish Tiwari, Kazi̇m Şahi̇n, Ömer Küçük, Shakir Ali

Turkish Journal of Biology

Wound healing is an orderly process driven by numerous cellular mediators that aim to accelerate it. In skin conditions such as leprosy and psoriasis, Centella asiatica, which contains high amounts of triterpenoid saponins (TSs), has been reported to have beneficial effects. This study examined the effects of TS fraction of the herb on tissue regeneration and excision wound repair in rat skin. Briefly, TS fraction was prepared from C. Asiatica and applied on the wound area for 7 consecutive days. The IL-1β, NF-κB, and other biochemical parameters were then estimated, followed by examination of inflammatory cell infiltration, epithelialization, angiogenesis, and …

Momentum: Research & Innovation For Spring 2016, University Of Rhode Island

Publications (Research and Economic Development)

The Spring 2016 issue of Momentum: Research & Innovation, a periodical focused on research at the University of Rhode Island.

18th Annual Student Academic Conference, Minnesota State University Moorhead

Student Academic Conference Abstract Books

Minnesota State University Moorhead Student Academic Conference abstract book.

Godey's, 1856, July-December, Vicki Betts

Godey’s Lady’s Book

Index to Godey's Lady's Book, July-December, 1856.

Examination Of Reticulocytosis Among Chronically Transfused Children With Sickle Cell Anemia., Megha Kaushal, Colleen Byrnes, Zarir Khademian, Natalie Duncan, Naomi L. Luban, Jeffery L Miller, Ross Fasano, Emily R. Meier

Pediatrics Faculty Publications

Sickle cell anemia (SCA) is an inherited hemolytic anemia with compensatory reticulocytosis. Recent studies have shown that increased levels of reticulocytosis during infancy are associated with increased hospitalizations for SCA sequelae as well as cerebrovascular pathologies. In this study, absolute reticulocyte counts (ARC) measured prior to transfusion were analysed among a cohort of 29 pediatric SCA patients receiving chronic transfusion therapy (CTT) for primary and secondary stroke prevention. A cross-sectional flow cytometric analysis of the reticulocyte phenotype was also performed. Mean duration of CTT was 3.1 ± 2.6 years. Fifteen subjects with magnetic resonance angiography (MRA) -vasculopathy had significantly higher …

26.0.E.2 Poster Session Titles And Format, Christopher F. Bauer

Day 26 Apr 28 Student poster session

WELCOME to WINDOWS on the INQUIRY CLASSROOM!

You have landed on a piece of a National Science Foundation Project (DUE 1245730) directed by Professor Chris Bauer, Chemistry Department, University of New Hampshire. This is one part of a completely documented inquiry-based university science course called “Fire & Ice” which explores the nature of heat and temperature. There are multiple video perspectives and commentary from instructors and students, and documents of all course materials (agenda, instructions, student work). It’s too complicated to explain here. Take a look at the user orientation document at this link.

Effect Of Different Tempering Methods On Sorghum Milling, Yumeng Zhao

Open Access Theses

Current sorghum milling processes result in high milling losses and inconsistent flour quality. Appropriate tempering methods could improve the quality and quantity of flour extracted from sorghum.

Iodination Of The Isoquinoline Moiety Of T-0632 To Generate Photolabile Analogs, Erin Yang

Honors Thesis Collection

Glugacon-like-peptide-1 receptor (GLP-1R) is a G protein-coupled receptor located on the β-cells of the pancreas. When the incretin hormone, glucagon-like-peptide-1 (GLP-1), binds to GLP-1R, it triggers intracellular signaling cascades that lead to insulin release from pancreatic β-cells. However, the half-life of GLP-1 in plasma is less than two minutes, which makes GLP-1 ineffective to administer as a drug for treatment of abnormal glucose levels. Previous studies have investigated GLP-1R agonists for use of glucose-lowering therapy. T-0632, a non-peptidic small molecule, is an inverse agonist of GLP-1R. Understanding the molecular interactions of binding between T-0632 and GLP-1R within the binding pocket …

An Automated Temporal, Amplitude, And Complexity-Based Comparison Of Commercial Plethysmographs, Matthew Mikhail

Yale Medicine Thesis Digital Library

The study of plethysmographic physiology has been limited by a lack of standardized and open plethysmographic hardware in clinical use. Fundamental differences in the processing of output between various devices obfuscate direct comparison, and the role played by physiology versus that by technology in the final viewable plethysmogram (PPG). This study proposes a largely automated, unbiased method for quantitatively comparing the outputs from proprietary pulse oximeter devices along three metrics: temporal delay, amplification, and complexity. It then applies these methods to the deconstruction of Masimo and Nellcor pulse oximeters.

