Digital Commons Network^™

The Pten Phosphatase Functions Cooperatively With The Fanconi Anemia Proteins In Dna Crosslink Repair, Elizabeth A. Vuono, Ananda Mukherjee, David A. Vierra, Morganne M. Adroved, Charlotte Hodson, Andrew J. Deans, Niall G. Howlett

Cell and Molecular Biology Faculty Publications

Fanconi anemia (FA) is a genetic disease characterized by bone marrow failure and increased cancer risk. The FA proteins function primarily in DNA interstrand crosslink (ICL) repair. Here, we have examined the role of the PTEN phosphatase in this process. We have established that PTEN-deficient cells, like FA cells, exhibit increased cytotoxicity, chromosome structural aberrations, and error-prone mutagenic DNA repair following exposure to ICL-inducing agents. The increased ICL sensitivity of PTEN-deficient cells is caused, in part, by elevated PLK1 kinase-mediated phosphorylation of FANCM, constitutive FANCM polyubiquitination and degradation, and the consequent inefficient assembly of the FA core complex, FANCD2, and …

November 7th 2016, Csusb

Coyote Chronicle (1984-)

Not an adult
While one is legally an adult at 18, some believe the age should be raised. p.5

Coyote approved
"Inferno" impressive viewers by staying true to the book.

Commentary: The Spinal Cord Has An Intrinsic System For The Control Of Ph, Joseph M. Santin, Tobias Wang, Saihari S. Dukkipati, Lynn K. Hartzler

Biological Sciences Faculty Publications

Most physiological processes are sensitive to pH (i.e., hydrogen ion activity) and regulation of pH within tissues and body fluids represents a fundamental homeostatic process in living organisms. At the organismal level, acid-base balance is achieved by fast respiratory modulations of the partial pressure of CO2 in combination with slower transepithelial ion movements to accommodate excretion and retention of bicarbonate and protons in response to acid-base disturbances. At the cellular and subcellular levels, acid-base balance is achieved by ion exchange.

Effects Of Anchor Structure And Glycosylation Of Fcî³ Receptor Iii On Ligand Binding Affinity, Ning Jiang, Wei Chen, Prithiviraj Jothikumar, Jaina M. Patel, Rangaiah Shashidharamurthy, Periasamy Selvaraj, Cheng Zhu

PCOM Scholarly Works

Isoforms of the Fcγ receptor III (FcγRIII or CD16) are cell surface receptors for the Fc portion of IgG and important regulators of humoral immune responses. Different ligand binding kinetics of FcγRIII isoforms are obtained in three dimensions by surface plasmon resonance and in two dimensions by a micropipette adhesion frequency assay. We show that the anchor structure of CD16 isoforms isolated from the cell membrane affects their binding affinities in a ligand-specific manner. Changing the receptor anchor structure from full to partial to none decreases the ligand binding affinity for human IgG1 (hIgG1) but increases it for murine IgG2a …

Replicated Risk Nicotinic Cholinergic Receptor Genes For Nicotine Dependence, Lingjun Zuo, Rolando Garcia-Milian, Xiaoyun Guo, Chunlong Zhong, Yunlong Tan, Zhiren Wang, Jijun Wang, Xiaoping Wang, Longli Kang, Lu Lu, Xiangning Chen, Chiang-Shan R. Li, Xingguang Luo

Psychology Faculty Research

It has been hypothesized that the nicotinic acetylcholine receptors (nAChRs) play important roles in nicotine dependence (ND) and influence the number of cigarettes smoked per day (CPD) in smokers. We compiled the associations between nicotinic cholinergic receptor genes (CHRNs) and ND/CPD that were replicated across different studies, reviewed the expression of these risk genes in human/mouse brains, and verified their expression using independent samples of both human and mouse brains. The potential functions of the replicated risk variants were examined using cis-eQTL analysis or predicted using a series of bioinformatics analyses. We found replicated and significant associations for ND/CPD at …

How Nurses Perceive The Impact Of Health It Applications On Their Performance And Satisfaction: Examining The Organizational, Social, And Personal Factors, Sadaf Ashtari

Master's Theses and Doctoral Dissertations

Applying information technology tools in the healthcare industry is an appropriate solution to integrate and record medical data and provide complete access of patients’ information. However, the effectiveness of these technologies depends on their successful implementation and adaptation. This study addresses the impact of result observability, autonomy, perceived barriers, task structure, privacy and security anxiety, and communication (social) patterns on the perception of the performance and satisfaction of nurses using IT applications in healthcare. Furthermore, the effects of nurses’ years of experience, age, different hospitals, different electronic medical records (EMR) applications, and personality factors are examined as a moderator factors …

State V. Anderson Respondent's Brief Dckt. 43673

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Simulation Of Value Stream Mapping And Discrete Optimization Of Energy Consumption In Modular Construction, Md Mukul Chowdhury

