Digital Commons Network^™

The Role Of Design Choice In Intellectual Property And Antitrust Law, Stacey Dogan

Faculty Scholarship

When is it appropriate for courts to second-guess decisions of private actors in shaping their business models, designing their networks, and configuring the (otherwise non-infringing) products that they offer to their customers? This theme appears periodically but persistently in intellectual property and antitrust, especially in disputes involving networks and technology. In both contexts, courts routinely invoke what I call a “non-interference principle” — the presumption that market forces ordinarily bring the best outcomes for consumers, and that courts and regulators should not meddle in the process. This non-interference principle means, for example, that intermediaries need not design their networks to …

The Current Volume 27 : Issue 11, Nova Southeastern University

Student Newspapers

No abstract provided.

The Dormant Commerce Clause As A Limit On Personal Jurisdiction, John F. Preis

Law Faculty Publications

For over 70 years, the Due Process Clause has defined the law of personal jurisdiction. This makes sense, because being forced to stand trial in a far-off state will sometimes be fundamentally unfair. What does not make sense, however, is the Dormant Commerce Clause’s apparent irrelevance to personal jurisdiction. The Dormant Commerce Clause addresses state laws affecting interstate commerce, and a plaintiff’s choice of forum is often a commercially driven choice between different state courts. So why isn’t the Dormant Commerce Clause part of personal jurisdiction doctrine?

This Article makes the case for its relevance, and demonstrates how the Dormant …

Cho Endonuclease Functions During Dna Interstrand Crosslink Repair In Escherichia Coli, Anthonige Vidya Perera, James Brian Mendenhall, Charmain T. Courcelle, Justin Courcelle

Biology Faculty Publications and Presentations

DNA interstrand crosslinks are complex lesions that covalently link both strands of the duplex DNA. Lesion removal is proposed to initiate via the UvrABC nucleotide excision repair complex, however less is known about the subsequent steps of this complex repair pathway. In this study, we characterized the contribution of nucleotide excision repair mutants to survival in the presence of psoralen-induced damage. Unexpectedly, we observed that the nucleotide excision repair mutants exhibit differential sensitivity to psoralen-induced damage, with uvrC mutants being less sensitive than either uvrA or uvrB. We show that Cho, an alternative endonuclease, acts with UvrAB and is …

Scientific Engagement At Fda: A Report To The Fda Science Board From The Scientific Engagement Subcommittee, Anthony Bahinski, Maria C. Friere, Mark R. Mclellan, Bruce M. Psaty, Dan M. Roden, Scott J. Steele

Biology Faculty Publications and Presentations

Maintaining active interactions with the broad external scientific community is vital for FDA to fulfill its expanding public health mission. It is essential for the Agency to be well positioned to address emerging areas of regulatory science and rapidly advancing technologies.

Scientific engagement also helps FDA accomplish its mission by increasing awareness of FDA’s responsibilities and helping with the Agency’s critical recruitment and succession planning needs. FDA uses a range of mechanisms for scientific exchange. The Subcommittee was charged with considering:

a. how FDA can improve its interface with the outside scientific community, particularly regarding public-private partnerships (PPPs) and fellowship …

Office Of Regulatory Affairs Strategies For Building An Integrated National Laboratory Network For Food And Feed, Barbara Kowalcyk, Mark R. Mclellan, Lynn Goldman, David Goldman, Harvey T. Holmes, Connie Weaver

Biology Faculty Publications and Presentations

An interconnected network of accredited federal, state, local, tribal, and territorial laboratories is critical to ensuring the safety of the U.S. food supply and the development of the Integrated Food Safety System (IFSS). In 2004, as part of a national policy to defend the U.S. food supply against terrorist attacks, major disasters, and other emergencies, the Food Emergency Response Network (FERN) was created to integrate the nation’s multilevel (i.e., federal, state, local, tribal, territorial) food-testing laboratories to detect, identify, respond to, and recover from a bioterrorism act affecting the safety of the food supply, or a public health emergency/outbreak involving …

Choice Of Business Entity, C. Wells Hall Iii

William & Mary Annual Tax Conference

No abstract provided.

