Digital Commons Network^™

Exosome-Mediated Transfer Of Αvβ3 Integrin From Tumorigenic To Nontumorigenic Cells Promotes A Migratory Phenotype., Amrita Singh, Carmine Fedele, Huimin Lu, Marja T. Nevalainen, James H. Keen, Lucia R. Languino

Department of Cancer Biology Faculty Papers

The αvβ3 integrin is known to be highly upregulated during cancer progression and promotes a migratory and metastatic phenotype in many types of tumors. We hypothesized that the αvβ3 integrin is transferred through exosomes and, upon transfer, has the ability to support functional aberrations in recipient cells. Here, for the first time, it is demonstrated that αvβ3 is present in exosomes released from metastatic PC3 and CWR22Pc prostate cancer cells. Exosomal β3 is transferred as a protein from donor to nontumorigenic and tumorigenic cells as β3 protein or mRNA levels remain unaffected upon transcription or translation inhibition in recipient cells. …

Getting Started: Identifying Funding Opportunities With Jefferson Resources, Molly Gerber, Avp, Gary Kaplan, Dana Marcus

Department of Surgery, Faculty Development Sessions

Section 1: Philanthropy Basics

Section 2: Fundraising for Research

Section 3: Information Resources

36 PowerPoint slides

Forage News [2016-11], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• The New Face of Forage News
• Changes to FSA Acreage Reporting Dates for 2017
• Heart of America Grazing Conference to be held in Quincy, IL January 18-19
• Forage News Quote of the Month: "Wasted Hay Means Wasted Money"
• Overseeding Small Grains into Pastures or Hayfields
• AFGC Annual Meeting - January 22-24, 2017
• Somerset KY Hosts Successful Kentucky Grazing Conference
• Featured Publication: Taking Soil Test Samples - AGR-16
• Dairy Market Continues to Struggle

Circumcision Status Is Not Associated With Condom Use And Prevalence Of Sexually Transmitted Infections Among Young Black Msm, Richard A. Crosby, Cynthia A. Graham, Leandro Mena, William L. Yarber, Stephanie A. Sanders, Robin R. Milhausen, Angelica Geter

Health, Behavior & Society Faculty Publications

This study investigated whether intact young Black MSM differed from their circumcised counterparts regarding condom use behaviors and perceptions and HIV/Chlamydia/gonorrhea. Young Black MSM completed a self-interview, including a pictorial item assessing circumcision status and measures of condom use. Twenty-seven percent of 388 participants reported not being circumcised. With one exception, no associations tested approached significance. The mean frequency of unprotected insertive anal sex for circumcised men was about twice as high compared to those intact (P = .04). Intact young Black MSM did not differ from circumcised men relative to prevalence of STIs (including HIV) or condom use behaviors …

The Intellectual Property Hostage In Trade Retaliation, Sarah R. Wasserman Rajec

Maryland Law Review

Intellectual property law has become bound up in a debate about appropriate remedies for violations of the World Trade Organization Agreement. As an alternative to traditional countermeasures that consist of retaliation under the violated agreement, the World Trade Organization “(WTO”) contemplates that violations of one of its covered agreements may be remedied through “cross-retaliation,” or retaliation under another agreement. One form of cross-retaliation has garnered interest in recent years: the threat to suspend intellectual property rights in response to unrelated trade violations.

Cross-retaliation through intellectual property rights suspension is theoretically appealing for its potential to avoid problems inherent in traditional …

Polymorphisms In Mthfr, Ms And Cbs Genes And Premature Acute Myocardial Infarction In A Pakistani Population, Mohammad Perwaiz Iqbal, Khalida Iqbal, Asal Khan Tareen, Siddiqa Parveen, Naseema Mehboobali, Ghulam Haider, Saleem Perwaiz Iqbal