With IRB approval, twelve healthy, awake subjects were studied. Each individual …

The Universal Language, Amelia Richards

Conspectus Borealis

No abstract provided.

The Importance Of Having Two X Chromosomes, Jenny Link, Arthur P. Arnold, Karen Reue, Mansoureh Eghbali, Eric Vilain, Xuqi Chen, Negar Ghahramani, Yuichiro Itoh, Jingyuan Li, Tuck Ngun, Shayna M. Williams-Burris

Biology

Historically, it was thought that the number of X chromosomes plays little role in causing sex differences in traits. Recently, selected mouse models have been used increasingly to compare mice with the same type of gonad but with one versus two copies of the X chromosome. Study of these models demonstrates that mice with one X chromosome can be strikingly different from those with two X chromosomes, when the differences are not attributable to confounding group differences in gonadal hormones. The number of X chromosomes affects adiposity and metabolic disease, cardiovascular ischaemia/reperfusion injury and behaviour. The effects of X chromosome …

Use Of A Mouse Model To Evaluate The Effect Of Statins On The Immune Response To An Influenza Virus Vaccine, Calvin Olsen, Bart Tarbet

Biology Posters

Statins are cholesterol lowering drugs that have shown a profound effect on human health by reducing cardiovascular disease. However, two recent publications in the Journal of Infectious Diseases showed that statin use had a negative impact on the influenza vaccine response in elderly individuals [1, 2]. We propose to evaluate the immune response following vaccination in mice undergoing statin treatment. An initial study will determine the therapeutic window for statin treatment of mice fed a lipid-enriched diet. From the literature this window is expected to be between 21-28 days. That therapeutic window will be used for evaluation of the immune …

Ex-Vivo Slaughterhouse Porcine Crystalloid-Perfused Beating Heart Via Langendorff Method, Rahiemin Talukder

Electronic Theses and Dissertations

The objective of this study was to resuscitate isolated beating porcine hearts obtained from slaughterhouse swine for a minimum of 1 hour with a crystalloid buffer reperfusion instead of blood via an extracorporeal Langendorff apparatus. The isolated beating heart functions outside of the body under simulated physiologic conditions. Live functional anatomy was controlled under benchtop experimental settings. Porcine hearts (26 total) were topically cooled with saline. 300mL of 25°C cardioplegia with 20KU Streptokinase was preflushed via aortic root. WIT was less than 5 minutes. 1L 4°C cardioplegia was flushed antegrade with aortic cannula (Group 1) or coronary catheterization (Group 2). …

Horizons Fall 2016, Nova Southeastern University

Horizons

No abstract provided.

Examination Of Reticulocytosis Among Chronically Transfused Children With Sickle Cell Anemia., Megha Kaushal, Colleen Byrnes, Zarir Khademian, Natalie Duncan, Naomi L.C. Luban, Jeffery L Miller, Ross M. Fasano, Emily Riehm Meier

Pediatrics Faculty Publications

Sickle cell anemia (SCA) is an inherited hemolytic anemia with compensatory reticulocytosis. Recent studies have shown that increased levels of reticulocytosis during infancy are associated with increased hospitalizations for SCA sequelae as well as cerebrovascular pathologies. In this study, absolute reticulocyte counts (ARC) measured prior to transfusion were analysed among a cohort of 29 pediatric SCA patients receiving chronic transfusion therapy (CTT) for primary and secondary stroke prevention. A cross-sectional flow cytometric analysis of the reticulocyte phenotype was also performed. Mean duration of CTT was 3.1 ± 2.6 years. Fifteen subjects with magnetic resonance angiography (MRA) -vasculopathy had significantly higher …

The Role Of Cyclic Nucleotide Gated Channels, Retrograde Ift Rate Change, And Chemical Concentration In The Olfactory Habituation Of C. Elegans, Michaela A. O'Driscoll

Honors Program Theses

The cilium is an organelle utilized by the cell for signaling purposes. Olfaction is a process that utilizes cilia for cell signaling, specifically as the starting point of the neuronal olfactory pathway, by which volatile odorant molecules trigger neuronal depolarization and subsequent behavioral modification. Related to cilia function and development is the process of intraflagellar transport (IFT): the bidirectional movement of channels, receptors, and other proteins by motors along the microtubules of the cilia, including odorant receptors. The phenomenon of odorant habituation upon continuous exposure to an attractant chemical has been previously confirmed, but the role of IFT in this …

Psyx 383.01: Health Psychology, Lindsey C. Grove

University of Montana Course Syllabi

No abstract provided.