Dynamic Patent Disclosure, Jeanne C. Fromer

Vanderbilt Law Review

Those who tout the role of disclosure as a benefit of the patent system emphasize-as the Supreme Court has-that the information in patents "add[s] to the general store of knowledge [and is] of such importance to the public weal that the Federal Government is willing to pay the high price of ... exclusive use for its disclosure, which disclosure ... will stimulate ideas and the eventual development of further significant advances in the art." As I excavate in this Article, the current state of patent disclosure-which many think is poor and does not achieve its objective of stimulating innovation-is impoverished …

The Targetable Epigenetic Tumor Protein Ezh2 Is Enriched In Intraocular Medulloepithelioma., Sarah E. Avedschmidt, Anna M. Stagner, Ralph C Eagle, George J. Harocopos, Yali Dou, Rajesh C. Rao

Wills Eye Hospital Papers

Purpose: Intraocular medulloepithelioma (IM), the second most common primary neuroepithelial tumor of the eye, can lead to blindness in the affected eye and in rare cases, is deadly. Intraocular medulloepithelioma lacks targetable biomarkers for potential pharmacologic therapy. The purpose of this study was to identify actionable, tumor-specific proteins for potential diagnostic or therapeutic strategies. We hypothesize that the tumor-specific epigenetic enzyme EZH2 is selectively expressed in IM.

Methods: We conducted a retrospective case series study of five IM from five eyes of four children and one adult. Hematoxylin and eosin (H&E) stains of sections from formalin-fixed, paraffin-embedded blocks of IM …

Single-Leg Squats Can Predict Leg Alignment In Dancers Performing Ballet Movements In "Turnout", Luke Hopper, Nahoko Sato, Andries L. Weidemann

Research outputs 2014 to 2021

The physical assessments used in dance injury surveillance programs are often adapted from the sports and exercise domain. Bespoke physical assessments may be required for dance, particularly when ballet movements involve “turning out” or external rotation of the legs beyond that typically used in sports. This study evaluated the ability of the traditional single-leg squat to predict the leg alignment of dancers performing ballet movements with turnout. Three-dimensional kinematic data of dancers performing the single-leg squat and five ballet movements were recorded and analyzed. Reduction of the three-dimensional data into a one-dimensional variable incorporating the ankle, knee, and hip joint …

Leadership Training In Medical School: A Student’S Perspective, Catherine Lee

USF-LVHN SELECT

No abstract provided.

The Influence Of Spousal Support On Air Force Senior Noncommissioned Officers' Pursuit Of A Bachelor's Degree: A Hermeneutic Phenomenological Study, Randy Croft

Doctoral Dissertations and Projects

The purpose of this hermeneutic phenomenological study was to explore perceptions of spousal support among active-duty Air Force Senior Noncommissioned Officers (Senior NCOs) in their pursuit of a bachelor’s degree. Senior NCOs are comprised of enlisted Airmen in the ranks of E-7 through E-9. Fourteen active-duty Air Force Senior NCOs, who have completed, or are enrolled in a bachelor’s degree program completed an online survey and a personal interview regarding their perceptions of spousal support in their pursuit of a bachelor’s degree. In addition, participants completed a written timeline, which helped provide context to college degree enrollment decisions and spousal …

Discipleship Counseling: Developing Healthy, Growing, Multiplying Followers Of Jesus, James Albritton

Doctoral Dissertations and Projects

This project will look at how professional or lay counseling can increase the effectiveness of making and maturing followers of Jesus. An effective strategy for disciple-making that targets the whole person will be established to help followers of Jesus overcome the emotional pain due to past sin and hurts which have left them ineffective and stagnant in their growth as disciples. Research will be conducted through articles, websites, and books dealing with the subject as well as a survey of at least 50 pastors to determine whether a clear process of disciple-making exists in their church and if any form …

Ethical Implications Of Auxiliary Practice Outside Of Scope, Michael G. Maihofer Dds

The Journal of the Michigan Dental Association

Regular column featuring ethical guidance and consideration for practicing dentists.