Theses and Dissertations

With the increased practice of modularization and prefabrication, the construction industry gained the benefits of quality management, improved completion time, reduced site disruption and vehicular traffic, and improved overall safety and security. Whereas industrialized construction methods, such as modular and manufactured buildings, have evolved over decades, core techniques used in prefabrication plants vary only slightly from those employed in traditional site-built construction. With a focus on energy and cost efficient modular construction, this research presents the development of a simulation, measurement and optimization system for energy consumption in the manufacturing process of modular construction. The system is based on Lean …

Celecoxib Inhibits Proliferation And Survival Of Chronic Myelogeous Leukemia (Cml) Cells Via Ampk-Dependent Regulation Of Β-Catenin And Mtorc1/2., Beatrice Riva, Marco De Dominici, Ilaria Gnemmi, Samanta A. Mariani, Alberto Minassi, Valentina Minieri, Paolo Salomoni, Pier Luigi Canonico, Armando A Genazzani, Bruno Calabretta, Fabrizio Condorelli

Kimmel Cancer Center Papers, Presentations, and Grand Rounds

CML is effectively treated with tyrosine kinase inhibitors (TKIs). However, the efficacy of these drugs is confined to the chronic phase of the disease and development of resistance to TKIs remains a pressing issue. The anti-inflammatory COX2 inhibitor celecoxib has been utilized as anti-tumour drug due to its anti-proliferative activity. However, its effects in hematological malignancies, in particular CML, have not been investigated yet. Thus, we tested biological effects and mechanisms of action of celecoxib in Philadelphia-positive (Ph+) CML and ALL cells.We show here that celecoxib suppresses the growth of Ph+ cell lines by increasing G1-phase and apoptotic cells and …

Effects Of Health Qigong Exercises On Relieving Symptoms Of Parkinson's Disease, Xiao L. Liu, Shihui Chen, Yongtai Wang

Nursing Faculty Publications and Presentations

The purpose of this study was to investigate the effects of Health Qigong on the treatment and releasing symptoms of Parkinson's disease (PD). Fifty-four moderate PD patients (N = 54) were randomly divided into experimental and control groups. Twenty-eight PD patients were placed in the experimental group in which the prescribed medication plus Health Qigong exercise will be used as intervention. The other 26 PD patients as the control group were treated only with regular medication. Ten-week intervention had been conducted for the study, and participants completed the scheduled exercises 5 times per week for 60 minutes each time (10 …

Bjc Today

BJC Today

No abstract provided.

Ohio University Faculty Senate Minutes November 7, 2016, Ohio University Faculty Senate

Faculty Senate Minutes

No abstract provided.

Assessment Of Motivational Cognitions In Diabetes Self-Care: The Motivation Thought Frequency Scales For Glucose Testing, Physical Activity And Healthy Eating, Sophie C. Parham, David Kavanagh, C Gericke, N King, Jon May, Jackie Andrade

School of Psychology

PurposeThere is a need for improved measurement of motivation for diabetes self-care. The Elaborated Intrusion Theory of Desire offers a coherent framework for understanding and identifying the cognitive-affective events that constitute the subjective experience of motivation and may therefore inform the development of such an instrument. Recent research has shown the resultant Motivation Thought Frequency scale (MTF) to have a stable factor structure (Intensity, Incentives Imagery, Self-Efficacy Imagery, Availability) when applied to physical activity, excessive snacking or alcohol use in the general population. The current study aimed to confirm the four-factor structure of the MTF for glucose testing, physical activity …

Evaluating The Impact Of Serious Games: The Effect Of Gaming On Entrepreneurial Intent, Robert Newbery, Jonathan Lean, Jonathan Moizer

Plymouth Business School

Purpose - Serious games are playing an increasingly significant role across a range of educational contexts. Business focused serious games can provide students with an authentic learning experience and their use has been increasingly taken up by business school faculty, including those delivering entrepreneurship education. This paper seeks to evaluate the impact of participation in a serious business game on the Entrepreneurial Intent of undergraduate students. Design/methodology/approach - The study adopts a pre-test / post-test quasi-experimental design. It employs a modified version of Linan et al.’s (2011) Entrepreneurial Intent model in the form of a questionnaire survey completed by 263 …

Multi-Omics Analysis Reveals Molecular Mechanisms Of Shoot Adaption To Salt Stress In Tibetan Wild Barley, Qiufang Shen, Liangbo Fu, Fei Dai, Lixi Jiang, Guoping Zhang, Dezhi Wu