Gonzaga University Factbook 2016-17, Institutional Research, Gonzaga University

Institutional Research

The Gonzaga University Factbook contains information on student enrollments, demographic profiles, admissions statistics, majors, retention and graduation rates, degree completions, faculty information, and more. It is updated annually with the most current and commonly-needed information about Gonzaga University.

Retention Of Cardiopulmonary Resuscitation Knowledge And Psychomotor Skill Among Undergraduate Nursing Students: An Integrative Review Of Literature, Fernanda Tirado

Honors Undergraduate Theses

Purpose: The purpose of this integrative literature review is to explore the effectiveness of different training modalities on the acquisition and retention of CPR knowledge and psychomotor skill among undergraduate nursing students. Background: It is well known that standard CPR-training is ineffective at preparing nurses for the rigors of a cardiac arrest event. Survival rates for in-hospital cardiac arrests remain low and the proportion of neurobehavioral sequelae among survivors is very high. Methods: A review of relevant literature published between 2006 and 2016 was conducted using the CINAHL and MEDLINE databases. The following key terms were used in the search: …

What Does The Development Of An Interprofessional Education (Ipe) Program Encompass: Including Outcomes, When Implementing The Curriculum Into A Small Technical College?, Glenn M. Levicki

MUSC Theses and Dissertations

The purpose of this case study was to determine what Interprofessional Education (IPE) encompasses, the outcomes of implementing IPE in college curricula, and how attainable it is to use IPE to enhance collaboration among healthcare professionals. The contemporary and correlated literature was reviewed to contribute to knowledge and solve the research dilemma that revolves around (IPE). The main areas investigated were what encompass IPE, the educational outcomes and erudition experiences of IPE students, development and implementation of IPE curriculum, and effects of IPE. The emphasis of the study was to establish what encompasses the development and implementation of IPE curriculum. …

How To Write A Doctoral Thesis, H R. Ahmad

Department of Biological & Biomedical Sciences

No abstract provided.

Slough: Revealing The Animal, Clay Dunklin

Honors Undergraduate Theses

When making my work I constantly reflect on past mythologies, images, and objects. These served people as a way to make sense of and understand the dynamics of the world around them. As we continue to alter and shape the world into one designed for exclusively human benefit, we need new models that reveal the dynamics of our relationship to the world around us. This is what artists have been doing for centuries, and I specifically look to those using animals and animal imagery in their work to further mythologize our contemporary understanding of the human-other animal relationship. My body …

The Mayo Framework Is Bad For Your Health, Christopher M. Holman

Faculty Works

This Article begins by providing a brief historical retrospective of the development of the patent eligibility doctrine, and then delves into the related questions of: (1) what are the Supreme Court’s policy objectives for the recent reinvigoration of the patent eligibility doctrine; and (2) has it achieved those objectives? The article then discusses three important out-standing questions regarding the application of the new test for patent eligibility: (1) what constitutes a natural phenomenon; (2) what constitutes an inventive step; and (3) what, if any, role does preemption play in the analysis? The article then provides four examples of recent lower …

A Neuroergonomics Study Of Brain Eeg's Activity During Manual Lifting Tasks, Awad Aljuaid

Electronic Theses and Dissertations

Electroencephalography (EEG) has been shown to be a reliable tool in neuroergonomics studies due to the relatively low cost of brain data collection and limited body invasion. The application of EEG frequency bands (including theta, alpha and beta), enjoyed a wide range of interest in physical and cognitive ergonomics. The psychophysical approach has been used for decades to improve safe work practices by understanding human limitations in manual materials handling. The main objective of this research project was to study the brain's EEG activity expressed by the power spectral density during manual lifting tasks related to: 1) the maximum acceptable …