Microplastic In Surface Waters Of Urban Rivers: Concentration, Sources, And Associated Bacterial Assemblages, Amanda Rae Mccormick, Timothy Hoellein, Maxwell G. London, Joshua Hittie, John J. Kelly, John W. Scott

Biology: Faculty Publications and Other Works

The ecological dynamics of microplastic (<5 mm) are well documented in marine ecosystems, but the sources, abundance, and ecological role of microplastic in rivers are unknown and likely to be substantial. Microplastic fibers (e.g., synthetic fabrics) and pellets (e.g., abrasives in personal care products) are abundant in wastewater treatment plant (WWTP) effluent, and can serve as a point source of microplastic in rivers. The buoyancy, hydrophobic surface, and long transport distance of microplastic make it a novel substrate for the selection and dispersal of unique microbial assemblages. We measured microplastic concentration and bacterial assemblage composition on microplastic and natural surfaces upstream and downstream of WWTP effluent sites at nine rivers in Illinois, United States. Microplastic concentration was higher downstream of WWTP effluent outfall sites in all but two rivers. Pellets, fibers, and fragments were the dominant microplastic types, and polymers were identified as polypropylene, polyethylene, and polystyrene. Mean microplastic flux was 1,338,757 pieces per day, although the flux was highly variable among nine sites (min = 15,520 per day, max = 4,721,709 per day). High-throughput sequencing of 16S rRNA genes showed bacterial assemblage composition was significantly different among microplastic, seston, and water column substrates. Microplastic bacterial assemblages had lower taxon richness, diversity, and evenness than those on other substrates, and microplastic selected for taxa that may degrade plastic polymers (e.g., Pseudomonas) and those representing common human intestinal pathogens (e.g., Arcobacter). Effluent from WWTPs in rivers is an important component of the global plastic “life cycle,” and microplastic serves as a novel substrate that selects and transports distinct bacterial assemblages in urban rivers. Rates of microplastic deposition, consumption by stream biota, and the metabolic capacity of microplastic biofilms in rivers are unknown and merit further research.

Draft Genome Sequence For A Urinary Isolate Of Nosocomiicoccus Ampullae, Catherine Putonti, Evann E. Hilt, Travis K. Price, Katherine Diebel, Alan J. Wolfe

Biology: Faculty Publications and Other Works

A draft genome sequence for a urinary isolate of Nosocomiicoccus ampullae (UMB0853) was investigated. The size of the genome was 1,578,043 bp, with an observed G+C content of 36.1%. Annotation revealed 10 rRNA sequences, 40 tRNA genes, and 1,532 protein-coding sequences. Genome coverage was 727× and consisted of 32 contigs, with an N₅₀ of 109,831 bp.

Decisions, Decisions: Factors That Influence A Patient's Medical Tourism Choices, Louis K. Falk, Thomas J. Prinsen

Faculty Work Comprehensive List

In the digital age, the amount of information and sources concerning Medical Tourism is overwhelming. Knowledge is power in an era of healthcare uncertainty. As health care options have grown in global proportions, it has become more difficult for potential patients to locate the material necessary to make informed decisions or to even know which factors to consider during their information search. Individual financial circumstances vary greatly. This paper suggests how medical tourism makes financial sense for many patients and payers. Proximity and culture play roles in that medical tourists may prefer locations that are not too far from home. …

Establishment Of Site Specific Multi Disciplinary Tumour Boards In Pakistan -Is It Really Necessary To Discuss All Cancer Cases In Multidisciplinary Tumour Board Meetings?, Ahmed Nadeem Abbasi

Department of Radiation Oncology

No abstract provided.

Body Image Perception And Internalization Problems Indicators In Mexican Adolescents, Cecilia Colunga-Rodríguez, Mercedes Gabriela Orozco-Solis, María Elena Flores-Villavicencio, José María De-La-Roca-Chiapas, Ricardo Gómez-Martínez, Alfonso Mercado, Julio César Vázquez-Colunga, Juan Carlos Barrera-De-León, Claudia Liliana Vázquez-Juárez, Mario Ángel-González

Psychological Science Faculty Publications

The aim of the study was to determine the existing differences by gender in the indicators of internalizing problems regarding the body image perception of Mexican adolescents. A descriptive and transversal study was developed. The participants were students from four public middle schools in Guadalajara Mexico. The instrument used was an online survey constituted by a sociodemographic section, an internalizing problems indicators scale (α = .85) and a body image perception scale (α = .70). Parental consent was obtained using a waiver of active consent. The survey was applied online, during school hours at the computer labs. Descriptive statistics were …

Alcohol Use Variability In A Community-Based Sample Of Nonstudent Emerging Adult Heavy Drinkers, Cathy Lau-Barraco, Abbly L. Braitman, Amy L. Stamates, Ashley N. Linden-Carmichael

Psychology Faculty Publications

BACKGROUND: While nonstudent emerging adults are at elevated risk for experiencing alcohol-related problems, there remains a paucity of research devoted specifically to addressing drinking in this group.