Department of Biological & Biomedical Sciences

High prevalence of premature coronary heart disease in Pakistanis compared to other populations points towards the genetic predisposition of this population to develop this disease. Since no investigations have been carried out in Pakistan to study the relationship of polymorphisms in genes involved in homocysteine cycle, the objective of the present study was to find out if there is any association of methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C; methionine synthase (MS) A2756G; cystathionine-beta-synthase (CBS) 844ins68, G919A polymorphisms with premature acute myocardial infarction (AMI) in a population of Pakistani patients with this disease. In a cross-sectional study, DNA samples of 143 AMI …

Adding And Slashing Serials, Zebulin Evelhoch

All Faculty Scholarship for the College of the Sciences

During a time of stagnating budgets and rising journal costs, Central Washington University’s Brooks Library evaluated and added a popular print magazine collection and worked with faculty to eliminate redundant and low-use resources. The process of identifying the need, researching, evaluating, and gaining student input for popular magazines to be added to a recently opened coffee shop is addressed first. Secondly, the systematic approach the library used to identify journal titles received in multiple formats and low-use/high-cost resources then worked with faculty to change access models to realize a net savings is discussed. Throughout, insights are provided into the processes …

Gerrymandering Revisited—Searching For A Standard, Theodore R. Boehm

Indiana Journal of Law and Social Equality

No abstract provided.

2016-November-01-Poorest And Wealthiest Counties, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Amnesty International's Empty Promises: Decriminalization, Prostituted Women, And Sex Trafficking, Darren Geist

Dignity: A Journal of Analysis of Exploitation and Violence

Through a close examination of Amnesty International’s (Amnesty) own arguments and sources, this paper demonstrates that Amnesty’s proposal to decriminalize prostitution or “sex work” will harm those it claims to help. It concludes that the best available evidence indicates that decriminalization of prostitution would: increase sex trafficking, leave prostituted women or “sex workers” more vulnerable to violence, and reduce access to healthcare, protection, and services. Prostituted women primarily enter the industry at a young age, often suffering from a history of sexual and physical abuse, coming from marginalized and vulnerable communities, and driven by emotional and economic desperation. It is …

Geochemical Comparison Of Ancient And Modern Eolian Dune Foresets Using Principal Components Analysis, David A. Little

Theses and Dissertations

Geochemistry has been used to determine the provenance and diagenetic history of eolian sandstone deposits. However, the grain size, sorting, cementation, and detrital composition of eolian units can change along dune foreset laminae. The purpose of this study was to test for consistent trends of compositional change along dune foresets. Such trends could increase the quality of geochemical sampling of eolian sandstones and possibly aid in estimating the original height of ancient sand dunes. XRF data was gathered for both major and trace elements from the Pennsylvanian to Permian Weber Sandstone, Early Jurassic Navajo Sandstone, and modern Coral Pink Sand …

The Unfinished Business Of Horne V. Department Of Agriculture, Richard A. Epstein

Articles

No abstract provided.

Transit Service Reliability: Analyzing Automatic Vehicle Location (Avl) Data For On-Time Performance And To Identify Conditions Leading To Service Degradation, Cutr

Research Reports

No abstract provided.

An Open Data Format For Visualization And Analysis Of Cross-Linked Mass Spectrometry Results., Michael R Hoopmann, Luis Mendoza, Eric W Deutsch, David Shteynberg, Robert L Moritz

Articles, Abstracts, and Reports

Protein-protein interactions are an important element in the understanding of protein function, and chemical cross-linking shotgun mass spectrometry is rapidly becoming a routine approach to identify these specific interfaces and topographical interactions. Protein cross-link data analysis is aided by dozens of algorithm choices, but hindered by a lack of a common format for representing results. Consequently, interoperability between algorithms and pipelines utilizing chemical cross-linking remains a challenge. pepXML is an open, widely-used format for representing spectral search algorithm results that has facilitated information exchange and pipeline development for typical shotgun mass spectrometry analyses. We describe an extension of this format …

Human-Associated Bacteroides Spp. And Human Polyomaviruses As Microbial Source Tracking Markers In Hawaii, Marek Kirs, Roberto A Caffaro-Filho, Mayee Wong, Valerie J. Harwood, Philip Moravcik, Roger S Fujioka