Publications

BACKGROUND: Tibetan wild barley (Hordeum spontaneum L.) has been confirmed to contain elite accessions in tolerance to abiotic stresses, including salinity. However, molecular mechanisms underlying genotypic difference of salt tolerance in wild barley are unknown. RESULTS: In this study, two Tibetan wild barley accessions (XZ26 and XZ169), differing greatly in salt tolerance, were used to determine changes of ionomic, metabolomic and proteomic profiles in the shoots exposed to salt stress at seedling stage. Compared with XZ169, XZ26 showed better shoot growth and less Na accumulation after 7 days treatments. Salt stress caused significant reduction in concentrations of sucrose and metabolites …

A Comparison Of The Immediate Effects Of Muscle Energy Technique And Joint Mobilizations On Posterior Shoulder Tightness In Youth Throwing Athletes, Maddox L. Reed

Theses and Dissertations

Background: Due to the extreme forces on the glenohumeral (GH) joint during the throwing motion, and the high number of repetitions that occur during overhead sports, alterations in range of motion are a common occurrence in overhead athletes, particularly baseball and softball players. The presence of limited GH motion that occurs as a result of posterior shoulder tightness can increase the risk of injury. Despite clinical evidence pointing to the use of joint mobilizations and muscle energy technique (MET) for the treatment of various pathologies, there currently is no data examining comparing the overall effectiveness of joint mobilizations and MET …

Week Of November 7, 2016, New York Medical College

InTouch

• It's Official: NYMC SOM Receives Full Eight-Year LCME Re-Accreditation
• White Coat Ceremony Marks Milestone for Class of 2020
• NYMC Honored at Doctors of Distinction Awards Ceremony
• Speed Dating for Research
• The Homecoming of Charles Henry Miller, M.D. (NYHMC Class of 1863)
• StuHE Makes Strides Against Breast Cancer

Faculty Senate Agenda, November 7, 2016, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• EPC Items (October) & Annual Report
• Athletics Council
• Faculty Evaluation Committee
• 402.12 Senate Standing Committees (First Reading)
• Election of Honorary Degree and Awards Committee Member

My News

My News (2014-2020)

• Homecoming 2016 kicks off today
• Georgia Southern mobilized resources to help those affected by Hurricane Matthew
• Holiday Helper Tree officially opens
• Don’t get ticketed on Homecoming Game Day!
• An eagle-­eyed look at this election season

(In)Equitable Subrogation: The Federal Circuit’S Irrational And Unworkable Progress Payment Framework In Balboa, Will F. Hawkins

Duke Law Journal

American taxpayers spend more than $100 billion per year on federal construction projects. Yet massive construction delays, huge budget overruns, and unorganized contractors increase the cost of construction for the federal government. Passed in 1935, the Miller Act attempted to protect the federal government in the event that the contractor defaulted or was unable to complete the project. By requiring contractors to enlist third party “sureties” as guarantors on projects, the Miller Act provides the government with the assurance that another party will step in to complete projects if need be. Contractors are typically paid via periodic progress payments, with …

A Validation Of The Efficacy Of Descriptive Instrumental Collective Case Study Research Methodology For Examining Pilot Cognitive Functioning, Clint R. Balog

International Journal of Aviation, Aeronautics, and Aerospace

The research conducted developed a descriptive understanding of how the cognitive processes of risk assessment, problem solving, and decision making, as well as other supportive processes, are employed by pilots-in-command (PICs) during the experience of extended, extreme, in-flight emergencies. This understanding is then applied to similar dynamic, operational environments. The research also validated the applicability and efficacy of Robert Stake’s 1995 descriptive, instrumental, collective case study methodology as a tool for investigating such phenomenon and developing such an understanding. Specifically, the research details the necessary procedures for employing this methodology successfully, and provides example of those procedures, and their results, …

Stress Coping Strategies In Indian Military Pilots-Preliminary Observations, Catherine Joseph

International Journal of Aviation, Aeronautics, and Aerospace

ABSTRACT

In aviators, stress coping has been linked to flying performance and has a bearing on flight safety and mission effectiveness. The objective of this research was to study coping strategies utilized by Indian military pilots. A sample of 160 military pilots was asked to complete a demographic data sheet and the Stress Coping Checklist. Preliminary findings suggest that, Indian pilots use flexible problem and emotion focussed coping strategies. This issue needs to be taken into account in both occupational and clinical realms of future research investigations on aviators.

2016-11-03 Newsletter, Morehead State University. Staff Congress.

Staff Congress Records

Staff Congress newsletter for November 7, 2016.