OBJECTIVES: The present study sought to offer unique insights into nonstudent drinking by examining drinking variability across 30 days using a retrospective diary method. Specific aims were to: (1) compare within- and between-person variability in alcohol use across 30 days, and (2) determine the extent to which central social-cognitive between-person factors (i.e., social expectancies, perceived drinking norms, social drinking motivations) predict between-person alcohol use as well as within-person variability in drinking.

METHODS: Participants …

Risk Factors Of Trastuzumab-Induced Cardiotoxicity In Breast Cancer: A Meta-Analysis, Zeeshan Jawa, Ruth M. Perez, Lydia Garlie, Maharaj Singh, Rubina Qamar, Bijoy K. Khandheria, Arshad Jahangir, Yang Shi

College of Nursing Faculty Research and Publications

Background: 

Trastuzumab targets the human epidermal growth factor receptor 2 oncogene and in combination with first-line therapy results in significantly improved survival outcomes and has thus become standard of care in both adjuvant and metastatic settings. While it is estimated that 1% to 4% of patients treated with trastuzumab will develop heart failure and ∼10% will experience a reduction in left ventricular ejection fraction (LVEF), the patient risk factors associated with trastuzumab-induced cardiotoxicity (TIC) are unclear. This meta-analysis aims to consolidate previously published data to identify the risk factors most likely leading to TIC.

Methods: 

A search of the MEDLINE …

Introduction To The Global Matrix 2.0: Report Card Grades On The Physical Activity Of Children And Youth Comparing 38 Countries, Mark S. Tremblay, Silvia A. Gonzalez, Peter T. Katzmarzyk, Vincent O. Onywera, John J. Reilly, Grant Tomkinson

Education, Health & Behavior Studies Faculty Publications

No abstract provided.

Autism Spectrum Disorder And The Child's Weight–Related Behaviors: A Parents' Perspective, Michele Polfuss, Norah L. Johnson, Susan A. Bonis, Fallon Apollon, Kathleen Sawin

College of Nursing Faculty Research and Publications

Purpose

To explore parent perspectives of how the attributes of their child's autism spectrum disorder(ASD) impact nutrition, physical activity, screen time behaviors and risk for obesity. Secondarily, we examined the parent's perception of the healthcare providers (HCP) influence on these weight-related behaviors.

Design and method

We conducted and audio-recorded telephone interviews with parents of children with ASD (n = 8) using a structured question guide. Data were transcribed and thematic analysis was conducted. Issues surrounding weight-related behaviors and parental strategies used were reported.

Results

Two overarching themes with eight subthemes emerged: (1) Challenges related to features of ASD (subthemes included …

Patient/Family Education For Newly Diagnosed Pediatric Oncology Patients, Wendy Landier, Joann Ahern, Lamia P. Barakat, Smita Bhatia, Kristin M. Bingen, Patricia G. Bondurant, Susan L. Cohn, Sarah K. Dobrozsi, Maureen Haugen, Ruth Anne Herring, Mary C. Hooke, Melissa Martin, Kathryn Murphy, Amy R. Newman, Cheryl C. Rodgers, Kathleen S. Ruccione, Jeneane Sullivan, Marianne E. Weiss, Janice Withycombe, Lise Yasui, Marilyn Hockenberry

College of Nursing Faculty Research and Publications

There is a paucity of data to support evidence-based practices in the provision of patient/family education in the context of a new childhood cancer diagnosis. Since the majority of children with cancer are treated on pediatric oncology clinical trials, lack of effective patient/family education has the potential to negatively affect both patient and clinical trial outcomes. The Children’s Oncology Group Nursing Discipline convened an interprofessional expert panel from within and beyond pediatric oncology to review available and emerging evidence and develop expert consensus recommendations regarding harmonization of patient/family education practices for newly diagnosed pediatric oncology patients across institutions. Five broad …

Interprofessional Health Team Communication About Hospital Discharge: An Implementation Science Evaluation Study, Sarah J. Bahr, Danielle M. Siclovan, Kristi Opper, Joseph Beiler, Kathleen Bobay, Marianne E. Weiss

College of Nursing Faculty Research and Publications

The Consolidated Framework for Implementation Research guided formative evaluation of the implementation of a redesigned interprofessional team rounding process. The purpose of the redesigned process was to improve health team communication about hospital discharge. Themes emerging from interviews of patients, nurses, and providers revealed the inherent value and positive characteristics of the new process, but also workflow, team hierarchy, and process challenges to successful implementation. The evaluation identified actionable recommendations for modifying the implementation process.