Integrative Biology Faculty and Staff Publications

Identification of sources of fecal contaminants is needed to (i) determine the health risk associated with recreational water use and (ii) implement appropriate management practices to mitigate this risk and protect the environment. This study evaluated human-associated Bacteroides spp. (HF183TaqMan) and human polyomavirus (HPyV) markers for host sensitivity and specificity using human and animal fecal samples collected in Hawaii. The decay rates of those markers and indicator bacteria were identified in marine and freshwater microcosms exposed and not exposed to sunlight, followed by field testing of the usability of the molecular markers. Both markers were strongly associated with sewage, although …

The Influence Of Exile, Sara K. Rankin

Maryland Law Review

Belonging is a fundamental human need, but human instincts are Janus-faced and equally strong is the drive to exclude. This exclusive impulse, which this Article calls “the influence of exile,” reaches beyond interpersonal dynamics when empowered groups use laws and policies to restrict marginalized groups’ access to public space. Jim Crow, Anti-Okie, and Sundown Town laws are among many notorious examples. But the influence of exile perseveres today: it has found a new incarnation in the stigmatization and spatial regulation of visible poverty, as laws that criminalize and eject visibly poor people from public space proliferate across the nation. These …

Nonmarriage, June Carbone, Naomi Cahn

Maryland Law Review

Now that the Supreme Court has reshaped the laws of marriage, attention is shifting to nonmarriage. The law no longer treats intimate couples who do not marry as either deviant or deprived. Yet, rather than regulate nonmarriage in a systematic way, the law applies two inconsistent doctrines to govern these relationships. This Article is the first to explore the fundamental contradiction in the legal approach to unmarried partners. While the laws governing financial obligations between unmarried couples are moving toward a deregulatory model that radically differs from the status-based regulation of marriage, the laws of custody and support insist on …

A Tribute To The Honorable Lynn A. Battaglia, Mary Ellen Barbera, Andrea Leahy, Thomas E. Lynch Iii, William L. Reynolds

Maryland Law Review

No abstract provided.

A Tribute To The Honorable Glenn T. Harrell, Jr., Mary Ellen Barbera, James A. Kenney Iii, Steven I. Platt, Robert A. Zarnoch

Maryland Law Review

No abstract provided.

Neurobehavioral Markers Of Resilience To Depression Amongst Adolescent Exposed To Child Abuse, Meg J. Dennison, Margaret A. Sheridan, Daniel S. Busso, Jessica L. Jenness, Matthew Peverill, Maya L. Rosen, Katie A. Mclaughlin

Neuroscience: Faculty Publications

Childhood maltreatment is strongly associated with depression, which is characterized by reduced reactivity to reward. Identifying factors that mitigate risk for depression in maltreated children is important for understanding etiological links between maltreatment and depression as well as improving early intervention and prevention. We examine whether high reward reactivity at behavioral and neurobiological levels is a marker of resilience to depressive symptomology in adolescence following childhood maltreatment. A sample of 59 adolescents (21 with a history of maltreatment; Mean Age = 16.95 years, SD = 1.44) completed an fMRI task involving passive viewing of emotional stimuli. BOLD signal changes to …

Reproductive Success Through High Pollinator Visitation Rates Despite Self Incompatibility In An Endangered Wallflower, Miranda K. Melen, Julie A. Herman, Jessica Lucas, Rachel E. O’Malley, Ingrid M. Parker, Aaron M. Thom, Justen B. Whittall

Biology

PREMISE OF THE STUDY: Self incompatibility (SI) in rare plants presents a unique challenge—SI protects plants from inbreeding depression, but requires a sufficient number of mates and xenogamous pollination. Does SI persist in an endangered polyploid? Is pollinator visitation sufficient to ensure reproductive success? Is there evidence of inbreeding/outbreeding depression? We characterized the mating system, primary pollinators, pollen limitation, and inbreeding/outbreeding depression in Erysimum teretifolium to guide conservation efforts.