Lanthorn, Vol. 51, No. 22, November 7, 2016, Grand Valley State University

Volume 51, July 11, 2016 - June 5, 2017

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Exploratory Study Into The Awareness Of Heart Diseases Among Emirati Women (Uae) And Their Health Seeking Behaviour- A Qualitative Study, Sarah Khan, Ayesha Khoory, Dhabia Al Zaffin, Meera Al Suwaidi

All Works

© 2016 The Author(s). Background: Cardiovascular diseases were the leading cause of death in women in the United Arab Emirates (UAE) in 2010. The UAE is expected to experience a tripling of heart diseases in the next two decades as risk factors for heart diseases increase. Research shows that first year survival rates of younger women suffering from a heart attack are lower than in men. Women present with a wider range of symptoms for heart diseases than men; non-recognition of atypical symptoms may explain the delay in seeking treatment and poor prognosis following heart diseases in women. No known …

Adsorptive And Kinetic Characterization Of Aqueous Zinc Removal By Biochars, Sergio Mireles, Yongsik Ok, Chu-Lin Cheng, James Jihoon Kang

School of Earth, Environmental, & Marine Sciences Faculty Publications

Biochars have shown a great potential to treat stormwater runoff contaminated with heavy metals due to their favorable physical and chemical characteristics. Biochar materials were produced from pyrolysis of oak tree and wood at 400C and 450C respectively, and their Zn adsorption behavior from aqueous solutions were evaluated to assess their applicability as a filter media for stormwater treatment. Two adsorption isotherm models, Freundlich and Langmuir, were used to fit the batch-scale experimental data. The kinetics of Zn adsorption was investigated under two contrasting physical condition (stagnant vs. agitated). The adsorption isotherm was better fitted with the Langmuir model (R2 …

A Measurement System For Science And Engineering Research Center Performance Evaluation, Elizabeth Carole Gibson

Dissertations and Theses

This research provides performance metrics for cooperative research centers that enhance translational research formed by the partnership of government, industry and academia. Centers are part of complex ecosystems that vary greatly in the type of science conducted, organizational structures and expected outcomes. The ability to realize their objectives depends on transparent measurement systems to assist in decision making in research translation.

A generalizable, hierarchical decision model that uses both quantitative and qualitative metrics is developed based upon program goals. Mission-oriented metrics are used to compare the effectiveness of the cooperative research centers through case studies.

The US National Science Foundation …

A Community Engaged Approach To Address Intimate Partner Violence Among Sexual Minority Women, Rachel Marie Smith

Dissertations and Theses

In response to a dearth of empirical literature concerning the mechanisms underlying female same-sex intimate partner violence (FSSIPV) perpetration, the purpose of this research is to inform intimate partner violence intervention and prevention strategies specific to sexual minority women. The research responds in particular, this research aims to inform a working intersectional model predicting FSSIPV perpetration, and to evaluate the face validity and construct coverage of existing survey measures related to gender, minority stress, and violence. Fourteen lesbian, gay, bisexual, transgender, and queer women recruited from the greater Portland, Oregon area participated in a series of in-depth, semi-structured, open-ended one-on-one …

Cd99 Triggering Induces Methuosis Of Ewing Sarcoma Cells Through Igf-1r/Ras/Rac1 Signaling., Maria Cristina Manara, Mario Terracciano, Caterina Mancarella, Marika Sciandra, Clara Guerzoni, Michela Pasello, Andrea Grilli, Nicoletta Zini, Piero Picci, Mario P. Colombo, Andrea Morrione, Katia Scotlandi

Department of Urology Faculty Papers

CD99 is a cell surface molecule that has emerged as a novel target for Ewing sarcoma (EWS), an aggressive pediatric bone cancer. This report provides the first evidence of methuosis in EWS, a non-apoptotic form of cell death induced by an antibody directed against the CD99 molecule. Upon mAb triggering, CD99 induces an IGF-1R/RAS/Rac1 complex, which is internalized into RAB5-positive endocytic vacuoles. This complex is then dissociated, with the IGF-1R recycling to the cell membrane while CD99 and RAS/Rac1 are sorted into immature LAMP-1-positive vacuoles, whose excessive accumulation provokes methuosis. This process, which is not detected in CD99-expressing normal mesenchymal …

Cardiovascular Disease Risk Factors And Left Ventricular Hypertrophy In Girls And Boys With Ckd., Rebecca L. Ruebner, Derek Ng, Mark Mitsnefes, Bethany J. Foster, Kevin Meyers, Bradley A. Warady, Susan L. Furth

Manuscripts, Articles, Book Chapters and Other Papers

Background and objectives: Prior studies suggested that women with CKD have higher risk for cardiovascular disease (CVD) and mortality than men, although putative mechanisms for this higher risk have not been identified. We assessed sex differences in (1) CVD risk factors and left ventricular hypertrophy (LVH), and (2) the relationship of left ventricular mass (LVM) with different measures of body size in children with CKD.

Design, setting, participants, and measurements: The study population comprised 681 children with CKD from the Chronic Kidney Disease in Children cohort, contributing 1330 visits. CVD risk factors were compared cross-sectionally by sex. LVH was defined …