Development And Psychometric Analysis Of The Patient Perceptions Of Patient-Empowering Nurse Behaviours Scale (Pppnbs), Teresa Jerofke-Owen, Marianne E. Weiss

College of Nursing Faculty Research and Publications

Aim

To (1) develop and psychometrically test the Patient Perceptions of Patient-Empowering Nurse Behaviours Scale, which measures patient perceptions of empowering nurse behaviours during hospitalization; and (2) refine to a shorter, more useful form, for measurement in clinical settings.

Background

Although patient empowerment has been promoted as a way to engage patients in chronic illness care, there is not a measure reported by patients as recipients of empowering nurse behaviours during hospitalization.

Design

Psychometric evaluation of construct and predictive validity, reliability and item reduction.

Method

Data gathered during hospitalization and six weeks postdischarge between April 2012 - August 2014 were …

Resilience In Adolescents Who Survived A Suicide Attempt From The Perspective Of Registered Nurses In Inpatient Psychiatric Facilities, Denise M. Matel-Anderson, Abir K. Bekhet

College of Nursing Faculty Research and Publications

The number of deaths by suicide has increased over the last few years. The purpose of this qualitative study is to explore components of resilience in adolescents who survived a suicide attempt from the perspective of nine psychiatric nurses. Resilience was used as a guiding conceptual framework which proposes that resilience is the interplay between risk and protective factors. Three categories emerged including risk factors, protective factors, and future recommendations of suicide prevention strategies. The perspectives gained from this study will help develop nursing interventions for adolescents to overcome risk factors and to build on their protective factors.

Anti-Müllerian Hormone Levels And Urinary Cortisol In Women With Chronic Abdominal Pain, Theresa M. Hardy, Donna O. Mccarthy, Nicolaas Fourie, Wendy Henderson

College of Nursing Faculty Research and Publications

Abstract

Objective

To explore the association of hypothalamic–pituitary–adrenal activity with ovarian functioning in women with and without chronic abdominal pain (CAP).

Design and Setting

A secondary data analysis was performed with data from female participants in a natural history protocol at the National Institutes of Health.

Participants

A total of 36 women (age range = 19–39 years, mean = 27.11 years) were included in the study.

Methods

This pilot study was conducted with a subset of participants enrolled in a natural history protocol conducted in the Hatfield Clinical Research Center at the National Institutes of Health. The parent study included …

Conformational States Of Cytochrome P450 Oxidoreductase Evaluated By Förster Resonance Energy Transfer Using Ultrafast Transient Absorption Spectroscopy, Elizaveta A. Kovrigina, Brian Pattengale, Chuanwu Xia, Azamat R. Galiakhmetov, Jier Huang, Jung Ja Kim, Evgenii L. Kovrigin

Chemistry Faculty Research and Publications

NADPH-cytochrome P450 oxidoreductase (CYPOR) was shown to undergo large conformational rearrangements in its functional cycle. Using a new Förster resonance energy transfer (FRET) approach based on femtosecond transient absorption spectroscopy (TA), we determined the donor–acceptor distance distribution in the reduced and oxidized states of CYPOR. The unmatched time resolution of TA allowed the quantitative assessment of the donor–acceptor FRET, indicating that CYPOR assumes a closed conformation in both reduced and oxidized states in the absence of the redox partner. The described ultrafast TA measurements of FRET with readily available red–infrared fluorescent labels open new opportunities for structural studies in chromophore-rich …

Engaging Parents With Sex And Relationship Education: A Uk Primary School Case Study, P Alldred, N Fox, R Kulpa

School of Law, Humanities and Social Sciences

Objective: To assess an intervention to familiarise parents with children’s books for use in primary (5–11 years) sex and relationship education (SRE) classes. Method: Case study of a 7-week programme in one London primary school, using ethnographic observation, semi-structured interviews and focus groups with parents (n = 7) and key stakeholders (n = 4), and pre- and post-programme self-completion questionnaires (n = 9). Results: Parents reported increased understanding of the SRE curriculum and awareness of relevant children’s books, enhanced interactions with their children on SRE topics and some positive effects on partners and attitudes towards the school. There was increased …