METHODS: We compared seed production following self pollination and within- and between-population crosses. Pollen tubes were visualized after self pollinations and between-population pollinations. Pollen limitation was tested in the field. Pollinator …

Detritus Quality And Locality Determines Survival And Mass, But Not Export, Of Wood Frogs At Metamorphosis, Joseph R. Milanovich, Kyle Barrett, John A. Crawford

Faculty Scholarship

Single-site experiments have demonstrated detritus quality in wetlands can have strongly negative, neutral, and even positive influences on wildlife. However, an examination of the influence of detritus quality across several regions is lacking and can provide information on whether impacts from variation in detritus quality are consistent across species with wide ranges. To address this gap in regional studies we examined effects of emergent and allochthonous detritus of different nutrient qualities on amphibians and assessed a mechanism that may contribute to potential impacts. We used aquatic mesocosms to raise wood frogs (Rana sylvatica) from two regions of the United States …

Nutrinews, Volume 22, November, 2016, Department Of Nutrition And Dietetics, University Of North Florida

NutriNews

This issue features Nutrition Updates, From Jessica's Table: Fall Desserts, The benefits of dietary cinnamon for diabetics

Scholastic Minutes 11/01/2016, Scholastic Committee

Scholastic Committee

No abstract provided.

Critical Integral Contemplative Education, David Forbes

Publications and Research

Mindfulness programs in education proceed with little awareness of the cultural, social, political, and developmental context in which they operate. This chapter first argues that social critique is a valuable practice in its own right and can be useful toward developing more socially just and inclusive education mindfulness programs. It is critical of how mindfulness is practiced in schools to the extent it shares qualities of McMindfulness and reinforces neoliberal ideologies, policies, and practices. Without this critical awareness of contexts programs tend to promote individualistic solutions to social problems and inequities and thereby serve to maintain the status quo of …

Modern Politics And The Passions, David Bradshaw

Institute for the Study of Free Enterprise Working Papers

Why is our society today so sharply divided—politically, socially and morally?

Professor Bradshaw argues that the answer can be found in two of the foundational philosophers of the modern era, John Locke and Jean-Jacques Rousseau. Although they are sharply opposed in many ways, they share some common features that set the pattern for modern politics.

Full Issue, Indiana Audubon Quarterly

Indiana Audubon Quarterly

No abstract provided.

The Life And Writings Of Donald H Boyd, Jerry Thomas Boyd

Indiana Audubon Quarterly

No abstract provided.

Lgbtq Topics And Christianity In Social Work: Tackling The Tough Questions, Laura E. Kaplan, Jeanna Jacobsen, David Mccarty-Caplan

Walden Faculty and Staff Publications

In 2014 the North American Association of Christians in Social Work (NACSW) convention offered a workshop whose abstract stated coverage of controversies, ethics, governmental policies, and faith related to reparative therapy. In this workshop, presenters expressed support for using reparative therapy at clients’ requests. In response to this, a member of the Caucus of LGBT Faculty and Doctoral Students in Social Work (LGBT Caucus) organized a letter with over 120 social work faculty and practitioner signatures and submitted it to NACSW expressing concern that reparative/conversion therapy was offered as a viable mental health treatment at a professional social work conference, …

A Case Study Of Upper Limb Joint Torques In An Elite Male Tenpin Bowler, R. Razman, J.P.G. Cheong

Research Publications (2016 to 2020)

In general, tenpin bowling is not considered to be a highly physical sport and is regarded to present minimal injury risks. The arm swing which is an integral part of delivery was assumed to be gravity driven. This study aimed to investigate whether the bowling arm generated torque, and if so, what is the magnitude at each related joint. A high ranked national male bowler volunteered to participate in the study. To calcu-late torque values at the shoulder, elbow and wrist joint of the bowling arm, kinematic data was derived from 3D motion capture and was combined with measured anthropometric …